Ligands organométalliques
Sous-catégories appartenant à la catégorie "Ligands organométalliques"
- Ligands de Buchwald(22 produits)
- DPEN(4 produits)
- DPHEN(4 produits)
- JOSIPHOS(4 produits)
- Phosphine(497 produits)
- Porphyrines(75 produits)
2889 produits trouvés pour "Ligands organométalliques"
SR 4835
CAS :SR 4835 is a synthetic compound, which is an advanced molecular entity derived from extensive medicinal chemistry efforts. This compound exhibits a novel mechanism of action, targeting specific cellular pathways implicated in disease processes. SR 4835 functions by modulating enzyme activity, thus influencing intracellular signaling cascades that play a critical role in pathophysiological conditions.
Formule :C21H20Cl2N10ODegré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :499.36 g/molDacomitinib
CAS :Pan-EGFR inhibitor (HER1, HER2 and HER4); antineoplasticFormule :C24H25ClFN5O2Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :469.95 g/molGilteritinib
CAS :Inhibitor of FLT3 and AXL tyrosine kinasesFormule :C29H44N8O3Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :552.71 g/molPF 05214030
CAS :PF 05214030 is a biosimilar monoclonal antibody, which is sourced from recombinant DNA technology and designed to inhibit tumor necrosis factor-alpha (TNF-α). This product functions by binding to TNF-α, a cytokine that plays a critical role in mediating inflammation. By preventing TNF-α from interacting with its receptors on cell surfaces, PF 05214030 effectively reduces the inflammatory response associated with various autoimmune and inflammatory conditions.
Formule :C17H13Cl2FN2O4SDegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :431.3 g/molMotesanib
CAS :Inhibitor of VEGFR, PDGR, c-Kit and Ret; inhibitor of angiogenesisFormule :C22H23N5ODegré de pureté :Min. 95%Masse moléculaire :373.45 g/molKenpaullone
CAS :Inhibitor of glycogen synthase 3 (GSK-3) and cyclin-dependent kinases CDK1, CDK2 and CDK5. Kenpaullone can substitute transcription factor Klf4 in reprogramming of fibroblast to induced pluripotent stem cells when using the method of ectopic expression of transcriptional factors. In an in vitro model for Alzheimer’s disease, kenpaullone decreased production of amyloid beta peptides Aβ40 and Aβ42.
Formule :C16H11BrN2ODegré de pureté :Min. 95%Couleur et forme :Yellow To Dark Yellow SolidMasse moléculaire :326.00548GSK 2606414
CAS :Inhibitor of EIF2AK3/PERK kinasesFormule :C24H20F3N5ODegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :451.44 g/molAZD-7648
CAS :AZD-7648 is a selective inhibitor of DNA-dependent protein kinase (DNA-PK), which is a pivotal enzyme involved in the non-homologous end joining (NHEJ) pathway of DNA repair. This product is derived from extensive chemical synthesis and optimization, designed for its specificity and efficacy in inhibiting DNA-PK activity. The mode of action involves binding to the ATP-binding site of DNA-PK, thereby obstructing its ability to facilitate the repair of double-strand DNA breaks.Formule :C18H20N8O2Degré de pureté :Min. 98 Area-%Couleur et forme :PowderMasse moléculaire :380.4 g/molAgomelatine - Bio-X ™
CAS :Produit contrôléAgomelatine is a potent agonist at melatonin receptors and an antagonist at serotonin receptors. It was designed to treat mood disorders, such as depression. It has been shown to improve mood by increasing the levels of certain neurotransmitters in the brain such as dopamine and noradrenaline. Agomelatine has beneficial phase-shifting effects in humans; it causes a sleep phase advance, a drop in body temperature, and an initial release of melatonin. According to controlled human studies, Agomelatine is equally effective at treating severe depression as the SSRI antidepressants paroxetine and sertraline.Formule :C15H17NO2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :243.3 g/molSB 239063
CAS :Inhibits p38 MAP kinase; anti-inflammatory; neuroprotectiveFormule :C20H21FN4O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :368.4 g/molZileuton- Bio-X ™
CAS :Zileuton is an inhibitor of the 5-lipoxygenase enzyme, thus preventing the leukotrienes LTE4, LDT4, LTB4 and LTC4 from being formed. This in turn reduces inflammation, bronchoconstriction and mucus secretion in the airways. As a result, Zileuton can be used in the treatment and management of asthma and allergic rhinitis. Studies have shown that Zileuton has the potential to reverse dementia-related brain damage.Formule :C11H12N2O2SDegré de pureté :(%) Min. 95%Couleur et forme :PowderMasse moléculaire :236.29 g/mol17:0-20:4Pi (4) P
CAS :17:0-20:4Pi (4) P is a synthetic phosphoinositide, which is a type of phospholipid. It is typically sourced from laboratory synthesis, often incorporating stable isotopes or specific fatty acid chains to mimic natural compounds found in cell membranes. This product functions primarily as a probe in biochemical experiments, particularly for studying lipid signaling pathways within cells.
