gsk-3
Les inhibiteurs de la GSK-3 sont des composés qui ciblent la Glycogène Synthase Kinase 3 (GSK-3), une enzyme impliquée dans de nombreux processus cellulaires, y compris le métabolisme du glycogène, la transcription génique et la prolifération cellulaire. La GSK-3 est impliquée dans diverses maladies, telles que le diabète, les troubles neurodégénératifs et le cancer. Les inhibiteurs de la GSK-3 sont des outils importants pour explorer ces voies et développer des thérapies potentielles. Chez CymitQuimica, nous fournissons des inhibiteurs de la GSK-3 pour soutenir vos recherches sur les maladies métaboliques, la neurobiologie et l'oncologie.
112 produits trouvés pour "gsk-3"
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Cromolyn sodium
CAS :<p>Cromolyn sodium (FPL-670) is a chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells.</p>Formule :C23H14Na2O11Degré de pureté :99.4% - 99.95%Couleur et forme :Colorless Crystals From Ethanol + Ether White Crystalline PowderMasse moléculaire :512.33Cyanoacetohydrazide
CAS :<p>Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.</p>Formule :C3H5N3ODegré de pureté :99.78%Couleur et forme :Stout Prisms From Alcohol Slightly Brown PowderMasse moléculaire :99.09BRD0705
CAS :<p>BRD0705: potent, selective GSK3α inhibitor, oral, IC50: 66 nM, 8x more selective than GSK3β.</p>Formule :C20H23N3ODegré de pureté :99.01%Couleur et forme :SolidMasse moléculaire :321.42Indazole
CAS :<p>Indazole, a heterocyclic compound, offers diverse biological activities.</p>Formule :C7H6N2Degré de pureté :99.59% - 99.85%Couleur et forme :White Or Beige Crystalline PowderMasse moléculaire :118.149-ING-41
CAS :<p>9-ING-41 is a glycogen synthase kinase-3 inhibitor.</p>Formule :C22H13FN2O5Degré de pureté :99.32%Couleur et forme :SolidMasse moléculaire :404.35GSK-3 inhibitor 4
CAS :<p>Orally active GSK-3 inhibitor 4 targets GSK-3α/β, CDK2/5 (IC50: 0.45-0.68 μM) and may aid in Alzheimer's research by lowering Tau protein.</p>Formule :C22H15F2N5ODegré de pureté :99.41%Couleur et forme :SoildMasse moléculaire :403.38MeBIO
CAS :<p>MeBIO is an agonist of aryl hydrocarbon receptor, with IC50 of 44 and 55 μM for GSK-3 and CDK1/CyclinB, respectively. MeBIO does not affect GSK-3β.</p>Formule :C17H12BrN3O2Degré de pureté :99.64%Couleur et forme :SolidMasse moléculaire :370.2BMP agonist 1
<p>BMP Agonist 1 (compound 2 b) is a small-molecule stimulator of bone morphogenic protein (BMP) signaling, crucial for the differentiation of C2C12 cells.</p>Formule :C21H16N2O6Couleur et forme :SolidMasse moléculaire :392.36GSK3-IN-1
CAS :<p>GSK3-IN-1 is a GSK3B-glycogen synthase kinase-3 beta inhibitor.</p>Formule :C14H10ClN3OSDegré de pureté :99.66%Couleur et forme :SolidMasse moléculaire :303.77FRATide
CAS :<p>FRATtide inhibits the phosphorylation of Axin and β-catenin, inhibits GSK-3 binding to Axin, and is a peptide derived from the GSK-3 binding protein.</p>Formule :C55H102N2O2Couleur et forme :SolidMasse moléculaire :823.4336-Me-ATP
CAS :<p>6-Me-ATP, a modified ATP, binds well to GSK3 and donates phosphate for GSK3β phosphorylation.</p>Formule :C11H18N5O13P3Couleur et forme :SolidMasse moléculaire :521.21GSK-3β inhibitor 23
<p>GSK-3β inhibitor23 (Compound 11726169) is an inhibitor of glycogen synthase kinase 3 (GSK-3), effectively inhibiting GSK-3β and GSK-3α with IC50 values of 12.1 nM and 18.8 nM, respectively. It demonstrates antiviral activity against HIV1 and exhibits good metabolic stability in mouse and human liver microsomes and plasma, although it has poor permeability in Caco-2 cells, indicating potentially low oral bioavailability.</p>Formule :C18H13Cl2N5O2SCouleur et forme :SolidMasse moléculaire :434.299GSK-3 Inhibitor 5
CAS :<p>4-Cyanophenacyl bromide, a ketone, used in drug-making and organic synthesis, blocks GSK-3.</p>Formule :C9H6BrNODegré de pureté :99.58%Couleur et forme :Off-White To Light Yellow Crystalline PowderMasse moléculaire :224.05GSK-3 inhibitor 3
CAS :<p>GSK-3 inhibitor 3 is a selective, orally active, brain-permeable GSK-3 inhibitor that inhibits GSK-3α and GSK-3β with IC50s of 0.35 nM and 0.25 nM, respectively</p>Formule :C23H15FN6ODegré de pureté :99.89%Couleur et forme :SoildMasse moléculaire :410.4CHIR-98023
