Composés deutérés

<p>Applications Diethyl-2,2,2,2',2',2'-d6-amine HCl (CAS# 1219805-68-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-Ethylaniline-d5 is labelled N-Ethylaniline (E899362) which is a versatile organic building block used for the synthesis of various pharmaceutical and biologically active compounds. It can be used for the synthesis of benzenesulfonamides as inhibitors of microsomal prostaglandin E2 synthase 1 (mPGES-1) in mice and in humans as potential anti-inflammatory agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hanke, Th., et al.: Biorg. Med. Chem., 21 (24), 7874 (2013)<br></p>

<p>Applications tert-Butyl-d9-phosphine is the labeled analogue of tert-Butylphosphine (B809330), a reactant in the synthesis of phosphine ligands in metal complexes.<br>References Wiedner, E.S., et. al.: Organometallics, 29, 5390 (2010)<br></p>

<p>Applications Sodium Octadecanoate-d35 (CAS# 1219794-97-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromo-2,6-difluorobenzene-d3 (CAS# 1219803-73-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4'-​Methoxy-[1,1'-biphenyl]​-​4-​methanamine-d3 is labelled 4'-​Methoxy-[1,1'-biphenyl]​-​4-​methanamine (M261345) which is used to prepare biphenylmethyl urea derivatves as MCH-R1 antagonists for reatment of obesity. It is also used to synthesize the Pseudomonas aeruginosa virulence factor LasB inhibitors.<br>References Galiano, S., et al.: Bioorg. Med. Chem., 15, 3896 (2007); Garner, A&gt;, et al.: ACS Med. Chem. Lett., 3, 668 (2012)<br></p>

<p>Applications 3-Nitro-1-pyrenol is an nitroarene which may contribute to genotoxicity associated with air pollution. This is the labeled analog.<br>References Kameda, T., et al.: J. Health. Sci., 57, 372 (2011); Van, B., et al.: Chem. Biol. interact., 117, 15 (1999);<br></p>

<p>Applications N-Descarbo(1,4-benzodioxine), N-Acetyl Doxazosin-d8 Hydrochloride is the isotope analog of N-Descarbo(1,4-benzodioxine), N-Acetyl Doxazosin Hydrochloride. N-Descarbo(1,4-benzodioxine), N-Acetyl Doxazosin Hydrochloride is an impurity of doxazosin, which is used in biological studies to evaluate the structure activity or prazosin pharmacophore for Transport-P inhibition.<br>References Zunszain, P.A., et al.: Bioorg. Med. Chem., 13, 3681 (2005); Al-Damluji, S., et al.: J. Pharmacol., 124, 693 (1998)<br></p>

<p>Applications Ethyl 2-(4-(2-(4-chlorobenzamido)ethyl)phenoxy)-2-methylpropanoate is an intermediate in the synthesis of Bezafibrate-d4 (B341002), a labeled antilipemic agent.<br>References Zimmerman, R., et al.: Atherosclerosis 29, 477 (1978); Monk, J.P., et al.: Drugs, 33, 539 (1987)<br></p>

<p>Applications 1-Bromoeicosane-d41 (CAS# 202480-71-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications (±)-(1-Bromoethyl-2,2,2-d3)benzene (CAS# 23088-42-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cyclopropane-1,2,2,3,3-d5-carbonyl chloride is a useful building block for organic synthesis<br></p>

<p>Applications 1-Bromopropane-1,1-d2 (CAS# 40422-05-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hexachloroethane-13C1 (CAS# 93952-15-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Methyl 5-Hydroxy-2-benzimidazolecarbamate-d3, is a labeled analogue of Methyl 5-Hydroxy-2-benzimidazolecarbamate (M312585), which is a derivative of Carbendazim (C175900).<br>References Zeng, Z., et al.: J. Agric. Food Chem., 44, 3374 (1996), Lewis, D., et al.: Xenobiotica, 28, 235 (1998), Hodgson, E., et al.: J. Biochem. Mol. Toxicol., 21, 182 (2007),<br></p>

<p>Applications Bromoethane-1,1,2,2-d4 (CAS# 25854-32-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications (1E)-1-(4-Chlorophenyl)-4,4-dimethyl-1-penten-3-one-D9 is an intermediate in the synthesis of Isotope labelled Tebuconazole (T013002), which is an ergosterol biosynthesis inhibitor present in most pesticide formulations (1,2). Various uptake is observed in plants (3). Drinking water Contaminant Candidate List 3 - CCL 3 as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br></p>

