Composés deutérés

<p>Applications Isotope labelled Urethane (U82500), which is a naturally occurring contaminant in fermented foods, particularly wine, stone-fruit brandies, and bread. This substance is reasonably anticipated to be a human carcinogen (1) despite being an additive in some alcoholic beverages and foods (2). It binds covalently with DNA however due to its low unavoidable daily intake, it is considered of negligible concern (3).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br>References 1. Mirvish, S. et al.: Adv. Cancer Res. 1968;11:1-42.2. Battaglia R. et al.: Food Addit Contam. 1990 Jul-Aug;7(4):477-96.3. Zimmerli B. et al.: Mutat Res. 1991 Mar-Apr;259(3-4):325-50.<br></p>

<p>Applications 2,2′,4,4′-Tetrahydroxybenzophenone-d4 is an isotopic analog of 2,2′,4,4′-Tetrahydroxybenzophenone (T295900), a benzophenone-type UV filter with known or suspected endocrine disrupting properties detected in surface waters, sunscreens, personal care products, clothing and food packaging. It is used to protect the skin and materials from the adverse effects of UV-radiation.<br>References Wu, M., et al.: Ecotoxicol. Environ. Saf., 141, 235-241 (2017); Krause, M., et al.: Environ. Int., 99, 177-184 (2017); Jimenez-Diaz, I., et al.: J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 1035, 57-66 (2016)<br></p>

<p>Applications Diphenyl-2,2',4,4',6,6'-d6-amine (CAS# 99234-91-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications tert-Butyl-d9 4-Nitrophenyl Carbonate (cas# 1190006-35-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Acetamide-2,2,2-d3 is used in infrared spectral studies and normal vibrations of acetamide and it’s deutrated analogs.<br>References Suzuki, I., et al.: Bull. Chem. Soc. of Jpn., 35, 1279 (1962); Knudsen, R., et al.: J. Mol. Struct., 321, 187 (1994)<br></p>

<p>Stability Hygroscopic<br>Applications 4,4'-Dipyridyl-d8 as a solid-solution approach to control the dynamics of molecular rotors in crystal solids.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Inukai, M., et al.: J. Amer. Chem. Soc., 137, 12183-12186 (2015)<br></p>

<p>Applications AOZ-HN-d4 is the isotope labelled analog of AOZ-HN (A699000); a metabolite of 3-Amino-2-oxazolidinone (AOZ, A618570) and 1-Formylnaphthalen-2-ol (F700825) which is a novel fluorescence agent.<br>References Sheng, L., et al.: Food Addit. Contam., 30, 2114 (2013); Du, N., et al.: J. Chromatogr. A, 1327, 90 (2014)<br></p>

<p>Applications 2,3,4-Trihydroxybenzophenone-2’,3’,4’,5’,6’-d5 is the isotope labelled analog of 2,3,4-Trihydroxybenzophenone; a trihydroxy derivative of Benzophenone (B204980) which is a compound used in the manufacturing of antihistamines, hypnotics, and insecticides.<br>References Wallace, W., et al.: Environ. Toxicol. Chem., 19, 962 (2000); Hayashi, T., et al.: Toxicol. Lett., 167, 1 (2006); Bechard, K., et al.: Aquat. Toxicol., 90, 310 (2008)<br></p>

<p>Applications Ethylbenzene-d10 (cas# 25837-05-2) is a useful research chemical.<br></p>

<p>Applications 2,4-Dichlorophenol-13C6 is the labelled analog of 2,4-Dichlorophenol (D435685). 2,4-Dichlorophenol is a chlorinated derivative of phenol and is used as an intermediate for the preparation of herbicide 2,4-dichlorophenoxyacetic acid (D435680).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhong, W., et al.: J. Hazard. Mat., 217, 286 (2012); Rowe, V.K., et al.: Am. J. Vet. Res., 15, 622 (1954), Way, J.M., et al.: Residue Rev., 26, 37 (1969)<br></p>

<p>Applications Methionine-methyl-d3 is the labeled Methionine-methyl, a useful building block.<br></p>

<p>Applications Norfloxacin-d5 is deuterium labeled Norfloxacin (N681000), a synthetic fluoroquinolone and an antibacterial agent. Norfloxacin can be used to treat urinary tract infections.<br>References Koga, H., et al.: J. Med. Chem., 23, 1358 (1980), Hirai, K., et al.: Antimicrob. Agents Chemother., 19, 188 (1981), Holmes, B., et al.: Drugs, 30, 482 (1985),<br></p>

