gsk-3
Les inhibiteurs de la GSK-3 sont des composés qui ciblent la Glycogène Synthase Kinase 3 (GSK-3), une enzyme impliquée dans de nombreux processus cellulaires, y compris le métabolisme du glycogène, la transcription génique et la prolifération cellulaire. La GSK-3 est impliquée dans diverses maladies, telles que le diabète, les troubles neurodégénératifs et le cancer. Les inhibiteurs de la GSK-3 sont des outils importants pour explorer ces voies et développer des thérapies potentielles. Chez CymitQuimica, nous fournissons des inhibiteurs de la GSK-3 pour soutenir vos recherches sur les maladies métaboliques, la neurobiologie et l'oncologie.
112 produits trouvés pour "gsk-3"
Trier par
Degré de pureté (%)
0
100
|
0
|
50
|
90
|
95
|
100
Indazole
CAS :<p>Indazole, a heterocyclic compound, offers diverse biological activities.</p>Formule :C7H6N2Degré de pureté :99.59% - 99.85%Couleur et forme :White Or Beige Crystalline PowderMasse moléculaire :118.14BRD0705
CAS :<p>BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.</p>Formule :C20H23N3ODegré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :321.42Cyanoacetohydrazide
CAS :<p>Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.</p>Formule :C3H5N3ODegré de pureté :99.78%Couleur et forme :Stout Prisms From Alcohol Slightly Brown PowderMasse moléculaire :99.09GSK-3 inhibitor 4
CAS :<p>Orally active GSK-3 inhibitor 4 targets GSK-3α/β, CDK2/5 (IC50: 0.45-0.68 μM) and may aid in Alzheimer's research by lowering Tau protein.</p>Formule :C22H15F2N5ODegré de pureté :99.41%Couleur et forme :SoildMasse moléculaire :403.389-ING-41
CAS :<p>9-ING-41 is a glycogen synthase kinase-3 inhibitor.</p>Formule :C22H13FN2O5Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :404.35Cromolyn sodium
CAS :<p>Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.</p>Formule :C23H14Na2O11Degré de pureté :99.4% - 99.95%Couleur et forme :Colorless Crystals From Ethanol + Ether White Crystalline PowderMasse moléculaire :512.33GSK-3β inhibitor 24
<p>GSK-3β inhibitor24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. It increases GSK-3β phosphorylation at the Ser9 site in a dose-dependent manner and inhibits tau protein hyperphosphorylation by reducing the abundance of p-tau-Ser396. The compound upregulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2), demonstrating significant anti-Alzheimer's disease (AD) activity.</p>Formule :C26H18N4O3Couleur et forme :SolidMasse moléculaire :434.446CHIR-98023
CAS :<p>CHIR-98023 is a bio-active chemical.</p>Formule :C20H16Cl2N8O2Couleur et forme :SolidMasse moléculaire :471.30GSK3β Inhibitor XI
CAS :<p>GSK3β Inhibitor XI has GSK3β inhibitory effect.</p>Formule :C18H15N5O3Couleur et forme :SolidMasse moléculaire :349.35GSK3-IN-4
CAS :<p>GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.</p>Formule :C18H20N4ODegré de pureté :98.33%Couleur et forme :SoildMasse moléculaire :308.38FRATide
CAS :<p>FRATtide inhibits the phosphorylation of Axin and β-catenin, inhibits GSK-3 binding to Axin, and is a peptide derived from the GSK-3 binding protein.</p>Formule :C55H102N2O2Couleur et forme :SolidMasse moléculaire :823.433GSK3β/mTOR modulator 1
<p>GSK3β/mTOR modulator 1 (derivative 2) is an agent that modulates the GSK3β/mTOR signaling pathway. It is applicable in research related to acute lung injury (ALI) and inflammation.</p>Formule :C19H28O5Couleur et forme :SolidMasse moléculaire :336.19367GSK3a-IN-38
CAS :<p>GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a.</p>Formule :C18H20N4ODegré de pureté :99.75%Couleur et forme :SoildMasse moléculaire :308.38GSK-3β inhibitor 21
