PI3K
Les inhibiteurs de PI3K sont des composés qui bloquent l'activité des phosphoinositide 3-kinases (PI3Ks), une famille d'enzymes impliquées dans un large éventail de processus cellulaires, y compris la croissance, la prolifération, la survie et le métabolisme. La voie PI3K/Akt/mTOR est souvent dérégulée dans le cancer, ce qui fait de PI3K une cible clé pour la thérapie anticancéreuse. Les inhibiteurs de PI3K sont des outils essentiels pour étudier la transduction du signal, la biologie du cancer et le développement de thérapies ciblées. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de PI3K pour soutenir vos recherches en signalisation cellulaire, en oncologie et en développement thérapeutique.
235 produits trouvés pour "PI3K"
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Sophocarpine monohydrate
CAS :Sophocarpine monohydrate, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.Formule :C15H22N2ODegré de pureté :99.55%Couleur et forme :SolidMasse moléculaire :246.35Parsaclisib
CAS :<p>Parsaclisib (INCB050465) is a potent and selective inhibitor of PI3Kδ(IC50 of 1 nM at 1 mM ATP)</p>Formule :C20H22ClFN6O2Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :432.88IPI-3063
CAS :IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).Formule :C25H25N7O2Degré de pureté :98.00%Couleur et forme :SolidMasse moléculaire :455.51Safingol hydrochloride
CAS :Safingol hydrochloride (L-threo-dihydrosphingosine hydrochloride) is a PKC-specific inhibitor that inhibits PKC and PI3k and induces cancer cell death.Formule :C18H40ClNO2Degré de pureté :99.39% - 99.71%Couleur et forme :SoildMasse moléculaire :337.969Thioridazine hydrochloride
CAS :Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4Formule :C21H27ClN2S2Degré de pureté :99.55% - 99.957%Couleur et forme :White To Off-White SolidMasse moléculaire :407.04Copanlisib dihydrochloride
CAS :Copanlisib dihydrochloride: ATP-competitive PI3K inhibitor, potent for PI3Kα/δ/β/γ, antitumor, 2000x selectivity over other kinases except mTOR.Formule :C23H30Cl2N8O4Degré de pureté :99.05% - 99.16%Couleur et forme :SolidMasse moléculaire :553.44Pictilisib dimethanesulfonate
CAS :Pictilisib dimethanesulfonate (GDC-0941 2 MeSO3H salt) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) andFormule :C25H35N7O9S4Degré de pureté :99.63%Couleur et forme :SolidMasse moléculaire :705.85Inavolisib
CAS :Inavolisib (GDC-0077) is an orally available selective PI3Kα inhibitor with an IC50 value of 0.038 nM.Cost-effective and quality-assured.Formule :C18H19F2N5O4Degré de pureté :97.36% - 99.90%Couleur et forme :SolidMasse moléculaire :407.37P110δ-IN-1
CAS :P110δ-IN-1 (PWT-143) is an effective and selective inhibitor of P110δ (IC50: 8.4 nM).Formule :C31H40N8O3SDegré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :604.77NSC781406
CAS :<p>NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).</p>Formule :C29H27F2N5O5S2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :627.68Recilisib
CAS :Recilisib (ON 01210) is a radioprotectant,can activate AKT, PI3K activities in cells.Formule :C16H13ClO4SDegré de pureté :98.85% - 98.96%Couleur et forme :SolidMasse moléculaire :336.79CGS 15943
