Composés deutérés

<p>Applications 2,6-Dimethyl-d6-nitrobenzene (CAS# 285138-83-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications (2S,2'S)-Ethambutol-d10 (1,1,1',1',2,2'-d6; ethylene-d4) (CAS# 1129526-24-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled Des[(5-Methyl-1,3,4-thiadiazol-2-yl)thio] Cefazolin-3-methanol is an impurity of Cefazolin (C242500). Cefazolin impurity X3.<br>References Kidwai, M., et al.: Chem. Lett., 6, 487 (1999), Kidwai, M., et al.: Bioorg. Med. Chem., 8, 69 (2000),<br></p>

<p>Applications n-Propyl-d7-amine HCl (CAS# 344298-88-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Bromohexane-1,1-d2 (CAS# 78904-38-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications A new substituted pyridazinone with tuberculostatic action.<br>References Wright, L., et al.: J. Antimicrob. Chemother., 12, 317 (1983), Choi, W., et al.: Anal. Biochem., 219, 368 (1994), Zacchino, S., et al.: J. Nat. Prod., 62, 1353 (1999), Urbina, J., et al.: Bioorg. Med. Chem., 8, 691 (2000),<br></p>

<p>Applications Pyrrole-2,3,4,5-d4 (CAS# 17767-94-1) is a useful isotopically labeled research compound.<br></p>

<p>Applications Phenyl Ether-13C12 is an intermediate used in the synthesis of Decabromodiphenyl Ether-13C12 (D212852), which is the labeled analogue of Decabromodiphenyl Ether (D212850), which is a brominated flame retardant that is used in conjunction with antimony trioxide in high impact polystyrene.<br>References Keum, Y.S., et al.: Environ. Sci. Technol., 39, 2280 (2005); Egeback, A.L., et al.: Chemosphere., 86, 264 (2012);<br></p>

<p>Applications Isopropyl Diphenyl Phosphate-d10 is a labelled analogue of Isopropyl Diphenyl Phosphate (I824470) which is a chemical reagent used in the synthesis of H-phosphonate synthesis of oligonucleotides. Also used in the preparation of flame retardants.<br>References Butt, C. et al.: Env. Sci. Tech., 48, 10432 (2014); Powles, N. et al.: Prg. Biomol. Chem., 10, 5940 (2012);<br></p>

<p>Applications 4-Chloroanisole-2,3,5,6-d4 (CAS# 1219804-86-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 1-Phenyl-3-pyrrolidinone-d5 is the isotope labelled analog of 1-Phenyl-3-pyrrolidinone (P336730); a reagent used in the synthesis of a series of non-classical antifolates which were evaluated for their in vitro cytotoxicity. Also used in the preparation of azetidine- and pyrrolidine-containing alkynes as mGluR5 regulators.<br>References Huang, Y., et al.: Bioorg. Med. Chem., 11, 145 (2003); Chen, L., et al.: PCT Int. Appl. WO 2014124560 A1 20140821. Aug 21, 2014<br></p>

<p>Applications Decyltrimethylammonium-d9 Iodide is an intermediate used in the synthesis of n-Decyltrimethylammonium-d9 Chloride (D525512), which is an isotope labelled quaternary ammonium salt used to study ionic interactions of detergents with lipid membranes.<br>References Beck, A., et al.: J. Phy. Chem., 48, 15862 (2010);<br></p>

<p>Applications Used for the preparation of labelled benzene derivatives as non-steroidal androgen receptor modulators.<br>References Xiao, H.-Y., et al.: Bioorg. Med. Chem. Lett., 20, 4491 (2010),<br></p>

<p>Applications Isopropanol (2-13c, 99%) (cas# 21388-65-8) is a useful research chemical.<br></p>

<p>Applications 2,4-Difluorotoluene-3,5,6-d3 (CAS# 1219798-79-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications N-[5-[2-[[2-(5-Amino-1,3,4-thiadiazol-2-yl)ethyl]thio]ethyl]-1,3,4-thiadiazol-2-yl]-benzeneacetamide-d5 is labelled N-[5-[2-[[2-(5-Amino-1,3,4-thiadiazol-2-yl)ethyl]thio]ethyl]-1,3,4-thiadiazol-2-yl]-benzeneacetamide (A630445) which can be used to prepare bis(phenylacetamidothiadiazolyl)ethyl sulfide analogs as glutaminase inhibitors and antitumor agents.<br>References Shukla, K., et al.: J. Med. Chem., 55, 10551 (2012)<br></p>