<p>Applications (4-Fluorophenyl)acetic-alpha,alpha-d2 Acid (CAS# 113715-48-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled 3-(Methylnitrosamine)propionaldehyde (MNPA) ( M325710). It was detected for the 1st time in the saliva of betel quid chewers and is a potent carcinogen. It exhibits higher cytotoxicity than Nitrosoguvacine (NGC), Nitrosoguvacoline (NG) and 3-(Methylnitrosamino)propionitrile (MNPN).<br>References Bartsch, H., et al.: Mutat. Res., 250, 103 (1991), Su, T., et al.: Drug Metab. Dispos., 24, 884 (1996), Guengerich, F., et al.: Chem. Res. Toxicol., 14, 611 (2001),<br></p>

<p>Applications 2-Bromoaniline-d4 is the labeled analogue of 2-Bromoaniline (B679950), a reagent used in the synthesis of substituted 2-carboxanilides as herbicides and antibacterials. Also used in the synthesis of benzisothiazol-3-one derivatives as caspase-3 inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kos, J. et al.: Molecules, 18, 7977 (2013); Liu, D. et al.: Bioorg. Med. Chem., 21, 2960 (2013)<br></p>

<p>Applications 1-(2,6-Dichlorophenyl)piperazine-d8 Hydrochloride is the isotope analog of 1-(2,6-Dichlorophenyl)piperazine Hydrochloride. 1-(2,6-Dichlorophenyl)piperazine Hydrochloride is used in the preparation of pyrazolopyrimidones and pyrazolopyridones as tankyrase inhibitors which are useful in the treatment of cancer.<br>References Feng, J., et al.: PCT Int. Appl., 2013:1906020 (2013)<br></p>

<p>Applications n-Pentyl 3-Methyl-2-pentyl Phthalate-d4, is the labeled form of n-Pentyl 3-Methyl-2-pentyl Phthalate (P283625), a phthalate ester, which are ubiquitous environmental contaminants that interact with peroxisome proliferator-activated receptors (PPARs), a family of nuclear receptors. It is used as a plasticizer to impart softness and flexibility to PVC products.<br>References Kaya, T., et al.: Chem. Res. Toxic., 19 (8), 999 (2006); Matter, H., et al.: Bioorg. Med. Chem., 20 (18), 5352 (2012);<br></p>

<p>Applications Hexanedioic-2,2,5,5-d4 Acid (CAS# 19031-55-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sodium 6-Hydroxyhexanoate-3,3,4,4,5,5-d6 (CAS# 1219794-58-7) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Aminobutyric-4,4-d2 Acid (CAS# 107022-06-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled antibacterial agent.<br>References Kind, T., et al.: Anal. Biochem., 363, 185 (2007), Spratlin, J., et al.: Clin. Cancer Res., 15, 431 (2009),<br></p>

<p>Applications Pyridine-2,6-d2 (CAS# 17265-96-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bis(3-methylpentyl) Phthalate-d4, is the labeled analogue of Bis(3-methylpentyl) Phthalate (B486010), used as a plasticizer to impart softness and flexibility to PVC products.<br>References Pierson, J. F., et al.: Angewandte Makromolekulare Chemie, 38, 167 (1979); Kaya, T., et al.: Chem. Res. Toxic., 19 (8), 999 (2006); Matter, H., et al.: Bioorg. Med. Chem., 20 (18), 5352 (2012);<br></p>

<p>Applications 4-Cyano-4'-n-pentyl-d11-biphenyl (CAS# 57078-20-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications Pentadecanoic-15,15,15-d3 Acid (CAS# 352431-40-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hexadecanoic-7,7,8,8-d4 Acid (CAS# 75736-49-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Hexadecanoic-13,13-d2 Acid (CAS# 62690-28-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Di(α-tocopherol) Phosphate-d12 is labelled Di(α-tocopherol) Phosphate (T526190) which is used as a vitamin E supplement.<br>References Libinaki, R., et al.: Food Chem. Toxicol., 44, 916 (2006)<br></p>

<p>Applications Dexamethasone Hemisuccinate-d4 is the isotope labelled analog of Dexamethasone Hemisuccinate (D298855); a derivative of Dexamethasone (D298800) which is a glucocorticoid used as an anti-inflammatory agent. It regulates T cell survival, growth, and differentiation. Dexamethasone also inhibits the induction of nitric oxide synthase.<br>References Wershil, B.K., et al.: Int. Arch. Allergy Immunol., 107, 323 (1995); Riccardi, C., et al.: Cell Death Diff., 6, 1182 (1999); Llanos, S.L. and Roldan, A.: Bio Cell, 23, 29 (1999)<br></p>

