Antibactérien

<p>Antimicrobial agent-11 is a SARS-CoV-2 inhibitor with antibacterial activity [1] .</p>

<p>Mtb-IN-10 (Compound P15) is an Rv1625c/Cya activator that influences the growth of Mycobacterium tuberculosis (Mtb) by modulating cAMP metabolism. It demonstrates an anti-tuberculosis activity with an EC50 of 1.96 µM in Mtb-infected macrophage models and achieves an oral bioavailability of 58.0% when administered orally to mice at 20 mg/kg. Mtb-IN-10 potentially regulates intracellular signaling and disrupts cholesterol metabolism within Mtb, thereby inhibiting bacterial proliferation. It holds promise for tuberculosis (TB) research, particularly targeting multidrug-resistant (MDR-TB) and extensively drug-resistant (XDR-TB) strains of Mtb.</p>

<p>QST4 possessed antitubercular and antifungal activities with a MIC value of 6.25 μM in Mycobacterium tuberculosis Mycobacterium tuberculosis H37Rv.</p>

<p>KT5823 is a cGMP-dependent protein kinase (PKG) inhibitor that increases iodide ion uptake by regulating the expression of sodium iodide symporter protein.</p>

<p>Ascr#18: nematode hormone boosts infection resistance in plants like Arabidopsis, tomato, potato, barley.</p>

<p>FLGFVGQALNALLGKL-NH2, an antimicrobial peptide derived from frogs, exhibits activity against Staphylococcus aureus ATCC 29213 with a minimum inhibitory</p>

<p>Chrysomycin B is an antibiotic isolated from Streptomyces sp.</p>

<p>Cephamycin C (CepC) is a nontoxic β-lactam antibiotic. CepC stands out from other cephalosporins for its greater resistance to β-lactamases.</p>

<p>RvD4, derived from docosahexaenoic acid, reduces neutrophil infiltration and promotes phagocytosis/clearance by human cells.</p>

<p>ONX-0914 (PR-957) TFA is a selective LMP7 inhibitor, blocking cytokines and arthritis progression, and reactivates HIV-1.</p>

<p>Batzelladine D inhibits Pdr5p, with IC50 of 7.1 µM, and exhibits antifungal, antiparasitic, antiviral, antibacterial, and antitumor properties.</p>

<p>BAL30072: Antibiotic effective against MDR Acinetobacter (4 μg/mL) and P. aeruginosa (8 μg/mL); a monocyclic beta-lactam.</p>

<p>Pyrindamycin B is an antibiotic,and actives against gram-positive and gram-negative bacterias</p>

<p>EBL-3183 is a reversible, competitive indole-2-carboxylate NDM-1 inhibitor with a pIC50 of 7.7, targeting metallo-β-lactamases.</p>

<p>MMV1578877 is an inhibitor of Mycobacterium ulcerans with an IC50 of 0.37 μM. It is applicable in research related to Buruli ulcer (BU).</p>

<p>Ansatrienin B: antibiotic, antifungal, inhibits PTH-induced calcium release and protein synthesis, enhances certain chemotherapies.</p>

<p>Antibacterial agent 153 is a broad-spectrum agent that eradicates bacteria by targeting their cell membranes and is employed in research on bacterial infections</p>

<p>dmDNA31: a rifamycin antibiotic, inhibits bacterial RNA polymerase, strongly kills Staphylococcus aureus.</p>

<p>Actinorhodin is a blue pigment and a redox-active microbial secondary metabolite. It is a potent, antibacterial, pH-responsive antibiotic (antibiotic) exhibiting antimicrobial activity against Gram-positive bacteria.</p>

<p>Monactin is a Marcrotetrolide antibiotic produced by cycloheximide producing species of Streptomyces. It is a homolog of nonactin from the same species.</p>

<p>Spiramycin III is an antibiotic within the erythromycin/carbomycin group of compounds.</p>

<p>Eremomycin, an antibiotic, can be used intramuscularly due to low toxicity.</p>

<p>DprE1-IN-5 (Compound 10), a potent DprE1 inhibitor, exhibits anti-TB activity with an MIC of 4 μM against the Mtb H37Rv strain and demonstrates</p>

<p>Psoracorylifol C is a useful organic compound for research related to life sciences and the catalog number is T124015.</p>

<p>Antibacterial agent 142, an aromatic hydrazide, exhibits bacteriostatic antibacterial activity and inhibits biofilm formation [1].</p>

<p>Blasticidin A, from S. resistomycificus, inhibits A. parasiticus aflatoxin (IC50s: 0.25 μM) but not growth; also halts protein synthesis in S. cerevisiae.</p>

<p>Cefetamet is a potent antibiotic to treat respiratory and urinary tract infections.</p>