<p>Applications Uracil-d4 is the labelled compound form of Uracil (U801000) which is a nitrogenous base on RNA nucleosides.<br>References Seth, P., et al.: J. Med. Chem., 53, 8309 (2010); Cui, H., et al.: Eur. J. Med. Chem., 45, 5140 (2010)<br></p>

<p>Stability Hygroscopic<br>Applications Hydrochloride Salt of 2-Methyl-3-isothiazolone-d3, a pesticidal substituted 3-isothiazolinone.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Thierse, H., et al.: J. Immunol., 172, 1926 (2004), Nilsson, A., et al.: Chem. Res. Toxicol., 18, 308 (2005), Nitsche, J., eet al.: J. Pharm. Sci., 95, 649 (2006),<br></p>

<p>Applications Bis(4-hydroxyphenyl) Sulfone-d8 is the isotope labelled compound commonly used as a reactant in epoxy reactions and is also used as a latent thermal catalyst for epoxy resin.<br>References Fu, J.W., et al.: Adv. Mat. Rsch., 266, 1022 (2011); Li, J.X., et al.: Polymers. Adv. Tech., 23, 803 (2012);<br></p>

<p>Applications Labelled Endosulfan Sulfate, a pesticide used in the control and protection of plant and vegetation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Weston, D. et al.: Env. Sci. Tech., 38, 2752 (2004); Antonious, G. et al.: Env. Tox. Chem., 16, 644 (1997);<br></p>

<p>Applications n-Triacontane-d62 is the labeled compound of Triacontane (CAS #: 638-68-6). Triacontane releases selective material in thermally degradable capsule. It also, increases charge carrier mobility and molecular packing of a solution sheared Diketopyrrolopyrrole-based donor-acceptor copolymer by Alkyl side chain modification.<br>References Shkolnikov, V., et al.; PCT Int. Appl., (2018); Hambsch, M., et al.: Journal of Materials Chemistry C: Materials for Optical and Electronic Devices, 7, 3665-3674, (2019);<br></p>

<p>Applications 4-Cumylphenol-d2 is a deuterated isotope of 4-Cumylphenol (C834580) which is a useful building block for polymers.<br></p>

<p>Applications Linagliptin-d3 is the isotope labelled analogue of a novel potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor with potential use in the treatment of type 2 diabetes.<br>References Prabavathy, N. et al.: Int. J. Pharm. Bio. Sci., 2, 438 (2011); Deacon, C.F.: Diab. Obes. Metab., 13, 7 (2011);<br></p>

<p>Applications 1-Bromobutane-2,2-d2 (CAS# 55724-40-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled 24 Bisphenol S (B519620) is a material used in thermal printing. 24 Bisphenol S is also used in the development of black leuco dyes.<br>References Shima, H. et al.: J. Imag. Sci. Technol., 54, 020502 (2010)<br></p>

<p>Applications Methoxyfenozide-d9 is deuterium labelled Methoxyfenozide (M262765). It is used primarily as an insecticide, and pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhao, Q., et al.: J. Agricul, Food Chem., 56, 10799 (2008);<br></p>

<p>Applications Labeled 1-Iodoethane, which is used in a variety of organic chemical reactions including the synthesis if disubstituted α-amino acids through alkylation reaction. Also used in electrochemical reduction reactions in the preparation of carbamates.<br>References Feroci, M. et al.: J. Org. Chem., 72, 200 (2007); Xu, P. et al.: J. Org. Chem., 71, 4364 (2006);<br></p>

<p>Applications 17beta-Estradiol-2,4,16,16,17-d5 (CAS# 221093-45-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled N-Nitrosomorpholine (N529985). It is a frequently used genotoxic model carcinogen. Toxicogenomic analysis of N-Nitrosomorpholine induced changes in rat liver.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cunningham, M., et al.: Toxicol. Sci., 70, 157 (2002), Ashida, S., et al.: Cancer Res., 64, 5963 (2004), Donninger, H., et al.: Oncogene, 23, 8065 (2004),<br></p>

<p>Applications 2,6-Dichlorobenzamide-3,4,5-d3 (CAS# 1219804-28-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications Geraniol-D6 is the deuterium labeled analog of Geraniol, which is used in the synthesis of insect repellant. It is also used in the synthesis of Angelicoin A and Herecinone J, which inhibit collagen-induced platelet aggregation.<br>References Barnard, D. et al.: J. Med. Entomol., 41, 726 (2004); Mori K. et al.: Phytomedicine, 17, 1082 (2010);<br></p>