<p>Applications 3',4'-Dimethoxyacetophenone-d3 (methyl-d3) (CAS# 350818-54-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications 21-(3-Carboxy-1-oxopropoxy)-17-hydroxy-pregn-4-ene-3,20-dione-d4 Monosodium Salt is deuterium labelled 21-(3-Carboxy-1-oxopropoxy)-17-hydroxy-pregn-4-ene-3,20-dione Monosodium Salt (a derivative of Cortisol) and exhibits multi-site antiglucocorticoid activity in vivo.<br>References Duncan, M. R. and Duncan, G. R. J. Steroid Biochem. 10, 245 (1979)<br></p>

<p>Applications An anticonvulsant, hypnotic. A labelled metabolite of Mephentoin.A representative lot was 85% d5; 15% d4 1% d3 with no detectable d0.<br>References Karlaganis, G., et al.: Drug Metab. Dispos., 8, 173 (1980), Knabe, J., et al.: Arch. Phar., 313, 538 (1980),<br></p>

<p>Applications 1-Piperidine-d10-carbonyl Chloride (CAS# 1219803-31-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Isopropyl-d7-piperazine (CAS# 2089679-76-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-Pentanone-d10 (CAS# 54927-77-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications 4-Chloro-N-(methyl-d3)pyridine-2-carboxamide (cas# 1189858-48-7) is a compound useful in organic synthesis.<br></p>

<p>Applications Dimethyl chlorothiophosphate-D6 is a labelled analog of Dimethyl chlorothiophosphate (D473292). Dimethyl chlorothiophosphate is an organophosphorus reagent that is used to synthesize phosphorus analogues of γ-aminobutyric acid, compounds that exhibit anticonvulsant properties. Dimethyl chlorothiophosphate is also used as a reagent to synthesize Parathion (P192220), a widely used pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cates, L., et al.: J. Med. Chem., 27, 654 (1984); DeBruin, K. &amp; Boros, E.: J. Org. Chem., 55, 609 (1990); Hall, S.: J. Am. Chem. Soci., 72, 2768 (1950); Kotronarou, A. &amp; Hoffmann, M.: Env. Sci. Tech., 26, 1460 (1992)<br></p>

<p>Applications Tetrabromobisphenol A Diglycidyl Ether-d10 is the isotope labelled analog of Tetrabromobisphenol A Diglycidyl Ether (T291305); a brominated flame retardant (BFR) with good stability and a thermal decomposition temperature over 300°.<br>References Oleszek S., et al.: Waste Manag., 33, 1835 (2013); Jia, X., et al.: Henan Daxue Xuebao, Ziran Kexueban, 36, 44 (2006)<br></p>

<p>Applications Naphthalene-2,3,4,5,6,7,8-d7 (CAS# 887-68-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications An intermediate for the synthesis of analogs of retinoid lactone.<br>References Lewin, A.H., et al.: Pharm. Res., 12, 983 (1995).<br></p>

<p>Applications 2-Aminofluorene-d11 (CAS# 347841-44-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Sodium Propionate-3,3,3-d3 (CAS# 1210410-35-7) is a useful isotopically labeled research compound. This compound can be used to demonstrate intereactions between ergosterol and amphotericin B in lipid bilayers using NMR spectroscopy to exert antifungal activity.<br>References Matsumori, N.,et.al., J.Am.Chem.Soc., 131,11855-11860,(2009);<br></p>

<p>Applications n-Hexadecyl-2,2,16,16,16-d5 Alcohol (CAS# 1219799-18-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Octanoic-8,8,8-d3 Acid (CAS# 156779-05-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Cycrimine Hydrochloride-d5 is the isotope labelled analog of Cycrimine Hydrochloride (C991450); a cholinolytic anti-Parkinson drug which can cause neuromuscular blockades in isolated rat diaphragms.<br>References Das, M., et al.: Toxicol. Appl. Pharm., 39, 149 (1977); Vedasiromoni, J.R., et al.: Arch. Int. Pharmacod. T., 219, 64 (1976)<br></p>

<p>Applications 4-Fluorotoluene-alpha,alpha,alpha-d3 (CAS# 4202-91-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Iodopropane-d7 is the labelled analogue of 1-Iodopropane [I718790] which is used in the synthesis of a new class of cesium selective ionophores. Also used to preparation of secondary amines and diamines.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Casnati, A. et al.: J. Am. Chem. Soc., 117, 2767 (1995); Fukuyama, T. et al.: Tetrahedron Lett., 38, 5831 (1997);<br></p>