<p>GSK-3β Inhibitor21 (compound 44) is an ATP-competitive inhibitor of GSK-3β with an IC50 value of 6.06 µM, characterized by its ability to inhibit tau phosphorylation and prevent amyloid protein aggregation. This compound is utilized in the research of Alzheimer's disease.</p>Couleur et forme :Odour SolidMeBIO
CAS :<p>MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.</p>Formule :C17H12BrN3O2Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :370.2GSK3-IN-1
CAS :<p>GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.</p>Formule :C14H10ClN3OSDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :303.776-Me-ATP
CAS :<p>6-Me-ATP, a modified ATP, binds well to GSK3 and donates phosphate for GSK3β phosphorylation.</p>Formule :C11H18N5O13P3Couleur et forme :SolidMasse moléculaire :521.21GSK-3β inhibitor 1
CAS :<p>GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.</p>Formule :C14H10N2ODegré de pureté :99.40%Couleur et forme :SolidMasse moléculaire :222.242B-(SP)
CAS :<p>Selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3)</p>Formule :C71H123N26O29PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1835.87GSK-3β inhibitor 22
CAS :<p>GSK-3β inhibitor22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM, showing potential for Alzheimer's disease research.</p>Formule :C18H12F3N3O2S2Couleur et forme :SolidMasse moléculaire :423.43GSK-3β inhibitor 14
CAS :<p>GSK-3β inhibitor 14 (1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-2-methyl-5-(phenylmethyl)-) is a weak GSK-3β inhibitor, IC50﹥ 100μM.</p>Formule :C17H17NOSDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :283.39GSK3β inhibitor II
CAS :<p>GSK3β inhibitor II is a GSK3β inhibitor. GSK3β inhibitor II exhibits the research potential of Alzheimer's disease (AD).</p>Formule :C14H10IN3OSDegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :395.22GSK-3 inhibitor 3
CAS :<p>GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively</p>Formule :C23H15FN6ODegré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :410.4GSK-3 Inhibitor 5
CAS :<p>4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.</p>Formule :C9H6BrNODegré de pureté :99.58%Couleur et forme :Off-White To Light Yellow Crystalline PowderMasse moléculaire :224.05GSK-3β inhibitor 19
<p>GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.</p>Formule :C15H12N4O2SCouleur et forme :SolidMasse moléculaire :312.35Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Couleur et forme :Odour SolidWnt/β-catenin agonist 2
CAS :<p>Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist.</p>Formule :C13H12N4O3Degré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :272.26BMP agonist 1
<p>BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells.</p>Formule :C21H16N2O6Couleur et forme :SolidMasse moléculaire :392.36GSK-3β inhibitor 23
<p>GSK-3β inhibitor23 (Compound 11726169) is an inhibitor of glycogen synthase kinase 3 (GSK-3), effectively inhibiting GSK-3β and GSK-3α with IC50 values of 12.1 nM and 18.8 nM, respectively. It demonstrates antiviral activity against HIV1 and exhibits good metabolic stability in mouse and human liver microsomes and plasma, although it has poor permeability in Caco-2 cells, indicating potentially low oral bioavailability.</p>Formule :C18H13Cl2N5O2SCouleur et forme :SolidMasse moléculaire :434.299Phospho-Glycogen Synthase Peptide-2(substrate)
CAS :<p>Phospho-Glycogen Synthase Peptide-2 is a GSK-3 substrate, useful for serine kinase affinity purification.</p>Formule :C123H191N40O48PCouleur et forme :SolidMasse moléculaire :3029.087Ceftriaxone Sodium