CAS :<p>CHIR-98023 is a bio-active chemical.</p>Formule :C20H16Cl2N8O2Couleur et forme :SolidMasse moléculaire :471.30GSK3a-IN-38
CAS :<p>GSK3a-IN-38 is a novel small molecule compound that has inhibitory effects on GSK-3a.</p>Formule :C18H20N4ODegré de pureté :99.75%Couleur et forme :SoildMasse moléculaire :308.38GSK-3β inhibitor 22
CAS :<p>GSK-3β inhibitor22 (compound 20o) is a GSK-3β inhibitor with an IC50 of 3.1 nM, showing potential for Alzheimer's disease research.</p>Formule :C18H12F3N3O2S2Couleur et forme :SolidMasse moléculaire :423.432B-(SP)
CAS :<p>Selective phosphopeptide substrate for glycogen synthase kinase-3 (GSK-3)</p>Formule :C71H123N26O29PDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :1835.87GSK-3β inhibitor 24
<p>GSK-3β inhibitor24 (Compound 41) is a potent GSK-3β inhibitor with an IC50 of 0.22 nM. It increases GSK-3β phosphorylation at the Ser9 site in a dose-dependent manner and inhibits tau protein hyperphosphorylation by reducing the abundance of p-tau-Ser396. The compound upregulates β-catenin and neurogenesis-related markers (GAP43 and MAP-2), demonstrating significant anti-Alzheimer's disease (AD) activity.</p>Formule :C26H18N4O3Couleur et forme :SolidMasse moléculaire :434.446GSK3β/mTOR modulator 1
<p>GSK3β/mTOR modulator 1 (derivative 2) is an agent that modulates the GSK3β/mTOR signaling pathway. It is applicable in research related to acute lung injury (ALI) and inflammation.</p>Formule :C19H28O5Couleur et forme :SolidMasse moléculaire :336.19367GSK3β inhibitor II
CAS :<p>GSK3β inhibitor II is a GSK3β inhibitor. GSK3β inhibitor II exhibits the research potential of Alzheimer's disease (AD).</p>Formule :C14H10IN3OSDegré de pureté :99.48%Couleur et forme :SolidMasse moléculaire :395.22Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Couleur et forme :Odour SolidGSK-3β inhibitor 21
<p>GSK-3β Inhibitor21 (compound 44) is an ATP-competitive inhibitor of GSK-3β with an IC50 value of 6.06 µM, characterized by its ability to inhibit tau phosphorylation and prevent amyloid protein aggregation. This compound is utilized in the research of Alzheimer's disease.</p>Couleur et forme :Odour SolidWnt/β-catenin agonist 2
CAS :<p>Wnt/β-catenin agonist 2 activates Wnt/β-catenin signaling and is an effective Wnt agonist.</p>Formule :C13H12N4O3Degré de pureté :99.35%Couleur et forme :SolidMasse moléculaire :272.26GSK-3β inhibitor 1
CAS :<p>GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.</p>Formule :C14H10N2ODegré de pureté :99.40%Couleur et forme :SolidMasse moléculaire :222.24GSK-3β inhibitor 14
CAS :<p>GSK-3β inhibitor 14 (1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-2-methyl-5-(phenylmethyl)-) is a weak GSK-3β inhibitor, IC50﹥ 100μM.</p>Formule :C17H17NOSDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :283.39GSK-3β inhibitor 19
<p>GSK-3β Inhibitor 19 (compound 36) is an inhibitor of GSK-3β with an IC50 value of 70 nM. It is applicable in research related to anti-inflammatory and Alzheimer's disease.</p>Formule :C15H12N4O2SCouleur et forme :SolidMasse moléculaire :312.35GSK3-IN-4
CAS :<p>GSK3-IN-4 is a GSK-3 inhibitor with IC50 of 0.101-1 μM of GSK-3α and GSK-3β in Calipe Assay.</p>Formule :C18H20N4ODegré de pureté :98.33%Couleur et forme :SoildMasse moléculaire :308.38GSK3β Inhibitor XI
CAS :<p>GSK3β Inhibitor XI has GSK3β inhibitory effect.</p>Formule :C18H15N5O3Couleur et forme :SolidMasse moléculaire :349.35Phospho-Glycogen Synthase Peptide-2(substrate)
CAS :<p>Phospho-Glycogen Synthase Peptide-2 is a GSK-3 substrate, useful for serine kinase affinity purification.</p>Formule :C123H191N40O48PCouleur et forme :SolidMasse moléculaire :3029.087Ceftriaxone Sodium
CAS :<p>Ceftriaxone Sodium is a sporotaxin antibiotic that inhibits GSK3β and Aurora B. It is used in the study of sepsis and infective endocarditis.</p>Formule :C18H17N8NaO7S3Couleur et forme :SolidMasse moléculaire :576.5627BIO
