mTOR
Les inhibiteurs de mTOR sont des composés qui inhibent l'activité de la Cible de la Rapamycine chez les Mammifères (mTOR), un régulateur central de la croissance cellulaire, de la prolifération, du métabolisme et de la survie. La voie mTOR est fréquemment altérée dans le cancer et d'autres maladies, ce qui en fait une cible critique pour l'intervention thérapeutique. Les inhibiteurs de mTOR sont largement utilisés dans la recherche liée au cancer, au vieillissement et aux troubles métaboliques. Chez CymitQuimica, nous proposons une variété d'inhibiteurs de mTOR pour soutenir vos recherches en transduction de signaux, oncologie et développement thérapeutique.
144 produits trouvés pour "mTOR"
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(32-Carbonyl)-RMC-5552
CAS :<p>(32-Carbonyl)-RMC-5552, a potent mTOR inhibitor, blocks mTORC1/C2, with pIC50 values >9 for p-P70S6K and p-4E-BP1, and 8~9 for p-AKT1/2/3.</p>Formule :C93H134N10O24Couleur et forme :SolidMasse moléculaire :1776.141YB-3-17
CAS :<p>YB-3-17 is a bifunctional molecule that can inhibit mTOR with an IC50 of 0.22 nM or degrade the G1 to S phase transition 1 gene (GSPT1) through the PROTAC mechanism, with a DC50 of 5 nM. It exhibits antiproliferative activity at nanomolar concentrations in various glioblastoma cell lines. Additionally, YB-3-17 shows antitumor activity in mouse models. (Pink: ligand for target protein; Black: linker; Blue: ligand for E3 ligase Cereblon)</p>Formule :C38H39N11O6Couleur et forme :SolidMasse moléculaire :745.786PI3K-IN-22
CAS :<p>PI3K-IN-22 is a dual kinase inhibitor of PI3Kα and mTOR, with IC50s of 0.9 and 0.6 nM respectively. PI3K-IN-22 could be used in cancer.</p>Formule :C31H35F3N8O3Couleur et forme :SolidMasse moléculaire :624.66RMC-6272
CAS :<p>RMC-6272 (RM-006) is a bi-steric mTORC1 inhibitor with selective potency over mTORC2 and shows greater effects than Rapamycin on TSC2-deficient tumors.</p>Formule :C95H141FN6O27SCouleur et forme :SolidMasse moléculaire :1850.25mTOR inhibitor-12
<p>mTOR inhibitor-12 (Compound 11), a selective, brain-penetrant mTOR inhibitor, exhibits no genotoxicity risk and is utilized in research pertaining to central</p>Formule :C19H24N6O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :400.5mTOR inhibitor-14
<p>mTOR Inhibitor-14 (compound 14c) is a potent inhibitor of mTOR with minimal inhibition of CYP2C8 and has demonstrated the capability to inhibit tumor growth [1</p>Degré de pureté :98%Couleur et forme :Odour SolidRMC-4627
CAS :<p>RMC-4627 is a selective mTORC1 inhibitor that activates 4EBP1 and inhibits tumor growth.</p>Formule :C93H141N11O23Couleur et forme :SolidMasse moléculaire :1781.17Cbz-B3A
CAS :<p>Cbz-B3A is a potent inhibitor of mTORC1 signalling, inhibits phosphorylation of eIF4E-binding protein 1 (4EBP1) and blocks translation by 68%.</p>Formule :C35H58N6O9Degré de pureté :98.59%Couleur et forme :SolidMasse moléculaire :706.87Anti-Phospho-mTOR (Ser2481) Antibody (4R8)
<p>Anti-Phospho-MTOR (Ser2481) Antibody (4R8) is an antibody targeting Phospho-MTOR (Ser2481). Anti-Phospho-MTOR (Ser2481) Antibody (4R8) can be used in ELISA, WB, IF.</p>Couleur et forme :Odour LiquidS6K1-IN-DG2
CAS :<p>S6K1-IN-DG2(S6K1InhibitorDG2) is a potent p70S6K inhibitor with an IC50 value of less than 100 nM.</p>Formule :C16H17BrN6ODegré de pureté :99.25%Couleur et forme :SolidMasse moléculaire :389.25RMC-5552
CAS :<p>RMC-5552 selectively inhibits mTORC1 with ~40-fold selectivity over mTORC2, demonstrating anticancer activity and research utility.</p>Formule :C93H136N10O24Couleur et forme :SolidMasse moléculaire :1778.16Anti-Phospho-MTOR (Ser2448) Antibody (2K503)
<p>Anti-Phospho-MTOR (Ser2448) Antibody (2K503) is an antibody targeting Phospho-MTOR (Ser2448). Anti-Phospho-MTOR (Ser2448) Antibody (2K503) can be used in ELISA, WB, IHC, IF.</p>Couleur et forme :Odour LiquidLupiwighteone
CAS :<p>Lupiwighteone has anti-angiogenesis potential, it also has anticancer and cancer preventive effects on SH-SY5Y cells.</p>Formule :C20H18O5Degré de pureté :98.92%Couleur et forme :SolidMasse moléculaire :338.35Omipalisib
CAS :<p>Omipalisib (GSK2126458) is a small-molecule pyridylsulfonamide inhibitor of phosphatidylinositol 3-kinase (PI3K) with potential antineoplastic activity.</p>Formule :C25H17F2N5O3SDegré de pureté :98% - 99.8%Couleur et forme :SolidMasse moléculaire :505.5mTOR inhibitor-1
CAS :<p>C-4 is a potential ATP-competitive inhibitor of mTOR. C-4 could inhibit cell growth and proliferation.</p>Formule :C16H15BrN2O3Degré de pureté :99.43%Couleur et forme :SolidMasse moléculaire :363.21Mito-LND
CAS :<p>Mito-LND (Mito-Loidamine) is an orally active and mitochondria-targeted inhibitor of oxidative phosphorylation.</p>Formule :C43H45BrCl2N3OPDegré de pureté :97.25% - 98.34%Couleur et forme :SolidMasse moléculaire :801.62Samotolisib
CAS :<p>Samotolisib (LY3023414) inhibits PI3K, DNA-PK, mTOR; tested for solid tumors including breast and colon cancer.</p>Formule :C23H26N4O3Degré de pureté :98.41% - 99.69%Couleur et forme :SolidMasse moléculaire :406.48Corynoxine
CAS :<p>Corynoxine is a tetracyclic oxindole alkaloid isolated from Uncaria macrophylla.</p>Formule :C22H28N2O4Degré de pureté :96.83% - 99.93%Couleur et forme :SolidMasse moléculaire :384.47Salidroside
CAS :<p>Salidroside is a bioactive phenolic glycoside compound isolated from Rhodiola rosea and is a prolyl endopeptidase inhibitor.Cost-effective and quality-assured.</p>Formule :C14H20O7Degré de pureté :97.81%Couleur et forme :Red-Brown Fine PowderMasse moléculaire :300.3PF-04691502
CAS :<p>PF-04691502 is a potent and selective inhibitor of PI3K and mTOR kinases with antitumor activity.</p>Formule :C22H27N5O4Degré de pureté :96.27% - ≥95%Couleur et forme :SolidMasse moléculaire :425.48
