Autres inhibiteurs

<p>Propargyl-PEG4-CH2COOH is a PEG-based linker for PROTACs that joins two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation via the ubiquitin-proteasome system within cells.</p>

<p>((2-Cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)methyl)triphenylphosphonium bromide is a useful organic compound for research related to life sciences. The catalog number is T66070 and the CAS number is 154057-58-6.</p>

<p>1-(3-Carboxy-2-pyridyl)-4-methyl-2-phenylpiperazine is a useful organic compound for research related to life sciences. The catalog number is T67037 and the CAS number is 61338-13-4.</p>

<p>Expression System: HEK293 Cells&lt;br&gt;Activity: Not Tested</p>

<p>N-(4-(2-Aminoacetyl)-5-methoxy-2-phenoxyphenyl)methanesulfonamide hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66231 and the CAS number is 149436-41-9.</p>

<p>AN-2898 is a potent and selective PDE4 inhibitor potentially for the treatment of fungal infection.</p>

<p>Dorsomorphin analog-8 is a Dorsomorphin analogue . Dorsomorphin (BML-275) is an anti-tumour AMPK inhibitor that induces autophagy.</p>

<p>Propyl 3-Phenylacrylate is a useful organic compound for research related to life sciences. The catalog number is T65375 and the CAS number is 7778-83-8.</p>

<p>Azodicarbonamide is the first nucleocapsid inhibitor known to inhibit HIV-1 and various retroviruses by targeting the nucleocapsid CCHC domains. In a standard cellular antiviral assay, the compound inhibited HIV-1RF-induced CEM-SS cytopathy with an EC50 value of 38 µM.</p>

<p>TL4830031 (8i), quinolone derivative, Axl inhibitor, IC50: 26 nM, blocks Axl phosphorylation, cell invasion &amp; migration; for cancer research.</p>

<p>(S)-3-Methyl-1-(2-(piperidin-1-yl)phenyl)butan-1-amine is a useful organic compound for research related to life sciences. The catalog number is T65764 and the CAS number is 147769-93-5.</p>

<p>Ethyl 4-(1-hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65755 and the CAS number is 144689-93-0.</p>

<p>L-Histidinyl-D-penicillaminatocobalt(III) can provide a model for the binding of D-penicillamine to metal ions.</p>

<p>NE58062 is a bioactive chemical.</p>

<p>2,2'-(2-Hydroxypropane-1,3-diyl)bis(isoindoline-1,3-dione) is a useful organic compound for research related to life sciences. The catalog number is T67040 and the CAS number is 73825-95-3.</p>

<p>N-Methyl-2-nitroaniline is a useful organic compound for research related to life sciences. The catalog number is T67031 and the CAS number is 612-28-2.</p>

<p>PF-6689840 is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 54 nM in biochemical assays; inhibits PTK6 phosphorylation at Y342 in engineered HET293T cells overexpressing PTK6 WT with IC50 of 0.25 uM; demonstrates superior kinase selectivity compared to the Type I inhibitors; inhibits tumor cell growth, which is independent of PTK6 expression levels in cells.</p>

<p>(S)-(-)-3-(N-Methylamino)-1-(2-thienyl)-1-propanol is a useful organic compound for research related to life sciences. The catalog number is T67011 and the CAS number is 116539-55-0.</p>

<p>VH032-PEG3-acetylene: a VHL ligand-linker for PROTACs, combines VH032 with PEG3-acetylene.</p>

<p>(S)-2-Ethylbutyl 2-(((S)-(4-nitrophenoxy)(phenoxy)phosphoryl)amino)propanoate is a useful organic compound for research related to life sciences. The catalog number is T64602 and the CAS number is 1354823-36-1.</p>

<p>2,4-Dihydroxy-5-methoxypyrimidine is a useful organic compound for research related to life sciences. The catalog number is T66505 and the CAS number is 6623-81-0.</p>

<p>Thalidomide-C2-amido-C2-COOH is a compound that includes a CRBN ligand for the E3 ubiquitin ligase, as well as a linker.</p>

<p>Benzyl (4-bromo-3-fluorophenyl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T66461 and the CAS number is 510729-01-8.</p>

<p>Vornorexant (ORN-0829; TS-142) is a potent dual OX1R and OX2R antagonist with IC50 values of 1.05 nM and 1.27 nM, respectively. It exhibits potent sleep-promoting effects in vivo and can be used for insomnia treatment research.</p>

<p>Equ c 1 Protein, Domestic horse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.1 kDa.</p>