CAS :CGS 15943 is an orally bioavailable non-xanthine antagonist of Adenosine Receptor.Formule :C13H8ClN5ODegré de pureté :97.4%Couleur et forme :SolidMasse moléculaire :285.69PI4KIIIbeta-IN-10
CAS :PI4KIIIbeta-IN-10 is a potent inhibitor of PI4KIIIβ (IC50 of 3.6 nM).Formule :C22H25N3O5S2Degré de pureté :99.76%Couleur et forme :SolidMasse moléculaire :475.58Tenalisib
CAS :Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)Formule :C23H18FN5O2Degré de pureté :99.71%Couleur et forme :SolidMasse moléculaire :415.42PI4KIIIbeta-IN-9
CAS :PI4KIIIbeta-IN-9 is a potent inhibitor of PI4KIIIβ(IC50 of 7 nM). .Formule :C23H25N3O5S2Degré de pureté :97.18%Couleur et forme :SolidMasse moléculaire :487.59FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Couleur et forme :LiquidDuvelisib (R enantiomer) hydrochloride
Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor.Formule :C22H18Cl2N6ODegré de pureté :99.86% - 99.88%Couleur et forme :SoildMasse moléculaire :453.32PI3K-AKT-mTOR Compound Library
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved withCouleur et forme :Odour SolidD-106669
CAS :D-106669 (comppun 150) is a potent inhibitor of PI3Kα, with an IC50 value of 0.129 μM, and plays a significant role in cancer research.Formule :C17H18N6OCouleur et forme :SolidMasse moléculaire :322.36PI3Kδ-IN-12
PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4Formule :C20H15Cl2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.27ARUK2001607
CAS :ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.Formule :C14H13N3O2S2Degré de pureté :99.75%Couleur et forme :SoildMasse moléculaire :319.40IHMT-PI3K-455
IHMT-PI3K-455 (Compound 15u) is a potent, selective PI3Kγ/δ dual inhibitor, demonstrating oral activity, with IC50 values of 7.1 nM for PI3Kγ and 0.57 nM forFormule :C26H21F2N7O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.49Umbralisib R-enantiomer
CAS :Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.Formule :C31H24F3N5O3Degré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :571.55PROTAC PI3K/110β degrader-1
CAS :PROTACPI3K/110β degrader-1 (J-9) acts as a PROTAC degrader specifically targeting PI3K/110β.Formule :C51H65N9O9SCouleur et forme :SolidMasse moléculaire :980.18Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Couleur et forme :Odour SolidGSK2292767 FA
<p>GSK2292767 FA: potent PI3Kδ inhibitor, pIC50=10.1, 500x selectivity, for respiratory research.</p>Formule :C25H30N6O7SDegré de pureté :99.52%Couleur et forme :SoildMasse moléculaire :558.61WYE-687
CAS :WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).Formule :C28H32N8O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :528.61mTOR inhibitor 9c
CAS :<p>mTOR inhibitor 9c is a selective mTOR inhibitor with IC50 of 0.7nM and 825nM for mTOR and PI3Kα, respectively.</p>Formule :C21H22FN5O2SDegré de pureté :99.23%Couleur et forme :SoildMasse moléculaire :427.5IHMT-PI3Kδ-372 S-isomer
CAS :<p>IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.</p>Formule :C26H23F2N7O2Degré de pureté :99.97%Couleur et forme :SoildMasse moléculaire :503.5PI3K-IN-41
PI3K-IN-41 (compound 2), a photocaged PI3K inhibitor (IC50=18.92 nM) with anticancer properties, demonstrates potent PI3K inhibition following UV lightFormule :C45H39F2N5O12SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :911.88PITCOIN4
