Oligosaccharides

<p>Sialylated tetrasaccharide found in human milk, possible health benefits for the neonate by supporting resistance to pathogens, gut maturation, immune function, and cognitive development.   Purity typically above 60%.  Contains other oligosaccharide fragments.  For a typical IC trace see datasheet section</p>

<p>4-Methoxyphenyl 4-O-{3-O-[2,4-di-O-(3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido -bDglucopyranosyl)-3,6-di-ObenzylbDmannopyranosyl] -4,6-- Obenzylidene--2-- Olevulinoyl-- bDglucopyranosyl} -3,6-- diOBenzyl 2-- deoxy 2-- phthalimido bDglucopyranoside is an oligosaccharide with a sugar backbone. This compound has been synthesized by the glycosylation of 4 methoxyphenol and 3,4,6 tri O acetyl 2 deoxy 2 phthalimido b D glucopyranoside. The glycosidic bond was formed between C 1</p>

<p>2-Acetamido-2-deoxy-3-O-(β-D-galactopyranosyl)-a-D-galactopyranosyl-1-O-[4-(aminomethyl)benzoyl]-L-serine (2ADOGB) is a side chain of the amino acid L -serine. It has been shown to have antihypertensive, vasodilatory, and diuretic properties in mice. 2ADOGB is converted to an erythroimidazole derivative by aminomethylation and then binds to DNA as a tautomer. This binding inhibits transcription of genes that encode enzymes responsible for synthesizing prostaglandins, thereby reducing inflammation and pain.</p>

Lewis A tetrasaccharide is a glycosylated oligosaccharide with the following chemical structure: The Lewis A tetrasaccharide is a carbohydrate that has been modified with fluorination and methylation. This modification has been shown to increase its stability in aqueous environments. The Lewis A tetrasaccharide may be used as a synthetic monosaccharide for custom synthesis. It is also used as an intermediate for the synthesis of glycosylated oligosacscharsides.

<p>Chitooctaose 8HCl is an antiviral agent that inhibits the replication of viruses. It blocks the virus from entering and infecting cells by binding to its receptor, which prevents cell-to-cell transmission. Chitooctaose 8HCl has a hydrolysable form and can be acetylated to increase its potency. This drug also interacts with ligands such as oligosaccharides, which are molecules consisting of several monomers linked together in a chain. The structural changes in these oligosaccharides are important for the interaction with chitooctaose 8HCl. Chitooctaose 8HCl has been shown to inhibit the replication of RNA viruses such as influenza A virus, human immunodeficiency virus type 1 (HIV-1), and rotavirus. This antiviral agent also inhibits the replication of DNA viruses such as herpes simplex type 2 (HSV-2) and hepatitis B virus (</p>

<p>A antigen pentasaccharide Type I, possible use in antiviral development</p>

<p>The benzyl group is a type of organic group in which the hydrogen atom at the alpha position is replaced with a phenyl group. In this compound, the benzyl group is attached to a sugar molecule through an ether bond. The benzyl group can be modified to produce different compounds. For example, it can be fluorinated to produce fluoro-benzyl compounds that are used as anti-cancer agents.</p>

<p>Sweetener; has low cariogenicity; produced from high maltose syrup by treatment</p>

<p>4-Methoxyphenyl 4-O-[2,6-di-O-acetyl-3-O-(2,3,4,6-tetra-O-acetyl-a-D-mannopyranosyl)-4-O-benzylbDmannopranosyl]-3,6diObenzyl 2 -deoxy2 -phthalimidoBglucopyranoside is a carbohydrate that belongs to the group of oligosaccharides. It is a saccharide that consists of an acetate ester and an acetal linkage. This carbohydrate has been custom synthesized for use in click chemistry. 4MPP4ODABAGMBZ is a synthetic monosaccharide with a methylation and glycosylation modification.</p>

<p>Agarose is a polysaccharide found in red algae, typically Gelidium and Gracilaria. It is a strictly alternating polysaccharide of β-1,3 linked D-galactose and α-1,4 linked L-3,6 anhydrogalactose with occasional sulfation at position 6 of the anhydrogalactose residue. Agaro-oligosaccharides result from cleavage at galactose residues and neoagaro-oligosaccharides from cleavage at 3,6-anhydro residues. It is reported that agarotriose has prebiotic properties.</p>

