Composés deutérés

Applications 2,3-Dimethylphenol-13C8 is an isotope labelled analog of 2,3-Dimethylphenol. 2,3-Dimethylphenol is a useful synthetic intermediate. It was used in the synthesis of hydroxychalcones and flavones with antiinflammatory activities. It was also used to prepare 3,3-bisaryloxindole analogs as mineralocorticoid receptor antagonists.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ballesteros, J., et al.: J. Med. Chem., 38, 2794 (1995); Neel, D., et al.: Bioorg. Med. Chem. Lett., 15, 2553 (2005)

Applications D-Phenyl-d5-alanine-N-t-BOC (CAS# 1213661-19-8) is a useful isotopically labeled research compound.

Applications N,N-Dimethylaniline-d3 (N-methyl-d3) (CAS# 88889-00-3) is a useful isotopically labeled research compound.

Applications Carboxymethoxyamine-d2 Hemihydrochloride (cas# 1246817-66-2) is a compound useful in organic synthesis.

Applications O-Demethoxypropane Aliskiren-d6 is the labeled analog of O-Demethoxypropane Aliskiren is an impurity of Aliskiren Hemifumarate (A536001), an orally active, synthetic nonpeptide renin inhibitor. Antihypertensive.
References Kumar, N.U., et. al.: Chem. Biol. Interface, 3, 304 (2013); Lefevre, G., et al.: J. Immunoassay, 21, 65 (2000); Allikments, K., et al.: Curr. Opin. Invest. Drugs, 3, 1479 (2002); Wood, J.M., et al.: Biochem. Biophys. Res. Commun., 308, 698 (2003); Grandman, A.H., et al.: Circulation, 111, 1012 (2005)

Applications O-Desaryl Ranolazine-d5 is the isotope labelled analog of O-Desaryl Ranolazine (D422050); a metabolite of Ranolazine (R122500).
References Chaitman, B.R., et al.: J. Am. Coll. Cardial., 43, 1375 (2004); McCormack, J.G., et al.: Gen. Pharmacol., 30, 639 (1998); Schofield, J.A.H., et al.: Expert Opin. Invest. Drugs, 11, 117 (2002)

Applications Ledipasvir-d6 is labelled Ledipasvir (L320100) which is most commonly used in combination with sofosbuvir for treatment in chronic hepatitis C genotype 1 patients. It inhibits an important viral phosphoprotein, NS5A, which is involved in viral replication, assembly, and secretion.
References Lawitz, E., et al.: J. Hepatol., 57, 24 (2012); Afdhal, N., et al.: New England J. Med., 370, 1889 (2014)

Applications n-Hexyl-d13 Alcohol (CAS# 204244-84-8) is a useful isotopically labeled research compound.

Applications 1-Bromopropane-3,3,3-d3 is labelled 1-Bromopropane (B687135) which is used as a solvent and for the cleaning of metal surfaces, removal of soldering residues from electronic circuit boards. It is anticipated to be human carcinogen.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lingyo Zh., et al.: Toxicology, 304, 76 (2013); Samukawa, M. et al.: Archives Internal Med., 172(16), 1257 (2012);

Applications (Ethoxycarbonylmethyl)triphenylphosphonium-13C2 bromide is an intermediate in the synthesis of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone-13C5, which is an isotope labelled Mutagen X (MX) is a chlorinated furanone that accounts for more of the mutagenic activity of drinking water than any other disinfection byproduct. DNA damages provoked by the six mutagens (furylframide, MX, 4-nitroquinoline N-oxide, sodium azide, 1-nitropyrene, and captan) used in the present study have been known to subject to the nucleotide excision repair system.
References Hakulinen, P., et al.: Toxicol. Lett., 151, 439 (2004), Richardson, S., et al.: Mutat. Res., 636, 178 (2007), Kim, J., et al.: Environ. Toxicol., 23, 319 (2008),

Applications 2-Chloropyrimidine-d3 was used in the study of IR vibrational spectroscopy of [Ru(bpy)2(bpm)]2+ and [Ru(bpy)3]2+ in the excited triplet state.
References Mukuta, T., et al.: Inorg. Chem., 53, 2481 (2014)

Applications Tetrahydrothiophene-2,2,5,5-d4 (CAS# 31081-24-0) is a useful isotopically labeled research compound.