PITCOIN4 is a Class II Alpha PI3K-C2α inhibitor with high selectivity, demonstrating nanomolar inhibition of PI3K-C2α and exhibiting over 100-fold selectivityDegré de pureté :98%Couleur et forme :Odour SolidGSK251
CAS :GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.Formule :C29H37FN6O4SDegré de pureté :99.8%Couleur et forme :SolidMasse moléculaire :584.71PI3K-IN-46
CAS :<p>PI3K-IN-46 is a specific inhibitor of PI3Kγ.</p>Formule :C13H9N3OSDegré de pureté :97.51%Couleur et forme :SoildMasse moléculaire :255.3PI3K-IN-57
PI3K-IN-57 (Compound 4a) is a PI3K inhibitor that shows strong inhibitory effects on the proliferation of HeLa tumor ectopic xenografts in vivo. It holds promise for anticancer agent research.Couleur et forme :Odour SolidPI3K-IN-47
PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50)Formule :C50H46F4N8O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1027.07PI3Kδ-IN-18
Se15, a selective PI3Kδ inhibitor, exhibits potency with an IC50 value of less than 0.1nM and is utilized in autoimmune research [1].Degré de pureté :98%Couleur et forme :Odour SolidBAY1082439
CAS :BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2].Formule :C25H30N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :494.54PI3Kα-IN-12
<p>PI3Kα-IN-12 (compound 13), a potent and selective PI3Kα inhibitor (IC50: 1.2 nM), effectively suppresses HCT-116 and U87-MG cell proliferation with IC50 values</p>Formule :C28H36F2N10O5S3Couleur et forme :SolidMasse moléculaire :726.84PI3Kα-IN-25
PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.Formule :C21H19ClN4O4Couleur et forme :SolidMasse moléculaire :426.853mTOR inhibitor 9e
CAS :<p>mTOR inhibitor 9e is a selective mTOR inhibitor with IC50 of 0.68nM and 1359nM for mTOR and PI3Kα, respectively.</p>Formule :C22H23N5O2SDegré de pureté :98.84%Couleur et forme :SoildMasse moléculaire :421.52PROTAC PI3Kα degrader-1
PROTACPI3Kα degrader-1 is a PI3Kα-targeting PROTAC degrader (DC50= 0.08 μM) that demonstrates notable selectivity in degrading PI3Kα over the PI3Kβ, PI3Kγ, and PI3Kδ isoforms. It degrades PI3Kα effectively in a time- and concentration-dependent manner and significantly inhibits the phosphorylation of AKT at the Ser473 site. Additionally, PROTACPI3Kα degrader-1 exhibits significant in vivo anticancer efficacy in HGC-27 and DOHH2 xenograft models.Couleur et forme :Odour Solid740 Y-P acetate
740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-Formule :C143H226N43O41PS3Degré de pureté :99.92%Couleur et forme :SoildMasse moléculaire :3330.79PI5P4Ks-IN-2
CAS :<p>PI5P4Ks-IN-2 inhibits PI5P4K isoforms α, β, γ, γ+ with IC50 <4.3, <4.6, 6.2, 0.32 µM, respectively.</p>Formule :C22H23N5Degré de pureté :98.36% - 99.02%Couleur et forme :SoildMasse moléculaire :357.45IHMT-PI3K-315
IHMT-PI3K-315 (20e) serves as a potent, selective inhibitor of PI3Kγ/δ, exhibiting IC 50 values of 4.0 nM for PI3Kγ and 9.1 nM for PI3Kδ. Additionally, it demonstrates antitumor activity.Formule :C22H20F2N6O4Couleur et forme :SolidMasse moléculaire :470.43(3S)-GSK-F1
CAS :(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3.Formule :C27H18F5N5O4SDegré de pureté :99.04%Couleur et forme :SoildMasse moléculaire :603.52STX-478