<p>Applications Mepanipyrim Phenyl-d5 is deuterium labelled Mepanipyrim (M223600).Mepanipyrim (M223600) is an anilinopyrimidine fungicide which have been used in the management of fungal diseases in strawberries.<br>References Tetada, M., et al.: Toxicol. Appl. Pharmacol., 154, 1 (1999); Hauke, K., et al.: Commun. Agri. Appl. Biol. Sci., 69, 743 (2004);<br></p>

<p>Applications 4-n-Propylphenol-d12 (CAS# 352431-21-1) is a useful isotopically labeled research compound.<br></p>

<p>Stability Light Sensitive<br>Applications Ethyl Palmitoleate-d5 is the isotope analog of Ethyl Palmitoleate. Ethyl Palmitoleate is used in biological studies for calcium relase-activated calcium channel blockade as a potential tool in antipancreatitis therapy.<br>References Gerasimenko, J.V., et al.: Proc. Natl. Acad. Sci. U.S.A., 110, 13186 (2013)<br></p>

<p>Stability Air sensitive<br>Applications Reagent used in the preparation of labelled non-steroidal anti-inflammatory drugs, dyes and pesticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cauchon, D., et al.: J. Appl. Toxicol., 17, 397 (1997),<br></p>

<p>Applications Labelled Lactose Monohydrate (L114000), which is used in the synthesis of casing for various methods of oral drug delivery, including dissolving pellets, and long-lasting pellets.<br>References Kamble, M. et al.: Int. J. Pharm. Chem. Biol. Sci., 3, 55 (2013); Hiorth, M. et al.: Int. J. Pharm., 441, 544 (2013);<br></p>

<p>Applications 2,5-Dichloroaniline-3,4,6-d3 (CAS# 783321-80-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Propionic Acid, used in the synthesis of novel inhibitors of signal transducer and activator of transcription 3 signaling pathway in the potential treatment of human cancers. In addition it is used in the synthesis of morphans.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang, M. et al.: Eur. J. Med. Chem., 62, 301 (2013); Bradshaw, B. et al.: Org. Lett., 15, 2458 (2013);<br></p>

<p>Applications 9-cis-Retinyl Stearate-d5, is the labeled analogue of 9-cis-Retinyl Stearate (R275600), a fatty acid ester of Retinol isomer, found mainly in the retina.<br>References Bridges, C.D.B., et al.: Methods Enzymol., 81, 463 (1982),<br></p>

<p>Leucocrystal violet-d6 is a dye that has been used for decades as a fluorescent marker for chromatographic analysis. It is commonly used as an indicator to determine the purity of acetonitrile in analytical methods. Leucocrystal violet-d6 is prepared by dissolving the dye in acetonitrile and adding it to a test sample. The solvent is then evaporated and the dye will be left behind. Leucocrystal violet-d6 has a strong absorption band at approximately 605 nm, which can be detected using a spectrometer. The major limitation of this method is that it cannot be used to analyze samples containing water or organic solvents such as methanol or ethanol.</p>

<p>Tolterodine-D14 is a postoperative drug that belongs to the class of non-selective muscarinic receptor antagonists. It has been evaluated for pharmacokinetic properties in plasma samples from patients undergoing surgery. Tolterodine-D14 undergoes extensive hepatic metabolism, with only about 50% of the drug being excreted unchanged in urine. The elimination half-life of this drug ranges from 2 to 3 hours. Tolterodine-D14 has been shown to be bioequivalent to the reference drug (tolterodine) and can be used as a control level for chromatographic analyses.</p>

<p>22-Fluorovitamin D3 is a synthetic analog of vitamin D3, which is derived from chemical synthesis involving fluorination at the C-22 position. This modification results in a compound that mimics the structure and activity of naturally occurring vitamin D3 but with altered pharmacokinetics and metabolic stability. The fluorine atom, due to its size and electronegativity, influences the binding affinity and activity of the compound at vitamin D receptors.</p>

Please enquire for more information about 4-Bromofluorobenzene-D4 including the price, delivery time and more detailed product information at the technical inquiry form on this page

<p>6-Fluorovitamin D3 is a synthetic analog of vitamin D3, which is a modified form of the naturally occurring hormone known as cholecalciferol. This molecule is typically derived through chemical synthesis, incorporating a fluorine atom at a specific position on the vitamin D3 structure. The introduction of the fluorine atom is designed to enhance the stability of the compound and potentially alter its biological activity.</p>

