Composés deutérés

<p>5-(Hydroxymethyl)-2’-deoxycytidine is an activator that can be used in the synthesis of nucleosides and phosphoramidites. It is a novel compound that has antiviral, anticancer, and ribonucleoside activities. 5-(Hydroxymethyl)-2’-deoxycytidine is a monophosphate derivative that can be used to synthesize diphosphates, which are important for DNA replication. The drug has been shown to have anticancer properties against breast cancer cells. It also inhibits the growth of leukemia cells by preventing the synthesis of DNA and RNA.</p>

Tolterodine-D14 is a postoperative drug that belongs to the class of non-selective muscarinic receptor antagonists. It has been evaluated for pharmacokinetic properties in plasma samples from patients undergoing surgery. Tolterodine-D14 undergoes extensive hepatic metabolism, with only about 50% of the drug being excreted unchanged in urine. The elimination half-life of this drug ranges from 2 to 3 hours. Tolterodine-D14 has been shown to be bioequivalent to the reference drug (tolterodine) and can be used as a control level for chromatographic analyses.

Glycine is an amino acid that is found in the human blood. It is a non-essential amino acid and has a high level of stability. Glycine can be used as an untreated control to measure the stability of other compounds; it has been shown to be stable for up to six months at room temperature and for more than one year when frozen. Glycine is not found in any food sources, but can be synthesized by the body from other amino acids. The following are sample product descriptions: Rifapentine Rifapentine is an anti-tuberculosis drug that belongs to the class of rifamycins. It is the most active of the rifamycins for the treatment of tuberculosis. Rifapentine inhibits bacterial growth by binding to DNA-dependent RNA polymerase, thereby preventing transcription and replication. The high frequency of human activity has been shown using a patch-clamp technique on human

<p>Amodiaquine-d10 is a quinoline derivative that is used in the treatment of malaria. It has been shown to have a good bioavailability and is not metabolized by the body. Amodiaquine-d10 has a low risk of toxicity, which makes it appropriate for use in patients with an uncomplicated malaria infection. The plasma concentrations are determined through an analysis of the presence of amodiaquine-d10 in plasma samples. The pharmacokinetic study was performed using an ionization interface and a spectrometer. The evaporation technique was used to measure the concentration of amodiaquine-d10 in plasma samples, which were then analyzed using high performance liquid chromatography (HPLC). This technique allows for the measurement of amodiaquine-d10 at low concentrations and can differentiate between drugs that are chemically similar.</p>

<p>Applications 3,5-Diamino-4-chlorobenzonitrile-15N2 is an intermediate in synthesizing Lodoxamide-15N2,d2 (L469367), a labelled form of Lodoxamide. It is an antiallergic drug that acts as a mast cell stabilizer. It is effective in the treatment of allergic conjunctivitis and in decreasing vascular permeability.<br>References Ciprandi, G., et al.: Allergy, 51(12), 946-951 (1996); Bayer, Atilla., et al.: Ophthalmologica, 217(2), 119-123 (2003)<br></p>

<p>Applications 2-Amino-5-chlorobenzophenone Oxime-d5 is an intermediate in synthesizing N-Demethyl Chlordiazepoxide-d5 (D230827), a deuterium labelled analogue of N-Demethyl Chlordiazepoxide (D230825), which is the main metabolite of anxiolytic drug Chlordiazepoxide (C327050).<br>References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 15 (1972); Greenblatt, D.J., et al.: Clin. Pharmacokinet., 3, 381 (1978); Barbone, F., et al.: Lancet, 352, 1331 (1998); Miki, A., et al.: J. Anal. Toxicol., 26, 87 (2002)<br></p>

<p>Applications Reagent used in labelled pyrimidine and purine synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Das, S., et al.: J. Med. Chem., 52, 5937 (2009), Kim, K., et al.: Bioorg. Med. Chem. Lett., 19, 5225 (2009),<br></p>

<p>Applications 4-Chlorophenyl-1,2-epoxybutane-d5 (cas# 1189717-28-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Methyl nicotinate-2,4,5,6-d4 is a labelled form of methyl nicotinate (M323240), a useful synthetic intermediate, which can be used to prepare biarylcarboxamide inhibitors of phosphodiesterase IV and tumor necrosis factor-α in treatment of rheumatoid arthritis.<br>References Chambers, R., et al.: Bioorg. Med. Chem. Lett., 7, 739 (1997).<br></p>

<p>Applications Ethyl 4-Chlorobutyrate-d4 is an isotope labelled reagent used in the preparation of cyclopropane derivatives.<br>References Antipenko, L., et al.: Chem. Pharm. Bull., 57, 580 (2009), Kumar, A., et al.: Bioorg. Med. Chem., 17, 5285 (2009),<br></p>

<p>Applications 2,4-Dichlorophenol-d3 (cas# 93951-74-7) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Methyl 4-(Dimethylamino)benzoate-D4 is an intermediate in the synthesis of DMABA-d4 NHS Ester (D678402), which is a labelled DMABA NHS ester (D678400). DMABA NHS ester is a reagent that reacts with the primary amine group of PE lipids. DMABA NHS ester has been used in combination with DMABA NHS ester-d4, -d6, and -d10 to study relative changes in PE lipid abundance before and after radical oxidation.<br>References Wester, H., et al.: Nucl. Med. Bio., 23, 365 (1996), Frees, D., et al.: Mol. Microbiol., 48, 1565 (2003), Michel, A., et al.: J. Bacteriol., 188, 5783 (2006), Voelker, T., et al.: Bioorg. Med. Chem., 17, 2047 (2009),<br></p>

<p>Applications 5-Chloro-N-cyclohexylpentanamide-d11 (cas# 1073608-18-0) is a compound useful in organic synthesis.<br></p>

<p>Applications 2,3-Dichlorobenzamidyl Guanidine-13C2 (cas# 1185047-08-8) is a compound useful in organic synthesis.<br></p>

<p>Applications 1,1,2-Trimethyl-3-(4-sulfobutyl)benz[e]indolium-d6 Inner Salt is a labelled analogue of 1,1,2-Trimethyl-3-(4-sulfobutyl)benz[e]indolium Inner Salt (T796740). It is a reactant used in the preparation of liposomally formulated indocyanine green (LP-ICG) derivatives for near infrared fluorescence imaging of lymph nodes.<br>References Toyota, T., et. al.: Bioorg. Med. Chem., 22, 721 (2014)<br></p>

<p>Applications Labelled Anabaseine intermediate.<br></p>

<p>Applications A labelled impurity of Lansoprazole.<br>References Barradell, L., et al.: Drugs, 44, 225 (1992), Aydogmus, Z., et al.: Acta Pharm. Sci., 48, 45 (2006), El-Sherif, Z., et al.: Chem. Pharm. Bull., 54, 814 (2006),<br></p>

<p>Applications 4-[4-(Diphenylmethoxy-d5)-1-piperidinyl]-1-[4-[(2-hydroxy-1,1-dimethyl)ethyl]phenyl]butyne (cas# 1189696-09-0) is a compound useful in organic synthesis.<br></p>

<p>Applications Alfuzosin labelled intermediate as potential α1-adrenoceptor antagonist.<br>References Manoury, P. M. , et al.: J. Med. Chem., 29, 19 (1986),<br></p>