CAS :<p>Ceftriaxone Sodium is a sporotaxin antibiotic that inhibits GSK3β and Aurora B. It is used in the study of sepsis and infective endocarditis.</p>Formule :C18H17N8NaO7S3Couleur et forme :SolidMasse moléculaire :576.562SB 415286
CAS :<p>SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.</p>Formule :C16H10ClN3O5Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :359.72R547
CAS :<p>R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with Ki of 2 nM/3 nM/1 nM.</p>Formule :C18H21F2N5O4SDegré de pureté :90% - 99.64%Couleur et forme :SolidMasse moléculaire :441.455-Bromoindole
CAS :<p>5-bromoindole is a potential inhibitor of glycogen synthase kinase 3 (GSK-3)and an important pharmaceutical chemical intermediate</p>Formule :C8H6BrNDegré de pureté :99.99%Couleur et forme :White To Beige Crystalline PowderMasse moléculaire :196.04AZD2858
CAS :AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.Formule :C21H23N7O3SDegré de pureté :98% - 99.25%Couleur et forme :SolidMasse moléculaire :453.52PF-04802367
CAS :<p>PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3β enzyme assay and 1.1 nM based on ADP-Glo assay.</p>Formule :C16H16ClN5O3Degré de pureté :98.76%Couleur et forme :SolidMasse moléculaire :361.78CHIR-99021
CAS :<p>View and buy CHIR-99021 from TargetMol.CHIR-99021 is a GSK-3α/β inhibitor.Cited in 10 publications.</p>Formule :C22H18Cl2N8Degré de pureté :97.94% - ≥95%Couleur et forme :SolidMasse moléculaire :465.34Indirubin-3′-oxime
CAS :<p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>Formule :C16H11N3O2Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :277.28TBB
CAS :<p>TBB (NSC-231634)(NSC-231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2).</p>Formule :C6HBr4N3Degré de pureté :98.51% - 99.45%Couleur et forme :Off-White SolidMasse moléculaire :434.71GSK3i XIII
CAS :<p>GSK3i XIII (GSK3 inhibitor XIII) is a GSK-3 ATP-binding site inhibitor.</p>Formule :C18H19N5Degré de pureté :98.87%Couleur et forme :SolidMasse moléculaire :305.38TDZD-8
CAS :<p>TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.</p>Formule :C10H10N2O2SDegré de pureté :97.13% - 99.61%Couleur et forme :White SolidMasse moléculaire :222.26Bisindolylmaleimide I
CAS :<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Formule :C25H24N4O2Degré de pureté :98.19% - 98.75%Couleur et forme :Orange SolidMasse moléculaire :412.48SB 216763
CAS :<p>SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).</p>Formule :C19H12Cl2N2O2Degré de pureté :98.9% - 99.13%Couleur et forme :SolidMasse moléculaire :371.22CP21R7
CAS :<p>CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.</p>Formule :C19H15N3O2Degré de pureté :96.14% - 99.16%Couleur et forme :SolidMasse moléculaire :317.34TWS119
CAS :<p>TWS119 is a GSK-3β inhibitor; capable of inducing neuronal differentiation</p>Formule :C18H14N4O2Degré de pureté :98.14% - 99.63%Couleur et forme :SolidMasse moléculaire :318.33Indirubin-3'-monoxime
CAS :<p>Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/</p>Formule :C16H11N3O2Degré de pureté :99.55%Couleur et forme :Dark Red SolidMasse moléculaire :277.28GSK 3 Inhibitor IX
CAS :<p>GSK 3 Inhibitor IX (6-BIO) is a selective reversible, ATP-competitive inhibitor of GSK-3α/β and CDK1-cyclinB complex.</p>Formule :C16H10BrN3O2Degré de pureté :98% - 99.72%Couleur et forme :SolidMasse moléculaire :356.17KY19382
CAS :<p>KY19382, a dual CXXC5-DVL and GSK3β inhibitor (IC50s: 19/10 nM), boosts Wnt/β-catenin signaling and may help in metabolic disease research.</p>Formule :C17H11Cl2N3O2Degré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :360.19IM-12
