Composés deutérés

Applications Octylamine-d17 is the isotope labelled analog of Octylamine. Octylamine is used as a reactant in the synthesis of 2H-indazoles and 1H-indazolones which are used as myeloperoxidase(MPO) inhibitor.
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References Roth, A., et al.: Bioorg. Med. Chem., 22, 6422 (2014);

Applications 2-Fluorobenzonitrile-d4 (CAS# 2256740-46-0) is a useful isotopically labeled research compound.

Applications trans,trans-2,4-Nonadienal-D2 is a labelled analogue of trans,trans-2,4-Nonadienal (N649315). trans,trans-2,4-Nonadienal is an unsaturated aldehyde that is responsible for the bean odour of soymilk. trans,trans-2,4-Nonadienal has also been identified as a potentially mutagenic substance by inducing oxidative DNA damage.
References Sjaastad, A. & Svendsen, K.: Ann. Occ. Hyg., 52, 739 (2008); Vara-Ubol, S., et al.: J. Sens. Stud., 19, 15 (2004); Yang, C., et al.: Chin. J. Physiol., 52, 151 (2009)

Stability Hygroscopic, Light Sensitive, Temperature Sensitive
Applications 3-Deoxyglucosone-13C6, is the labeled anologue of 3-Deoxyglucosone (D239150), an intermediate in the Maillard reaction of proteins with glucose, which is metabolised to 3-Deoxyfructose. An intermediate in the formation of pyrraline, which might contribute to a pathological effect, such as carcinogenesis.
References Kato, H. et al.: Agric. Biol. Chem., 51, 683 (1987), Hayase, F. et al.: J. Biol. Chem., 264, 3758 (1989), Kato, H. et al.: Biochimica et Biophysica Acta, 1035, 71 (1990)

Applications Tri-p-tolylamine-15N (CAS# 311761-87-2) is a useful isotopically labeled research compound. This compound has been used in structural studies relating to photoconductivity of various polymers.
References Kesling, B., et.al., J Labelled Compd Rad., 43,1059-1068,(2000);

Applications Potassium Tetradecanoate-2,2-d2 (CAS# 352438-85-8) is a useful isotopically labeled research compound.

Applications Isotope labelled 2,2,4-Trimethyl-1,3-pentanediol used in the synthesis of monoisobutyrate derivatives used in film forming auxilleries in paint substances.
References Li, Y. et al.: Chem. Papers, 68, 422 (2014);

Applications 5-Ethyl-3-[[(2R)-1-methyl-2-pyrrolidinyl]methyl]-1H-indole-d5 is an isotope labelled impurity of Eletriptan (E505000), a serotonin 5-HTIB/ID receptor agonist and an antimigraine agent.
References Madasu, S. B., et al.: Beilstein. J. Org. Chem., 8, 1400 (2012); Willems, E., et al.: Arch. Pharmacol., 358, 212 (1998), Napier, C., et al.: Eur. J. Pharmacol., 368, 259 (1999), Goadsby, P.J., et al.: Neurology, 54, 156 (2000)

Applications Bis(1,3-dithian-2-yl)methane-d2 (cas# 105479-87-6) is a compound useful in organic synthesis.

Applications 2,2,3,5-Tetramethylhexanoic Acid-d3 is the isotope analog of 2,2,3,5-Tetramethylhexanoic Acid. 2,2,3,5-Tetramethylhexanoic Acid is used in analytical studies as a method to quantitatively determine the total organic acid content in aqueous coolant.
References Lynn, T.B., et al.: PCT Int. Appl., 2012:1561111 (2012)

Applications N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide -d4 is labelled N-Cyclopropyl-5-(thiophen-2-yl)isoxazole-3-carboxamide (C988880) which was shown to exhibit regulatory effects towards the expression of pH sensing G protein-coupled receptor-68 and is now a new drug target for ischemic heart disease.
References Russell, J.L., et al.: ACS. Chem. Biol., 7, 1077 (2012); Schneider, J.W., et al.: ACS. Chem. Neurosci., 3, 557 (2012);

Applications Pyrrolidine-2,2,5,5-d4 (CAS# 42403-25-8) is a useful isotopically labeled research compound.

Applications DL-Phenyl-d5-alanine (CAS# 284664-89-7) is a useful isotopically labeled research compound.