Signalisation du cytosquelette
Les inhibiteurs de la signalisation du cytosquelette sont des composés qui perturbent les voies de signalisation régulant le cytosquelette, essentiel pour la forme, la motilité, la division des cellules et le transport intracellulaire. Ces inhibiteurs sont utilisés pour étudier la dynamique des protéines du cytosquelette, telles que l'actine et la tubuline, et leur rôle dans des processus comme la migration cellulaire, l'adhésion et la métastase du cancer. Les inhibiteurs de la signalisation du cytosquelette sont précieux dans la recherche en biologie cellulaire, en cancérologie et en neurobiologie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la signalisation du cytosquelette de haute qualité pour soutenir vos recherches dans ces domaines.
1382 produits trouvés pour "Signalisation du cytosquelette"
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Carotegrast
CAS :<p>Carotegrast, an orally available α4 integrin receptor inhibitor, has anti-inflammatories activities.</p>Formule :C27H24Cl2N4O5Couleur et forme :SolidMasse moléculaire :555.41Synstatin (92-119)
CAS :<p>Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 and</p>Formule :C133H207N35O46Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :3032.27THK-5105
CAS :<p>THK-5105, a tau-binding arylquinoline, could be an 18F-PET imaging probe for Alzheimer's disease.</p>Formule :C20H21FN2O2Couleur et forme :SolidMasse moléculaire :340.39EG-011
CAS :<p>EG-011, a potent first-in-class WASP activator, enhances actin polymerization, showing selective anti-tumor effects in lymphomas.</p>Formule :C28H26N4O4Couleur et forme :SolidMasse moléculaire :482.53Gly-Arg-Gly-Asp-Ser TFA
CAS :<p>Gly-Arg-Gly-Asp-Ser (TFA), osteopontin domain, binds αvβ3 and αvβ5 integrins; IC50s: ~5 μM, ~6.5 μM.</p>Formule :C19H31F3N8O11Couleur et forme :SolidMasse moléculaire :604.49Pin1 modulator 1
CAS :<p>Pin1 modulator 1 (compound IIb-219) is a specific β-Catenin targeting agent that inhibits the Wnt pathway and is applicable in researching Wnt-mediated diseases, including cancer [1].</p>Formule :C18H15NO3S2Couleur et forme :SolidMasse moléculaire :357.44β-Catenin modulator-3
CAS :<p>β-Catenin modulator-3 (compound IIa-112), an oxazole and thiazole-based chemical entity, serves as a potent and selective modulator of β-Catenin [1].</p>Formule :C21H22N2O3SCouleur et forme :SolidMasse moléculaire :382.483CAI
CAS :<p>3CAI inhibits AKT1/2, reduces mTOR/GSK3β, and triggers apoptosis in colon cancer cells.</p>Formule :C10H8ClNODegré de pureté :98.13%Couleur et forme :SolidMasse moléculaire :193.63Pterostilbene-isothiocyanate
CAS :<p>Pterostilbene-isothiocyanate (PTER-ITC) demonstrates strong anticancer properties in vitro, particularly disrupting the interaction between β-catenin and TCF-4</p>Formule :C18H19N3O3SCouleur et forme :SolidMasse moléculaire :357.43AT7867 hydrochloride
CAS :<p>AT7867 hydrochloride is a potent inhibitor of AKT and p70 S6 kinase, displaying oral activity and demonstrating an anticancer effect [1].</p>Formule :C20H21Cl2N3Couleur et forme :SolidMasse moléculaire :374.31α7β1 integrin modulator-1
CAS :<p>α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].</p>Formule :C23H29N3O6SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :475.56Lotrafiban
CAS :<p>Lotrafiban: Oral GP IIb/IIIa inhibitor for treating coronary and cerebrovascular disease.</p>Formule :C23H32N4O4Couleur et forme :SolidMasse moléculaire :428.52L-739758
CAS :<p>L-739758 is a glycoprotein IIb/IIIa inhibitor.</p>Formule :C22H26N4O5S3Couleur et forme :SolidMasse moléculaire :522.66PVZB1194
CAS :<p>PVZB1194, a biphenyl-type inhibitor of Kinesin spindle protein Eg5 (KIF11), exhibits anticancer potential by inducing cell cycle arrest and apoptosis through</p>Formule :C13H9F4NO2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :319.28BCR-ABL-IN-4
CAS :<p>BCR-ABL-IN-4: Anticancer BCR-ABL inhibitor; stops K562 cells (IC50: 0.67 nM), targets T315I Ba/F3 cells (IC50: 16 nM).</p>Formule :C27H24ClF2N5O4Couleur et forme :SolidMasse moléculaire :555.96β-catenin-IN-4
CAS :<p>β-Catenin-IN-4 is a β-catenin inhibitor characterized by a K_i value of 0.64 μM.</p>Formule :C38H33ClF3N5O9Couleur et forme :SolidMasse moléculaire :796.14SB-743921 free base
CAS :<p>SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).</p>Formule :C31H33ClN2O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :517.06SEN461
CAS :<p>SEN461 is a wnt inhibitor.</p>Formule :C25H34N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :486.56Heclin
CAS :<p>Heclin is an inhibitor of HECT E3 ubiquitin ligase that acts by inhibiting Smurf2, Nedd4, and WWP1 with IC50 values of 6.8, 6.3, and 6.9 μM, respectively.</p>Formule :C17H17NO3Degré de pureté :95.79%Couleur et forme :SolidMasse moléculaire :283.32(-)-Indolactam V
CAS :<p>(-)-Indolactam V: PKC activator, antitumor, Ki 3.36 nM/1.03 μM for η/γ-CRD2, Kd 5.5-213 nM for C1 domains.</p>Formule :C17H23N3O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :301.38Antitumor agent-86
CAS :<p>Antitumor agent-86 targets MCF-7 cells with 2.62 µM IC50, induces apoptosis, and disrupts RAS/PI3K/Akt/JNK pathways.</p>Formule :C29H31N5O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :513.65Demethylasterriquinone B1
CAS :<p>insulin receptor (IR) activator</p>Formule :C32H30N2O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :506.59HSP90-IN-19
CAS :<p>HSP90-IN-19: potent Hsp90 inhibitor, IC50 = 0.27 μM, used in research on viral diseases, neurodegeneration, inflammation.</p>Formule :C29H38O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :498.61Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2
CAS :<p>Ac-Val-Gln-aIle-Val-aTyr-Lys-NH2 demonstrates serum stability and non-toxicity to neuronal cells, while selectively inhibiting the fibrilization of tau in</p>Formule :C38H65N11O9Couleur et forme :SolidMasse moléculaire :819.9922-(4′-py)-JA