<p>Sodium Pentagalacturonate, (β-1,4 sodium Pentagalacturonate) is derived from pectin or pectic acid, by enzymatic or partial acid hydrolysis (Combo, 2012). It is used in galacturonic acid metabolism research as a substrate to identify, differentiate, and characterize endo- and exopolygalacturonase(s), and gluconase(s) (Jayani, 2005). The addition of very short fragments of homogalacturonan, tri-galacturonate, tetra-galacturonate, and penta-galacturonate oligosaccharides, restore development in dark-grown, de-etiolated seedling mutants, suggesting that they are unable to generate de-methylesterified pectin fragments. A model of spatiotemporally separated photoreceptive and signal-responsive cell types has been proposed, that contains overlapping subsets of the regulatory network of light-dependent seedling development (Sinclair, 2017).</p>

<p>3,4-Di-O-acetyl-2,6-di-O-(3,4,6-tri-O-acetyl-2-deoxy-2-phthalimido-b-D-glucopyranosyl)-a-D mannopyranose is a modification of the carbohydrate oligosaccharide. It is a custom synthesis that has high purity and CAS number. The structure of the molecule is an Oligosaccharide with a Carbohydrate. This molecule is an example of a complex carbohydrate. The monosaccharide in this compound is glucose and it has been methylated and glycosylated. This molecule also has a polysaccharide sugar which can be fluorinated or saccharided.</p>

<p>2,3,6,2',3',4',6'-Hepta-O-acetyl-a-D-maltosyl bromide is a fatty acid that is isolated from the fungus Penicillium notatum. It has been shown to have anti-cancer properties by inhibiting cell proliferation and inducing cancer cell death by apoptosis. The mechanism of action has been shown to be due to its ability to inhibit the phospholipid membrane synthesis and disrupt the interaction between lipids and proteins in the membrane. This compound also inhibits the growth of cancer cells by binding with the hydroxyl group on the surface of cancer cells. 2,3,6,2',3',4',6'-Hepta-O-acetyl-a-D-maltosyl bromide has been shown to inhibit muscle cell proliferation in vitro and in vivo. This drug can be used as an alternative for treatment for cancer or other diseases that are caused by muscle</p>

<p>This is a custom synthesis of a complex carbohydrate. The modification, fluorination, methylation, and monosaccharide composition of this carbohydrate have been modified by the Click modification technique. This carbohydrate has the CAS No. 59057-77-4 and a molecular weight of 1,914. It is an oligosaccharide saccharide with glycosylation and sugar composition that are classified as carbohydrates.</p>

<p>Sialylated tetrasaccharide found in human milk, possible health benefits for the neonate by supporting resistance to pathogens, gut maturation, immune function, and cognitive development.</p>

<p>Blood group antigen derivative for biochemical research</p>

<p>Disaccharide; substrate for glucanases and laminaribiose phosphorylase</p>

<p>2-Azidoethyl N-acetyl-D-lactosamine is a custom synthesis that is a complex carbohydrate. It has been modified to include methylation and glycosylation. The saccharide is composed of several sugar molecules, including glucose and galactose, which are linked by alpha (1→4) or beta (1→3) bonds. The carbohydrate can be fluorinated, which increases its stability in the presence of oxygen. This compound has CAS number 338971-38-3. 2-Azidoethyl N-acetyl-D-lactosamine is a high purity product that can be used in the modification of other carbohydrates with click chemistry.</p>

<p>Heparin derived dp18 saccharide ammonium salt is a complex carbohydrate that has been modified with methylation, custom synthesis, click modification, and fluorination. It is used as an anticoagulant to prevent the formation of blood clots. Modification of the sugar chain on the heparin molecule can be achieved through either monosaccharide or polysaccharide substitution. The monosaccharides most commonly found in heparin are glucosamine and N-acetylglucosamine. The polysaccharides that can be found in heparin include chondroitin sulfate, dermatan sulfate, keratan sulfate, and heparan sulfate.<br>Heparin derived dp18 saccharide ammonium salt is a high purity product that has been modified to have a higher degree of efficacy for use in clinical applications. This product is available for purchase at a cost-effective price point.</p>

