Autres inhibiteurs

<p>(E)-3-(4-Propoxyphenyl)acrylic acid is a useful organic compound for research related to life sciences and the catalog number is T67473.</p>

<p>4-((3-Chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic acid is a useful organic compound for research related to life sciences and the catalog number is T66523.</p>

<p>N-(4-(Bis(4-(diethylamino)phenyl)methylene)cyclohexa-2,5-dien-1-ylidene)-N-ethylethanaminium chloride is a useful organic compound for research related to life sciences. The catalog number is T65162 and the CAS number is 2390-59-2.</p>

<p>Funobactam is a potent β-lactamase inhibitor.</p>

(1R,2S)-2-Phenylcyclopropanamine is a useful organic compound for research related to life sciences. The catalog number is T66420 and the CAS number is 3721-26-4.

<p>4-(2-(1-(p-Tolyl)ethylidene)hydrazinyl)benzenesulfonamide is a useful organic compound for research related to life sciences. The catalog number is T64550 and the CAS number is 1061214-06-9.</p>

<p>Diacetato[(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]ruthenium(II) is a useful organic compound for research related to life sciences. The catalog number is T66567 and the CAS number is 325146-81-4.</p>

4-Isobutylpyrrolidin-2-one is a useful organic compound for research related to life sciences. The catalog number is T65647 and the CAS number is 61312-87-6.

(S)-4-Isobutylpyrrolidin-2-one is a useful organic compound for research related to life sciences and the catalog number is T67247.

7-TMCA is a useful organic compound for research related to life sciences. The catalog number is T65878 and the CAS number is 24209-38-9.

3-Hydroxyephedrine is a bioactive chemical.

<p>Azido-PEG24-acid is a PEG-based linker for PROTACs, crucial for joining two essential ligands and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

<p>Rebimastat is a sulfhydryl-based second-generation matrix metalloproteinase (MMP) inhibitor with potential antineoplastic activity. Rebimastat selectively inhibits several MMPs (MMP 1, 2, 8, 9, and 14), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.</p>

<p>Ceramide (Egg, Chicken) plays a major role in the anabolic and catabolic pathways of sphingolipid. Ceramide (Egg, Chicken) stimulates many cell differentiation, growth inhibition, cell senescence and apoptosis.</p>

<p>(4-Amino-2-methyl-5-pyrimidinyl)methanol is a useful organic compound for research related to life sciences. The catalog number is T67640 and the CAS number is 73-67-6.</p>

2,3-Dimethyl-4-nitropyridine 1-oxide is a useful organic compound for research related to life sciences. The catalog number is T65951 and the CAS number is 37699-43-7.

<p>5-Bromo-2-(2H-tetrazol-5-yl)pyridine is a useful organic compound for research related to life sciences. The catalog number is T64895 and the CAS number is 380380-60-9.</p>

2-Fluoro-[1,1'-biphenyl]-4-carboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66535 and the CAS number is 137045-30-8.

Ligustrazine Hydrochloride, is a natural substance discovered in the plant Ligusticum chuanxiong Hort. It inhibits platelet aggregation, improves atherosclerosis situation, protects endothelium injury, and has antithrombotic effects.in vivo,ligustrazine hydrochloride at 10 and 20 mg/kg produced significant analgesic effects against mechanical stimuli,and ligustrazine hydrochloride at 80 mg/kg, also significantly alleviated cold hypersensitivity manifested by reduction in cold vocalization temperature.

<p>Sinoporphyrin sodium hinders cell growth, induces early apoptosis, disrupts F-actin, impairs movement, and may treat cancer; it's a photosensitizer.</p>

Coumberone, a fluorogenic probe, is reduced by AKR1C family to fluorescent coumberol; vital for AKR1C research.

Methanesulfonato[4,6-bis(diphenylphosphino)phenoxazine](2'-amino-1,1'-biphenyl-2-yl)palladium(II) is a useful organic compound for research related to life sciences and the catalog number is T67254.

<p>Octyl glucose neopentyl glycol (OGNG) is a detergent derived from neopentyl glycol, designed to stabilize membrane proteins [1].</p>

<p>4-Chloro-N,N-dimethylpicolinamide is a useful organic compound for research related to life sciences. The catalog number is T67664 and the CAS number is 114780-06-2.</p>

<p>Cbz-PEG2-bromide is a useful organic compound for research related to life sciences and the catalog number is T64710.</p>

