Composés deutérés

Applications Fumaric Acid Monomethyl Ester-13C4, is the labeled analogue of Fumaric Acid Monomethyl Ester (F500390). monomethyl ester is one of the most bioactive anti-psoriatic fumaric acid ester metabolite.
References de Jong, R. et al.: Eur. J. Immunol., 26, 2067 (1996); Litjens, N.H.R. et al.: Br. J. Dermatol., 154, 211 (2006); Schimrigk, S., et al.: Eur. J. Neurol., 13, 604 (2006); Tang, H. et al.: Biochem. Biophys. Res. Comm., 375, 562 (2008);

Applications Methyl trans-Cinnamate-d7 (CAS# 2022152-96-9) is a useful isotopically labeled research compound.

Applications N,N-Dibutyl-4,6-dichloro-1,3,5-triazin-2-amine-d4 is an intermediate used in the synthesis of 6-(Dibutylamino)-1,3,5-triazine-2,4-dithiol-d4 (D462764), which is a labelled form of 6-(Dibutylamino)-1,3,5-triazine-2,4-dithiol (D462763), which is a compound capable of electrochemical polymerization on magnesium alloy plates.
References Mori, K.; et al.: Materials Science Forum, 350, 223 (2000).

Applications Dipotassium Cyclobutane-1,1-dicarboxylate-D2 is an intermediate in the synthesis of Carboplatin-d4 (C177502), which is an analog of Cisplatin with reduced nephrotoxicity. Antineoplastic.
References Harland, S.J., et al.: Cancer Res., 44, 1693 (1984), Smith, I.E., et al.: Cancer Treat. Rep., 69, 43 (1985), Lygidakis, N.J., et al.: Interferon Cytokine Res., 15, 467 (1995),

Applications 4-Nitrobiphenyl-d9 (CAS# 350818-59-6) is a useful isotopically labeled research compound.

Applications D,L-Azetidine-2-carboxylic Acid-d5 is a useful synthetic intermediate.

Applications 1-(4-Nitrophenyl)cyclopentanecarbonitrile-d8 is an intermediate used in the synthesis of Apatinib-d8 Hydrochloride (A726152), which is labelled Apatinib (A726150). Apatinib is an orally available, small molecule multitargeted tyrosine kinase inhibitor. Apatinib selectively inhibits the vascular endothelial growth factor receptor-2 (VEGFR2). Apatinib functions by inhibiting VEGF-mediated endothelial cell migration and proliferation thus blocking new blood vessel formation in tumor tissue. Recent studies have shown that Apatinib enhances the efficacy of conventional chemotherapeutical drugs in side population (SP) cells and ABCB1-overexpressing leukemia cells.
References Mi, Y. et al.: Cancer Res., 70, 7981 (2010); Tong, X.Z. et al.: Biochem. Pharmacol., 83, 586 (2012); Ding, J, et al.: J. Chrom B Anal. Technol. Biomed. Life Sci., 895, 108 (2012);

Applications Labelled analogue trans-1,2-Dihydroxy-1,2-dihydronaphthalene, a metabolite of Naphthalene.
References Sun, Y. et al.: Arch. Toxicol., 80, 280 (2006); Cho, T. et al.: Drug Metab. Drug Interact., 22, 235 (2007); Iwamoto, N. et al.: J. Biol. Chem., 282, 33396 (2007);

Applications 1-Bromoeicosane-20,20,20-d3 (CAS# 202480-72-6) is a useful isotopically labeled research compound.

Applications 2-Acetyl-3,4,5,6-tetrahydropyridine-d4 Hydrochloride, is the labeled analogue of 2-Acetyl-3,4,5,6-tetrahydropyridine Hydrochloride (A188500), the most important bread flavor component.
References Buttery, R.G., et al.: J. Agric. Food Chem., 43, 1878 (1995),

Applications Isotope labelled Indene is an organic building block that has been used in the synthesis of isatins as selective inhibitors of carboxylesterases.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hyatt, J.L., et. al.: J. Med. Chem., 50, 1876 (2007)

Applications Labelled Malic Acid. The naturally occuring isomer is the L-form which has been found in apples and many other fruits and plants. Selective α-amino protecting reagent for amino acid derivatives. Versatile synthon for the preparation of chiral compounds including κ-opioid receptor agonists, 1α,25-dihydroxyvitamin D3 analogue, and phoslactomycin B.
References Rindi, G., et al.: Biochem. J., 80, 214 (1961), Wolfgang, M., et al.: J. Biol. Chem., 281, 37265 (2006), Navarro, D., et al.: Metab. Brain Dis., 23, 115 (2008),