Composés deutérés

<p>Applications An intermediate in the synthesis of the Daspone metabolite.<br></p>

<p>Applications Farnesyl Pyrophosphate Triammonium Salt-13C3 is labelled Farnesyl Pyrophosphate Triammonium Salt (F102470) which is an isoprenoid from the intracellular mevalonate pathway used for prenylation of several low molecular mass G proteins, including Ras.<br>References Correll, C., et al.: J. Biol. Chem., 269, 17390 (1994), Moura, I., et al.: Antimicrob. Agents Chemother., 45, 2553 (2001), Gana-Weisz, M., et al.: Clin. Cancer Res., 8, 555 (2002),<br></p>

<p>Applications 2-Amino-5-chlorobenzophenone Oxime-d5 is an intermediate in synthesizing N-Demethyl Chlordiazepoxide-d5 (D230827), a deuterium labelled analogue of N-Demethyl Chlordiazepoxide (D230825), which is the main metabolite of anxiolytic drug Chlordiazepoxide (C327050).<br>References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 15 (1972); Greenblatt, D.J., et al.: Clin. Pharmacokinet., 3, 381 (1978); Barbone, F., et al.: Lancet, 352, 1331 (1998); Miki, A., et al.: J. Anal. Toxicol., 26, 87 (2002)<br></p>

<p>Applications 2-Chloro-ethanamine-d4 Hydrochloride (cas# 172333-26-5) is a compound useful in organic synthesis.<br></p>

<p>Applications Ammonium-15N hydroxide Solution is a solution prepared from ammonium-15N sulfate for studying fertilizer use efficiency and is an important fertilizer for soil fertilization of the sugarcane crop in Brazil.Ammonium-15N hydroxide Solution is also used in the preparation of isotope-labeled oligonucleotides for their use in NMR studies of protein-DNA complexes.Ammonium-15N hydroxide Solution is the 15N-labeled compound for A634020, which is used in numerous household cleaning agents.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bendassolli, Jose Albertino., Scientia Agricola (Piracicaba, Brazil), 59, 595-603, (2002)Kellenbach, E. R., Nucleic Acids Research, 20, 653-7, (1992)Lokshin, E.P., et al.: Russ. J. App. Chem., 86, 450 (2013)<br></p>

<p>Applications Labelled Anabaseine intermediate.<br></p>

<p>Applications An intermediate in the preparation of deuterated cytidine derivatives<br>References Chamorro, C., et al.: Bioorg. Med. Chem. Lett., 11, 3085 (2001), Bornemann, B., et al.: Bioorg. Med. Chem., 14, 6235 (2006), Desbouis, D., et al.: J. Med. Chem., 51, 6689 (2008),<br></p>

<p>Applications A deuterated intermediate in the synthesis of the metabolite of Terbinafine, an orally active, antimycotic allylamine related to naftifine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications [(3-Ethyl-1-cyclohexen-1-yl)oxy]trimethylsilane-d5 is an intermediate in the synthesis of metabolites of Bis(2-ethylhexyl) Phthalate (DEHP) (B433850).<br>References Denmark, S. E., et la.: J. Am. Chem. Soc., 112, 3466 (1990);<br></p>

<p>Applications 4-Chloro Resorcinol-13C6 (cas# 953390-32-4) is a compound useful in organic synthesis.<br></p>

<p>Applications 2-(2-Formamidothiazol-4-yl)acetic Acid-13C,15N2 is an intermediate used in the synthesis of Cefotiam Dihydrochloride-13C, 15N2 (C243007), which is labelled Cefotiam Dihydrochloride (C243005), which is an antibiotic product used in injections to treat bacterial infections. Cefotiam Dihydrochloride can also reduce allergic reactions and mixed with pharmaceutical carriers for medical formulations.<br>References Jiang, C., et al.: Faming Zhuanli Shenqing, CN 105646539 A, 20160608 (2016); Liu, X.: Faming Zhuanli Shenqing, CN 105193819 A, 20151230, (2015); Weng, Y., et al.: Faming Zhuanli Shenqing, CN 103601737 A. 20140226 (2014)<br></p>

<p>Applications Chemical building block used in the synthesis of more complex structures.<br></p>

<p>Applications 5-[2-[(3-Chloro-2-hydroxypropyl)thio]-4-thiazolyl]-2-thiophenecarboxamide-d5 is an intermediate in synthesizing Arotinolol-D5 Hydrochloride (A771502), which is a labelled analogue of Arotinolol (A771500). Arotinolol is both and alpha- and beta-adrenoceptor antagonist and is used to treat essential tremors and hypertension.<br>References Kuroda, Y., et al.: Neurology, 38, 650 (1988); Miyagishi, A., et al.: Arch. Pharmacodyn. Ther., 271, 249 (1984); Wu, H., et al.: Hypertens. Res.: Off. J. Jpn. Soc. Hypertens., 24, 605 (2001);<br></p>

<p>Applications Reagent used in labelled pyrimidine and purine synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Das, S., et al.: J. Med. Chem., 52, 5937 (2009), Kim, K., et al.: Bioorg. Med. Chem. Lett., 19, 5225 (2009),<br></p>

<p>Applications Anticonvulsant against audiogenic convulsion.<br>References Goeres, E., et al.: Acta Biol. Med. Ger., 23, 679 (1969)<br></p>

<p>Stability Volatile<br>Applications 1-Bromobutane-d3 is used in the synthesis of specifically-deuterated procaine and tetracaine.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Boulanger, Y., et al.: J. Labelled Comp. Radiopharm., 18, 1197 (1981),<br></p>

<p>Applications 4-Nitrobenzonitrile-d4 (CAS# 1219798-46-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications Intermediate in the production of labelled Folic Acid<br>References Jones, P., et al.: J. Med. Chem., 41, 3062 (1998), Uto, Y., et al.: Bioorg. Med. Chem., 16, 6042 (2008),<br></p>

<p>Applications 4-[4-(Diphenylmethoxy-d5)-1-piperidinyl]-1-[4-[(2-hydroxy-1,1-dimethyl)ethyl]phenyl]butyne (cas# 1189696-09-0) is a compound useful in organic synthesis.<br></p>

<p>Applications α,α-Diphenyl-1-azabicyclo[2.2.2]octane-4-methanol-d10 is an intermediate in the synthesis of Umeclidinium Bromide-d5, which is considered as a potentially long-acting antimuscarinic agent.<br>References Cazzola, M., et al.: Pharmacol., Rev., 64, 450 (2012); Laine, D., et al.: J. Med. Chem., 52, 2493 (2009)<br></p>