<p>Arginomycin is a nucleoside antibiotic (antibiotic) that inhibits the growth of Gram-positive bacteria and fungi in vitro.</p>

<p>Antibiotic LB 10517 is a catechol-substituted cephalosporin with a broad spectrum of antibacterial.</p>

<p>A 201A is a nucleoside antibiotic, it is isolated from Streptomyces capreolus.</p>

<p>Antibacterial agent 32 fights E. coli (NCTC 13351, M 50, 7 MP) with MICs: 1, 2, 8 mcg/mL.</p>

<p>KPC-IN-1 (compound 1e) is an inhibitor of Klebsiella pneumoniae carbapenemase KPC-2, with an IC50 value of 8.3 nM. KPC is a β-lactamase expressed in Gram-negative bacteria that hydrolyzes carbapenems, leading to significant bacterial resistance to carbapenem antibiotics.</p>

<p>nTZDpa is an antibiotic with antimicrobial activity.</p>

<p>LL-37 scrambled peptide acetate is a scrambled peptide of LL-37 and is often used as a negative control for LL-37 peptide.</p>

<p>Elf18 is an N-terminal segment of the bacterial elongation factor Tu. In Arabidopsis, it acts as a pathogen-associated molecular pattern (PAMP) recognized by pattern recognition receptors (PRR), thereby triggering an immune response.</p>

<p>Cervinomycin A2 is an antibiotic effective against anaerobic bacteria, isolated from the Streptomyces genus, specifically Cervinomycetes. It exhibits strong inhibitory effects on Clostridium perfringens, Peptostreptococcus, and Bacteroides fragilis.</p>

<p>Macropin (MAC-1 peptide) is an antimicrobial peptide found in the venom of the solitary bee Macropis fulvipes. It exhibits antibacterial properties against both Gram-positive and Gram-negative bacteria, demonstrates inhibitory effects on fungi, and possesses moderate hemolytic activity on human red blood cells. Macropin is utilized in research for anti-infective therapies.</p>

<p>Somantadine has antiviral activities and can be used for research on preventing and treating coronavirus-related diseases.</p>

<p>Antimicrobial agent-36 (Compound 8b) is an antimicrobial compound that significantly inhibits DNA gyrase with an IC50 value of 4.56 µM. It is also utilized in the preparation of nanoparticle drug formulations and can be employed in the research and development of new antibiotics.</p>

<p>Antibacterialagent 274 (Compound 18b) is an antibacterial agent that targets bacterial cell membranes, exhibiting a minimum inhibitory concentration (MIC) of 8 μg/mL against Acinetobacter baumannii ATCC 17978. It functions by disrupting membrane integrity, causing intracellular accumulation of ROS, which leads to DNA and protein leakage, thereby exerting its antibacterial effects. Antibacterialagent 274 is applicable in research on infections caused by Gram-negative bacteria.</p>

<p>DNA gyrase B-IN-2 (Compound E), a 2-aminobenzothiazole derivative, serves as a potent inhibitor of DNA gyrase B with substantial efficacy against ESKAPE</p>

<p>Isodihydroauroglaucin is a useful organic compound for research related to life sciences. The catalog number is T124274 and the CAS number is 74886-31-0.</p>

<p>Apigravin, a potent antibacterial compound, demonstrates activity against Bacillus subtilis, exhibiting a minimum inhibitory concentration (MIC) value of 61 μM</p>

<p>Antibacterial agent 31 exhibits (shows) efficacy (activity) in combating (against) rice bacterial leaf streak.</p>

<p>Antibacterial agent 59 (example 24) is a antibacterial agent.</p>

<p>Tirandamycin A is a useful organic compound for research related to life sciences and the catalog number is T124996.</p>

<p>3-Phenyl-1H-indole has antibacterial activity and can inhibit Klebsiella pneumoniae, Escherichia coli, Candida albicans, Staphylococcus aureus, etc.</p>

<p>Calpinactam, from M. alpina, fights M. smegmatis (MIC 0.78 μg/ml), boosts silkworm survival, but ineffective against 13 other species.</p>

<p>Compound Fr13643, with CAS No. 622-62-8, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound Fr13643 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.</p>

<p>Antitubercular agent-35 (42l) inhibits Mtb H37Rv (MIC 90=1.25 μg/mL) and M. Marinum (MIC 90=2 μg/mL), resists liver degradation, for TB research.</p>

<p>Antimicrobial Agent-10 demonstrates exceptional antibacterial activity and inhibits SARS-CoV-2, positioning it as a potent antimicrobial compound [1].</p>

<p>Crabrolin is a 13-peptide that can be extracted from the venom of the European hornet (Vespa crabro). Its minimum inhibitory concentration/minimum bactericidal concentration (MIC/MBC) values against Staphylococcus aureus (S. aureus) (NCTC 10788), methicillin-resistant Staphylococcus aureus (MRSA) (NCTC 12493), and Enterococcus faecium (E. faecium) (NTCC 12697) are 2/2, 16/64, and 4/8 μM, respectively.</p>

