mTOR
Les inhibiteurs de mTOR sont des composés qui inhibent l'activité de la Cible de la Rapamycine chez les Mammifères (mTOR), un régulateur central de la croissance cellulaire, de la prolifération, du métabolisme et de la survie. La voie mTOR est fréquemment altérée dans le cancer et d'autres maladies, ce qui en fait une cible critique pour l'intervention thérapeutique. Les inhibiteurs de mTOR sont largement utilisés dans la recherche liée au cancer, au vieillissement et aux troubles métaboliques. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de mTOR pour soutenir vos recherches en transduction de signaux, oncologie et développement thérapeutique.
144 produits trouvés pour "mTOR"
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NSC781406
CAS :<p>NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).</p>Formule :C29H27F2N5O5S2Degré de pureté :99.58%Couleur et forme :SolidMasse moléculaire :627.68Thioridazine hydrochloride
CAS :<p>Thioridazine hydrochloride (Mellaril) , an antipsychotic drug, is used in the therapy of psychosis and schizophrenia and shows serotonin antagonism or D4</p>Formule :C21H27ClN2S2Degré de pureté :99.55% - 99.957%Couleur et forme :White To Off-White SolidMasse moléculaire :407.04ICSN3250 HCl
CAS :<p>ICSN3250 HCl is an mTOR inhibitor that specifically targets cancer cells, preventing mTOR activation and leading to cytotoxicity.</p>Formule :C31H41ClN4O8Degré de pureté :98.46% - 99.60%Couleur et forme :SoildMasse moléculaire :633.13MT 63-78
CAS :<p>MT 63-78 is a specific and effective direct AMPK activator (EC50: 25 μM).</p>Formule :C21H14N2O2Degré de pureté :97.11%Couleur et forme :SolidMasse moléculaire :326.35SN32976
CAS :<p>SN32976 is a pan PI3K inhibitor. SN32976 potently inhibited PI3K isoforms and mTOR, displaying preferential activity for PI3Kα and sparing of PI3Kδ.</p>Formule :C24H33F2N9O4SDegré de pureté :98.06%Couleur et forme :SolidMasse moléculaire :581.64NV-5138
CAS :<p>NV-5138 is a selective and orally active activator of brain mTORC1, with antidepressant effects.Cost-effective and quality-assured.</p>Formule :C7H13F2NO2Degré de pureté :98% - ≥98%Couleur et forme :SolidMasse moléculaire :181.18Rapamycin
CAS :<p>Rapamycin, a macrolide from Streptomyces hygroscopicus, inhibits mTOR (IC50: 0.1 nM) and promotes autophagy with immunosuppressive effects.</p>Formule :C51H79NO13Degré de pureté :97.08% - 99.80%Couleur et forme :Yellow SolidMasse moléculaire :914.17QL-IX-55
CAS :<p>QL-IX-55 has a wide range of applications in life science related research.</p>Formule :C24H14F4N4OCouleur et forme :SolidMasse moléculaire :450.39RMC-4627
CAS :<p>RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.</p>Formule :C93H141N11O23Couleur et forme :SolidMasse moléculaire :1781.17mTOR inhibitor-14
<p>mTOR Inhibitor-14 (compound 14c) is a potent inhibitor of mTOR with minimal inhibition of CYP2C8 and has demonstrated the capability to inhibit tumor growth [1</p>Degré de pureté :98%Couleur et forme :Odour SolidmTOR inhibitor-12
<p>mTOR inhibitor-12 (Compound 11), a selective, brain-penetrant mTOR inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to central</p>Formule :C19H24N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.5Kinase Inhibitor Library
<p>A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;</p>Couleur et forme :Odour SolidYB-3-17
CAS :<p>YB-3-17 is a bifunctional molecule that can inhibit mTOR with an IC50 of 0.22 nM or degrade the G1 to S phase transition 1 gene (GSPT1) through the PROTAC mechanism, with a DC50 of 5 nM. It exhibits antiproliferative activity at nanomolar concentrations in various glioblastoma cell lines. Additionally, YB-3-17 shows antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon)</p>Formule :C38H39N11O6Couleur et forme :SolidMasse moléculaire :745.7862DII