CAS :STX-478 (compound 80), an orally administered, CNS-penetrant allosteric mutant-selective PI3Kα inhibitor, demonstrates significant and sustained tumorFormule :C16H12F5N5O2Degré de pureté :98.31% - 99.78%Couleur et forme :SolidMasse moléculaire :401.29PI3Kδ-IN-14
<p>PI3Kδ-IN-14 (Compound (S)-29), a selective PI3Kδ inhibitor with an IC50 of 0.8 nM and a Kd of 84.8 nM, targets the ATP-binding site within the kinase domain of</p>Formule :C26H20ClFN8ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :514.94PF-06843195
CAS :PF-06843195 is a potent and selective PI3Kα inhibitor prevents it catalyzing the conversion of PIP2 to PIP3, inhibit the activation of AKT, anti-tumor .Formule :C20H25F3N8O4Degré de pureté :98.01%Couleur et forme :SolidMasse moléculaire :498.46Alpelisib
CAS :Alpelisib (BYL-719) is a PI3Kα inhibitor (IC50=5 nM) with selective, potent, and oral activity.Formule :C19H22F3N5O2SDegré de pureté :98% - 99.73%Couleur et forme :SolidMasse moléculaire :441.47Flupentixol dihydrochloride
CAS :Flupentixol dihydrochloride is used in therapy of schizophrenia as well as in anxiolytic and depressive disorders.Formule :C23H27Cl2F3N2OSDegré de pureté :98.76% - >99.99%Couleur et forme :White Or Off-White SolidMasse moléculaire :507.431,3-Dicaffeoylquinic acid
CAS :<p>1,3-Dicaffeoylquinic acid (CYNARIN) is a natural product. It shows antioxidant and choleretic properties and is a potential immunosuppressive agent.</p>Formule :C25H24O12Degré de pureté :98% - 98.81%Couleur et forme :SolidMasse moléculaire :516.45Apitolisib
CAS :Apitolisib (RG 7422) is a PI3K inhibitor, used in cancer trials, targeting PI3Kα, β, δ, γ (IC50= 5, 27, 7, 14 nM).Formule :C23H30N8O3SDegré de pureté :98.28% - 99.64%Couleur et forme :SolidMasse moléculaire :498.6Brevianamide F
CAS :<p>Brevianamide F (Cyclo(L-Pro-L-Trp)), also known as cyclo-(L-Trp-L-Pro), belongs to a class of naturally occurring 2,5-diketopiperazines.</p>Formule :C16H17N3O2Degré de pureté :97.30% - 98.82%Couleur et forme :SolidMasse moléculaire :283.33Euscaphic acid
CAS :Euscaphic acid has anti-diabetic and anti-inflammatory effects, blocking IKK/MAPKs and NF-κB activation by disrupting TRAF6/IRAK1/TAK1 clustering.Formule :C30H48O5Degré de pureté :98.93%Couleur et forme :SolidMasse moléculaire :488.7PIK-75 hydrochloride
CAS :PIK-75 hydrochloride (PIK-75 HCl) is a p110α inhibitor, isoform-specific mutants at Ser773, and potently inhibits DNA-PK with IC50 of 2 nM in cell-free assay.Formule :C16H14BrN5O4S·HClDegré de pureté :97.82%Couleur et forme :SolidMasse moléculaire :488.74Glaucocalyxin A
CAS :<p>Glaucocalyxin A improves drug delivery, activates apoptosis, inhibits cell growth, with potential as an antiplatelet agent.</p>Formule :C20H28O4Degré de pureté :99.55% - 99.80%Couleur et forme :SolidMasse moléculaire :332.43YS-49
CAS :YS-49 is an activator of PI3K/Akt (a downstream target of RhoA).Formule :C20H20BrNO2Degré de pureté :99.65%Couleur et forme :SolidMasse moléculaire :386.28NIBR-17
CAS :NIBR-17 is a pan class I PI3K inhibitor. NIBR-17 inhibits PI3KKα, PI3KKβ, PI3KKγ, and PI3KKδ with IC50 of 1 nM, 9.2 nM, 9 nM, and 20 nM respectively.Formule :C18H20N8O2Degré de pureté :97.79%Couleur et forme :SolidMasse moléculaire :380.4Rigosertib