<p>Piperazine (2HCl) is gamma-aminobutyric acid (GABA) agonists and its major effects appear to be on the central nervous system. Piperazine was the anthelmintic with the greatest number of reports of toxicoses and suspected toxicoses in cats. Piperazine neurotoxicity in cats and dogs usually was manifested by muscle tremors, ataxia, and/or behavioral disturbances within 24 hours after estimated daily dose(s) between 20 and 110 mg/kg[1]. For di-substituted derivatives, ciprofloxacin was selected and hybrids were synthesized via substitution at piperazinyl-N4. The reaction of piperazinyl-NH of ciprofloxacin with selected drugs resulted in pronounced growth inhibition of standard as well as resistant bacterial strains[2]. The parent piperazine 6 was found to exhibit a reasonable activity toward the HeLa and MDA MB 231 tumor cell lines (IC50= 9.2 and 8.4 μΜ, respectively)[3]. Piperazine adipate (10 mM) causes mortality of A. galli and H. gallinae after a maximum of 30 min exposure, inhibits malate oxidation by 78%, and inhibits aldolase activity in both parasites. Piperazine adipate (10 mM) also inhibits cholinesterase activity by 96% in Ascaridia galli (A. galli) and 93% in Heterakis gallinae (H. gallinae). Piperazine adipate inhibits oxaloacetate reduction by 26% and 55% in A. galli and H. gallinae, resepctively[4].</p>

<p>Mal-PEG8-Boc, a PEG-based linker for PROTACs, connects two essential ligands, facilitating the formation of PROTAC molecules and enabling selective protein degradation by leveraging the ubiquitin-proteasome system within cells.</p>

2-Acetamidothiazole is a useful organic compound for research related to life sciences. The catalog number is T67350 and the CAS number is 2719-23-5.

<p>N3-PEG3-CH2COOH (PROTAC Linker 14) is a PEG-based compound employed in PROTAC synthesis.</p>

GCLE is a useful organic compound for research related to life sciences. The catalog number is T65660 and the CAS number is 104146-10-3.

<p>Di-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-[1,1'-biphenyl]-2-yl)phosphine is a useful organic compound for research related to life sciences. The catalog number is T66183 and the CAS number is 1160861-53-9.</p>

4-Chloroquinazoline-6,7-diol is a useful organic compound for research related to life sciences. The catalog number is T66020 and the CAS number is 1145671-36-8.

<p>(R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4-difluorophenyl)butanoic acid is a useful organic compound for research related to life sciences. The catalog number is T66697 and the CAS number is 851307-12-5.</p>

tert-Butyl ((S)-4-methyl-1-((R)-2-methyloxiran-2-yl)-1-oxopentan-2-yl)carbamate is a useful organic compound for research related to life sciences. The catalog number is T66629 and the CAS number is 247068-82-2.

<p>Epiquinidine, an analogue of quinine, serves as an agonist for ggTas2r1, exhibiting activation at concentrations of 10 μM or higher.</p>

<p>2', 3'-cGAMP-C2-SH is a ADC cytotoxin.</p>

1H-Pyrazole-3,5-dicarboxylic acid is a useful organic compound for research related to life sciences. The catalog number is T66472 and the CAS number is 3112-31-0.

<p>Guanylthiourea is a useful organic compound for research related to life sciences. The catalog number is T64909 and the CAS number is 2114-02-5.</p>

5-FAM-Alkyne is a highly selective and sensitive fluorescent biosensor designed for detecting alkaline phosphatase (ALP).

<p>GEM-5, a gemcitabine conjugate with HIF-1α inhibitor YC-1 (IC50=30 nM), down-regulates HIF-1α, up-regulates p53, and induces A2780 cell apoptosis.</p>

<p>2-(Trifluoromethyl)cinnamic acid is a useful organic compound for research related to life sciences. The catalog number is T64859 and the CAS number is 2062-25-1.</p>

<p>4-Morpholinopicolinic acid is a useful organic compound for research related to life sciences. The catalog number is T67611 and the CAS number is 66933-68-4.</p>

<p>Compound G541-1338 is a useful organic compound for research related to life sciences.Cost-effective and quality-assured.</p>

<p>2-(Fluoromethyl)-6-nitro-3-(o-tolyl)quinazolin-4(3H)-one is a useful organic compound for research related to life sciences. The catalog number is T67189 and the CAS number is 56287-73-1.</p>

<p>4-(2-Chloroethyl)morpholine hydrochloride is a useful organic compound for research related to life sciences. The catalog number is T65948 and the CAS number is 3647-69-6.</p>

(3-Methyl-4-(2,2,2-trifluoroethoxy)pyridin-2-yl)methanol is a useful organic compound for research related to life sciences. The catalog number is T67415 and the CAS number is 103577-66-8.

<p>FlAsH-EDT2 is a membrane-permeable fluorescent reagent that can label proteins. FlAsH-EDT2 can bind to CCXXCC motifs and nonspecific endogenous cysteine-rich proteins. FlAsH-EDT2 can only be used to label recombinant proteins that are expressed at very high levels.</p>

BisMalt-24 is a useful organic compound for research related to life sciences. The catalog number is TF0007 and the CAS number is 1198081-48-9.