<p>2DII is a potent and selective mTORC2 inhibitor. It specifically binds to the mSin1 PH domain, resulting in a decreased phosphorylation of AKT1.</p>Formule :C54H76ClN7O11SCouleur et forme :SolidMasse moléculaire :1066.74PI3K-AKT-mTOR Compound Library
<p>A unique collection of 420 compounds targeting PI3K/Akt/mTOR signaling for research in PI3K/Akt/mTOR signaling, and drug discovery in diseases involved with</p>Couleur et forme :Odour SolidMCX 28
CAS :<p>MCX 28, a triple PI3K/mTOR/PIM inhibitor, displays low nanomolar activity.</p>Formule :C25H19N5O4S3Couleur et forme :SolidMasse moléculaire :549.64WYE-687
CAS :<p>WYE-687 is a selective mTOR inhibitor (IC50: 7 nM), over 100x more selective for mTOR than PI3Kα/γ, affecting mTORC1/pS6K and mTORC2/P-AKT(S473).</p>Formule :C28H32N8O3Degré de pureté :99.93%Couleur et forme :SolidMasse moléculaire :528.61Aschantin
CAS :<p>Aschantin is a useful organic compound for research related to life sciences. The catalog number is T126072 and the CAS number is 13060-15-6.</p>Formule :C22H24O7Couleur et forme :SolidMasse moléculaire :400.427PF-06465603
CAS :<p>PF-06465603 is a metabolite of PF-04691502, a highly potent and selective ATP competitive kinase inhibitor of class 1 PI3Ks and mTOR.</p>Formule :C22H25N5O5Couleur et forme :SolidMasse moléculaire :439.46MKC-1
CAS :<p>MKC-1 (Ro-31-7453) is an oral bisindolylmaleimide inhibitor that disrupts tubulin polymerization, potentially halting cancer cell division.</p>Formule :C22H16N4O4Degré de pureté :99.63% - 99.85%Couleur et forme :SolidMasse moléculaire :400.39HN2210
<p>Compound HN2210 (compund HN2210) is an inhibitor of mTORC2.</p>Couleur et forme :Odour SolidmTOR inhibitor WYE-28
CAS :<p>Compound 28 (mTOR inhibitor WYE-28) is a selective inhibitor of mTOR (IC50=0.08 nM). Also inhibits PI3Kα (IC50 6 nM).</p>Formule :C30H34N8O5Couleur et forme :SolidMasse moléculaire :586.653RMC-4529
CAS :<p>RMC-4529 is a chemical compound that demonstrates potent inhibition, with an IC50 value of 1.0 nM, against p-4E-BP1-(T37/46) in mTOR kinase cellular assays.</p>Formule :C90H139N13O23Couleur et forme :SolidMasse moléculaire :1771.17RMC-6272
CAS :<p>RMC-6272 (RM-006) is a bi-steric mTORC1 inhibitor with selective potency over mTORC2 and shows greater effects than Rapamycin on TSC2-deficient tumors.</p>Formule :C95H141FN6O27SCouleur et forme :SolidMasse moléculaire :1850.25PI3K-IN-22
CAS :<p>PI3K-IN-22 is a dual kinase inhibitor of PI3Kα and mTOR, with IC50s of 0.9 and 0.6 nM respectively. PI3K-IN-22 could be used in cancer.</p>Formule :C31H35F3N8O3Couleur et forme :SolidMasse moléculaire :624.66FDA-Approved Kinase Inhibitor Library
<p>A unique collection of 263 kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.</p>Couleur et forme :Liquid(32-Carbonyl)-RMC-5552
CAS :<p>(32-Carbonyl)-RMC-5552, a potent mTOR inhibitor, blocks mTORC1/C2, with pIC50 values >9 for p-P70S6K and p-4E-BP1, and 8~9 for p-AKT1/2/3.</p>Formule :C93H134N10O24Couleur et forme :SolidMasse moléculaire :1776.141RMC-5552
CAS :<p>RMC-5552 selectively inhibits mTORC1 with ~40-fold selectivity over mTORC2, demonstrating anticancer activity and research utility.</p>Formule :C93H136N10O24Couleur et forme :SolidMasse moléculaire :1778.16Cbz-B3A
CAS :<p>Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.</p>Formule :C35H58N6O9Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :706.87Anti-Phospho-MTOR (Ser2448) Antibody (2K503)
<p>Anti-Phospho-MTOR (Ser2448) Antibody (2K503) is an antibody targeting Phospho-MTOR (Ser2448). Anti-Phospho-MTOR (Ser2448) Antibody (2K503) can be used in ELISA, WB, IHC, IF.</p>Couleur et forme :Odour LiquidAnti-Phospho-mTOR (Ser2481) Antibody (4R8)
<p>Anti-Phospho-MTOR (Ser2481) Antibody (4R8) is an antibody targeting Phospho-MTOR (Ser2481). Anti-Phospho-MTOR (Ser2481) Antibody (4R8) can be used in ELISA, WB, IF.</p>Couleur et forme :Odour LiquidS6K1-IN-DG2