CAS :<p>22-(4′-py)-JA, a semisynthetic derivative of junamycin A isolated from the Thai blue sponge (Xestospongia sp.), exhibits antimetastatic properties by inhibiting</p>Formule :C32H30N4O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :598.6PBB3
CAS :<p>PBB3 is a tau-specific PET tracer.</p>Formule :C17H15N3OSCouleur et forme :SolidMasse moléculaire :309.39PKC-θ inhibitor 1
CAS :<p>PKC-theta inhibitor 1 is an inhibitor of PKCθ (Ki of 6 nM)</p>Formule :C17H15F3N4ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :348.32L 738167
CAS :<p>L 738167 is a potent antagonist of the long-acting fibrinogen receptor.</p>Formule :C25H34N6O6SCouleur et forme :SolidMasse moléculaire :546.64TC-I 15
CAS :<p>α2β1 integrin inhibitor</p>Formule :C23H28N4O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :520.62SC-52012
CAS :<p>SC-52012 is a novel and potent fibrinogen receptor antagonist, an RGD mimetic, which inhibits platelet aggregation.</p>Formule :C25H30N4O6Degré de pureté :97.20%Couleur et forme :SolidMasse moléculaire :482.53Lamifiban
CAS :<p>Lamifiban is a nonpeptide glycoprotein IIb/IIIa antagonist. It prevents platelet loss during experimental cardiopulmonary bypass.</p>Formule :C24H28N4O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :468.5KU-177
CAS :<p>KU-177 is an Aha1 inhibitor that disrupts the interaction between Hsp90 and Aha1, eliminating cell proliferation and PI resistance induced by elevated AHSA1.</p>Formule :C27H23NO8Degré de pureté :96.92% - 98.54%Couleur et forme :SolidMasse moléculaire :489.47IWP 12
CAS :<p>IWP 12 is a potent inhibitor of porcupine (Porcn), blocking Wnt signaling and inhibiting fin regeneration in adult and juvenile fish.</p>Formule :C18H18N4O2S3Degré de pureté :98.88%Couleur et forme :SolidMasse moléculaire :418.56BIO-7662
CAS :<p>BIO-7662 is an effective and highly selective antagonist of α4β1 integrin.</p>Formule :C38H48N6O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :748.89Solenopsin
CAS :<p>Solenopsin is an ATP-competitive inhibitor of AKT(IC50 : 10 μM) .</p>Formule :C17H35NDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :253.47Palmitic acid calcium
CAS :<p>Calcium palmitate, a long-chain saturated fatty acid prevalent in animals and plants, induces the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in mouse granulosa cells. It is employed to establish a cell steatosis model [1] [2].</p>Formule :C16H32O2CaCouleur et forme :SolidMasse moléculaire :275.463-Hydroxyxanthone
CAS :<p>3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical vein</p>Formule :C13H8O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :212.2MK-6240
CAS :<p>MK-6240: A tau PET tracer with high specificity for NFTs binding.</p>Formule :C16H11FN4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :278.28NTRC 0066-0
CAS :<p>NTRC 0066-0 is a TTK inhibitor that can be used in cancer research.</p>Formule :C33H39N7O2Degré de pureté :98.30%Couleur et forme :SolidMasse moléculaire :565.71HDAC-IN-55
CAS :<p>HDAC-IN-55(8j) is a small-molecule inhibitor that enhances E-cadherin expression and suppresses cancer cell proliferation [1].</p>Formule :C17H17N3O3Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :311.34Levocabastine hydrochloride
CAS :<p>Levocabastine HCl is an agent with antihistaminic activity.</p>Formule :C26H30ClFN2O2Couleur et forme :SolidMasse moléculaire :456.98TRV-1387
CAS :<p>TRV-1387, a benzofurazan derivative, inhibits the aggregation of tau and amyloid-β [1].</p>Formule :C23H25F3N4O2Couleur et forme :SolidMasse moléculaire :446.47Kif15-IN-2
CAS :<p>Kif15-IN-2 is a kinesin Kif15 inhibitor with potential anticancer activity and can be used in prostate cancer research.</p>Formule :C20H20N6O4SDegré de pureté :98.17%Couleur et forme :SolidMasse moléculaire :440.48CT-721
CAS :<p>CT-721: potent, time-bound Bcr-Abl inhibitor, IC50 21.3 nM, effective against CML.</p>Formule :C30H29ClN6ODegré de pureté :98%Couleur et forme :SolidMasse moléculaire :525.04TCS 21311
CAS :<p>TCS 21311 (NIBR3049) selectively inhibits JAK3 (IC50: 8 nM) and PKCα/θ & GSK3β; >100x selective over JAK1, JAK2, TYK2.</p>Formule :C27H25F3N4O4Degré de pureté :99.39% - ≥98%Couleur et forme :SolidMasse moléculaire :526.51HSP90-IN-27
CAS :<p>HSP90-IN-27, also known as compound 19, is an inhibitor of HSP90 [1].</p>Formule :C18H21N3O2SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :343.44Ifebemtinib
CAS :<p>Ifebemtinib (BI-853520) is an adhesion plaque kinase inhibitor with anti-tumour activity for the study of breast cancer.</p>Formule :C28H28F4N6O4Degré de pureté :98.84% - 99.85%Couleur et forme :SolidMasse moléculaire :588.55UCL-TRO-1938
CAS :<p>UCL-TRO-1938 is a subtype-selective PI3Kα allosteric activator with cardioprotective and neuroregenerative effects.</p>Formule :C27H32N6ODegré de pureté :99.95%Couleur et forme :SolidMasse moléculaire :456.58αvβ1 integrin-IN-1
CAS :<p>αvβ1 integrin-IN-1 is a potent and selective inhibitor of αvβ1 integrin (IC50 of 0.63 nM) with antifibrotic effects.</p>Formule :C26H34N6O6SDegré de pureté :99.74% - >99.99%Couleur et forme :SolidMasse moléculaire :558.65CFI-402257
CAS :<p>CFI-402257 is a selective inhibitor of Mps1/TTK kinase (Mps1 Ki = 0.09 nM; EC50 = 6.5 nM)and can be used in studies about hepatocellular carcinoma diseases.</p>Formule :C28H30N6O3Degré de pureté :96.66% - 99.51%Couleur et forme :SolidMasse moléculaire :498.58M2698
CAS :<p>M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.</p>Formule :C21H19ClF3N5ODegré de pureté :99.88%Couleur et forme :SolidMasse moléculaire :449.86Roxifiban acetate
CAS :<p>Roxifiban acetate（DMP 754 acetate） is a potent GP IIb / IIIa antagonist that exhibits antiplatelet aggregation activity via immune mediation and can be used in</p>Formule :C23H33N5O8Degré de pureté :97.91% - 98.36%Couleur et forme :SolidMasse moléculaire :507.54Zamaporvint