<p>Microcystin-LY, from Microcystis aeruginosa, is a heptapeptide toxin that triggers oxidative stress by activating the Nrf2 pathway, most effective at 3μM.</p>

<p>8-Methylquinolin-4(1H)-one is a useful organic compound for research related to life sciences. The catalog number is T66738 and the CAS number is 23432-44-2.</p>

<p>Thiol-PEG4-alcohol is a PEG-based linker for PROTACs that connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation through the ubiquitin-proteasome system within cells.</p>

<p>(2'-Methylamino-1,1'-biphenyl-2-yl)methanesulfonatopalladium(II) dimer is a useful organic compound for research related to life sciences and the catalog number is T67263.</p>

<p>1-(4-(4-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)thieno[3,2-d]pyrimidin-2-yl)phenyl)-3-(pyridin-4-yl)urea is a useful organic compound for research related to life sciences. The catalog number is T67700 and the CAS number is 1144075-47-7.</p>

<p>5-Chlorohexanoyl chloride is a useful organic compound for research related to life sciences. The catalog number is T64515 and the CAS number is 99585-01-0.</p>

<p>Thiol-PEG3-acid, a PEG-based linker for PROTACs, facilitates the connection of two essential ligands to form PROTAC molecules, enabling selective protein degradation through the ubiquitin-proteasome system within cells.</p>

<p>Stephalonine L is a natural product for research related to life sciences. The catalog number is TN6290 and the CAS number is 2379277-60-6.</p>

<p>5-(2-Bromoacetyl)-2-hydroxybenzaldehyde is a useful organic compound for research related to life sciences. The catalog number is T66272 and the CAS number is 115787-50-3.</p>

<p>4-Iodo-N-[(phenylmethoxy)carbonyl]-L-phenylalanine (catalog number T66874, CAS number 220400-04-4) is a valuable organic compound for life sciences research.</p>

<p>Triethyl 2-phosphonopropionate is a useful organic compound for research related to life sciences. The catalog number is T65480 and the CAS number is 3699-66-9.</p>

<p>2-(Trifluoromethyl)cinnamic acid is a useful organic compound for research related to life sciences. The catalog number is T64859 and the CAS number is 2062-25-1.</p>

<p>1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 2-ethoxy-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65490 and the CAS number is 170791-09-0.</p>

<p>(S)-2-Amino-3-(2-hydroxyphenyl)propanoic acid hydrochloride is a valuable organic compound for life sciences research [Catalog No. T66634, CAS No. 1810074-88-4].</p>

<p>4-Ethylcyclohexanecarboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T67671 and the CAS number is 91328-77-7.</p>

<p>PEG3-C4-OBn, a polyethylene glycol (PEG)-based PROTAC linker, is utilized in crafting the PROTAC SGK3 degrader-1, a potent SKG3 degrader leveraging PROTAC technology [1][2].</p>

<p>Azido-PEG5-NHS ester is a PEG-based linker for PROTACs that joins two essential ligands, crucial for the formation of PROTAC molecules, enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

<p>PMAL-C16 has a wide range of applications in life science related research.</p>

<p>DiAzK has a wide range of applications in life science related research.</p>

<p>2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine, with catalog number T66608 and CAS number 90213-66-4, is a valuable organic compound for life sciences research.</p>

<p>Expression System: HEK293 Cells&lt;br&gt;Activity: Not Tested</p>

<p>Guanylthiourea is a useful organic compound for research related to life sciences. The catalog number is T64909 and the CAS number is 2114-02-5.</p>

<p>GCLE is a useful organic compound for research related to life sciences. The catalog number is T65660 and the CAS number is 104146-10-3.</p>

<p>Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine is a useful organic compound for research related to life sciences. The catalog number is T66183 and the CAS number is 1160861-53-9.</p>

<p>Diazodiiodoarsenic acid was used to isolate plasma membrane proteins from platelets by means of affinity chromatography.</p>

<p>2-Acetamidothiazole is a useful organic compound for research related to life sciences. The catalog number is T67350 and the CAS number is 2719-23-5.</p>

<p>Methanesulfonato[4,6-bis(diphenylphosphino)phenoxazine](2'-amino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences and the catalog number is T67254.</p>

<p>2-(4-Chlorophenyl)quinoline-4-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T67172 and the CAS number is 5466-31-9.</p>

<p>1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66214 and the CAS number is 503614-92-4.</p>

<p>H-Arg(Mtr)-OH, an amino acid derivative, has a wide range of applications in life science-related research.</p>