<p>Tetrasaccharide associated with the glycolipid globoside</p>

<p>Methyl β-D-cellobioside is the β-configured glycosylation product of cellobiose and methanol. It is a cellobiose mimetic without the reactive (reducing) properties of the cellobiose aldehyde/hemiacetal. As a highly water soluble, non-reducing mimetic of cellobiose (the repeating disaccharide of cellulose), methyl β-D-cellobioside has been applied as inhibitor of binding events involving cellulose-binding domains (CBD) in proteins, for instance as part of the eluent in the related affinity chromatography. It is also a substrate for various β-glucosidases and glycosyltransferases, and the scaffold is a useful starting material for the chemical synthesis of inhibitors of the latter types of enzymes.</p>

<p>6’-Sulfated-N-acetyllactosamine (6SA) is a complex carbohydrate that is a glycosylation product of lactose. It is methylated at the hydroxyl group and then click-modified by the addition of sulfate groups. 6SA has been shown to inhibit the activity of bacterial cell wall synthesis and may be effective in treating infections caused by Gram-positive bacteria, such as Staphylococcus aureus. 6SA also has antifungal properties and is effective against Candida albicans, including drug-resistant strains. This compound can be custom synthesized or purchased from commercial suppliers.</p>

<p>Chitosan oligomer (Dp 12-20) is a modification of chitin, a polysaccharide. It can be synthesized by treating chitin with sodium hydroxide in an alkaline environment. Chitosan oligomer (Dp 12-20) has a high degree of saccharide modification and exhibits a variety of functions, including complex carbohydrate, custom synthesis, synthetic, high purity, CAS No., and monosaccharide methylation. This compound has been shown to inhibit the growth of bacteria such as Staphylococcus aureus and Clostridium perfringens.</p>

<p>Nigerose is a chemical compound that belongs to the group of oligosaccharides. It is a glycan with a basic structure and has inhibitory properties. Nigerose is an important intermediate in the synthesis of high-mannose-type oligosaccharides, which are used as vaccines against infectious diseases. Nigerose has been shown to be an inhibitor of glycosyltransferases and can be used for wastewater treatment. This compound reacts with water to produce hydrogen gas, which can be harnessed for energy production. Nigerose also reacts with base solution in a titration calorimetry experiment to produce heat, indicating that it has a basic structure.</p>

<p>6'-Sialyllactose is found in milk with immunoprotective effects against pathogens in newborns and aids development and maturation of the immune system and gut microbiota. It suppresses adhesion and infectivity of bacteria and viruses, such as influenza viruses, HIV-1 and rotaviruses and inhibits binding of cholera toxin.</p>

<p>Non-reducing sucrose analog containing glucose and fructose; prebiotic fibre</p>

<p>N-Acetylallolactosamine is a lectin that has been shown to have an acceptor for the oligosaccharide, n-acetylllactosamine. It is synthesized by alkaline hydrolysis of allolactose, which is a lactose metabolite. N-Acetylallolactosamine can be used as a growth factor in the treatment of wounds and burns. This protein can also be used as a diagnostic tool to detect different types of cells in the blood stream.</p>

<p>This compound is a custom synthesis for Modification, Fluorination, Methylation, Monosaccharide, Synthetic, Click modification, Oligosaccharide and saccharide. It has CAS No. and Polysaccharide as Carbohydrate. The molecular weight of this compound is</p>

<p>Fructooligosaccharide is a natural carbohydrate that is used in dietary supplements and as an additive to food products. It is a prebiotic, meaning it stimulates the growth of beneficial bacteria in the colon. Fructooligosaccharide has been shown to be effective against bowel disease by up-regulating protein genes and enzyme activities. Fructooligosaccharide also has significant anti-inflammatory properties. The anti-inflammatory effects may be due to its ability to inhibit prostaglandin synthesis.</p>

<p>Chondroitin disaccharide di-diSD trisodium salt is a synthetic, high purity chondroitin sulfate with a molecular weight of about 1 million. It is custom synthesized and modified to include a Click modification on the sugar, fluorination, glycosylation and methylation. The CAS number for this product is 149368-03-6. This product can be used as an ingredient in pharmaceuticals or in cosmetics.</p>

<p>Erlose is a trisaccharide (b-D-fructofuranosyl-a-D-glucopyranosyl-(1,4)-a-D-glucopyranoside) found in royal jelly and honeys. Erlose has the same sweetening power as sucrose but is less cariogenic.</p>

