Toxicologie

<p>Applications Carcinogenic compound commonly found in hair dyes and henna ink, also a commonly used synthetic intermediate<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mulyono; T., et al.: J. Biosci. Bioeng., 103, 147 (2007), Mosley-Foreman, C., et al.: Food Chem. Toxicol., 46, 3780 (2008), Patel, A.K., et al.: J. Agric. Food Chem., 56, 9236 (2008), Akyuz, M., et al.: J. Pharm. Biomed. Anal., 47, 68 (2008),<br></p>

<p>Applications A substituted benzamide derivative structurally related to STI-571 (Imatinib Mesylate). It was identified as highly potent Bcr-Abl kinase inhibitor. It is a COVID19-related research product.<br>References Li, Q., et al.: J. Med. Chem., 39, 3070 (1996), Ptasznik, A., et al.: Nat. Med., 10, 1187 (2004), Tetsuo, A., et al.: Bioorg. Med. Chem. Lett., 16, 1421 (2006),<br></p>

<p>Stability Moisture Sensitive<br>Applications Fenquizone is a thiazide-like diuretic commonly used for antihypertensive therapy.<br>References Costa, F., et al.: J. Clin. Pharmacol., 30, 254 (1990); Maggi, G., et al.: Arzneimittel-Forsch., 35, 994 (1984);<br></p>

<p>Stability Hygroscopic<br>Applications Labelled rac-trans-N-Methyl Sertraline (M326470). rac-trans-N-Methyl Sertraline is a related compound of rac-trans Sertraline (S279980).<br>References Welch, W.M., et al.: J. Med. Chem., 27, 1508 (1984),<br></p>

<p>Applications Oxazepam-d5 Acetate is the deuterated Oxazepam Acetate (O845710), a benzodiazepine derivative with anticonvulsant and muscle relaxant properties. An ester of Oxazepam (O845700).Controlled Substance.<br>References Klopman, G. et al.: Molec. Pharmacol., 27, 86 (1985); Maksay, G. et al.: J. med. Chem., 24, 499 (1981)<br></p>

<p>Applications Paclitaxel Succinate-d4 is the labeled analogue of Paclitaxel Succinate (P132530), which ahs been used as a reactant for the preparation of molecular hydrogelators to be used as local delivery systems for chemotherapy.<br>References Wang, H., et. al.: J. Mater. Chem., 22, 16933 (2012)<br></p>

<p>Applications A toxic metabolite of Fenamiphos, a pesticide in fruits and vegetables.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schenck, F., et al.: Bull. Environ. Contam. Toxicol., 73, 24 (2004), Okihashi, M., et al.: J. Pestic. Sci., 30, 368 (2005), Lopez, M., et al.: J. Agric. Food Chem., 56, 1553 (2008),<br></p>

<p>Applications trans-3'-Hydroxy Cotinine-d3 Acetate is an intermediate in the synthesis of trans-3'-Hydroxy Cotinine-d3 (Racemic Mixtures) (H924510), which is useful in organic synthesis.<br>References Desai, D., et al.: Chem. Res. Toxicol., 3, 47 (1990)<br></p>

<p>Applications Labelled metabolite of Flurbiprofen (F598700).<br>References Van Breemen, R., et al.: Drug Metab. Disposition, 14, 197 (1986), Spraul, M., et al.: J. Pharm. Biomed. Anal., 11, 1009 (1993),<br></p>

<p>Applications 3-Benzyloxybutyrylcarnitine O-Benzyl Chloride is an intermediate used in the synthesis of 3-Hydroxybutyrylcarnitine Chloride (H830900), which is a reagent used to study acylcarnitine profile in thyroid disease.<br>References Wong, S., et al.: Clinical Biochem., 46, 180 (2013); Alu, F., et al.: Heredity, 110, 253 (2013); Adam, B., et al.: Clinical Biochem., 44, 1445 (2011)<br></p>

<p>Applications Endosulfandiol is a metabolite of Endosulfan (E555505), an insecticide that poses health risks to humans and animals that acquire it through ingestion, inhalation, and percutaneous contact. Despite its potential risks, it is still being widely used all around the globe to protect cotton, sugarcane, and vegetable crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cerrillo, I., et al.: Environ. Res., 98, 233 (2005); Bhalerao, T. &amp; Puranik, P.: Int. Biodeter. Biodegr., 59, 315 (2007); Kalender, S., et al.: Toxicology, 202, 227 (2004); Naqvi, S. &amp; Vaishnavi, C.: Comp. Biochem. Phys. C, 105, 347 (1993)<br></p>