CAS :<p>IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.</p>Formule :C22H20FN3O2Degré de pureté :99.42% - >99.99%Couleur et forme :SolidMasse moléculaire :377.41Tideglusib
CAS :<p>Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities.</p>Formule :C19H14N2O2SDegré de pureté :98.40% - 99.35%Couleur et forme :SolidMasse moléculaire :334.39LY2090314
CAS :<p>LY2090314, a potent GSK-3α/β blocker (IC50: 1.5/0.9 nM), could boost platinum chemo. Tested in leukemia and advanced cancers.</p>Formule :C28H25FN6O3Degré de pureté :99.21% - 99.91%Couleur et forme :SolidMasse moléculaire :512.53GS87
CAS :<p>GS87 is a highly specific inhibitor of GSK3 (glycogen synthase kinase 3) that induces extensive differentiation of AML cells.</p>Formule :C16H11N5O2SDegré de pureté :98.86%Couleur et forme :SolidMasse moléculaire :337.36AZD1080
CAS :<p>AZD1080 is a selective, orally active, brain permeable GSK3 inhibitor.</p>Formule :C19H18N4O2Degré de pureté :97.72% - 99.75%Couleur et forme :SolidMasse moléculaire :334.37BIO-acetoxime
CAS :<p>BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.</p>Formule :C18H12BrN3O3Degré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :398.21Bikinin
CAS :<p>Bikinin (Abrasin), a potent inhibitor of plant GSK-3/Shaggy-like kinase, activates BR signaling downstream of the BR receptor.</p>Formule :C9H9BrN2O3Degré de pureté :99.86% - >99.99%Couleur et forme :SolidMasse moléculaire :273.08GSK-3β inhibitor 10
CAS :<p>GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.</p>Formule :C12H12N2O3SDegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :264.3RGB-286638 free base
CAS :<p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>Formule :C29H35N7O4Degré de pureté :98% - 99.91%Couleur et forme :SolidMasse moléculaire :545.63GNF4877
CAS :<p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>Formule :C25H27FN6O4Degré de pureté :98.68% - 99.40%Couleur et forme :SolidMasse moléculaire :494.52(E/Z)-GSK-3β inhibitor 1
CAS :<p>(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.</p>Formule :C14H10N2ODegré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :222.247BIO
CAS :<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Formule :C16H10BrN3O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :356.174-Chloro-2'-bromoacetophenone
CAS :<p>4-Chloro-2'-bromoacetophenone against glycogen synthase kinase-3 (GSK-3beta).</p>Formule :C8H6BrClODegré de pureté :98.34% - 99.41%Couleur et forme :White To Beige SolidMasse moléculaire :233.49KenPaullone
CAS :<p>KenPaullone (9-Bromopaullone), a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation.</p>Formule :C16H11BrN2ODegré de pureté :97.14% - 98.99%Couleur et forme :Tan SolidMasse moléculaire :327.18VP3.15 dihydrobromide
CAS :<p>VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.</p>Formule :C20H24Br2N4OSDegré de pureté :99.67% - ≥95%Couleur et forme :SolidMasse moléculaire :528.3CHIR-98014
CAS :<p>CHIR-98014 (CT98014) is a selective GSK3 inhibitor; potentiate insulin activation of glucose transport and utilization in vitro and in vivo.</p>Formule :C20H17Cl2N9O2Degré de pureté :97.25% - 99.59%Couleur et forme :SolidMasse moléculaire :486.31ALSTERPAULLONE
CAS :<p>Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec</p>Formule :C16H11N3O3Degré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :293.28AR-A014418
CAS :<p>AR-A014418 (GSK 3β inhibitor VIII) is an ATP-competitive, and selective GSK3β inhibitor.</p>Formule :C12H12N4O4SDegré de pureté :>99.99% - ≥95%Couleur et forme :SolidMasse moléculaire :308.31CHIR 98024