CAS :<p>Zamaporvint (RXC004) , a Wnt pathway inhibitor with antitumor and antiproliferative activity, blocks Wnt ligand palmitoylation and secretion.</p>Formule :C21H16F3N7ODegré de pureté :97.5%Couleur et forme :SolidMasse moléculaire :439.39Gossypolone
CAS :<p>Gossypolone is is a proposed major metabolite of gossypol. Gossypolone reduces Notch/Wnt signaling and induces apoptosis.</p>Formule :C30H26O10Degré de pureté :96.66%Couleur et forme :SolidMasse moléculaire :546.52GNF-6231
CAS :<p>GNF-6231 is a potent, selective, and orally bioavailable Porcupine inhibitor that blocks Wnt signaling.</p>Formule :C24H25FN6O2Degré de pureté :99.74% - >99.99%Couleur et forme :SolidMasse moléculaire :448.49ATM-3507
CAS :<p>ATM-3507 is an inhibitor of tropomyosin. In human melanoma cell lines, the IC50s are from 3.83-6.84 μM.</p>Formule :C37H46FN5O2Degré de pureté :96.77% - 98.81%Couleur et forme :SolidMasse moléculaire :611.79PKC-IN-1
CAS :<p>PKC-IN-1 is an ATP-competitive and reversible conventional PKC enzymes inhibitor (PKCα, PKCβI, PKCβII, PKCθ, PKCγ, PKC mu and PKCε with IC50s of 2.3, 8.1, 7.6,</p>Formule :C25H37FN8O2Degré de pureté :98% - 98.79%Couleur et forme :SolidMasse moléculaire :500.61AMXI-5001 hydrochloride
<p>AMXI-5001 hydrochloride, an oral inhibitor of PARP1/2 and microtubules, shows greater potency and selective anti-cancer effects.</p>Formule :C25H21ClFN5O3Couleur et forme :SolidMasse moléculaire :493.92Tubulin inhibitor 16
<p>Tubulin inhibitor 16 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 16 exhibits cytotoxicity in HepG2 cells [1].</p>Formule :C16H12FNO2Couleur et forme :SolidMasse moléculaire :269.27AKT-IN-10
CAS :<p>AKT-IN-10, a potent AKT inhibitor, has potential for breast and prostate cancer research, impacting cell growth and survival pathways.</p>Formule :C26H34ClN5O2Couleur et forme :SolidMasse moléculaire :484.03TTBK1/2-IN-1
CAS :<p>TTBK1/2-IN-1 (compound 3) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 816 nM and 384 nM, respectively.</p>Formule :C17H16N4OCouleur et forme :SolidMasse moléculaire :292.335Hsp90-IN-34
CAS :<p>Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.</p>Formule :C22H14F2N6OCouleur et forme :SolidMasse moléculaire :416.38Tubulin polymerization-IN-75
CAS :<p>Tubulin polymerization-IN-75 (Compound 6) is an inhibitor of tubulin polymerization, with an IC50 value of 30 μM. It effectively suppresses the proliferation of cancer cells Huh7 and 293T, demonstrating IC50 values of 14.3 μM and 13.8 μM, respectively.</p>Formule :C14H11NOCouleur et forme :SolidMasse moléculaire :209.243DCEM1
CAS :<p>DCEM1 binds to heat shock protein 60 (HSP60) and inhibits the interaction between HSP60 and ClpP, thereby blocking the mitochondrial unfolded protein response. Additionally, DCEM1 suppresses the expression of β-catenin and reduces ATP production in PC-3 and TKO cells. It is utilized in research related to prostate cancer.</p>Formule :C22H23N3O2SCouleur et forme :SolidMasse moléculaire :393.50FAK inhibitor 7
CAS :<p>FAK inhibitor7, a potent FAK inhibitor, demonstrates an IC50 of 3.58 nM. This compound effectively inhibits downstream signaling cascades of FAK (such as Src and AKT), which leads to cell cycle arrest at the G0/G1 phase and induces cytotoxic autophagy in ovarian cancer cells. Additionally, FAK inhibitor7 has been shown to suppress tumor metastasis and growth in ovarian cancer mouse models.</p>Formule :C32H37N7O3Couleur et forme :SolidMasse moléculaire :567.68Dictyostatin
CAS :<p>Dictyostatin: potent microtubule stabilizer & anticancer agent with antiproliferative effects; researched for tauopathies.</p>Formule :C32H52O6Couleur et forme :SolidMasse moléculaire :532.75OXA-11
CAS :<p>OXA-11 (FAK-IN-16) is a FAK inhibitor with anti-tumor activity, useful for cancer research.</p>Formule :C37H49F3N7O5PDegré de pureté :98.70% - 99.20%Couleur et forme :SolidMasse moléculaire :759.8Uprosertib hydrochloride
CAS :<p>Uprosertib hydrochloride is a potent and selective inhibitor of pan-Akt (IC50: 180/328/38 nM for Akt1/Akt2/Akt3, respectively).</p>Formule :C18H17Cl3F2N4O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :465.71AMG28
CAS :<p>AMG28 is an inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 805 nM and 988 nM, respectively. Additionally, AMG28 suppresses the phosphorylation of tau protein at the Ser422 site, with an IC50 of 1.85 μM.</p>Formule :C20H20N4OCouleur et forme :SolidMasse moléculaire :332.399Tubulin inhibitor 19
<p>Tubulin inhibitor 19 (9b), a potent indole chalcone, strongly blocks tubulin, valuable in cancer studies.</p>Formule :C21H23NO5Couleur et forme :SolidMasse moléculaire :369.41PKCTheta-IN-2
CAS :<p>PKCTheta-IN-2 (compound 14) is a potent and selective inhibitor of PKCθ, with an IC50 value of 0.25 nM. It demonstrates good selectivity across a broad range of kinases, including the PKC subfamily (30 kinases). Additionally, PKCTheta-IN-2 effectively inhibits the production of IL-2 in mice, where it exhibits an IC50 of 682 nM.</p>Formule :C24H23N5O2Couleur et forme :SolidMasse moléculaire :413.47Lisavanbulin
CAS :<p>Lisavanbulin (BAL-101553) is a prodrug of Avanbulin (BAL 27862), a microtubule-targeting agent. It exhibits antitumor activity, particularly effective against tumors with high expression of end-binding protein 1.</p>Formule :C26H29N9O3Couleur et forme :SolidMasse moléculaire :515.57PI3K-IN-29
CAS :<p>PI3K-IN-29: Strong PI3K block, inhibits Akt phosphorylation. IC50: U87MG 0.264µM, HeLa 2.04µM, HL60 1.14µM.</p>Formule :C27H22ClN7O3SCouleur et forme :SolidMasse moléculaire :560.03Tubulin polymerization-IN-32
<p>Tubulin polymerization-IN-32: a cancer cell growth inhibitor used for research in cancers like lymphoma.</p>Formule :C29H30N2O7Couleur et forme :SolidMasse moléculaire :518.56Hsp90-IN-37