<p>Applications Forchlorfenuron-d5 is the labeled analogue of Forchlorfenuron (F691050), a diphenylurea-derivative cytokinin. Forchlorfenuronis is used as a plant growth regulator (PGR). Forchlorfenuronis is commonly used in horticulture to stimulate the growth of kiwi fruit and grapes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Iwahori, S. et al.: Sci. Horticult., 35, 109 (1988); Peppi, M.C. et al.: Horscience, 43, 173 (2008); Woolley, D. et al.: Acta Horticult., 727, 291 (2005)<br></p>

<p>Stability Hygroscopic<br>Applications Mefenamic acid metabolite.<br>References Besunder, J., et al.: Clin. Pharmacokinet., 14, 261 (1988), Smith, P., et al.: Drug Metab. Dipos., 18, 639 (1990), Kraus, D., et al.: Clin. Pharmacol. Ther., 54, 351 (1993), Sato, J., et al.: Biol. Pharm. Bull., 16, 811 (1993),<br></p>

<p>Applications Ursodeoxycholic Acid-24-13C is the labeled compound of Ursodeoxycholic Acid (U850000). It is used as an anticholelithogenic. Epimer with Chenodiol with respect to the hydroxyl group at C7.<br></p>

<p>Applications Clothianidin-d3 (N-methyl-d3) (CAS# 1262776-24-8) is a useful isotopically labeled research compound. This compound can be used to detect trace levels of neonicotinoid insecticides in honey bee royal jelly using ultra-sound assisted liquid-liquid extraction-UHPLC/MS.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Giroud, B., et.al., Microchemical J., 151,104249,(2019);<br></p>

<p>Applications L-Carnitine-15N is an isotopically labelled analog of L-Carnitine (C184110), which is an essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001);Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002);Karlic, H., et al.: Nutr. J., 20, 709 (2004)<br></p>

<p>Applications 1S-cis-Bifenthrin is a pyrethroid which was evaluated in vitro and the interactions with estrogen receptor were predicted to determine disruption of the hormonal network and the enantioselectivity of bifenthrin in trophoblast. 1S-cis-Bifenthrin was observed to have greater effects of consistent enantioselective interference o hormone signaling. Thus, 1S-cis-Bifenthrin are of significant concern to maternal-fetal health.Third generation synthetic pyrethroid. Insecticide, acaricide. Used in Pesticide detection<br>References Zhao, Meirong., Environmental Science &amp; Technology, 48, 8109-8116, (2014)Plummer, E.L., et al.: Pestic. Sci., 14, 560 (1983), Trumble, J.T., et al.: J. Econ. Entomol., 81, 608 (1988), Ross, M., et al.: Biochem. Pharmacol., 71, 657 (2006), Hillegass, J., et al.: Toxicol. Sci., 102, 413 (2008),<br></p>

<p>Applications Labelled 2-Chloropyridine (C380605). (2-CPY) has been identified as a trace organic chemical in process streams, wastewater and even drinking water. Furthermore, it appears to be formed as a secondary pollutant during the decomposition of specific insecticides. 2-CPY was found to be genotoxic agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Demsia, G., et al.: Mutat. Res., 634, 32 (2007), Stapleton, D., et al.: Water Res., 43, 3964 (2009),<br></p>

<p>Applications PropamocarbHydrochloride (CAS# 25606-41-1) is a useful research chemical compound.<br></p>

<p>Applications Used as an anticholinergic<br>References Goldenthal, E.I.: Toxicol. Appl. Pharmacol., 18, 185 (1971)<br></p>

<p>Applications Dihydrotestosterone Laurate is a derivative of testosterone(T155000), which is used in analytical studies to determine testosterone and nandrolone esters in race horse plasma for doping control through UPLC-ESI-MS-MS.<br>References You, Y., et al.: J. Chromato., 1218, 3982 (2011); Guan, F., et al.: Mass Spectrom., 45, 1270 (2010)<br></p>

<p>Applications (R)-Dimethenamid is the R-enantiomer of Dimethenamid (D460580(P)), which is a preemergence herbicide for use in food crops.<br>References Couderchet, M., et al.: Pestic. Sci., 50, 221 (1997), Barriuso, E., et al.: Environ. Sci. Technol., 42, 1845 (2008), Matthies, M., et al.: Environ. Pollut., 156, 99 (2008),<br></p>