CAS :<p>Rigosertib, a multi-kinase inhibitor targeting PLK1 (IC50: 9 nM), induces apoptosis and G2/M arrest by disrupting PI3K/Akt.</p>Formule :C21H25NO8SDegré de pureté :99.53%Couleur et forme :SolidMasse moléculaire :451.49VS-5584
CAS :VS-5584 (SB2343) is a pan-PI3K/mTOR kinase inhibitor.Formule :C17H22N8ODegré de pureté :97.82% - 99.54%Couleur et forme :SolidMasse moléculaire :354.41Periplocin
CAS :Periplocin fights lung cancer, induces apoptosis, stunts growth via beta-catenin/Tcf, and treats rheumatoid arthritis/traditional ailments.Formule :C36H56O13Degré de pureté :99.66% - 99.74%Couleur et forme :SolidMasse moléculaire :696.82PIK-108
CAS :PIK-108 is an allosteric inhibitor of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunits β and δ (PI3Kβ/δ).Formule :C22H24N2O3Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :364.44Erucic acid
CAS :Increased levels of erucic acid (22:1n9) have been found in the red blood cell membranes of autistic subjects with developmental regression (PMID: 16581239 ).Formule :C22H42O2Degré de pureté :99.64%Couleur et forme :Needles From Alcohol Liquid OthersolidMasse moléculaire :338.571-Deoxynojirimycin hydrochloride
CAS :1-Deoxynojirimycin hydrochloride (Moranoline) is a potent and selective inhibitor of alpha-glucosidase, most commonly found in mulberry leaves.Formule :C6H14ClNO4Degré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :199.63AZD-7648
CAS :AZD-7648 is an inhibitor of DNA-dependent protein kinase (DNA-PK) with the IC50 of 0.63 nM in an enzyme assay,has anti-tumor activity.Formule :C18H20N8O2Degré de pureté :99.03% - 99.85%Couleur et forme :SolidMasse moléculaire :380.4Omipalisib
CAS :Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.Formule :C25H17F2N5O3SDegré de pureté :98% - 99.8%Couleur et forme :SolidMasse moléculaire :505.5PIK-294
CAS :PIK-294 is a excellently specific p110δ inhibitor(IC50=10 nM).Formule :C28H23N7O2Degré de pureté :97.22% - >99.99%Couleur et forme :SolidMasse moléculaire :489.53Oroxin B
CAS :Oroxin B (Hypocretin-2) has antioxidant activity.Formule :C27H30O15Degré de pureté :98.22% - 99.81%Couleur et forme :SolidMasse moléculaire :594.52Desmethylglycitein
CAS :Desmethylglycitein (6,7,4'-Trihydroxyisoflavone) , is a novel inhibitor of PKCα in suppressing solar UV-induced matrix metalloproteinase 1, which hasFormule :C15H10O5Degré de pureté :97.93%Couleur et forme :SolidMasse moléculaire :270.24PI-103
CAS :PI-103 is a potent, cell-permeable, ATP-competitive inhibitor of PI3K family members (IC50s: 2/3/3/15/30/23 nM for p110α/β/δ/γ, mTOR, and DNA-PK).Formule :C19H16N4O3Degré de pureté :97.79% - 99.3%Couleur et forme :SolidMasse moléculaire :348.361-Deoxynojirimycin
CAS :1-Deoxynojirimycin (Moranoline) is a potent α-glucosidase inhibitor, suppressing postprandial blood glucose, thereby possibly preventing diabetes mellitus.Formule :C6H13NO4Degré de pureté :99.65% - 99.98%Couleur et forme :White-Beige Solid CrystallineMasse moléculaire :163.17AS-605240
CAS :AS-605240 is an effective and specific inhibitor of PI3Kγ (IC50/Ki: 87.8 nM).Formule :C12H7N3O2SDegré de pureté :97% - 99.91%Couleur et forme :SolidMasse moléculaire :257.27Taurolithocholic acid sodium salt