CAS :<p>Hsp90-IN-37 (Z-2) is an inhibitor of heat shock protein 90 (Hsp90), demonstrating a 69% inhibition rate on Hsp90 enzyme activity. It exhibits antitumor properties.</p>Formule :C12H15N3O2Couleur et forme :SolidMasse moléculaire :233.266L 734217
CAS :<p>L 734217 is an antagonist of the fibrinogen receptor.</p>Formule :C18H31N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :353.46EV206
CAS :<p>EV206 is an effective inhibitor of Hsp70, exhibiting antiproliferative properties. This compound induces cell apoptosis (apoptosis) and enhances the protein expression of cleaved PARP and caspase-3. Additionally, EV206 demonstrates antitumor activity.</p>Formule :C21H19N3OCouleur et forme :SolidMasse moléculaire :329.40Tubulin inhibitor 22
<p>Compound 4c: Strong tubulin inhibitor with anti-cancer & anti-angiogenic effects; halts MGC-803 cells in G2/M, triggers Caspase-mediated apoptosis.</p>Formule :C20H17BrFNO4Couleur et forme :SolidMasse moléculaire :434.26PROTAC α-synuclein degrader 6
CAS :<p>PROTACα-synuclein degrader 6 (compound T3) is a PROTAC degrader of α-synuclein and tau, with an EC50 of 1.57 μM and 4.09 μM, respectively. This compound plays a significant role in neurodegenerative disease (ND) research.</p>Formule :C37H39N5O9SMasse moléculaire :729.80FPDT
<p>FPDT combats glioblastoma by inhibiting the AKT pathway; IC50: >100 μM (astrocytes), 45-68 μM (GBM cells).</p>Formule :C16H12FNO2SCouleur et forme :SolidMasse moléculaire :301.34Tubulin polymerization-IN-63
CAS :<p>Tubulin polymerization-IN-63 (compound 6) is an inhibitor of tubulin polymerization. It exhibits an IC50 value of 0.29 μM against MES-SA cells, making it suitable for use in cancer research.</p>Formule :C20H24ClCuN5O2SCouleur et forme :SolidMasse moléculaire :497.5EX05
CAS :<p>EX05, an effective KIF18A inhibitor, exhibits an IC50 of 8.2 nM and holds potential for cancer research applications.</p>Formule :C26H30F2N4O5SCouleur et forme :SolidMasse moléculaire :548.60Tubulin polymerization-IN-34
<p>"Tubulin-IN-34 inhibits oxazolylisoindole microtubule assembly, selective for VL51 lymphoma."</p>Formule :C31H35N3O6Couleur et forme :SolidMasse moléculaire :545.63Tubulin polymerization-IN-74
CAS :<p>Tubulin polymerization-IN-74 (compound 11) is an inhibitor of tubulin polymerization, with an IC50 value of 15 μM. It is applicable to cancer research.</p>Formule :C14H11NSCouleur et forme :SolidMasse moléculaire :225.309DDO-6691
CAS :<p>DDO-6691 is an inhibitor of heat shock protein 90 (HSP90). It exhibits antiproliferative effects against various tumor cells, with the highest sensitivity observed in HCT-116 colon cancer cells (IC50: 1.08 μM). DDO-6691 also demonstrates potent tumor growth inhibition in HCT-116 xenograft mouse models.</p>Formule :C22H17N3O2SCouleur et forme :SolidMasse moléculaire :387.45Latrunculins A
CAS :<p>Latrunculins A is a novel marine toxin, disrupts microfilament organization in cultured cells.</p>Formule :C22H31NO6SCouleur et forme :SolidMasse moléculaire :437.55Macbecin I
CAS :<p>Hsp90 inhibitor</p>Formule :C30H42N2O8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :558.66Cemdomespib
CAS :<p>Cemdomespib (KU-596) is a potent Hsp90 modulator with neuroprotective effects and can improve diabetic neuropathy.</p>Formule :C24H30FNO6Couleur et forme :SolidMasse moléculaire :447.5AKT-IN-11
<p>AKT-IN-11 is one of the most potent antibacterial agents against human hepatocellular carcinoma Bel-7402 cell line (IC50: 1.15 μM).</p>Formule :C27H27ClF3NO4Couleur et forme :SolidMasse moléculaire :521.96Wikstrol A
CAS :<p>Wikstrol A: antifungal, anti-mitotic, anti-HIV agent with various IC50/MDC values (67.8-131 µM) and deforms P. oryzae mycelia.</p>Formule :C30H22O10Couleur et forme :SolidMasse moléculaire :542.49Tubulin inhibitor 15
<p>Tubulin inhibitor 15 is a potent tubulin inhibitor with antiproliferative activity. Tubulin inhibitor 15 exhibits cytotoxicity in HepG2 cells [1].</p>Formule :C16H12FNO2Couleur et forme :SolidMasse moléculaire :269.27HG-7-86-01
CAS :<p>HG-7-86-01 is a selective type II tyrosine kinase inhibitor with antiproliferative activity against mutant T315I- Bcr-Abl for chronic myeloid leukemia (CML).</p>Formule :C28H21F3N6O2SDegré de pureté :99.07%Couleur et forme :SolidMasse moléculaire :562.57ZLY06
CAS :<p>ZLY06 is a dual agonist of peroxisome proliferator-activated receptors (PPAR) δ and γ with oral activity (PPAR δ: EC50=341 nM; PPARγ: EC50=237 nM). It mediates the upregulation of CD36 and induces hepatic lipid accumulation by inhibiting the phosphorylation of AKT1. Moreover, ZLY06 significantly improves glucose and lipid metabolism without increasing body weight, primarily by enhancing the β-oxidation of fatty acids and reducing hepatic lipid synthesis, thereby alleviating fatty liver disease.</p>Formule :C25H26O6Couleur et forme :SolidMasse moléculaire :422.47GSD-11
<p>GSD-11: Potent, selective anti-austerity agent; blocks Akt/mTOR pathway, hinders PANC-1 cell migration & colony growth. Promising for pancreatic cancer study.</p>Formule :C20H28O2Couleur et forme :SolidMasse moléculaire :300.44HSP90α-IN-1
CAS :<p>HSP90α-IN-1 is an HSP90α inhibitor (IC50= 111 nM) that demonstrates anti-aging activity across various cellular senescence models. Belonging to the xanthine family, HSP90α-IN-1 is involved in research focused on combating age-related inflammation, senescence, and diseases (including cancer), and it may contribute to extending healthy lifespan.</p>Formule :C19H16N4O2Couleur et forme :SolidMasse moléculaire :332.356G-9791
CAS :<p>G-9791 is an effective and selective inhibitor of group-I PAK.</p>Formule :C26H26ClFN6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :508.98Mps1-IN-8
CAS :<p>Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].</p>Formule :C35H47N8O6PCouleur et forme :SolidMasse moléculaire :706.77Dioleyl phosphatidylserine
