PI3K
Les inhibiteurs de PI3K sont des composés qui bloquent l'activité des phosphoinositide 3-kinases (PI3Ks), une famille d'enzymes impliquées dans un large éventail de processus cellulaires, y compris la croissance, la prolifération, la survie et le métabolisme. La voie PI3K/Akt/mTOR est souvent dérégulée dans le cancer, ce qui fait de PI3K une cible clé pour la thérapie anticancéreuse. Les inhibiteurs de PI3K sont des outils essentiels pour étudier la transduction du signal, la biologie du cancer et le développement de thérapies ciblées. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de PI3K pour soutenir vos recherches en signalisation cellulaire, en oncologie et en développement thérapeutique.
231 produits trouvés pour "PI3K".
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740 Y-P acetate
740 Y-P acetate (740YPDGFR acetate) is a potent and cell-permeable PI3K activator.740 Y-P acetate tends to bind to GST fusion proteins containing the N- and C-Formule :C143H226N43O41PS3Degré de pureté :99.92%Couleur et forme :SoildMasse moléculaire :3330.79PI3Kδ-IN-12
PI3Kδ-IN-12 (compound 13), a PI3Kδ inhibitor with a pIC50 of 5.8, exhibits differential binding affinities with pKi values of 8.0 for PI3Kδ, 6.5 for PI3Kγ, 6.4Formule :C20H15Cl2N5O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :444.27GSK251
CAS :GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.Formule :C29H37FN6O4SDegré de pureté :99.8%Couleur et forme :White SolidMasse moléculaire :584.71(3S)-GSK-F1
CAS :(3S)-GSK-F1 is a selective small molecule inhibitor of Type III Phosphatidylinositol 4‑Kinase Alpha (PI4KIIIα), pIC50=8.3.Formule :C27H18F5N5O4SDegré de pureté :99.04%Couleur et forme :SolidMasse moléculaire :603.52Ref: TM-T67837
1mg70,00€5mg133,00€1mL*10mM (DMSO)182,00€10mg210,00€25mg371,00€50mg532,00€100mg837,00€IHMT-PI3Kδ-372 S-isomer
CAS :IHMT-PI3Kδ-372 S-isomer is a potent and selective PI3Kδ inhibitor with an IC50 of 14 nM.Formule :C26H23F2N7O2Degré de pureté :99.97%Couleur et forme :White SolidMasse moléculaire :503.5Ref: TM-T60196
1mg109,00€2mg163,00€5mg241,00€1mL*10mM (DMSO)294,00€10mg354,00€25mg532,00€50mg745,00€100mg1.018,00€Duvelisib (R enantiomer) hydrochloride
Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor.Formule :C22H18Cl2N6ODegré de pureté :99.86% - 99.88%Couleur et forme :White SolidMasse moléculaire :453.32Ref: TM-T11129L
1mg296,00€5mg718,00€1mL*10mM (DMSO)895,00€10mg982,00€25mg1.485,00€50mg2.008,00€100mg2.637,00€PROTAC PI3K/110β degrader-1
CAS :PROTACPI3K/110β degrader-1 (J-9) acts as a PROTAC degrader specifically targeting PI3K/110β.Formule :C51H65N9O9SCouleur et forme :SolidMasse moléculaire :980.18PI3K-IN-46
CAS :PI3K-IN-46 is a specific inhibitor of PI3Kγ.Formule :C13H9N3OSDegré de pureté :97.26%Couleur et forme :SolidMasse moléculaire :255.3Ref: TM-T64392
1mg62,00€1mL*10mM (DMSO)133,00€5mg149,00€10mg213,00€25mg319,00€50mg450,00€100mg605,00€ARUK2001607
CAS :ARUK2001607 selectively inhibits PI5P4Kγ (Kd=7.1 nM) with high selectivity over 150+ kinases.Formule :C14H13N3O2S2Degré de pureté :99.75%Couleur et forme :SolidMasse moléculaire :319.40GSK2292767 FA
GSK2292767 FA: potent PI3Kδ inhibitor, pIC50=10.1, 500x selectivity, for respiratory research.Formule :C25H30N6O7SDegré de pureté :99.52%Couleur et forme :SolidMasse moléculaire :558.61PI3K-IN-57
PI3K-IN-57 (Compound 4a) is a PI3K inhibitor that shows strong inhibitory effects on the proliferation of HeLa tumor ectopic xenografts in vivo. It holds promise for anticancer agent research.Couleur et forme :Odour SolidPenetratin-PI3Kγ(126-150)
Penetratin-PI3Kγ(126-150) is a peptide inhibitor of PI3Kγ that plays a significant role in respiratory diseases.Formule :C229H362N76O57SCouleur et forme :SolidMasse moléculaire :5120.74849IHMT-PI3K-315
IHMT-PI3K-315 (20e) serves as a potent, selective inhibitor of PI3Kγ/δ, exhibiting IC 50 values of 4.0 nM for PI3Kγ and 9.1 nM for PI3Kδ. Additionally, it demonstrates antitumor activity.Formule :C22H20F2N6O4Couleur et forme :SolidMasse moléculaire :470.43Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Couleur et forme :Odour SolidRef: TM-L1600
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderBAY1082439
CAS :BAY1082439, an orally bioavailable, selective inhibitor of PI3Kα/β/δ, demonstrates high efficacy in inhibiting the growth of Pten-null prostate cancer [1][2].Formule :C25H30N6O5Degré de pureté :98%Couleur et forme :White SolidMasse moléculaire :494.54PI3K-AKT-mTOR Compound Library
A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved withCouleur et forme :Odour SolidRef: TM-L1300
1mgÀ demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderUmbralisib R-enantiomer
CAS :Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.Formule :C31H24F3N5O3Degré de pureté :97.34%Couleur et forme :SolidMasse moléculaire :571.55Ref: TM-T13140
1mg177,00€5mg432,00€1mL*10mM (DMSO)532,00€10mg620,00€25mg1.108,00€50mg1.431,00€100mg1.783,00€PI3Kα-IN-25
PI3Kα-IN-25 (Compound Djh1) is a selective inhibitor of PI3Kα, suitable for research in triple-negative breast cancer.Formule :C21H19ClN4O4Couleur et forme :SolidMasse moléculaire :426.853FDA-Approved Kinase Inhibitor Library
A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Couleur et forme :LiquidRef: TM-L1610
1mgÀ demander10μL*10mM (DMSO)À demander20μL*10mM (DMSO)À demander30μL*10mM (DMSO)À demander50μL*10mM (DMSO)À demander100μL*10mM (DMSO)À demander250μL*10mM (DMSO)À demanderPI3K-IN-47
PI3K-IN-47 (Compound 27) is a potent bivalent inhibitor targeting the phosphoinositide 3-kinases (PI3K) family, exhibiting inhibitory concentration (IC50)Formule :C50H46F4N8O8S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :1027.07