CAS :<p>7BIO triggers nonapoptotic death, blocks FLT3, DYRK1A/2, Aurora B/C kinases.</p>Formule :C16H10BrN3O2Degré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :356.17Tideglusib
CAS :<p>Tideglusib (NP031112), a non-ATP competitive inhibitor of glycogen synthase kinase 3 (GSK-3), is with anti-inflammatory and neuroprotective activities.</p>Formule :C19H14N2O2SDegré de pureté :98.40% - 99.35%Couleur et forme :SolidMasse moléculaire :334.39LY2090314
CAS :<p>LY2090314, a potent GSK-3α/β blocker (IC50: 1.5/0.9 nM), could boost platinum chemo. Tested in leukemia and advanced cancers.</p>Formule :C28H25FN6O3Degré de pureté :99.21% - 99.91%Couleur et forme :SolidMasse moléculaire :512.53VP3.15 dihydrobromide
CAS :<p>VP3.15 dihydrobromide: potent, oral, CNS-penetrant PDE7/GSK3 inhibitor; IC50s: PDE7- 1.59 μM, GSK- 0.88 μM.</p>Formule :C20H24Br2N4OSDegré de pureté :99.67% - ≥95%Couleur et forme :SolidMasse moléculaire :528.3GNF4877
CAS :<p>GNF4877 inhibits DYRK1A/GSK3β (IC50: 6/16 nM), blocks NFATc export, and boosts β-cell growth.</p>Formule :C25H27FN6O4Degré de pureté :98.68% - 99.40%Couleur et forme :SolidMasse moléculaire :494.52Indirubin-3′-oxime
CAS :<p>Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.</p>Formule :C16H11N3O2Degré de pureté :98.34%Couleur et forme :SolidMasse moléculaire :277.28TDZD-8
CAS :<p>TDZD-8 (NP 01139) is an inhibitor of GSK-3β, with an IC50 of 2 μM; minimal inhibitory effect observed on CDK1, casein kinase II, PKA and PKC.</p>Formule :C10H10N2O2SDegré de pureté :97.13% - 99.61%Couleur et forme :White SolidMasse moléculaire :222.26IM-12
CAS :<p>IM-12, an effective GSK-3β inhibitor(IC50=53 nM), regulates Wnt signalling.</p>Formule :C22H20FN3O2Degré de pureté :99.42% - >99.99%Couleur et forme :SolidMasse moléculaire :377.41(E/Z)-GSK-3β inhibitor 1
CAS :<p>(E/Z)-GSK-3β inhibitor 1 is a glycogen synthase kinase 3β (GSK-3β) inhibitor and demonstrates high antidiabetic efficacy.</p>Formule :C14H10N2ODegré de pureté :98.60%Couleur et forme :SolidMasse moléculaire :222.24RGB-286638 free base
CAS :<p>RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.</p>Formule :C29H35N7O4Degré de pureté :98% - 99.91%Couleur et forme :SolidMasse moléculaire :545.63CP21R7
CAS :<p>CP21 is a specific GSK3β inhibitor, used to activate stem cells for differentiation, often paired with BMP4 for mesodermal fate.</p>Formule :C19H15N3O2Degré de pureté :96.14% - 99.16%Couleur et forme :SolidMasse moléculaire :317.34SB 415286
CAS :<p>SB 415286 is a potent GSK3α inhibitor with IC50/Ki of 78 nM/31 nM with equally effective inhibition of GSK-3β.</p>Formule :C16H10ClN3O5Degré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :359.72CHIR-99021
CAS :<p>View and buy CHIR-99021 from TargetMol.CHIR-99021 is a GSK-3α/β inhibitor.Cited in 10 publications.</p>Formule :C22H18Cl2N8Degré de pureté :97.94% - ≥95%Couleur et forme :SolidMasse moléculaire :465.34GSK-3β inhibitor 10
CAS :<p>GSK-3β inhibitor 10 has skin-whitening, anti-oxidizing and PPAR activities.</p>Formule :C12H12N2O3SDegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :264.3SB 216763
CAS :<p>SB 216763 (SB216763) is an effective and specific GSK-3α/β inhibitor (IC50: 34.3 nM).</p>Formule :C19H12Cl2N2O2Degré de pureté :98.9% - 99.13%Couleur et forme :SolidMasse moléculaire :371.22AZD2858
CAS :AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.Formule :C21H23N7O3SDegré de pureté :98% - 99.25%Couleur et forme :SolidMasse moléculaire :453.52BIO-acetoxime
CAS :<p>BIO-acetoxime (GSK-3 Inhibitor X) is a potent dual GSK3α/β inhibitor with IC50 of 10 nM, >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B.</p>Formule :C18H12BrN3O3Degré de pureté :97.15%Couleur et forme :SolidMasse moléculaire :398.21Indirubin-3'-monoxime
CAS :<p>Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/</p>Formule :C16H11N3O2Degré de pureté :99.55%Couleur et forme :Dark Red SolidMasse moléculaire :277.28Bisindolylmaleimide I
CAS :<p>Bisindolylmaleimide I (GF109203X) is a potent and highly selective protein kinase C (PKC) inhibitor with a Ki of 14 nM.</p>Formule :C25H24N4O2Degré de pureté :98.19% - 98.75%Couleur et forme :Orange SolidMasse moléculaire :412.48