CAS :<p>Dioleyl phosphatidylserine is a phospholipid that can activate PKC-γ (Protein Kinase C-gamma) when the Ca2+ concentration is below 0.5 μM, specifically at a concentration of 100 μM.</p>Formule :C42H78NO10PCouleur et forme :SolidMasse moléculaire :788.04HSP90-IN-32
CAS :<p>HSP90-IN-32, a carboxy-terminus inhibitor of Hsp90C, exhibits antiproliferative activity in various cell lines including SKMel173, SKMel103, SKMel19, and A375, with IC50 values of 1.01 μM, 0.782 μM, 0.607 μM, and 1.413 μM, respectively. This compound holds potential for research in anticancer agents.</p>Formule :C33H40N2O4Couleur et forme :SolidMasse moléculaire :528.68FAK-IN-21
CAS :<p>FAK-IN-21 (compound 9) is a FAK inhibitor with an IC50 value of 37.52 nM. It inhibits cell growth and the phosphorylation of FAK, making it useful for research into diffuse gastric cancer.</p>Formule :C22H22F2N8O3SCouleur et forme :SolidMasse moléculaire :516.52KY-02327 acetate
<p>KY-02327 acetate inhibits Dvl-CXXC5, stabilizes Wnt/β-catenin signaling, and enhances osteoblast differentiation.</p>Formule :C22H31N3O6Couleur et forme :SolidMasse moléculaire :433.5RMS-07
CAS :<p>RMS-07, a covalent MPS1/TTK inhibitor, has an IC50 of 13.1 nM, targeting a kinase hinge cysteine.</p>Formule :C35H40N8O2Couleur et forme :SolidMasse moléculaire :604.74SR121566A
CAS :<p>SR121566A is a novel non-peptide antagonist of Glycoprotein IIb/IIIa (GP IIb-IIIa).</p>Formule :C20H25N5O4SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :431.51C086
CAS :<p>C086 is a novel and potent Hsp90 inhibitor that suppresses cell cycle progression, induces apoptosis, and exhibits anti-metastatic properties by modulating various mechanisms in different cell types.</p>Formule :C29H28O8Couleur et forme :SolidMasse moléculaire :504.536-B345TTQ
CAS :<p>6-B345TTQ is an α4 integrin inhibitor that can impede the interaction between α4 and Leupaxin. This compound is applicable for studies focused on inflammation research.</p>Formule :C22H20BrNO4Couleur et forme :SolidMasse moléculaire :442.303MT-134
<p>MT-134 is a SkMII -specific inhibitor and has excellent exposure in muscles.</p>Formule :C19H16N4O3Couleur et forme :SolidMasse moléculaire :348.36Tau ligand-1
CAS :<p>Tau ligand-1 (Compound 75) is a ligand of aggregated tau protein that can penetrate the blood-brain barrier. In tissues affected by Alzheimer's disease, progressive supranuclear palsy, corticobasal degeneration, and Pick's disease, Tau ligand-1 shows high affinity for aggregated tau protein, with equilibrium dissociation constants (KD) ranging from 1 to 3.8 nM. It holds potential as a positron emission tomography (PET) tracer for imaging studies of tau-related diseases within the central nervous system.</p>Formule :C17H16FN3OCouleur et forme :SolidMasse moléculaire :297.327Nrf2/HO-1 activator 2
<p>Compound 13m, a difluoro derivative, activates Nrf2/HO-1, showing neuroprotective and antioxidant effects, useful in PD research.</p>Formule :C20H16F2O5Couleur et forme :SolidMasse moléculaire :374.33GR 83895
CAS :<p>GR 83895 is an antagonist of prototype fibrinogen receptor.</p>Formule :C29H39N9O8SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :673.74Des-ethyl-carafiban
CAS :<p>Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.</p>Formule :C22H23N5O5Couleur et forme :SolidMasse moléculaire :437.448POSH-IN-2
CAS :<p>POSH-IN-2 (MIDI) is a mitochondrial fission inhibitor and a DRP1 inhibitor that effectively prevents mitochondrial fragmentation caused by cellular stress and genetic mitochondrial damage. It covalently interacts with DRP1-C367 to target the interaction of DRP1 with multiple receptors.</p>Formule :C22H16N2O2Couleur et forme :SolidMasse moléculaire :340.37GSK3335103
CAS :<p>GSK3335103 is a non-peptide, orally active inhibitor of αvβ6 integrin (pIC50=8), employed in the study of pulmonary fibrosis.</p>Formule :C27H36FN3O4Couleur et forme :SolidMasse moléculaire :485.59FO-4-15
CAS :<p>FO-4-15 is an activator of mGluR1/CaMKIIα. It exhibits protective effects against H2O2 in human neuroblastoma (SH-SY5Y) cells. In mice with Alzheimer's disease, FO-4-15 enhances cognitive function by activating the mGluR1/CaMKIIα pathway, reducing Aβ accumulation, Tau hyperphosphorylation, and synaptic damage.</p>Formule :C18H20N4O4SCouleur et forme :SolidMasse moléculaire :388.44NRX-2663
CAS :<p>NRX-2663 boosts β-catenin binding to E3 ligase SCFβ-TrCP (Kd: 54.8 nM, EC50: 22.9 nM).</p>Formule :C20H13F3N2O5Couleur et forme :SolidMasse moléculaire :418.32Fradafiban
CAS :<p>Fradafiban binds to the human platelet GP IIb/IIIa complex with a Kd value of 148 nM. Fradafiban is a non-polypeptide platelet glycoprotein IIb/IIIa antagonist.</p>Formule :C20H21N3O4Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :367.40Hsp110-STAT3 interaction-IN-1
CAS :<p>Row174336 (compound 29) serves as an efficient inhibitor of the Hsp110-STAT3 interaction, exhibiting antiproliferative activity in the HPAEC cell line with an IC50 of 22.67 μM.</p>Formule :C23H31N3O4SCouleur et forme :SolidMasse moléculaire :445.58Tubulin polymerization-IN-8
CAS :<p>Compound IIc inhibits tubulin polymerization, arrests cell cycle at G2/M in HCT116 cells, IC50 12.7 μM, potential for cancer research.</p>Formule :C21H24N4O4SCouleur et forme :SolidMasse moléculaire :428.5Ack1 inhibitor 1
CAS :<p>Ack1 inhibitor 1 is a potent and selective orally active inhibitor of ACK1 kinase, with an IC50 value of 2.1 nM. It effectively inhibits the phosphorylation of ACK1 and the activation of downstream AKT, demonstrating anti-tumor activity [1].</p>Formule :C39H40F3N7O4Couleur et forme :SolidMasse moléculaire :727.77TTBK1/2-IN-3
CAS :<p>TTBK1/2-IN-3 (compound 10) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 can reduce the expression of primary cilia on the surface of human induced pluripotent stem cells (iPSC).</p>Formule :C21H22N4OCouleur et forme :SolidMasse moléculaire :346.426ETB