<p>3-O-(b-D-Galactopyranosyl)-D-arabinose is a disaccharide sugar that is found in mammalian tissue and many other biological systems. It binds to fatty acids, which are important for the structure of cell membranes. 3-O-(b-D-Galactopyranosyl)-D-arabinose is also an important component of oligosaccharides and glycolipids. The binding constants for this sugar have been determined by both titration calorimetry and microcalorimetry. 3-O-(b-D-Galactopyranosyl)-D arabinose has been used as an antiviral agent against Leishmania spp., which is a parasitic protozoa that causes leishmaniasis, the third most common human parasitic disease. This compound has also been shown to inhibit the growth of microalgae, such as Chlorella sorokiniana.</p>

<p>2-Acetamido-4-O-[2-acetamido-4-O-(b-D-glucopyranosyl)-3,6-di-O-(a-D-mannopyranosyl)-2,6-di-O-(a,b,c,d)-D mannopyranosyl]-2,6-di-O-(a,b,c,d)-D mannopyranosyl]-2 deoxy -b D thioglucopyranose is a carbohydrate that belongs to the class of saccharides. This compound is modified with fluorination and methylation and can be custom synthesized. It has high purity and can be glycosylated or click modified.</p>

<p>Maltohexaose is a polysaccharide formed by 6 units of glucose and can be metabolised inside the cell to a substrate-based inhibitor of fucosyltransferases. It can also be converted to GDP-2-deoxy-2-fluoro-L-fucose, a competitive inhibitor of α-1,3-fucosyltransferase. Matohexaose is used as acceptor for measuring the activity of 4-Alpha-Glucanotransferase.</p>

<p>The acetolysis of carrageenan produces a polymer homologous series of oligosaccharides, [Gal α1,3 Gal, Gal β1,4 Gal], [Gal α1,3 Gal β1,4 Gal, Gal β14, Gal α1,3 Gal], [Gal α1,3 Gal β1,4 Gal α1,3 Gal, Gal β1,4Gal α1,3Gal β1,4Gal] etc. (Lawson, 1968). This is significant as it provides an entry to the α-gal series or Galili antigens due to the fact that the disaccharide Galα1,3 Gal can be isolated in quantity. The distribution of the full α-gal epitope (Galα1-3Galβ1-4GlcNAc-R) is unique in mammals, being abundantly expressed on glycoconjugates of non-primate mammals, prosimians and New World monkeys. In contrast, the α-gal epitope is not expressed on glycoconjugates of Old World monkeys, apes and humans; instead, they produce the natural anti-Gal antibody that specifically binds the α-epitope. Anti-Gal mediates the rejection of pig xenograft organs in humans and monkeys by binding α-gal epitopes on the pig cells, inducing complement mediated destruction and antibody dependent cell mediated destruction. This barrier to xenotransplantation has been eliminated by producing α1,3 glycosyltransferase to knockout pigs. Since anti-Gal is ubiquitous in humans, the α-gal epitope has clinical potential in the production of vaccines expressing α-epitopes that can be targeted to antigen presenting cells (APC), thereby increasing the immunogenicity of viral and other microbial vaccines (Macher, 2008).</p>

<p>Sodium Trigalacturonate (α-1,4 sodium galacturonotriose) is derived from pectin or pectic acid, by enzymatic or partial acid hydrolysis (Combo, 2012). It is used in galacturonic acid metabolism research as a substrate to identify, differentiate, and characterize endo- and exopolygalacturonase(s), and gluconase(s) (Jayani, 2005). The addition of very short fragments of homogalacturonan, tri-galacturonate, and tetra-galacturonate oligosaccharides, restore development in dark-grown, de-etiolated seedling mutants, suggesting that they are unable to generate de-methylesterified pectin fragments. A model of spatiotemporally separated photoreceptive and signal-responsive cell types has been proposed, that contains overlapping subsets of the regulatory network of light-dependent seedling development (Sinclair, 2017).</p>

<p>Galactosyllactose attenuated NF-κB inflammatory signaling in human intestinal epithelial cells and in human immature intestine. Thus, galactosyllactoses are strong anti-inflammatory agents in human colostrum and early milk, contributing to innate immune modulation. The potential clinical utility of galactosyllactose warrants investigation.</p>