CAS :<p>CHIR 98024: strong GSK-3α/β blocker, IC50 0.65/0.58 nM, selective over Cdc2/ERK2.</p>Formule :C20H17Cl2N9O2Degré de pureté :96.74%Couleur et forme :SolidMasse moléculaire :486.311-Azakenpaullone
CAS :<p>1-Azakenpaullone (azakenpaullone) is a potent and selective GSK-3β inhibitor with IC50 of 18 nM, >100-fold selectivity over CDK1/cyclin B and CDK5/p25.</p>Formule :C15H10BrN3ODegré de pureté :99.73%Couleur et forme :Tan SolidMasse moléculaire :328.16BRD0209
CAS :<p>BRD0209 is a highly selective and potent GSK3 inhibitor.</p>Formule :C22H25N3ODegré de pureté :99.92%Couleur et forme :SolidMasse moléculaire :347.45TC-G 24
CAS :<p>GSK-3β inhibitor</p>Formule :C15H11ClN4O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :330.73Cazpaullone
CAS :<p>Cazpaullone inhibits GSK-3 and briefly boosts Pax4 mRNA expression.</p>Formule :C16H10N4OCouleur et forme :SolidMasse moléculaire :274.28VP3.15
CAS :<p>VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).</p>Formule :C20H22N4OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :366.48BRD1652
CAS :<p>BRD1652 is a highly selective and potent GSK3 inhibitor.</p>Formule :C20H20F3N3ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :375.39ZDWX-25
CAS :<p>ZDWX-25, a strong GSK-3β & DYRK1A inhibitor, kills SH-SY5Y/HL-7702 cells, may aid Alzheimer's research; IC50: 71 nM for GSK-3β.</p>Formule :C17H15N3O3Couleur et forme :SolidMasse moléculaire :309.32PfGSK3/PfPK6-IN-2
CAS :<p>PfGSK3/PfPK6-IN-2 inhibits Plasmodium falciparum GSK3/PK6 (IC50: 172 nM/11 nM) for Malaria research.</p>Formule :C24H25Cl2N5OSCouleur et forme :SolidMasse moléculaire :502.46PIMPC
CAS :<p>PIMPC, a compound endowed with antioxidant and metal-chelating properties, acts as a novel inhibitor of glycogen synthase kinase 3 (GSK-3), and exhibits</p>Formule :C21H19N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :357.413F8
CAS :<p>3F8 is a selective GSK-3β inhibitor that can be used as a new tool and potential therapeutic candidate compound for GSK3-related diseases, and can be used in</p>Formule :C15H14N2O4Degré de pureté :98.14% - 98.25%Couleur et forme :SolidMasse moléculaire :286.28TCS 2002
CAS :<p>GSK-3β inhibitor 9b: potent, selective, oral, IC50=35 nM, good pharmacokinetics, BBB-permeable, researched for Alzheimer's.</p>Formule :C18H14N2O3SCouleur et forme :SolidMasse moléculaire :338.38GSK-3β inhibitor 12
CAS :<p>GSK-3β inhibitor 12 is a selective GSK-3β inhibitor.GSK-3β inhibitor 12 inhibits 49.11% of 25 μM GSK-3β activity and 37.11% of 50 μM GSK-3β activity.GSK-3β</p>Formule :C14H13N3OSDegré de pureté :98.58%Couleur et forme :SolidMasse moléculaire :271.34Aloisine B
CAS :<p>Aloisine B (AloisineB) inhibited cyclin-dependent kinase and glycogen synthase kinase with IC50 values of 0.85 µM and 0.75 µM, respectively.</p>Formule :C15H14ClN3Degré de pureté :95.15%Couleur et forme :SolidMasse moléculaire :271.74GSK3-IN-2
CAS :<p>GSK3-IN-2 is a potent GSK3 inhibitor for the treatment of diabetes and neurodegenerative diseases.</p>Formule :C17H19N3OSDegré de pureté :98.8%Couleur et forme :SolidMasse moléculaire :313.42BRD3731
CAS :<p>BRD3731 selectively inhibits GSK3β with IC50 of 15 nM; it's promising for PTSD, psychiatric issues, diabetes, and neurodegeneration.</p>Formule :C24H31N3OCouleur et forme :SolidMasse moléculaire :377.5218BIOder
CAS :18BIOder is a neuroprotective inhibitor of GSK-3β, highly selectively inhibiting HIV-1. It is the second generation derivative of 6BIO.Formule :C9H7ClN2O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :210.62MRT80