CAS :<p>ETB is a potent inhibitor of Hsp60 chaperone activity. It can impede the chaperone function of both wild-type proteins and the C237A and C447A mutant proteins. ETB binds to Hsp60 at Cys442, and the C442A mutant demonstrates resistance to ETB inhibition.</p>Formule :C24H33NO6Masse moléculaire :431.52Kolavenic acid analog
CAS :<p>KAA, an anticancer compound, inhibits centrosome clustering and targets HSET+ yeast and cancer cells.</p>Formule :C25H38O4Couleur et forme :SolidMasse moléculaire :402.57Tubulin polymerization-IN-33
<p>Tubulin-IN-33, an oxazoloisoindole, hinders microtubule assembly; effective against NCI cancer cells.</p>Formule :C27H28N2O6Couleur et forme :SolidMasse moléculaire :476.52TPI-287
CAS :<p>TPI 287: synthetic taxane; may halt cancer by stabilizing microtubules, blocking cell division, inducing apoptosis.</p>Formule :C46H63NO15Couleur et forme :SolidMasse moléculaire :869.99Nrf2/HO-1 activator 1
CAS :<p>Compound 24: Potent Nrf2/HO-1 activator with neuroprotective, antioxidant properties; useful in PD research.</p>Formule :C21H18O5Couleur et forme :SolidMasse moléculaire :350.36Tubulin polymerization-IN-35
<p>Tubulin-IN-35 inhibits oxazolylisoindole microtubule formation, targeting VL51 marginal zone lymphoma.</p>Formule :C31H35N3O5Couleur et forme :SolidMasse moléculaire :529.63Onalespib lactate
CAS :<p>Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor with antitumor activity.</p>Formule :C27H37N3O6Couleur et forme :SolidMasse moléculaire :499.6Antitumor agent-200
CAS :<p>Antitumor agent-200 (Compound 2g) is a microtubule synthesis inhibitor that binds to the colchicine site on tubulin, causing G2/M cell cycle arrest and inducing reactive oxygen species (ROS) production. It demonstrates significant inhibitory activity against P-glycoprotein (P-gp) overexpressing cell lines MCF7/ADR and KBV200, with resistance indices (DRI) of 0.83 and 0.58, respectively. In an MCF-7 xenograft model, Antitumor agent-200 (at 25 mg/kg, administered intraperitoneally) achieves a 57.2% tumor growth inhibition rate. This compound is applicable for research in the field of cancer therapy.</p>Formule :C19H21FN2O3SeCouleur et forme :SolidMasse moléculaire :423.34Tubulin inhibitor 49
CAS :<p>Tubulin inhibitor 49 (Compound 18) is an inhibitor of tubulin polymerization with an IC50 of 48 μM. It disrupts the microtubule network of cells, causing cell cycle arrest in the G2 phase, and exhibits cytotoxicity with an IC50 of 8.8 μM in HeLa cells.</p>Formule :C18H14F3N3OSCouleur et forme :SolidMasse moléculaire :377.383Quinagolide hydrochloride
CAS :<p>Quinagolide hydrochloride is a selective agonist of dopamine D2 receptor.</p>Formule :C20H34ClN3O3SDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :432.02XD23
CAS :<p>XD23 is a potent osteosarcoma inhibitor that functions by downregulating DKK1 and activating the WNT/β-catenin signaling pathway.</p>Formule :C22H26ClN7O3Couleur et forme :SolidMasse moléculaire :471.94HSP90-IN-9
<p>HSP90-IN-9: potent HSP90 inhibitor, dose-dependent fungicide, impedes biofilm/morphology with FLC, reverses FLC resistance.</p>Couleur et forme :SolidAChE/GSK-3β-IN-1
CAS :<p>AChE/GSK-3β-IN-1 is a potent dual AChE/GSK-3β inhibitor that crosses the blood-brain barrier and acts on hAChE (IC50: 1.2 nM), hBChE (IC50: 149.8 nM) and hGSK-</p>Formule :C31H35N7O3SCouleur et forme :SolidMasse moléculaire :585.72SPA0355
CAS :<p>SPA0355 is a thiourea derivative with antioxidant and anti-inflammatory properties. It inhibits RANKL (receptor activator of nuclear factor κB ligand)-induced osteoclastogenesis in primary bone marrow-derived macrophages and suppresses the activation of MAPKs, Akt, and NF-κB pathways. Furthermore, SPA0355 enhances osteoblast differentiation by increasing alkaline phosphatase activity and mineralized nodule formation. It protects ovariectomized mice from bone loss by stimulating osteoblast differentiation and inhibiting osteoclast resorption, making it a potential candidate for studying postmenopausal osteoporosis.</p>Formule :C22H21N3O2SCouleur et forme :SolidMasse moléculaire :391.486SF0166
CAS :<p>SF0166: potent αvβ3 antagonist, IC50: 0.6 nM. Blocks cell adhesion, IC50: 7.6 pM-76 nM. Reduces neovascularization in mice.</p>Formule :C23H27F2N5O4Couleur et forme :SolidMasse moléculaire :475.49HSN748
CAS :<p>HSN748 is an analog of ponatinib and acts as a multi-kinase inhibitor. It exhibits inhibitory activity against kinases such as FLT3, ABL1, RET, PDGFRα/β, MNK1, and MNK2. HSN748 can suppress the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines, making it a useful compound in leukemia research.</p>Formule :C27H24F3N7OCouleur et forme :SolidMasse moléculaire :519.521Ethaboxam
CAS :<p>Ethaboxam is a β-tubulin inhibitor and antifungal agent used against oomycete pathogens.</p>Formule :C14H16N4OS2Degré de pureté :99.37%Couleur et forme :SolidMasse moléculaire :320.43AKT-IN-26
CAS :<p>AKT-IN-26 (Compound 453) is an AKT inhibitor that binds to the Pleckstrin Homology (PH) domain of AKT. It is useful for research related to cell proliferation and cancer involving the AKT pathway.</p>Formule :C21H17N5O4SCouleur et forme :SolidMasse moléculaire :435.456Hsp90-IN-38
CAS :<p>Hsp90-IN-38 (compound 20m) is an inhibitor of HSP90 (heat shock protein). It demonstrates a strong binding affinity to HSP90 with a Kd of 87 nM. The compound inhibits ATPase activity with an IC50 of 0.13 μM. Hsp90-IN-38 also shows inhibitory effects on HCT116, MCF-7, SKBr3, K562, and A549 cells with IC50 values of 0.187, 0.072, 0.105, 0.403, and 0.031 μM, respectively.</p>Formule :C28H35N3O5Couleur et forme :SolidMasse moléculaire :493.595NAP1051