<p>Vitamin D2 is a fat-soluble vitamin that is required for the absorption of calcium and phosphate. It can be obtained through dietary supplements or by exposure to sunlight. Vitamin D2 is a prohormone that needs to undergo two hydroxylation reactions in the liver and kidney before it becomes the active form, calcitriol. Vitamin D2 has been shown to have beneficial effects on bone mineralization and phosphatase activity, as well as an inhibitory effect on the production of parathyroid hormone. Hydroxyapatite, a component of bone tissue, has been shown to react with vitamin D2 in vitro, which may be due to its ability to act as an additive or stabilizer.END&gt;&gt;</p>

<p>L-Proline-13C5 is a high quality, reagent grade, complex compound that is useful as an intermediate for the synthesis of fine chemicals. It has CAS No. 201740-83-2 and can be used in a variety of chemical reactions to produce useful scaffolds or building blocks. L-Proline-13C5 is also a versatile building block that can be used in research or pharmaceutical applications. It is a speciality chemical that has many uses including reaction components for the synthesis of other compounds.</p>

<p>Choline O-sulfate is a choline salt that is used as a dietary supplement. It has been shown to be effective in the prevention of neural tube defects in pregnant women. Choline O-sulfate has been shown to increase acetylcholine levels in the brain and may be useful in the treatment of Alzheimer's disease. The biological activity of this compound is due to its ability to act as a substrate for enzymes such as polymerase chain reaction and calcium pantothenate, which are required for cell growth and energy metabolism respectively. The structural formula of this compound was determined using x-ray diffraction data collected from wild-type strains and an atherosclerotic lesion model system.</p>

<p>Amodiaquine-d10 is a quinoline derivative that is used in the treatment of malaria. It has been shown to have a good bioavailability and is not metabolized by the body. Amodiaquine-d10 has a low risk of toxicity, which makes it appropriate for use in patients with an uncomplicated malaria infection. The plasma concentrations are determined through an analysis of the presence of amodiaquine-d10 in plasma samples. The pharmacokinetic study was performed using an ionization interface and a spectrometer. The evaporation technique was used to measure the concentration of amodiaquine-d10 in plasma samples, which were then analyzed using high performance liquid chromatography (HPLC). This technique allows for the measurement of amodiaquine-d10 at low concentrations and can differentiate between drugs that are chemically similar.</p>

<p>5-(Hydroxymethyl)-2’-deoxycytidine is an activator that can be used in the synthesis of nucleosides and phosphoramidites. It is a novel compound that has antiviral, anticancer, and ribonucleoside activities. 5-(Hydroxymethyl)-2’-deoxycytidine is a monophosphate derivative that can be used to synthesize diphosphates, which are important for DNA replication. The drug has been shown to have anticancer properties against breast cancer cells. It also inhibits the growth of leukemia cells by preventing the synthesis of DNA and RNA.</p>

<p>25-Hydroxyvitamin D3 monohydrate is a vitamin D analog that has been shown to reduce elevated levels of parathyroid hormone and improve bone mineral density. It is used for the treatment of chronic kidney disease, hyperparathyroidism, and osteoporosis. 25-Hydroxyvitamin D3 monohydrate has been found to be effective in the treatment of these conditions because it increases the body's production of calcitriol, the active form of vitamin D. Calcitriol promotes calcium absorption in the gut and reduces renal excretion of calcium by inhibiting parathyroid hormone synthesis. This drug also inhibits pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α.</p>

<p>Chlorobenzene-d5 is a synthetic compound that can be used as an analytical reference material. It is reactive and has been shown to have chemical ionization, vibrational, and light emission properties. Chlorobenzene-d5 has been used in the analysis of solutes in the environment, detection of volatile organic compounds (VOCs), and identification of unknown substances. The usefulness of chlorobenzene-d5 as a reference material is due to its stability and high abundance in nature.</p>

<p>DL-Pipecolic acid-d9 is a form of pipecolic acid that is used to prepare samples for analysis. It is analysed in the form of a nonresponsive interaction with bioanalysis, which is then profiled to provide population data. This compound has been validated for neonates and infants. The flow rate for DL-pipecolic acid-d9 is 3 mL/min.</p>

<p>YD2-o-C8 is a low light, metal-coordinating organic molecule that has been shown to enhance the performance of perovskite solar cells. It is a multi-walled carbon nanotube with a metal atom at each end. The interactions between the YD2-o-C8 and the perovskite are believed to be due to an electron transfer process that takes place within the perovskite's molecular orbitals. This interaction leads to increased efficiencies in these devices.</p>