Signalisation du cytosquelette
Les inhibiteurs de la signalisation du cytosquelette sont des composés qui perturbent les voies de signalisation régulant le cytosquelette, essentiel pour la forme, la motilité, la division des cellules et le transport intracellulaire. Ces inhibiteurs sont utilisés pour étudier la dynamique des protéines du cytosquelette, telles que l'actine et la tubuline, et leur rôle dans des processus comme la migration cellulaire, l'adhésion et la métastase du cancer. Les inhibiteurs de la signalisation du cytosquelette sont précieux dans la recherche en biologie cellulaire, en cancérologie et en neurobiologie. Chez CymitQuimica, nous offrons une gamme complète d'inhibiteurs de la signalisation du cytosquelette de haute qualité pour soutenir vos recherches dans ces domaines.
1534 produits trouvés pour "Signalisation du cytosquelette"
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APN/AKT-IN-1
APN/AKT-IN-1, a dual APN (IC50=0.21μM) & AKT (IC50=0.27μM) inhibitor, hinders GSK3β phosphorylation.Formule :C18H27N7O3Couleur et forme :SolidMasse moléculaire :389.45Tyrosine kinase-IN-9
CAS :Tyrosine kinase-IN-9 (Compound B) is an inhibitor of c-Abl. It is useful for studying neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease.Formule :C20H14ClN3O3Couleur et forme :SolidMasse moléculaire :379.796Des-ethyl-carafiban
CAS :Des-ethyl-carafiban (Compound 44) is an antagonist of the fibrinogen receptor, effectively inhibiting platelet aggregation induced by various agonists. It is useful for research in thrombotic diseases.Formule :C22H23N5O5Couleur et forme :SolidMasse moléculaire :437.448Mps1-IN-8
CAS :Mps1-IN-8, a Mps1 inhibitor, can be utilized in the study of various tumors [1].Formule :C35H47N8O6PCouleur et forme :SolidMasse moléculaire :706.77Tubulin polymerization-IN-8
CAS :Compound IIc inhibits tubulin polymerization, arrests cell cycle at G2/M in HCT116 cells, IC50 12.7 μM, potential for cancer research.Formule :C21H24N4O4SCouleur et forme :SolidMasse moléculaire :428.5TTBK1/2-IN-1
CAS :TTBK1/2-IN-1 (compound 3) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 816 nM and 384 nM, respectively.Formule :C17H16N4OCouleur et forme :SolidMasse moléculaire :292.335PP487
CAS :PP487 is a dual tyrosine kinase/PI(3)K inhibitor, exhibiting IC50 values of 0.017 μM, 0.072 μM, 0.004 μM, 0.01 μM, 0.55 μM, 0.22 μM, and < 0.01 μM against DNA-PK, mTOR, Hck, Src, EGFR, EphB4, and PDGFR, respectively. It is applicable in cancer research [1].Formule :C14H14BrN5OCouleur et forme :SolidMasse moléculaire :348.2Tubulin polymerization-IN-77
CAS :Tubulin polymerization-IN-77 (Compound 15c) is a microtubule polymerization inhibitor that exhibits anti-glioblastoma activity by hindering microtubule polymerization. It demonstrates significant blood-brain barrier permeability, effectively induces G2/M phase arrest in GBM cells, and triggers apoptosis, while also markedly inhibiting tumor cell migration.Formule :C22H19BrF3NO7Couleur et forme :SolidMasse moléculaire :546.288Epothilone E
CAS :Epothilone E, a derivative of epothilone, functions by inhibiting microtubule protein activity, thereby halting cell division and exhibiting anti-tumorFormule :C26H39NO7SCouleur et forme :SolidMasse moléculaire :509.66HS-345