<p>Stability very hygroscopic<br>Applications Labelled Ivabradine (I940500). Selective bradycardic agent with direct effect on the pacemaker If current of the sinoatrial node. Antianginal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Thollon,C., et al.: Br. J. Pharmacol., 112, 37 (1994), Ragueneau, I., et al.: Clin. Pharmacol. Ther., 64, 192 (1998), Borer, J.S., et al.: Circulation, 107, 817 (2003), DiFrancesco, D., et al.: Drugs, 64, 1757 (2004),<br></p>

<p>Applications 2-(4-chlorophenyl)-3-methylbutanoic acid (cas# 2012-74-0) is a useful research chemical.<br></p>

<p>Applications Flufenoxuron-d3 (2,6-difluorobenzoyl-d3) is a useful isotopically labeled compound of Flufenoxuron (F435100), which is a known insecticide and acts as an insect growth regulator by inhibiting chitin synthesis.<br>References Abbaszadeh, G., et al.: Pesticide. Res. J., 23, 52 (2011); Yang, A., et al.: Food. Control., 28, 99 (2012);<br></p>

<p>Applications β-Estradiol-d3 3,17-Disulfate Dipotassium Salt is the labeled analogue of β-Estradiol 3,17-Disulfate Dipotassium Salt (E888945), which increases equilibrium distribution rations by inhibiting efflux without an appreciable action on influx of amino acids in Ehrlich ascites tumor cells.<br>References Riggs, T.R., Walker, L.M.: Endocrinology, 74, 483 (1964)<br></p>

<p>Applications N-Methyl Ticlopidine-13C,D3 iodide is a labelled analogue of N-Methyl Ticlopidine iodide (M330270). N-Methyl Ticlopidine iodide is a derivative of Ticlopidine (T438325), a compound that antagonizes adenosine diphosphate-stimulated platelet aggregation.<br>References Kimchi, N., et al.: Digestion, 75, 36 (2007)<br></p>

<p>Applications O-Desethyl O-Isopropyl Dabigatran Etexilate-d13 is the labelled form of O-Desethyl O-Isopropyl Dabigatran Etexilate (D289378). O-Desethyl O-Isopropyl Dabigatran Etexilate is an impurity of Dabigatran Etexilate Mesylate (D100150). Dabigatran Etexilate Mesylate is a nonpeptide, direct thrombin inhibitor and an Antithrombotic agent.<br>References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002); Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002); Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005)<br></p>

<p>Applications MCPA methyl ester is a derivative of MCPA which is a herbicide.<br>References Elliott, B., et al.: Mutagenesis, 20, 3 (2005), Pfleeger, T., et al.; Environmental Toxicology and Chemistry 30, 455 (2010)<br></p>

<p>Applications Plumbagin-d3 is labelled Plumbagin (P627000) which induces apoptosis in cancer cells. It also inhibits NADPH oxidase 4 in a time- and dose-dependent manner.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Klotz, L., et al.: Molecules, 19 14902 (2014); Gupta, S., et al.: Cancer Metastasis Rev., 29, 405 (2010); Schramm, A., et al.: Vascul. Pharmacol., 56, 216 (2012)<br></p>

<p>Applications Afatinib N-Oxide is a derivative of Afatinib {BIBW 2992) (B377000), an aminocrotonylamino-substituted quinazoline derivative used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder. An anilino-quinazoline that irreversibly inhibits EGFR and HER2 kinase activity.<br>References Ham, J. et al.: Cancer Cell., 29, 159 (2016);<br></p>

<p>Applications Desamino Chloro Carbamazepine-d2 is an intermediate in the synthesis of Carbamazepine-d2,15N (C175841), the labeled analogue of Carbamazepine (C175840), used in treatment of pain associated with trigeminal neuralgia. Anticonvulsant.<br>References Stenger, E.G., et al.: Med. Exp., 11, 191 (1964), Pynnonen, S., et al.: Ther. Drug Monit., 1, 409 (1979), Sidebottom, A., et al.: J. Clin. Pharm. Ther., 20, 31 (1995)<br></p>

<p>Applications Isotope labelled cis-5-Dodecenoyl Carnitine Inner Salt is an L-carnitine metobolite which are often used to diagnose specific inherited metabolic diseases especially glucose related ones.<br>References Yang, S. et l.: J. Chrom. B., Anal. Tech. Biomed. Life Sci., 857, 251 (2007);<br></p>

<p>Applications 3,4-Dichloroaniline-d2 (cas# 1219803-22-1) is a compound useful in organic synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Tetrahydrocortisol 21-O-(1-Ethoxy Ethyl) Ether-d6 is an isotope labelled intermediate in the synthesis of Tetrahydro Cortisone-d6 (T293377), which is a normal mammalian metabolite of Cortisone (C696500).<br>References Schneider, et al.: J. Biol. Chem., 183, 365 (1950), Barkemeyer, et al.: Appl. Microbiol., 8, 237 (1960),<br></p>