<p>Applications Benzene-1,2,4-d3 (CAS# 14941-53-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications Ethyl 2-Cyanoacetate-13C 15N, is the labeled analogue of Ethyl Cyanoformate (E907820), which can be used as an intermediate for insecticide, such as Fipronil (F342202).<br>References Cole, L., et al.: Pestic. Biochem. Physiol., 46, 47 (1993), Cole, L., et al.: Life Sci., 56, 757 (1995), Hosie, A., et al.: Br. J. Pharmacol., 115, 909 (1995),<br></p>

<p>Applications Fumaric Acid Monomethyl Ester-13C4, is the labeled analogue of Fumaric Acid Monomethyl Ester (F500390). monomethyl ester is one of the most bioactive anti-psoriatic fumaric acid ester metabolite.<br>References de Jong, R. et al.: Eur. J. Immunol., 26, 2067 (1996); Litjens, N.H.R. et al.: Br. J. Dermatol., 154, 211 (2006); Schimrigk, S., et al.: Eur. J. Neurol., 13, 604 (2006); Tang, H. et al.: Biochem. Biophys. Res. Comm., 375, 562 (2008);<br></p>

<p>Applications L-Homocystine-3,3,3’,3’,4,4,4’,4’-d8 is the labeled form of L-Homocysteine (H591360), an increased levels lead to hyperhomocysteinemia; a cardiovascular risk factor in prediction of coronary heart disease as well as being associated with congenital birth defects, pregnancy complications and cancer.<br>References Geisel, J. et al.: Clin. Chem. Lab. Med., 41, 1513 (2003); Geisel, J. et al.: Clin. Chem. Lab. Med., 41, 1513 (2003);<br></p>

<p>Applications Methyl trans-Cinnamate-d7 (CAS# 2022152-96-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Bromocyclohexane-d11 is used in the synthetic preparation and regioselective bromination of sp3 C-H bonds by organophotoredox catalysis.<br>References Kee, C.W., et al.: Asian. J. Org. Chem., 3, 536 (2014);<br></p>

<p>Applications n-Tetradecyl-d29 Alcohol (CAS# 284474-78-8) is a useful isotopically labeled research compound.<br></p>

<p>Applications [4-(4-Aminophenoxy)(2-pyridyl)]-N-(methyl-d3)carboxamide (cas# 1189975-18-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Potassium Octadecanoate-d35 (CAS# 352438-89-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications p-Toluidine-d3 (methyl-d3) (CAS# 23346-25-0) is a useful isotopically labeled research compound.<br></p>

<p>Applications 2,4'-Dibromoacetophenone-2-13C (CAS# 335081-05-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Dipotassium Cyclobutane-1,1-dicarboxylate-D2 is an intermediate in the synthesis of Carboplatin-d4 (C177502), which is an analog of Cisplatin with reduced nephrotoxicity. Antineoplastic.<br>References Harland, S.J., et al.: Cancer Res., 44, 1693 (1984), Smith, I.E., et al.: Cancer Treat. Rep., 69, 43 (1985), Lygidakis, N.J., et al.: Interferon Cytokine Res., 15, 467 (1995),<br></p>

<p>Applications 4-Nitrobiphenyl-d9 (CAS# 350818-59-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications D,L-Azetidine-2-carboxylic Acid-d5 is a useful synthetic intermediate.<br></p>

<p>Applications 1-(4-Nitrophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.<br>References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);<br></p>

<p>Applications 6-Dodecanoate-1,4-anhydro-D-glucitol-d23 is the isotopic form of 6-Dodecanoate-1,4-anhydro-D-glucitol (D494710). 6-Dodecanoate-1,4-anhydro-D-glucitol is used in the synthetic preparation of nonionic surfactant.<br>References Giacometti, J. et al.: J. Agr. Food Chem., 44, 3950 (1996)<br></p>

<p>Applications 2-(4-Nitrophenyl-d4)propane (CAS# 1219803-36-7) is a useful isotopically labeled research compound.<br></p>