CAS :HS-345, a TrkA/Akt inhibitor, exhibits potent anti-pancreatic cancer properties. This compound inhibits the growth and proliferation of pancreatic cancer cells by blocking the TrkA/Akt signaling pathway and induces cell apoptosis (Apoptosis). Additionally, HS-345 inhibits angiogenesis by reducing the expression of HIF-1α and VEGF. It holds promise for use in pancreatic cancer research.Formule :C19H18N6O2SCouleur et forme :SolidMasse moléculaire :394.45Auristatin S
CAS :AuristatinS is a potent anti-tumor agent that serves as an Auristatin payload. It effectively reduces the bystander effect and decreases off-target toxicity. In the Karpas/KarpasBVR cell model, AuristatinS exhibits excellent tolerability. It can be used as the cytotoxic component in antibody-drug conjugates (ADCs) for treating various types of cancer.Formule :C38H65N5O8Couleur et forme :SolidMasse moléculaire :719.95Tubulin polymerization-IN-35
Tubulin-IN-35 inhibits oxazolylisoindole microtubule formation, targeting VL51 marginal zone lymphoma.Formule :C31H35N3O5Couleur et forme :SolidMasse moléculaire :529.63AChE/GSK-3β-IN-1
CAS :AChE/GSK-3β-IN-1 is a potent dual AChE/GSK-3β inhibitor that crosses the blood-brain barrier and acts on hAChE (IC50: 1.2 nM), hBChE (IC50: 149.8 nM) and hGSK-Formule :C31H35N7O3SCouleur et forme :SolidMasse moléculaire :585.72KUNG65
CAS :KUNG65 acts as a selective Grp94 inhibitor, demonstrating a target dissociation constant (K_d) of 540 nM. It exhibits a minimum selectivity of 73-fold compared to other Hsp90 isoforms.Formule :C23H20ClFO4Couleur et forme :SolidMasse moléculaire :414.85Hsp90-IN-34
CAS :Hsp90-IN-34 (compound HAM-1) is a chemical inhibitor that targets the Aha1-Hsp90 chaperone complex with high affinity (KDapp=23.5 µM). It modulates the ATPase activity of Hsp90 by affecting the interaction between Hsp90 and Aha1.Formule :C22H14F2N6OCouleur et forme :SolidMasse moléculaire :416.38NVP-BQS481
CAS :NVP-BQS481 (Compound 1) is a selective inhibitor of spindle motor protein 5 (Eg5), with an IC50 of less than 0.5 nM. It demonstrates significant anti-mitotic and anti-tumor activities, exhibiting an IC50 of 0.09 nM against SK-OV-3ip cells. NVP-BQS481 is suitable for use as a cytotoxic payload in the synthesis of antibody-drug conjugates (ADCs).Formule :C27H33F3N4O2Couleur et forme :SolidMasse moléculaire :502.57Symplostatin 1
CAS :Symplostatin 1 is a dolastatin 10 analog from the marine cyanobacterium Symploca hydnoides.Formule :C43H70N6O6SCouleur et forme :SolidMasse moléculaire :799.12TTBK1/2-IN-3
CAS :TTBK1/2-IN-3 (compound 10) is a potent inhibitor of Tau tubulin kinase 1 (TTBK1) and TTBK2, with IC50 values of 579 nM and 258 nM, respectively. TTBK1/2-IN-3 can reduce the expression of primary cilia on the surface of human induced pluripotent stem cells (iPSC).Formule :C21H22N4OCouleur et forme :SolidMasse moléculaire :346.426Onalespib lactate
CAS :Onalespib lactate is a second-generation, potent and selective HSP90 Inhibitor with antitumor activity.Formule :C27H37N3O6Couleur et forme :SolidMasse moléculaire :499.6HSP90α-IN-1
CAS :HSP90α-IN-1 is an HSP90α inhibitor (IC50= 111 nM) that demonstrates anti-aging activity across various cellular senescence models. Belonging to the xanthine family, HSP90α-IN-1 is involved in research focused on combating age-related inflammation, senescence, and diseases (including cancer), and it may contribute to extending healthy lifespan.Formule :C19H16N4O2Couleur et forme :SolidMasse moléculaire :332.356