<p>Compound N060-0121 is a useful organic compound for research related to life sciences and the catalog number is T131219.</p>

<p>Valiloxibic acid is a prodrug for GHB, a natural psychoactive neurotransmitter and weak GABAB agonist.</p>

<p>Osteopontin (OPN), bone sialoprotein (BSPII), and osteonectin (ON) belong to a family of glycoproteins, which have been linked to cancer metastasis and</p>

<p>HT-2 Toxin, a deacetylated metabolite of T-2 toxin, impairs protein synthesis and hinders cell proliferation in plants.</p>

<p>CLEC12A/MICL/CLL-1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>

<p>S100A8 &amp; S100A9 Heterodimer Protein, Human, Recombinant (Flag &amp; His) is expressed in Baculovirus insect cells with Flag and His tag.</p>

<p>Heterocyclic compounds-pyridine,</p>

<p>CF502 (STING agonist-23) is a non-nucleotide that activates STING pathway, boosts immune responses, and shows activity against SARS-CoV.</p>

<p>BCL-W Protein, Human, Recombinant (His) is expressed in E.</p>

<p>HSP70 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag.</p>

<p>Lipocalin-2/LCN2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>Alpha-Synuclein Protein, Human, Recombinant is expressed in E.</p>

<p>Hantaan virus HTNV (strain 84FLi) Nucleocapsid/NP Protein (His) is expressed in Baculovirus insect cells with His tag.</p>

<p>LPL Protein, Chinese hamster, Recombinant (His) is expressed in E.</p>

<p>Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta).</p>

<p>R-spondin 3 (RSPO3) is a member of the R-Spondin (RSPO) family in vertebrates that activate Wnt/beta-catenin signaling, plays a key role in these processes.</p>

<p>CLEC12A/MICL/CLL-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.</p>

Intermediates and building blocks - phosphorous compounds; nucleophile

<p>Bikunin/AMBP Protein, Human, Recombinant (aa 1-203, His) is expressed in HEK293 mammalian cells with His tag.</p>

<p>7-Methoxy-1-tetralone may have insecticidal activity.</p>

Decyl-TPP bromide ((1-Decyl)triphenylphosphonium bromide) may be used as an intermediate for chemical synthesis and an inactive control or as a reference to

<p>Elamipretide (SS-31, MTP-131, Bendavia) is a mitochondria-focused peptide that curbs toxic ROS and stabilizes cardiolipin.</p>

<p>10Z-Nonadecenoic acid is a long-chain fatty acid with anti-tumor activity.</p>

<p>4-Methoxycoumarine has antitumour effects.</p>

<p>Danoprevir sodium is an NS3/4A protease inhibitor used in the treatment of Hepatitis C</p>

<p>NBQX (FG9202), an AMPA/kainate receptor blocker, counters glutamate toxicity; water-soluble as disodium salt, has anticonvulsant properties.</p>

<p>Ethyl 4-hydroxyphenylacetate is a selective inhibitor of monoamine oxidase A.</p>

<p>Oxindole (Indolin-2-one) is an aromatic heterocyclic building block. 2-indolinone derivatives have become lead compounds in the research of kinase inhibitors.Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.</p>

<p>4-Hydroxy-6-methylcoumarin (4-HMC) is a naturally occurring phenolic compound, a derivative of coumarin, found in a variety of plants, fungi, and bacteria. It has anti-inflammatory and anti-tumor activity.4-HMC is used as a flavoring agent, preservative and antioxidant in the food industry.</p>

<p>Tropinone used as an intermediate in the synthesis of atropine sulfate, and is a decane alkaloid.</p>

<p>Elamipretide 2TFA (RX-31 2TFA) is a novel mitochondrion-targeted antioxidant.</p>

<p>MTP 131 (acetate) is a small mitochondrially-targeted tetrapeptide.</p>

<p>Salvianolic acid B (Dan Shen Suan B) is a water-soluble antioxidant from Salvia miltiorrhiza extract with antiplatelet aggregation and antithrombotic effects.</p>

<p>Ammonium Glycyrrhizinate (Glycyram) inhibits the cytopathology and growth of several unrelated DNA/RNA viruses.</p>

<p>α-Lipoic Acid (Alphalipoic acid) inhibits NF-κB-dependent HIV-1 LTR activation.</p>

<p>Dimethylamine hydrochloride, found in urine, comes from food compound TMAO and NO synthesis inhibitor ADMA, processed by DDAH enzyme.</p>

<p>FLT3 Ligand Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag.</p>

<p>IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. IGFBP-1 Protein, Rat, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 26.9 kDa and the accession number is P21743.</p>

<p>SLC1A2 Protein, Mouse, Recombinant (GST) is expressed in E. coli. The accession number is P43006.</p>

<p>May act as a negative regulator of collagen matrix deposition.</p>

<p>Pomalidomide 4'-PEG5-azide, a cereblon (CRBN) ligand based on Pomalidomide, facilitates the recruitment of CRBN protein. It can be conjugated through a linker to another ligand, forming a proteolysis-targeting chimera (PROTAC) [1].</p>

D(-)-Octopamine CSA salt is an agonist of octopamine receptors.

