Composés deutérés

Applications Naphthalene-2,3,4,5,6,7,8-d7 (CAS# 887-68-3) is a useful isotopically labeled research compound.

Applications 1-Isopropyl-d7-piperazine (CAS# 2089679-76-3) is a useful isotopically labeled research compound.

Applications Methyl Octanoate-d15 (CAS# 1219798-91-0) is a useful isotopically labeled research compound.

Applications 1-Piperidine-d10-carbonyl Chloride (CAS# 1219803-31-2) is a useful isotopically labeled research compound.

Applications An anticonvulsant, hypnotic. A labelled metabolite of Mephentoin.A representative lot was 85% d5; 15% d4 1% d3 with no detectable d0.
References Karlaganis, G., et al.: Drug Metab. Dispos., 8, 173 (1980), Knabe, J., et al.: Arch. Phar., 313, 538 (1980),

Applications Di(α-tocopherol) Phosphate-d12 is labelled Di(α-tocopherol) Phosphate (T526190) which is used as a vitamin E supplement.
References Libinaki, R., et al.: Food Chem. Toxicol., 44, 916 (2006)

Applications Labelled Dihydroisoferulic Acid 3-O-Sulfate, the sulfate conjugate of Dihydroisoferulic Acid (H946365). Dihydroisoferulic Acid 3-O-Sulfate is a minor circulating metabolite in human plasma after coffee consumption.
References Fumeaux, R. et al.: Org. Biomol. Chem., 8, 5199 (2010); Redeuil, K. et al.: J. Chrom. A, 1218, 4678 (2011);

Applications 4-Cyano-4'-n-pentyl-d11-biphenyl (CAS# 57078-20-3) is a useful isotopically labeled research compound.

Applications 1-(2,6-Dichlorophenyl)piperazine-d8 Hydrochloride is the isotope analog of 1-(2,6-Dichlorophenyl)piperazine Hydrochloride. 1-(2,6-Dichlorophenyl)piperazine Hydrochloride is used in the preparation of pyrazolopyrimidones and pyrazolopyridones as tankyrase inhibitors which are useful in the treatment of cancer.
References Feng, J., et al.: PCT Int. Appl., 2013:1906020 (2013)

Applications 2-Chloropropane-2-d1 (CAS# 53778-42-0) is a useful isotopically labeled research compound.

Applications N-1-Butyl-d9-1-demethylethyl Torsemide is labelled N-1-Butyl-1-demethylethyl Torsemide (B692375) which is an impurity of Torsemide (T548750), diuretic.
References Lesne, M., et al.: In. J. Clin. Pharmacol. Ther. Toxicol., 20, 382 (1982), Brater, D.C., et al.: Clin. Pharmacol. Ther., 42, 187 (1987),

Applications 2-Bromoaniline-d4 is the labeled analogue of 2-Bromoaniline (B679950), a reagent used in the synthesis of substituted 2-carboxanilides as herbicides and antibacterials. Also used in the synthesis of benzisothiazol-3-one derivatives as caspase-3 inhibitors.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kos, J. et al.: Molecules, 18, 7977 (2013); Liu, D. et al.: Bioorg. Med. Chem., 21, 2960 (2013)

Applications 1-Bromopropane-1,1-d2 (CAS# 40422-05-7) is a useful isotopically labeled research compound.

Applications (±)-(1-Bromoethyl-2,2,2-d3)benzene (CAS# 23088-42-8) is a useful isotopically labeled research compound.

Applications tert-Butyl-d9-phosphine is the labeled analogue of tert-Butylphosphine (B809330), a reactant in the synthesis of phosphine ligands in metal complexes.
References Wiedner, E.S., et. al.: Organometallics, 29, 5390 (2010)

Applications N-Ethylaniline-d5 is labelled N-Ethylaniline (E899362) which is a versatile organic building block used for the synthesis of various pharmaceutical and biologically active compounds. It can be used for the synthesis of benzenesulfonamides as inhibitors of microsomal prostaglandin E2 synthase 1 (mPGES-1) in mice and in humans as potential anti-inflammatory agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hanke, Th., et al.: Biorg. Med. Chem., 21 (24), 7874 (2013)

Applications Hexanedioyl-d8 Chloride (CAS# 284487-62-3) is a useful isotopically labeled research compound.