Formule :C46H88N2O16P2Degré de pureté :Min. 95%Masse moléculaire :987.14 g/molVU 6010608
CAS :This compound is a novel negative allosteric modulator of glutamate metabotropic receptor mGlu7. It is highly selective for mGlu7 over other receptors of mGlu class with IC50 = 795 nM. Although VU 6010608 showed favourable brain penetration in rats, it has been proposed as an in vitro tool for electrophysiology studies. The mGlu7 is broadly distributed within the mammalian central nervous system and it plays a key role in neuronal function and synaptic plasticity.
Formule :C18H15F3N4O4Degré de pureté :Min. 95%Couleur et forme :Solid.Masse moléculaire :408.33 g/molSertindole
CAS :Antagonist of cardiac potassium channel HERG; anti-psychoticFormule :C24H26ClFN4ODegré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :440.94 g/molValiglurax
CAS :Potent and selective positive allosteric modulator (PAM) of metabotropic glutamate receptor mGlu4. Valiglurax is orally bioavailable and CNS-penetrant mGlu4 PAM in preclinical development for the Parkinson’s disease therapy and alleviation of the motor symptoms.Formule :C16H10F3N5Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :329.28 g/molElacridar
CAS :Inhibitor of ABC transporters; oral bioenhancer for anti-cancer therapyFormule :C34H33N3O5Degré de pureté :Min. 98 Area-%Couleur et forme :Yellow PowderMasse moléculaire :563.64 g/molEptifibatide acetate
CAS :Produit contrôléInhibits platelet glycoprotein IIb/IIIa receptorsFormule :C35H49N11O9S2·xC2H4O2Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :831.96 g/molBKM 120
CAS :Inhibitor of pan-class I PI3K family of lipid kinases; antineoplastic
Formule :C18H21O2N6F3Degré de pureté :Min. 95%Couleur et forme :White PowderMasse moléculaire :410.39 g/molJNJ 10198409
CAS :Selective inhibitor of the platelet derived growth factor receptor PDGFRβ with IC50 value of 4.2 nM. JNJ 10198409 inhibits the PDGFRβ kinase activity and its downstream signalling leading to anti-proliferative and anti-angiogenic effects, which were confirmed in various tumoral cell lines.Formule :C18H16FN3O2Degré de pureté :Min. 95%Couleur et forme :SolidMasse moléculaire :325.34 g/molPhosphorylated LRRKtide
LRRKtide (also called moesin) is a peptide substrate for leucine-rich repeat kinase 2 (LRRK2). The sequence of LRRKtide has been derived from the ERM proteins: Ezrin (amino acids 561-573), radixin (amino acids 558-570) and moesin (amino acids 539-553). These proteins influence cytoskeletal dynamics by anchoring the cytoskeleton to the plasma membrane. LRRK2 phosphorylates LRRKtide at its Thr558 site. This peptide contains the phosphorylated threonine residue.LRRK2 is a large, ubiquitous protein of unknown function. LRRK2 has GTPase and kinase activity, and is located in multiple areas of the cell, associated with intracellular membranes and vesicular structures- suggesting LRRK2 may be involved in several cellular pathways. LRRK2 is also found in most organs and mutations in LRRK2 have been identified in Parkinson's disease.The threonine residue at position 9 of this peptide has been phosphorylated.Degré de pureté :Min. 95%Couleur et forme :PowderMasse moléculaire :2,009.1 g/mol