CAS :Taurolithocholic acid sodium salt (Sodium taurolithocholate) is the major human metabolite, a bile acid which inhibits radioligand binding to muscarinic M1, butFormule :C26H44NNaO5SDegré de pureté :99.79% - 99.93%Couleur et forme :SolidMasse moléculaire :505.69ZSTK474
CAS :<p>PI3K Inhibitor ZSTK474 is an orally available, s-triazine derivative, ATP-competitive phosphatidylinositol 3-kinase (PI3K) inhibitor with potential</p>Formule :C19H21F2N7O2Degré de pureté :98.29% - 99.95%Couleur et forme :White PowderMasse moléculaire :417.413-Methyladenine
CAS :3-Methyladenine (3-MA) is a PI3K inhibitor that selectively inhibits class IB PI3Kγ (IC50=60 μM) and class III VPS34 (IC50=25 μM).Formule :C6H7N5Degré de pureté :98% - 99.51%Couleur et forme :SolidMasse moléculaire :149.15Flavanomarein
CAS :Flavanomarein: Antioxidant with radical scavenging, lipid peroxidation inhibition, and lipid-lowering in HepG2 cells.Formule :C21H22O11Degré de pureté :98.63% - 99.54%Couleur et forme :SolidMasse moléculaire :450.39SKI V
CAS :<p>SKI V is a potent and noncompetitive non-lipid sphingosine kinase (SPHK; SK) inhibitor (GST-hSK,IC50 : 2 μM), and is a PI3K inhibitor(hPI3k,IC50 : 6 μM),</p>Formule :C15H10O4Degré de pureté :98.78%Couleur et forme :SolidMasse moléculaire :254.24Hederacolchiside A1
CAS :Hederacolchiside A1 exhibits anti-leishmanial and anticancer activities by disrupting cell membranes and inducing apoptosis via the PI3K/Akt/mTOR pathway.Formule :C47H76O16Degré de pureté :98.76% - 99.92%Couleur et forme :SolidMasse moléculaire :897.1BEBT-908
CAS :BEBT-908 (PI3Kα inhibitor 1) is a selective PI3Kα inhibitor (IC50 <0.1 μM). BEBT-908 also inhibits HDAC (0.1 μM≤IC50≤1 μM).Formule :C23H25N9O3SDegré de pureté :99.67%Couleur et forme :SolidMasse moléculaire :507.57(E)-Akt inhibitor-IV
CAS :(E)-Akt inhibitor-IV ((E)-AKTIV) ((E)-AKTIV) is an inhibitor of PI3K-Akt.Formule :C31H29IN4SDegré de pureté :99.74% - 99.9%Couleur et forme :SolidMasse moléculaire :616.56Rigosertib sodium
CAS :Rigosertib sodium (ON-01910), a non-ATP-competitive inhibitor of PLK1(IC50=9 nM), exhibits 30-fold higher specificity activity over Plk2 and no effect on Plk3.Formule :C21H24NNaO8SDegré de pureté :98% - 99.37%Couleur et forme :SolidMasse moléculaire :473.47Fimepinostat
CAS :Fimepinostat (CUDC 907) is an orally bioavailable inhibitor of both PI3K class I and pan-HDAC enzymes, with potential antineoplastic activity.Formule :C23H24N8O4SDegré de pureté :98.27% - 99.87%Couleur et forme :SolidMasse moléculaire :508.55Idelalisib
CAS :Idelalisib (GS-1101) is a small molecule inhibitor of the PI3K catalytic subunit p110δ (IC50: 2.5 nM).Formule :C22H18FN7ODegré de pureté :98% - 99.39%Couleur et forme :SolidMasse moléculaire :415.42GNE-493
CAS :GNE-493 is potent, selective, and orally available PI3K and mTOR inhibitor with potential anticancer activity.IC50s of 3.4 nM, 12 nM, 16 nM, 16 nM and 32 nM forFormule :C17H20N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :372.44TASP0415914
CAS :TASP0415914 is an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ). TFormule :C13H17N5O3SDegré de pureté :98.14%Couleur et forme :SolidMasse moléculaire :323.37Wortmannin