<p>KP372-1, an Akt inhibitor, blocks PI3K signaling, arrests cell growth, and triggers apoptosis in head/neck squamous cell carcinoma.</p>

<p>(E)-Crotylbarbital, a Crotylbarbital isomer, is a sedative with hypnotic, anticonvulsant properties, aiding sleep and mental stability.</p>

<p>Anti-TNBC agent-3 (compound 3g) is a compound that induces apoptosis and possesses anti-cancer cell proliferation properties.</p>

<p>HPK1-IN-18: Potent, specific inhibitor of HPK1, a MAP4K enzyme, for cancer research and treatment.</p>

<p>Albuterol stearate, a salt form of Albuterol, is a selective beta2 agonist for treating asthma and COPD, with 29x preference for beta2 over beta1.</p>

Dioxifedrine is a beta-2 -adrenergic agonist with bronchodilator activity.

Aminobutane bisphosphonate curbs bone loss; may manage hypercalcemia in cancer.

(Rac)-LM11A-31 dihydrochloride is an isomer of LM11A-31 dihydrochloride, a potent antagonist of proNGF (nerve growth factor).

IDX-375, a HCV NS5B polymerase inhibitor, is used potentially for the treatment of HCV infection.

<p>Phenazolam is an analytical reference standard categorized as a benzodiazepine. [1] This product is intended for research and forensic applications.</p>

<p>Radafaxine hydrochloride is an inhibitor of DAT and NET transporters, and nAChR family modulator.</p>

<p>Culmerciclib is a cell cycle protein-dependent kinase (CDK) inhibitor that exhibits antitumour effects.</p>

<p>CCK-inactivating serine protease (tripeptidyl peptidase II) inhibitor</p>

TRPP3 channel inhibitor

<p>PS372424 activates CXCR3, triggers ERK phosphorylation, and inhibits CXCL11's effect on CD45+ cell migration in humanized mice.</p>

Guancydine is an antihypertensive agent.

CH-100 is a Chinese herbal medicine previously used in the treatment of human hepatitis C.

PSB-6426 is the first potent and selective human nucleoside triphosphate diphosphohydrolase-2 inhibitor.

<p>Saxitoxinol is an analog of saxitoxin, a known voltage-gated sodium channel blocker.</p>

<p>AKOS-22: potent VDAC1 inhibitor, Kd=15.4 μM; prevents mitochondrial dysfunction and apoptosis.</p>

CK176 is an HIV-1 inhibitor, 11x more effective than I-XW-053 in human PBMCs.

Fosfonet sodium is a sodium salt of phosphonoacetic acid, effective against herpesviruses by inhibiting viral DNA polymerase.

<p>Questiomycin A derivative 18 TFA exhibits antibacterial, anticancer properties and inhibits GRP78.</p>

MDK-2959 is a potent inhibitor of protein tyrosine phosphatase sigma (PTPsigma).

<p>Cebranopadol ((1α,4α)stereoisomer) is a stereoisomer of cebranopadol which is a potent ORL-1 agonist.</p>

Tifenazoxide is an effective and SUR1/Kir6.2 selective KATP channels opener. Tifenazoxide has an anti-diabetic effect, can inhibit glucose-stimulated insulin release in vitro and in vivo.

H 35-25 is a beta 2-antagonist.

<p>PL265 is a long-acting dual ENKephalinase inhibitor (DENKi) with analgesic potential.</p>

Trimetoquinol hydrochloride possesses differential and selective beta-adrenergic properties.

<p>Erythrityl Tetranitrate, a vasodilator similar to nitroglycerin, was first in "sustained release" tablets; may cause "nitro headache."</p>

<p>Benzovindiflupyr: a fungicide that inhibits SDH (IC50=5.2nM), halts S. sclerotiorum growth (EC50=0.011μg/ml), and protects crops like eggplants.</p>

DPX-3778, a triethanolamine salt, boosts tobacco callus growth 4-5x at 0.124-2.48 μM and slows aging with IAA and kinetin.

<p>BChE-IN-17 (compound 6n) is a potent, selective inhibitor of butyrylcholinesterase (BChE), demonstrating inhibitory half-maximal inhibitory concentrations (</p>