CAS :<p>NAP1051, a biomimetic analog of Lipoxin A4, serves an anti-tumor role by targeting the inflammatory tumor microenvironment. It inhibits the chemotaxis of neutrophils to fMLP and stimulates macrophage efferocytosis by activating AKT. NAP1051 is utilized in research on colorectal cancer.</p>Formule :C23H34O5Couleur et forme :SolidMasse moléculaire :390.51Tubulin polymerization-IN-77
CAS :<p>Tubulin polymerization-IN-77 (Compound 15c) is a microtubule polymerization inhibitor that exhibits anti-glioblastoma activity by hindering microtubule polymerization. It demonstrates significant blood-brain barrier permeability, effectively induces G2/M phase arrest in GBM cells, and triggers apoptosis, while also markedly inhibiting tumor cell migration.</p>Formule :C22H19BrF3NO7Couleur et forme :SolidMasse moléculaire :546.288Terpendole E
CAS :<p>Terpendole E is an atypical L5 site inhibitor.</p>Formule :C28H39NO3Couleur et forme :SolidMasse moléculaire :437.61KU-32
CAS :<p>KU-32 is a novel and novobiocin-based Hsp90 inhibitor. It can protect against neuronal cell death.</p>Formule :C20H25NO8Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :407.41JC168
CAS :<p>JC168 is a phenyl analog of peloruside and functions as a microtubule inhibitor with antiproliferative and anticancer properties. It enhances tubulin polymerization, thereby disrupting microtubule dynamics, making it a useful agent in the study of microtubule-associated diseases.</p>Formule :C26H40O7Couleur et forme :SolidMasse moléculaire :464.592APN/AKT-IN-1
<p>APN/AKT-IN-1, a dual APN (IC50=0.21μM) & AKT (IC50=0.27μM) inhibitor, hinders GSK3β phosphorylation.</p>Formule :C18H27N7O3Couleur et forme :SolidMasse moléculaire :389.45Si306
CAS :<p>Si306, an Src inhibitor, exhibits antitumor activity by reducing the phosphorylation of focal adhesion kinase (FAK) and the expression of epidermal growth factor receptor (EGFR), thereby inhibiting the invasion of human glioblastoma (GBM).</p>Formule :C25H26BrClN6OSCouleur et forme :SolidMasse moléculaire :573.94Nic-15
CAS :<p>Nic-15 (compound 4n) serves as an anti-constrictive agent targeting the low vascular characteristics of pancreatic tumors. These characteristics enable cancer cells to adapt to the nutrient-deficient tumor microenvironment and develop resistance to treatment. Nic-15 modulates the PI3K/Akt/mTOR pathway and alleviates ER stress induced by Gemcitabine. It significantly inhibits migration and colony formation in MIA PaCa-2 and PANC-1 pancreatic cancer cells. When used in combination with Gemcitabine, Nic-15 effectively addresses resistance issues in pancreatic tumors. In xenograft models in vivo, Nic-15 notably enhances the efficacy of Gemcitabine.</p>Formule :C25H26F2O3Couleur et forme :SolidMasse moléculaire :412.47Myoseverin B
CAS :<p>Myoseverin B is a microtubule assembly inhibitor that impedes tubulin polymerization (IC50 = 2 μM) and generally exhibits low cytotoxicity across most cell types. It is utilized in antitumor agent research.</p>Formule :C27H32N6O2Couleur et forme :SolidMasse moléculaire :472.582β-Catenin modulator-8
CAS :<p>β-Catenin modulator-8 (Compound Ⅸa) is a specific β-catenin modulator for use in cancer research.</p>Formule :C17H20N2O2SDegré de pureté :99.97%Couleur et forme :SolidMasse moléculaire :316.42Epothilone E
CAS :<p>Epothilone E, a derivative of epothilone, functions by inhibiting microtubule protein activity, thereby halting cell division and exhibiting anti-tumor</p>Formule :C26H39NO7SCouleur et forme :SolidMasse moléculaire :509.66HSP90-IN-11
<p>HSP90-IN-11: potent HSP90 inhibitor, akin to AUY-922; hinders CRC/NSCLC cell proliferation; degrades EGFR, Akt proteins.</p>Formule :C27H30FN3O6Couleur et forme :SolidMasse moléculaire :511.54MKLP2-IN-1
CAS :<p>MKLP2-IN-1 (compound 12a) is an inhibitor of MKLP2 that demonstrates excellent oral bioactivity. In vitro, MKLP2-IN-1 inhibits the ATPase activity stimulated by recombinant MKLP2 microtubules and, in a mouse Calu-6 lung cancer model, it effectively suppresses tumor growth.</p>Formule :C23H19BrFN3O2Couleur et forme :SolidMasse moléculaire :468.318Tyrosine kinase-IN-9
CAS :<p>Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.</p>Formule :C20H14ClN3O3Couleur et forme :SolidMasse moléculaire :379.796AM-9022
CAS :<p>AM-9022 is a potent and selective KIF18A inhibitor, orally active and suitable for cancer research [1].</p>Formule :C27H36F2N6O4SCouleur et forme :SolidMasse moléculaire :578.67Antitubulin agent 1
<p>Antitubulin agents-1 disrupts microtubules, ups α-tubulin acetylation, and has anticancer properties.</p>Formule :C21H19N3O3Couleur et forme :SolidMasse moléculaire :361.39TACC3 inhibitor 2
CAS :<p>TACC3 inhibitor 2 (Compound 13b) is a TACC3 inhibitor with an IC50 of 200 nM. It induces mitotic arrest, apoptosis (Apoptosis), and DNA damage. TACC3 inhibitor 2 is applicable for research in the field of cancer.</p>Formule :C20H22FN5O2Couleur et forme :SolidMasse moléculaire :383.419KUNG65
CAS :<p>KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.</p>Formule :C23H20ClFO4Couleur et forme :SolidMasse moléculaire :414.85α5β1 integrin agonist-1
CAS :<p>α5β1 integrin agonist-1 is an α5β1 integrin agonist that selectively delivers 5-FU to tumour cells and induces tumour cell death.</p>Formule :C24H26FN5O9Couleur et forme :SolidMasse moléculaire :547.49Zalunfiban dihydrochloride
<p>Zalunfiban (RUC-4) is a potent αIIbβ3 platelet antagonist, IC50 45 nM, used in myocardial infarction research.</p>Formule :C16H20Cl2N8O2SCouleur et forme :SolidMasse moléculaire :459.35PP487
CAS :<p>PP487 is a dual tyrosine kinase/PI(3)K inhibitor, exhibiting IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. It is applicable in cancer research [1].</p>Formule :C14H14BrN5OCouleur et forme :SolidMasse moléculaire :348.2Tasidotin hydrochloride
CAS :<p>Tasidotin hydrochloride, a dolastatin 15 analog, inhibits microtubule assembly and dynamics.</p>Formule :C32H59ClN6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :643.30Icafolin-methyl