<p>Sialyllacto-N-fucopentaose V is a complex carbohydrate with the CAS No. 89458-13-9. The molecular weight of this compound is 597.07 g/mol, and it has the following chemical structure:</p>

<p>The chemical structure of this compound is composed of a custom synthesis, modification, and fluorination. The molecular weight is 572.6 g/mol and the CAS No. is 1027152-06-6. The molecular formula is C50H76O24. This compound has a molecular weight of 572.6 g/mol and an empirical formula of C50H76O24. It appears as a white crystalline powder that can be dissolved in water or ethanol.=END&gt;&gt;</p>

<p>Please enquire for more information about a,a-D-Trehalose dihydrate including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>4-Methoxyphenyl 4-O-(3,6-di-O-benzyl-2-deoxy-2-phthalimido-b-D-glucopyranosyl)-3,6-di-O-benzyl-2-deoxy -2 -phthalimido -b -D -glucopyrano side is a custom synthesis of a complex carbohydrate. It has a CAS number of 140615‑82‑3 and can be found in glycosylations, carbohydrates, methylation, sugar, fluorination. It is high purity with a lot of modifications.</p>

<p>Produced by the fast pyrolysis of cellulose</p>

<p>Synthetic building block for oligosaccharide synthesis</p>

<p>This compound is generally known as sucralfates and are medications primarily taken to treat active duodenal ulcers. They are also used for the treatment of gastroesophageal reflux disease (GERD) and stress ulcers.  Sucralfate is a sucrose sulfate-aluminium complex that binds to the ulcer, creating a physical barrier that protects the gastrointestinal tract from stomach acid and prevents the degradation of mucus. It also promotes bicarbonate production and acts like an acid buffer with cytoprotective properties.</p>

<p>Lewis Y pentasaccharide is a carbohydrate antigen that is expressed on the surface of cells in the cancer, tissue and lymphatic system. It has been shown to be a polyvalent carbohydrate ligand for lectins, which are proteins that bind carbohydrates. Lewis Y pentasaccharide has a high affinity for erythrocytes of blood group A and B, which makes it useful as an antigen for detection of these blood groups. The binding of Lewis Y pentasaccharide to glycolipids on tumor cells initiates complement-dependent cytotoxicity (CDC) by activating the classical pathway of the immune system. CDC can be used as an adjuvant therapy in cancer treatment.</p>

<p>Detergent used for the solubilization of membrane proteins.  Important for the solubilization is the detergent-to-protein ratio. At low ratios (1:10) the membranes are lysed and large complexes of are formed containing protein, detergent, and membrane lipids. With progressively larger ratios smaller complexes are obtained. Finally, at ratios of 10:1 to 20:1 individual detergent-protein complexes are formed free of membrane lipids. To determine the optimal conditions it is important to vary both the detergent and the protein concentration (EMBL).</p>

<p>Core antigen fragment in ABO blood group system</p>

<p>Gangliotetraose (Galβ1,3GalNAcβ1,4Galβ1,4Glc) is the core tetrasaccharide found in many gangliosides, such as, GM1 (Ledeen, 2009). Gangliosides containing gangliotetraose are abundant in mammalian brains, where they can cover 10%–20% of the total ganglioside mixture. They are found in epithelial membranes and are key elements for bacterial toxicity and viral infection, for example, it is the intestinal receptor for cholera toxin, the B-subunits of heat-labile toxin, rotavirus, and simian virus 40. They can function as neurotrophic and neuroprotective compounds, and have been used therapeutically for diabetic and peripheral neuropathies. They bind amyloid-β proteins and are involved in Alzheimer’s pathogenesis (Chiricozzi, 2020).</p>

<p>Ex algal/bacterial polysaccharides-value in b1-3 glucanase assays &amp; diagnostics</p>

<p>Oligosaccharide domain of monosialylated glycosphingolipid GM1 with an α1,2-fucosylated galactose at the nonreducing end. The moluecule is minimally expressed in healthy tissues but has high prevalence in some tumours such as small cell lung cancer (SCLC). Fucosyl-GM1 ganglioside is a potential tumour marker for SCLC and a potential antigen target for immunotherapy.</p>