<p>Ligustrazine Hydrochloride, is a natural substance discovered in the plant Ligusticum chuanxiong Hort. It inhibits platelet aggregation, improves atherosclerosis situation, protects endothelium injury, and has antithrombotic effects.in vivo,ligustrazine hydrochloride at 10 and 20 mg/kg produced significant analgesic effects against mechanical stimuli,and ligustrazine hydrochloride at 80 mg/kg, also significantly alleviated cold hypersensitivity manifested by reduction in cold vocalization temperature.</p>

<p>Questiomycin A derivatives 12 is a Questiomycin A derivative.</p>

<p>Ethyl 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65575 and the CAS number is 112811-71-9.</p>

<p>Arsenazo I is a calcium-sensitive, metallochromic dye used as reagent.</p>

<p>Deoxyribonucleic Acid Sodium (Salmon testes) is a natural DNA used in studies of DNA binding agents that modulate DNA structure and function.</p>

<p>(S)-Methyl 3-([1,1'-biphenyl]-4-yl)-2-((tert-butoxycarbonyl)amino)propanoate is a useful organic compound for research related to life sciences and the catalog number is T67025.</p>

<p>1-(9H-Fluoren-9-yl)-3-oxo-2,7,10,13,16,19,22,25,28,31,34,37-dodecaoxa-4-azatetracontan-40-oic acid is a useful organic compound for research related to life sciences and the catalog number is T64564.</p>

<p>(1R,2S)-2-Phenylcyclopropanamine is a useful organic compound for research related to life sciences. The catalog number is T66420 and the CAS number is 3721-26-4.</p>

<p>3-Nitrocinnamic acid is a useful organic compound for research related to life sciences. The catalog number is T66043 and the CAS number is 555-68-0.</p>

Fmoc-PEG1-CH2CH2-NHS ester is a polyethylene glycol (PEG)-derived linker engineered for the synthesis of proteolysis-targeting chimeras (PROTACs) [1].

<p>Poly (hexamethylene biguanide) hydrochloride is a useful organic compound for research related to life sciences and the catalog number is T65926.</p>

<p>(4-Methoxy-3,5-dimethylpyridin-2-yl)methyl acetate is a useful organic compound for research related to life sciences. The catalog number is T67186 and the CAS number is 91219-90-8.</p>

<p>4-Isobutylpyrrolidin-2-one is a useful organic compound for research related to life sciences. The catalog number is T65647 and the CAS number is 61312-87-6.</p>

<p>Cyclofos-4 is a useful organic compound for research related to life sciences. The catalog number is TF0104 and the CAS number is 675126-15-5.</p>

<p>2-(4-((4-Chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethanol dihydrochloride is a useful organic compound for research related to life sciences. The catalog number is T64940 and the CAS number is 164726-80-1.</p>

<p>Azido-PEG24-acid is a PEG-based linker for PROTACs, crucial for joining two essential ligands and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

<p>2,6-Bis[[(R)-2-[hydroxy(diphenyl)methyl]-1-pyrrolidinyl]methyl]-4-methylphenol is a useful organic compound for research related to life sciences and the catalog number is T66791.</p>

<p>Cpd.7 of 1326852-06-5 is a useful organic compound for research related to life sciences. The catalog number is T9559 and the CAS number is 2411843-75-7.</p>

<p>Ibiglustat (Venglustat) succinate is an orally active, brain-penetrant inhibitor of glucosylceramide synthase (GCS) utilized in the investigation of Gaucher disease type 3, Parkinson's disease associated with GBA mutations, Fabry disease, GM2 gangliosidosis, and autosomal dominant polycystic kidney disease.</p>

<p>TLR7/8 agonist-7d is a useful organic compound for research related to life sciences and the catalog number is T64606.</p>

<p>m-PEG3-Aminooxy is a PEG-based linker for PROTACs that connects two essential ligands, playing a crucial role in forming PROTAC molecules and enabling selective protein degradation by utilizing the ubiquitin-proteasome system within cells.</p>

<p>(S)-7,7'-Bis(bis(3,5-dimethylphenyl)phosphaneyl)-2,2',3,3'-tetrahydro-1,1'-spirobi[indene] is a useful organic compound for research related to life sciences and the catalog number is T65595.</p>

<p>Benzyl 2-(2-benzyl-3-mercaptopropanamido)acetate is a useful organic compound for research related to life sciences and the catalog number is T66864.</p>