<p>Applications Sorbic Acid-13C2 is an isotope labelled compound of Sorbic Acid (S676890). Sorbic Acid is a naturally occurring organic compound first isolated from unripe berries. Sorbic acid has been used as a food preservative and as an inhibitor of Clostridium Botulinum bacteria in meat products in order to reduce the amount of nitrites which produce carcinogenic nitroamines.<br>References Van, M.C., et al.: Int. J. Food. Microbiol., 160, 124 (2012); Li, J., et al.: J. Am. Soc. Mass. Spec., 23, 1625 (2012);<br></p>

<p>Applications Oxymorphone-13Cd3 is the labelled analogue of Oxymorphone (Cat. O876800). This opiate can be used as a analgesic.<br>References Gimbel, J., et al.: Anesth. Analg., 99, 1472 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications Mycophenolic Acid β-D-Glucuronide Disodium Salt is A metabolite of Mycophenolic Acid (M831500), an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.<br>References Senda, M., et al.: Transplantation, 60, 1143 (1995); Nimmesgern, E., et al.: J. Biol. Chem., 271, 19421 (1996); Gummert, J.F., et al.: J. Pharmacol. Exp. Ther., 291, 1100 (1999)<br></p>

<p>Impurity Abacavir EP Impurity C; Abacavir USP Related Compound A<br>Applications Descyclopropyl Abacavir (Abacavir EP Impurity C; Abacavir Related Compound A) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively.<br>References (1) Jackson, A., et al.: Antivir Ther. 17, 19 (2012) (2) Yuen, G. J., et al.: Clin Pharmacokinet. 47, 351 (2008)<br></p>

<p>Applications Metamizole Magnesium Salt is an analgetic, non-opioid drug used in human and veterinary medicinal treatments.<br>References Jasiecka, A. et al.: Polish J. Vet. Sci., 17, 207 (2014); Rogosch, T. et al.: Bioorg. Med. Chem., 20, 101 (2012);<br></p>

<p>Applications 2,4-Dimethylphenol is used both as a pesticide to ward of insects or other common pests from crops from crops as well as in the synthesis of anti-oxidant compounds due to the phenol moiety in the structure. This is a labelled analog.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Liu, B. et al.: J. Agri. Chem., 58, 2673 (2010); Guillen, M. et al.: J. Agri. Chem., 47, 3016 (1999); J. Agri. Chem., 46, 1276 (1999); Kim, S. et al.: J. Agri. Chem., 59, 4570 (2011);<br></p>

<p>Applications Chlorhexidine Digluconate Impurity N-d4 Hydrochloride, is labelled Chlorhexidine Digluconate Impurity N (C377660), which is a degradation product found in chlorhexidine digluconate solution.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Revelle, L., et. al.: Pharmaceut. Res., 10, 1777 (1993)<br></p>

<p>Applications Malathion-d7 (dimethyl-d6; 3-d1) (CAS# 352438-94-9) is a useful isotopically labeled research compound.<br></p>

<p>Applications Gatifloxacin derivative; a new antimycobacterial.<br>References Sanchez, J., et al.: J. Med. Chem., 35, 361 (1992), Cecchetti, V., et al.: Bioorg. Med. Chem., 7, 2465 (1999), Alovero, F., et al.: Antimicrob. Agents Chemother., 44, 320 (2000),<br></p>

<p>Applications Testosterone 17-Hexahydrobenzoate-d11 is the isotope analog of Testosterone 17-Hexahydrobenzoate. Testosterone 17-Hexahydrobenzoate is a metabolite of testosterone (T155000), which is used in biological studies to determine the hemolytic and lipophilic activity of this anabolic steroid.<br>References Biagi, G.L., et al.: J. Med. Chem., 13, 944 (1970); Biagi, G. L., et al.: J. Med. Chem., 18, 873 (1975)<br></p>

<p>Applications Chlorflurenol-methyl is an auxin polar transport inhibitor that effects elongation growth of the excised fourth internode of tulips. As well as a pesticide.<br>References Wegrzynowicz-Lesiak, E., et al.: J. Hort. Res., 21, 31-39 (2013);<br></p>

<p>Applications Bosentan Acetate is a mixed endothelin receptor antagonist. Used as a vasodilator. Antihypertensive.<br>References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994), Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996), Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996), Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)<br></p>