<p>Ibezapolstat hydrochloride is an antibacterial agent.</p>

<p>Razupenem (SMP-601, PTZ601), a broad-spectrum injectable carbapenem, counters antibiotic-resistant bacteria.</p>

<p>Compound 1h (Antibacterial agent 108) is a potent antibacterial agent, demonstrating a minimum inhibitory concentration (MIC) of 3 μM against both MRSA and</p>

<p>Clovibactin, a novel antibiotic, effectively eradicates drug-resistant bacterial pathogens and demonstrates no discernible resistance.</p>

<p>Penicillin V: orally active antibiotic against Streptococci, C. difficile, and S. aureus; treats otitis, sinusitis, pharyngitis, tonsillitis.</p>

<p>Valclavam is a biochemical.</p>

<p>Amino acids 17-41 of lactoferrin, lactoferricin B, enhance anti-fungal effects, targeting Candida Albicans.</p>

<p>DprE1-IN-13 (Compound 42) is an inhibitor of decaprenyl-phosphoryl-β-d-ribose oxidase (DprE1) with an IC50 value of 12.72 μM. It effectively inhibits Mycobacterium tuberculosis H37Ra, with a MIC50 of 1.071 μM.</p>

<p>Kalimantacin A: a potent antibiotic effective against MRSA and other staphylococci.</p>

<p>Ro 24-6778 is a dual action cephalosporin with antimicrobial activity.</p>

<p>Deethylindanomycin, a polyether antibiotic from S. setonii, combats Gram-positive bacteria and in vitro coccidia; ionophore selective for K+ ions.</p>

<p>Saccharocarcin A, an antibiotic from S. aerocolonigenes, combats various bacteria and inhibits C. trachomatis at 0.5 μg/ml, non-toxic to McCoy cells.</p>

<p>Temocillin, a semi-synthetic 6-alpha-methoxy penicillin, targets aerobic Gram-negative bacteria.</p>

<p>Repromicin is a chemical compound whose derivatives have strong antibacterial characteristics.</p>

<p>7-Oxoganoderic acid Z is a useful organic compound for research related to life sciences. The catalog number is T123920 and the CAS number is 929248-72-6.</p>

<p>Vecantoxatug is a humanized monoclonal antibody designed to target Clostridium tetani toxin (TeNT, a neurotoxin). It specifically binds to the tetanus toxin, preventing the toxin from interacting with cell receptors and thus exhibits antitoxin activity. Vecantoxatug holds potential for tetanus research.</p>

<p>NagZ-IN-1 (Compound 11h) is a β-N-acetylglucosaminidase inhibitor with a Ki of 3.3 μM. It is applicable in antibacterial research, especially for studies related to Pseudomonas aeruginosa infections.</p>

<p>"Ribostamycin (Vistamycin) is a broad-spectrum antibiotic, effective against many bacteria and inhibits PDI."</p>

<p>Oral nitroimidazole antibiotic; treats anaerobic infections; may cause inflammation and muscle contractions with long-term use.</p>

<p>IPMCL-28b is an antimicrobial agent targeting bacterial cell membranes, with a minimum inhibitory concentration (MIC) of 1.56 μg/mL for Staphylococcus aureus ATCC 25923 and an MIC of 6.25 μg/mL for methicillin-resistant Staphylococcus aureus (MRSA). IPMCL-28b shows potential for research in the field of infection control.</p>

<p>Ambazone hydrate has anti-cancer activity.</p>

<p>AVX 13616: potent antibacterial vs. drug-resistant Staph, similar to mupirocin with single-use efficiency. MIC: 2-4 ug/ml. Targets various staph, MRSA.</p>

<p>Antifungalagent 123 (Compound 4b) demonstrates strong affinity for the oxidoreductase of Staphylococcus aureus or membrane proteins of Candida albicans, exhibiting both antibacterial and antifungal properties. Additionally, it is capable of scavenging free radicals, showcasing antioxidant effects. Antifungalagent 123 also inhibits the TLR signaling pathway and possesses anti-inflammatory activity.</p>

<p>HBA(111-142), a C-terminal 32-mer fragment of alpha-hemoglobin, exhibits antibacterial activity against the ESKAPE panel of pathogens, forms amyloid fibrils,</p>

<p>Aurein 2.4, an antibiotic antimicrobial peptide, exhibits activity against Gram-positive bacteria [1] [2].</p>

<p>Sitafloxacin (DU6859a) is a potent fluoroquinolone, effective against a wide spectrum of bacteria and used for respiratory and urinary infections.</p>