CAS :<p>MRT80 is an inhibitor of GSK-3 in vitro. MRT80 de-stabilizes MDM2 and stabilizes p53 protein and E2F-1.</p>Formule :C15H15N5ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :281.31DIF-3
CAS :<p>DIF-3 activates GSK-3β, degrades cyclin D1/c-Myc, and inhibits Wnt/β-catenin in DLD-1 cells, curbing HeLa cell proliferation.</p>Formule :C13H17ClO4Degré de pureté :99.57%Couleur et forme :SolidMasse moléculaire :272.72EHT 1610
CAS :<p>EHT 1610 (EHT 5372) is a potent inhibitor of DYRK, with an IC50 of 0.36 nM and 0.59 nM for DYRK1A and DYRK1B, respectively.</p>Formule :C18H14FN5O2SDegré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :383.4ARN25068
CAS :<p>ARN25068 inhibits GSK-3β, FYN, DYRK1A kinases; acts in sub-micromolar range; combats tau hyperphosphorylation.</p>Formule :C19H18N6SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :362.45GSK-3β inhibitor 2
CAS :<p>GSK-3β inhibitor 2 (5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-) is a BBB-crossing and selective inhibitor of GSK-3β (IC50</p>Formule :C14H14N4O3SDegré de pureté :99.08%Couleur et forme :SolidMasse moléculaire :318.35BIP-135
CAS :<p>BIP-135 is a potent and selective ATP-competitive GSK-3 inhibitor.</p>Formule :C21H13BrN2O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :421.24GSK-3 Inhibitor XIII
CAS :<p>GSK-3 InhibitorXIII, an ATP-competitive GSK-3 inhibitor (Ki: 24 nM), can be used to study diabetes and obesity.</p>Formule :C18H15N5Degré de pureté :99.85% - 99.86%Couleur et forme :SolidMasse moléculaire :301.35ABC1183
CAS :<p>ABC1183, an oral diaminothiazole, inhibits GSK3α/β, CDK9, hinders cancer cell growth, induces G2/M arrest, and modulates phosphorylation.</p>Formule :C18H14N4OSDegré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :334.39GSK-3β inhibitor 11
CAS :<p>GSK-3β inhibitor 11 (compound 21) is a potent inhibitor of glycogen synthase kinase-3β (GSK-3β) with an inhibitory concentration (IC50) of 10.02 μM.</p>Formule :C20H15N3O4SDegré de pureté :97.33%Couleur et forme :SolidMasse moléculaire :393.42BRD5648
CAS :<p>BRD5648 ((R)-BRD0705) is an inactive (R)-enantiomer of BRD0705.</p>Formule :C20H23N3ODegré de pureté :99.89%Couleur et forme :SolidMasse moléculaire :321.42PT-65
CAS :<p>PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].</p>Formule :C51H63N13O12SCouleur et forme :SolidMasse moléculaire :1082.19Antitrypanosomal agent 14
CAS :Antitrypanosomal agent 14 (Compound 1), a potent T.Formule :C14H23N3OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :281.42SAR502250
CAS :<p>SAR502250: potent, selective GSK3 inhibitor, IC50=12nM, oral, brain-penetrant, potential for AD research, antidepressant-like properties.</p>Formule :C19H18FN5O2Couleur et forme :SolidMasse moléculaire :367.38GSK-3β inhibitor 8
CAS :<p>GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine</p>Formule :C20H20ClN5OSDegré de pureté :98.46%Couleur et forme :SolidMasse moléculaire :413.92(Rac)-BRD0705
CAS :<p>(Rac)-BRD0705 is a less active racemate of BRD0705. BRD0705 is an effective and selective inhibitor of GSK3α.</p>Formule :C20H23N3ODegré de pureté :99.7%Couleur et forme :SolidMasse moléculaire :321.42A 1070722
CAS :<p>A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.</p>Formule :C17H13F3N4O2Degré de pureté :99.9%Couleur et forme :SolidMasse moléculaire :362.31TCS 21311
CAS :<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Formule :C27H25F3N4O4Degré de pureté :99.39% - ≥98%Couleur et forme :SolidMasse moléculaire :526.51