CAS :Wortmannin (SL-2052) is a PI3K inhibitor (IC50=3 nM) that is covalent and irreversible.Formule :C23H24O8Degré de pureté :95.84% - 99.77%Couleur et forme :White SolidMasse moléculaire :428.43NIH-12848
CAS :NIH-12848 is a putative inhibitor of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) with an IC50 of 1 μM.Formule :C20H14F3N3SDegré de pureté :99.84% - 99.9%Couleur et forme :SolidMasse moléculaire :385.41BGT226
CAS :BGT226 (NVP-BGT226) is a novel dual PI3K / mTOR inhibitor, it acts on PI3K α/β/γ with IC50 of 4 nM / 63 nM / 38 nM, respectively.Formule :C28H25F3N6O2Degré de pureté :95.74% - 99.78%Couleur et forme :SolidMasse moléculaire :534.53Bimiralisib
CAS :Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.Formule :C17H20F3N7O2Degré de pureté :97.58% - 98.92%Couleur et forme :SolidMasse moléculaire :411.38AS-252424
CAS :AS-252424 is a potent and selective inhibitor of PI3Kγ with IC50 of 33 nM; >10 fold selectivity for PI3Kγ versus PI3Kα.Formule :C14H8FNO4SDegré de pureté :99.06% - 99.09%Couleur et forme :SolidMasse moléculaire :305.28iMDK
CAS :iMDK quarterhydrate, a PI3K inhibitor, blocks MDK growth factor and enhances NSCLC treatment with MEK inhibitors, sparing normal cells.Formule :C21H13FN2O2SDegré de pureté :99.99%Couleur et forme :SolidMasse moléculaire :376.4PI3K-IN-1
CAS :PI3K-IN-1 (Voxtalisib Analogue) is a dual inhibitor of mTOR/PI3K, mostly for p110γ , also inhibits DNA-PK and mTOR.Formule :C31H29N5O6SDegré de pureté :97.03% - 98%Couleur et forme :SolidMasse moléculaire :599.66PI-3065
CAS :PI-3065 is a novel potent and selective PI3K p110δ inhibitor.Formule :C27H31FN6OSDegré de pureté :99.84% - ≥95%Couleur et forme :SolidMasse moléculaire :506.64PF-04691502
CAS :PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.Formule :C22H27N5O4Degré de pureté :96.27% - ≥95%Couleur et forme :SolidMasse moléculaire :425.48Eganelisib
CAS :Eganelisib (IPI-549) is an inhibitor of PI3Kγ (IC50 = 16, 3,200, 3,500, and >8,400 nM for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively)Formule :C30H24N8O2Degré de pureté :98.92% - 99.28%Couleur et forme :SolidMasse moléculaire :528.56GDC0084
CAS :<p>GDC0084 (RG7666) is a PI3K inhibitor with potential antineoplastic activity.</p>Formule :C18H22N8O2Degré de pureté :99.72% - 99.87%Couleur et forme :SolidMasse moléculaire :382.42Arnicolide D
CAS :Arnicolide D is a sesquiterpene lactone.Formule :C19H24O5Degré de pureté :96.66% - 99.93%Couleur et forme :SolidMasse moléculaire :332.39PF-4989216
CAS :PF-4989216 is a potent and selective PI3K inhibitor with IC50 of 2 nM, 142 nM, 65 nM, 1 nM, and 110 nM for p110α, p110β, p110γ, p110δ, and VPS34, respectively.Formule :C18H13FN6OSDegré de pureté :99.85%Couleur et forme :SolidMasse moléculaire :380.4Copanlisib
CAS :<p>Copanlisib (BAY 80-6946), a PI3K inhibitor, may block tumor growth and improve cancer treatment efficacy.</p>Formule :C23H28N8O4Degré de pureté :99% - 99.88%Couleur et forme :SolidMasse moléculaire :480.52AMG 511
CAS :AMG 511: oral class I PI3K inhibitor (α, β, δ, γ Kis: 4, 6, 2, 1 nM), anti-tumor in mouse glioblastoma model, reduces p-Akt (Ser473).Formule :C22H28FN9O3SDegré de pureté :≥98%Couleur et forme :SolidMasse moléculaire :517.58