Applications Bis(2-isopropylphenyl) Phenyl Phosphate-d5 is the deuterated form of Bis(2-isopropylphenyl) Phenyl Phosphate (B451445), which is a triaryl phosphate used as plasticizers in polyvinyl chloride (PVC) as well as a flame retardant. Studies show that Bis(2-isopropylphenyl) Phenyl Phosphate inhibits the human androgen receptor.
References Duke, A.J.: Chimia, 32, 457 (1978); Honkakoski, P. et al.: Biochem. Pharmacol., 67, 97 (2004); Nobile, E.R. et al.: Bull. Environ. Contam. Toxicol., 25, 755 (1980);

Stability Hygroscopic
Applications 6-N-Acetyl-L-lysine-d8 is an isotopic analog of N-Acetyl-L-lysine (E588725(P)), which is used in the metabolomics study on the combined effect of cocaine and ethanol via liquid chromatography-mass spectrometry metabolomics approach.
References Sanchez-Lopez, E., et al.: J. Pharm. Biomed. Anal., 140, 313 (2017)

Applications Furfuryl-d5 Alcohol (CAS# 1398065-62-7) is a useful isotopically labeled research compound.

Stability Extremely Volatile
Applications 1-Hexene-d3, an isotopically labelled 1-Hexene, is used in the synthesis of ethylene polymers and copolymers. An olefin used to synthesize diols through oxidation reactions.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tao, X. et al.: Organometal., 32, 4185 (2013); Clerici, M. et al.: J. Catal., 140, 71 (1993);

Applications Glyceryl Tri(octadecanoate-d35) (CAS# 125941-88-0) is a useful isotopically labeled research compound.

Applications Isotope labelled Methylboronic Acid is an methylated derivative of boronic acid, an building block towards various intermediates in suzuki coupling.
References Baker, J. O., et al.: Biochem.. 22, 2098 (1983); Garner, C.W., et al.: J. Biol. Chem., 255, 5064 (1980);

Applications Pentanedioic-d6 Anhydride (CAS# 1219794-53-2) is a useful isotopically labeled research compound.

Applications Labelled D-Glucose is a simple sugar that is present in plants. A monosaccharide that may exist in open chain or cyclic conformation if in solution. It plays a vital role in photosynthesis and fuels the energy required for cellular respiration. D-Glucose is used in various metabolic processes including enzymic synthesis of cyclohexyl-α and β-D-glucosides. Can also be used as a diagnostic tool in detection of type 2 diabetes mellitus and potentially Huntington's disease through analysis of blood-glucose in type 1 diabetes mellitus.
References Wang, R., et al.: J. Mol. Catal. B. Enz., 56, 131 (2009); Springhorn, C. et al.: J. Clin. Endocrinol. Metab., 97, 4640 (2012); Hashimoto, K. et al.: J. Clin. Endocrinol. Metab., 97, 3016 (2012); Avelange, M. et al.: Plant. Phys., 94, 1157 (1990); Cramer, C. et al.: J. Chem. Soc., 115, 5745 (1993);

Applications Ethyl-alpha,alpha-d2-benzene (CAS# 1861-01-4) is a useful isotopically labeled research compound.

Applications N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N,4-dimethyl-1-naphthalenemethanamine-d3 is an isotope labelled impurity of Terbinafine (T107500), an orally active, antimycotic allylamine and a specific inhibitor of squalene epoxidase.
References Petranyi, G., et al.: Science, 224, 1239 (1984); Ryder, N.S., et al.: Antimicrob. Agents Chemother., 27, 252 (1985); Evans, E.G.V., et al.: Br. Med. J., 318, 1031 (1999);

Applications 3-Benzoylpropanoic Acid-13C6 (cas# 1346600-75-6) is a compound useful in organic synthesis.

Applications Isotope Labelled Bitolterol is a is a β2-adrenergic receptor agonist used for the relief of bronchospasm in conditions such as asthma and COPD.
References Friedel, H., et al.: Drugs., 35, 22 (1988); Cronin, M.T.D., et al.: J. Chem. Info. Comp. Sci., 42, 869 (2002); Shargel, L., et al.: Drug. Meta. Disp., 4, 72 (1976);

Applications 4-Aminophenol-13C6 is carbon-13 labeled 4-Aminophenol (A618920), a nephrotoxic metabolite of Acetaminophen (A161220) and Phenacetin (P294580) (1). 4-Aminophenol is also used as a N-formylating agent for solvent-and catalyst-free N-formylations of amines at ambient condition (2).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References (1) Watanabe, et al.: Drug Metab. Dispos., 38, 1532 (2010)(2) Batuta, S. and Begum, N. A. Synth. Commun. 47, 137-147 (2017)