<p>BMS 180680 is a novel catechol-containing monolactam antibacterial active agent, which is the most effective compound against many species of Enterobacteriaceae</p>

<p>Adenoregulin (Dermaseptin b2), an antimicrobial peptide antibiotic, exhibits efficacy against both Gram-negative and Gram-positive bacteria, as well as yeast</p>

<p>Antimicrobial-IN-1 (compound 17) demonstrates potent antibacterial activity against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), exhibiting inhibition zone diameters of 18 mm/mg and 16 mm/mg, respectively.</p>

<p>Menaquinone 6, an active product found in *Wolinella succinogenes*, is a form of vitamin K2 with antimicrobial activity [1].</p>

<p>Hc-CATH (Sea snake cathelicidin) is a broad-spectrum antibacterial peptide effective against Shigella dysenteriae and Klebsiella pneumoniae, with MIC values ranging from 0.16 to 20.67 mM. Additionally, Hc-CATH demonstrates anti-inflammatory efficacy.</p>

<p>Cefalexin lysine is a derivative of Cefalexin which is an antibiotic.</p>

<p>Fuscin, a quinonoid from O. fuscum, inhibits ADP/ATP translocase, depletes glutathione, disrupts NADH oxidation, and blocks MIP-1α/CCR5 binding (IC50: 21µM).</p>

<p>Cephaloridine hydrate, a broad-spectrum antibacterial antibiotic, exhibits dose-related nephrotoxicity [1] [2].</p>

<p>Bio-AMS (TFA) inhibits bacterial biotin protein ligase, targets M. tuberculosis, and stops fatty acid/lipid synthesis.</p>

<p>Oxytetracycline calcium is a tetracycline antibiotic effective against Gram-negative and Gram-positive bacteria, inhibits protein synthesis, and fights HSV-1.</p>

<p>Diaporthein B, a potent pimarane diterpene, inhibits M. tuberculosis (MIC: 3.1 μg/mL) and combats colon cancer cells (IC50: 1.5-3 μM/L).</p>

<p>Angustifoline HCl, from Lupinus angustifolius, has antimicrobial effects on S. aureus, B. subtilis, E. coli, P. aeruginosa, B. thuringiensis.</p>

<p>Kyotorphin is a Morphine-like dipeptide.</p>

<p>Erythromycin aspartate is a enzyme.</p>

<p>Emeguisin A, a depsidone from E. unguis, fights S. aureus, MRSA, C. neoformans (MIC 0.5 μg/ml), and P. falciparum (IC50 2.2 μM).</p>

<p>Arisostatin B is a tetracycline antibiotic (antibiotic) with activity against Gram-positive bacteria and tumor cells.</p>

<p>Potassium clavulanate cellulose is a mixture of potassium clavulanate and cellulose, is an inhibitor of beta-lactamase.</p>

<p>Demethyl linezolid, an impurity in linezolid (WO199500721A1, ex. 9), has antimicrobial effects on human and veterinary pathogens.</p>

<p>Furazolidone (Furoxone), a nitrofuran derivative, inhibits AML1-ETO transformed cells with IC50 value of 12.7 μM.</p>

<p>Mycobacterium Tuberculosis-IN-8 (Compound 6g) is a selective inhibitor of Mycobacterium tuberculosis (MTB), with a MIC value of 6.25 µg/mL against MTB H37Rv. It demonstrates potent antitubercular activity by inhibiting mycolic acid biosynthesis, which is crucial for maintaining bacterial cell wall integrity. Mycobacterium Tuberculosis-IN-8 holds potential for research in antitubercular agents.</p>

<p>Amycolatopsin A, a macrolide from Amycolatopsis, fights M. bovis/tuberculosis and some cancers, not effective on common bacteria.</p>

<p>DprE1-IN-7 (Compound 64) is a DprE1 inhibitor with potent anti-tuberculosis (TB) activity, demonstrating a minimum inhibitory concentration (MIC) of 1 μM</p>

<p>MraY-IN-1 (compound 12a) is a potent inhibitor of MraY, exhibiting an IC50 of 140 µM.</p>

<p>4-Methoxycoumarine has antitumour effects.</p>

<p>Antibacterial agent 55 (example 21) is a antibacterial agent.</p>

<p>K 41 is a polycyclic polyether antibiotic from Streptomyces hygroscopicus.</p>

<p>Dapdiamide A is an antibiotic identified in the Pantoea agglomerans CU0119 strain, displaying antibacterial activity and offering potential for research in anti-infective treatments.</p>

<p>Lymecycline is a semisynthetic antibiotic. It is related to TETRACYCLINE.</p>

<p>Tur1A, an antimicrobial peptide sourced from the bottlenose dolphin (Tursiops truncates), impedes bacterial protein synthesis.</p>