CAS :<p>S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.</p>Formule :C16H17BrN6ODegré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :389.25Lupiwighteone
CAS :<p>Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.</p>Formule :C20H18O5Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :338.35Omipalisib
CAS :<p>Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.</p>Formule :C25H17F2N5O3SDegré de pureté :98% - 99.8%Couleur et forme :SolidMasse moléculaire :505.5mTOR inhibitor-1
CAS :<p>C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.</p>Formule :C16H15BrN2O3Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :363.21Mito-LND
CAS :<p>Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.</p>Formule :C43H45BrCl2N3OPDegré de pureté :97.25% - 98.34%Couleur et forme :SolidMasse moléculaire :801.62Samotolisib
CAS :<p>Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.</p>Formule :C23H26N4O3Degré de pureté :98.41% - 99.69%Couleur et forme :SolidMasse moléculaire :406.48WYE-687 dihydrochloride
CAS :<p>WYE-687 dihydrochloride is an mTOR inhibitor with IC50 of 7 nM, also targeting PI3Kα (81 nM) and PI3Kγ (3.11 μM).</p>Formule :C28H34Cl2N8O3Couleur et forme :SolidMasse moléculaire :601.53Corynoxine
CAS :<p>Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.</p>Formule :C22H28N2O4Degré de pureté :96.83% - 99.93%Couleur et forme :SolidMasse moléculaire :384.47Salidroside
CAS :<p>Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor.Cost-effective and quality-assured.</p>Formule :C14H20O7Degré de pureté :97.81%Couleur et forme :Red-Brown Fine PowderMasse moléculaire :300.3PF-04691502
CAS :<p>PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.</p>Formule :C22H27N5O4Degré de pureté :96.27% - ≥95%Couleur et forme :SolidMasse moléculaire :425.48GNE-477
CAS :<p>GNE-477 is a potent and efficacious dual PI3K/mTOR inhibitor.</p>Formule :C21H28N8O3S2Degré de pureté :98.88% - 99.55%Couleur et forme :SolidMasse moléculaire :504.63OSI-027
CAS :<p>OSI-027 (ASP4786) is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM.</p>Formule :C21H22N6O3Degré de pureté :97.42%Couleur et forme :SolidMasse moléculaire :406.44Bimiralisib
CAS :<p>Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity.</p>Formule :C17H20F3N7O2Degré de pureté :97.58% - 98.92%Couleur et forme :SolidMasse moléculaire :411.38SC99
CAS :<p>SC99 inhibits JAK2-STAT3, reducing STAT3 genes, platelet activity, and has anti-myeloma, anti-thrombotic effects.</p>Formule :C15H8Cl2FN3ODegré de pureté :99.56%Couleur et forme :SolidMasse moléculaire :336.15Cyclovirobuxine D
CAS :<p>Cyclovirobuxine D (Bebuxine) is extracted from Buxus microphylla.</p>Formule :C26H46N2ODegré de pureté :97.78% - 98%Couleur et forme :SolidMasse moléculaire :402.6625(R,S)-Ruscogenin
CAS :<p>25(R,S)-Ruscogenin is able to regulate the PI3K/Akt/mTOR signalling pathway, and hinder the metastasis of hepatocellular carcinoma.</p>Formule :C27H42O4Degré de pureté :99.32% - 99.89%Couleur et forme :SolidMasse moléculaire :430.62NV-5138 hydrochloride
<p>NV-5138 hydrochloride: a leucine analog, oral brain mTORC1 activator via Sestrin2, for antidepressant research.</p>Formule :C7H14ClF2NO2Couleur et forme :SolidMasse moléculaire :217.64WYE-354
CAS :<p>WYE-354 is a selective mTOR inhibitor (IC50=5 nM), targeting mTORC1/C2 over PI3Kα (>100x) and PI3Kγ (>500x), sparing P-AKT(T308).</p>Formule :C24H29N7O5Degré de pureté :97.86% - 99.61%Couleur et forme :SolidMasse moléculaire :495.53AZD-8055
CAS :<p>AZD8055 is an ATP-competitive mTOR inhibitor (IC50: 0.8 nM in MDA-MB-468 cells). It is ~1,000-fold selective for mTOR over all PI3K isoforms.</p>Formule :C25H31N5O4Degré de pureté :98% - 99.69%Couleur et forme :SolidMasse moléculaire :465.54