<p>5-Bromo-2-(2-methyl-2H-tetrazol-5-yl)pyridine is a useful organic compound for research related to life sciences. The catalog number is T66868 and the CAS number is 380380-64-3.</p>

<p>Morpholino C subunit is a useful organic compound for research related to life sciences and the catalog number is T64772.</p>

<p>Podoblastin A (D-mannitol) is a useful organic compound for research related to life sciences and the catalog number is TSP-41077145.</p>

<p>PROTAC VEGFR-2 degrader-2 has minimal VEGFR-2 inhibition (IC50 &gt; 1μM) and low anti-proliferative effect on EA.hy926 cells (IC50 &gt; 100μM).</p>

<p>3-Bromo-2-methylaniline, catalog number T65643 [CAS number 55289-36-6], is a valuable organic compound for life sciences research.</p>

<p>Ethyl 2-(3-formyl-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T65566 and the CAS number is 161798-03-4.</p>

<p>N-(3-Chloro-4-hydroxyphenyl)acetamide is a useful organic compound for research related to life sciences. The catalog number is T67206 and the CAS number is 3964-54-3.</p>

<p>3-Amino-1H-pyrazole-4-carbonitrile is a useful organic compound for research related to life sciences. The catalog number is T66363 and the CAS number is 16617-46-2.</p>

<p>Ligustrosidic acid, a natural compound, is extracted from Ligustrum japonicum and Ligustrum lucidum.</p>

<p>Fmoc-Cys(Trt)-OPFP, with catalog number T65699 and CAS number 115520-21-3, is a valuable organic compound utilized in life sciences research.</p>

<p>Thalidomide-based cereblon ligand-linker for selective dBRD9 synthesis, enabling BAF complex study.</p>

<p>Methyl 4,5-dichlorothiophene-2-carboxylate is a useful organic compound for research related to life sciences. The catalog number is T66373 and the CAS number is 89281-29-8.</p>

<p>Triphenylmethanol is a useful organic compound for research related to life sciences. The catalog number is T65488 and the CAS number is 76-84-6.</p>

<p>Usaramine N-oxide is a flavonoid isolated from Crotalaria pallida, and possesses anti-inflammatory activities.</p>

<p>5-Chloro-2-(methylamino)benzophenone is a useful organic compound for research related to life sciences. The catalog number is T65450 and the CAS number is 1022-13-5.</p>

<p>(R)-3-((tert-Butoxycarbonyl)amino)-4-(2-fluorophenyl)butanoic acid is a useful organic compound for research related to life sciences. The catalog number is T65537 and the CAS number is 218608-98-1.</p>

<p>6-Methyl-4-phenylchroman-2-one is a useful organic compound for research related to life sciences. The catalog number is T65573 and the CAS number is 40546-94-9.</p>

4-Chloro-N-(2,5-dimethylphenyl)benzenesulfonamide is a useful organic compound for research related to life sciences. The catalog number is T64554 and the CAS number is 7454-68-4.

<p>22(S)-hydroxy Cholesterol is a synthetic oxysterol and a modulator of the liver X receptor (LXR). [1] t prevents monocyte chemoattractant protein 1 (MCP-1) expression induced by the LXR agonist GW 3965 in primary hepatocytes and downregulates mRNA expression of the LXR target genes CD36, ACSL1, and SCD-1 in human myotubes. It decreases triacylglycerol and diacylglycerol synthesis from labeled palmitate and acetate, respectively, in human myoblasts by 50% when used at a concentration of 10 uM. 22(S)-hydroxy Cholesterol also reduces fatty acid synthase (FAS) reporter activity through an LXR response element in the promoter region in COS-1 cells transfected with RXRα and LXRα and decreases the expression of MCP-1 and CCR2 in a mouse model of chronic ethanol consumption.[1] [2] Dietary supplementation of 22(S)-hydroxy cholesterol (30 mg/kg per day) leads to less body weight gain and lower liver triacylglycerol levels in rats when fed either a regular chow or high-fat diet as well as prevents an increase in plasma triacylglycerol levels resulting from a high-fat diet.[3]</p>

<p>λ-Carrageenan, a seaweed-derived polysaccharide, is commonly utilized as a proinflammatory agent in basic research and has also been identified as a potent antitumor agent [1].</p>

<p>exo-2-Aminonorbornane is a useful organic compound for research related to life sciences. The catalog number is T65169 and the CAS number is 7242-92-4.</p>

<p>4-Perhydroazepinone hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T66790 and the CAS number is 50492-22-3.</p>