CAS :<p>Icafolin-methyl is a plant-specific herbicide that acts as an inhibitor of tubulin polymerization. In plants, it metabolizes into the carboxylic acid icafolin, potentially inhibiting plant tubulin polymerization by binding to β-tubulin.</p>Formule :C18H18F2N2O5Couleur et forme :SolidMasse moléculaire :380.34316,16-Dimethyl prostaglandin E2
CAS :<p>16,16-Dimethyl prostaglandin E2 regulates hematopoietic stem cells via EP2/EP4 and Wnt, taken orally.</p>Formule :C22H36O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :380.52AS2521780
CAS :<p>AS2521780 is an inhibitor of PKCθ (IC50: 0.48 nM).</p>Formule :C30H41N7OSDegré de pureté :98%Couleur et forme :SolidMasse moléculaire :547.76GSK3β-IN-2
CAS :<p>GSK3β-IN-2 (Compound S01) is an inhibitor of GSK3β with an IC50 of 0.35 nM. It activates the Wnt/β-catenin signaling pathway, promoting neurogenesis and neurite outgrowth. GSK3β-IN-2 reduces tau protein phosphorylation induced by Aβ at the Ser396 site, thereby decreasing neurofibrillary tangles. Furthermore, GSK3β-IN-2 improves Alzheimer's disease symptoms in a zebrafish model.</p>Formule :C25H18N4OCouleur et forme :SolidMasse moléculaire :390.437PM-060184
CAS :<p>PM-060184, a tubulin polymerisation inhibitor, is used potentially for the treatment of solid tumours and breast cancer.</p>Formule :C31H45N3O7Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :571.7Alfalone
CAS :<p>Alfalone (compound 9ia) is an antimitotic agent. It induces cleavage arrest and initiates the formation of tubercular eggs.</p>Formule :C17H14O5Couleur et forme :SolidMasse moléculaire :298.29Monomethyl auristatin E intermediate-17
CAS :<p>MonomethylauristatinE intermediate-17 is an intermediate compound used in the synthesis of MonomethylauristatinE. MonomethylauristatinE (MMAE) functions as a microtubule/tubulin inhibitor with anticancer properties. It is widely utilized as the cytotoxic component in antibody-drug conjugates (ADCs).</p>Formule :C27H35NO7SMasse moléculaire :517.63NRX-103094
CAS :<p>NRX-103094 boosts β-catenin binding to SCFβ-TrCP ligase with EC50 62 nM and Kd 0.6 nM.</p>Formule :C20H11Cl2F3N2O4SDegré de pureté :99.13%Couleur et forme :SolidMasse moléculaire :503.28NRX-252114
CAS :<p>NRX-252114 promotes mutant β-catenin degradation, binding it to E3 ligase SCFβ-TrCP (EC50: 6.5 nM; Kd: 0.4 nM).</p>Formule :C22H12Cl2F3N3O2SDegré de pureté :99.70%Couleur et forme :SolidMasse moléculaire :510.32AKT Kinase Inhibitor
CAS :<p>AKT Kinase Inhibitor is an Akt inhibitor with antitumor activity that selectively inhibits cell proliferation in a dose-dependent manner.Cost-effective and quality-assured.</p>Formule :C16H19N7O3Degré de pureté :97.83% - 99.13%Couleur et forme :SolidMasse moléculaire :357.37Ombrabulin
CAS :<p>Ombrabulin is a derivative of CA-4 phosphate. It is known to show antivascular effects through selective disruption of the tubulin cytoskeleton of endothelial cells.</p>Formule :C21H26N2O6Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :402.44ZW4864
CAS :<p>ZW4864 is a selective inhibitor of the β-catenin/B-Cell Lymphoma 9 protein (β-catenin/BCL9 PPI) interaction, demonstrating oral activity. It inhibits β-catenin/BCL9 PPI with a K_i value of 0.76 μM and an IC_50 value of 0.87 μM.</p>Formule :C33H43ClN6O3Couleur et forme :SolidMasse moléculaire :607.224-Methylenecycloartanyl ferulate
CAS :<p>24-Methylenecycloartanyl ferulate, a compound belonging to the γ-oryzanol family, demonstrates the ability to enhance parvin-beta expression within human breast cancer cells. Furthermore, it exhibits potential as an ATP-competitive Akt1 inhibitor, with an EC 50 value of 33.3 μM.</p>Formule :C41H60O4Couleur et forme :SolidMasse moléculaire :616.927Cercosporin
CAS :<p>Cercosporin, produced by the plant pathogen Cercospora kikuchii and the elsinochromes, is a potent photosensitizer with a short activation wavelength. Cercosporin contains perylene quinone structural features essential for PKC activity (IC50: 0.6-1.3 μM).</p>Formule :C29H26O10Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :534.51Tau tracer 2
CAS :<p>Tau tracer 2 (Pl-2620) is a specific imaging agent designed to detect and visualize Tau protein aggregates, primarily used for diagnosing neurodegenerative diseases [1].</p>Formule :C15H9FN4Couleur et forme :SolidMasse moléculaire :264.26320-HETE
CAS :<p>20-HETE is a CYP450 product, vasoconstrictor, modulates K+ channels, affects NADPH, ROS, NF-κB, NO synthase, and cell apoptosis/proliferation.</p>Formule :C20H32O3Degré de pureté :99.79%Couleur et forme :SolidMasse moléculaire :320.47Sevasemten
CAS :<p>Sevasemten is an allosteric inhibitor that targets skeletal muscle myosin. It displays selectivity in its inhibition, demonstrated by IC50 values of ≤10 μM for skeletal muscle myosin and >100 μM for cardiac myosin, respectively.</p>Formule :C16H11F4N5O2Couleur et forme :SolidMasse moléculaire :381.28PF-03814735
CAS :<p>PF-03814735 is a novel, potent and reversible inhibitor of Aurora A/B with IC50of 0.8 nM/5 nM, is less potent to Flt3, FAK, TrkA, and minimally active to Met and FGFR1. Phase 1.</p>Formule :C23H25F3N6O2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :474.48CMX-2043
CAS :<p>CMX-2043 is a drug potentially to block oxidative damage and activate cell survival pathways.</p>Formule :C16H26N2O6S2Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :406.52Cevipabulin fumarate
CAS :<p>Cevipabulin (TTI-237) fumarate is a microtubule-active antitumor compound and inhibits the binding of [3H] vinblastine to tubulin (IC50: 18-40 nM in the human tumor cell line).</p>Formule :C22H22ClF5N6O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :580.89BCR-ABL-IN-8
CAS :<p>BCR-ABL-IN-8 (compound 26f) is a BCR-ABL inhibitor featuring a trimethoxy group [1].</p>Formule :C30H33N7O5Degré de pureté :98%Couleur et forme :SolidMasse moléculaire :571.63