<p>Applications 1,3-Dioleoyl-2-stearoylglycerol-d5 is the isotope labelled analog of 1,3-Dioleoyl-2-stearoylglycerol (D484305); a triglyceride found in various natural sources such as coconut oil, palm oil, rice bran oil, sunflower oil and sesame oil.<br>References Reena, M.B. et al.: Eur. J. Lipid Sci. Technol., 111, 346 (2009); Huey, S. et al.: J. Food Sci., 74, E177 (2009)<br></p>

<p>Applications (±)-2-Iodobutane-d9 (CAS# 1219795-41-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Phenylboronic Acid-13C6 is the isotope labelled 13C6 analog of Phenylboronic Acid (P319590); a compound used in the organic synthesis of various pharmaceutical goods.<br>References Ainley, A.D., et al.: J. Chem. Soc., 2171 (1930)<br></p>

<p>Applications N2-Acetyl Acyclovir-d4 is the isotope labelled analog of N2-Acetyl Acyclovir (A168015); an impurity of Acyclovir (A192400) which is an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Also an antiviral.<br>References Collins, P., et al.: J. Antimicrob. Chemother., 5, 431 (1979); Matsumoto, H., et al.: Chem. Pharm. Bull., 36, 1153 (1988); Whitley, R.J., et al.: N. Engl. J. Med., 327, 782 (1992)<br></p>

<p>Applications n-Nonyl-d19 Alcohol (CAS# 349553-86-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications 3-(2,6-Dimethylphenyl)-2-oxazolidinone-d6 is an intermediate used in the synthesis of Dimethachlor Ethane Sulfonic Acid Sodium Salt-d6 (D460284), which is the deuterium labelled form of Dimethachlor Ethane Sulfonic Acid Sodium Salt (D460283), which is a pesticide metabolite and pollutant found in groundwater, surface water, and wastewater.<br>References Huntscha, S., et al.: J. Chromatogr. A, 1268, 74 (2012); Reemtsma, T., et al.: J. Chromatogr. A, 1271, 95 (2013);<br></p>

<p>Applications N,N,N',N'-Tetramethyl-1,3-propanediamine-d18 (CAS# 1398065-52-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromoundecane-1,1,2,2-d4 (CAS# 1219802-82-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,3,5-Triphenylbenzene-d18 (CAS# 34496-33-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bromoethane-1,2,2-d3 (CAS# 23705-69-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications DL-Tryptophan-d8 (CAS# 1233395-85-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Unlabeled 3,3'-Dibromodiphenyl-d8 is used in the synthesis of novel aromatic compounds as electroluminescent materials and organic semiconductor materials for organic light emitting devices.<br>References Ham, H.; et al.: PCT Int. Appl. 64pp. Patent 2016 CODEN:PIXXD2<br></p>

<p>Applications 2-[(Tetrahydro-2H-pyran-2-yl)oxy]ethanol-d4 is an intermediate used in the synthesis of Roxithromycin-d7 (R700852), which is a semisynthetic labelled Erythromycin derivative. Antibacterial.<br>References Jones, R.N., et al.: Antimicrob. Agents Chemother., 24, 209 (1983), Barry, A.L., et al.: Eur. J. Clin. Microbiol., 5, 536 (1986), Grassi, C., et al.: Chemioterapia, 6, 41 (1987),<br></p>

<p>Applications cis-Apovincamine-d3 is labelled cis-Apovincamine (A729245) which is a vinca alkaloid and a chemical precursor of Vinpocetine (V332500), a derivative of Vincamine with vasodilating activity. Vasodilator (cerebral).<br>References Han, et al.: J. Biol. Chem., 274, 22337 (1999), O’Donnell, et al.: Pharmacol. Biochem. Behav., 63, 185 (1999),<br></p>

<p>Applications 1-Bromo-3,4-difluorobenzene-d3 (CAS# 1219799-14-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1,2-Propylene-d6 Carbonate (cas# 202480-74-8) is a compound useful in organic synthesis.<br></p>

<p>Applications (4-Carboxybutyl-d4)triphenylphosphonium Bromide is a reactant in the preparation of deuterated nocloprost.<br>References Krause, W., et. al.: Prostaglandins, 40, 283 (1990)<br></p>

<p>Applications 8-Bromo-3,7-dihydro-3-methyl-7-(1-methylethyl)-1H-purine-2,6-dione-d7, is the labeled analogue of (B683490), which is a substituted derivative of Xanthine (X499950).<br>References Mueller, C. et. al: Handbook Exp. Pharmacol. 200,151(2011)<br></p>