Toxicologie

<p>Applications (S)-10-Monohydroxy-10,11-dihydro Carbamazepine-D3 is a labelled analogue of (S)-10-Monohydroxy-10,11-dihydro Carbamazepine (M546510), a metabolite of Eslicarbazepine acetate (E659000) a novel central nervous system drug.<br>References Duncan, J., et al.: Br. J. Clin. Pharmacol., 53, 123 (2002), Almeida, L., et al.: J. Clin. Pharmacol., 45, 1062 (2005), Coppola, G., et al.: CNS Drugs, 18, 133 (2004),<br></p>

<p>Impurity Fluconazole EP Impurity A<br>Applications Iso Fluconazole (Fluconazole EP Impurity A) is an impurity of Fluconazole (F421000). Fluconazole USP impurity A.<br>References Rogers, T., et al.: Antimicrob. Agents Chemother., 30, 418 (1986), Itoh, H., et al.: Chem. Pharmaceut. Bull., 48, 1148 (2000),<br></p>

<p>Applications Ganciclovir derivative.<br>References Albers, E., et al.: J. Pharm. Sci., 81, 756 (1992), Dias, C., et al.: J. Pharm. Sci., 91, 6607 (2002), Macha, S., et al.: Drug Metab. Dispos., 30, 670 (2002),<br></p>

<p>Applications Hexaflumuron-D3 is an isotope labeled compound of Hexaflumuron (H293885). Hexaflumuron is an benzoylphenylurea based chitin synthesis inhibitor used against Ephestia figulilella.<br>References Sun, C.X., et al.: Bull. Environ. Contamin. Toxicol., 89, 868 (2012); Khajepour, S., et al.: J. Insect. Sci., 12, 102 (2012);<br></p>

<p>Applications Homotaurine-d6 is the isotope labelled analog of Homotaurine (H656200). Homotaurine is an important GABA mimetic agent. It evokes neurological responses similar to those elicited by g-aminobutyric acid.<br>References Riv. Farmacol. Ter., 7, 155 (1976), Neuropharmacology, 17, 13 (1978), Br. J. Pharmacol., 59 373 (1977)<br></p>

<p>Applications 4,4'-Dichlorodiphenyldichloroethane - d8 is a synthetic organochlorine insecticide. 4,4'-Dichlorodiphenyldichloroethane- d8 is a metabolite of 4,4'-Dichlorodiphenyltrichloroethane - d8 (D434197). 4,4'-Dichlorodiphenyldichloroethane - d8 is a probable carcinogen (Group B2).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tao, S. et al.: Environ. Sci. Technol., 39, 2494 (2005); Zhou, Q. et al.: J. Chrom. A, 1216, 6680 (2009); Weiderpass, E. et al.: Cancer Epidemiol. Biomark. Prev,., 9, 487 (2000)<br></p>

<p>Applications (2S,4R)-Itraconazole is an enantiomer of Itraconazole (I937500), an orally active antimycotic structurally related to Ketoconazole. Antifungal. It is a COVID19-related research product.<br>References Espinel-Ingroff, A., et al.: Antimicrob. Agents Chemother., 26, 5 (1984), Heykants, J., et al.: Mycoses, 32, Suppl 1, 67 (1989), Sugar, A.M.,et al.: Curr. Clin. Top. Infect. Dis., 13, 74 (1993),<br></p>

<p>Applications Terbutryn-d5 (ethyl-d5) (CAS# 1219804-47-3) is a useful isotopically labeled research compound.<br></p>

<p>Applications A labelled impurity of the anti-viral Lamivudine (L172500).<br>References Dwyer, O.: Synlett, 11, 1163 (1995);<br></p>

<p>Stability Moisture Sensitive, Toxic<br>Applications Benzyl Chloromethyl Ether is a reagent in the preparation of benzoyl-hydroxypyrimidine-diones, which are dual inhibitors of HIV reverse transcriptase and integrase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tang, J., et al.: Bioorg. Med. Chem. Lett., 21, 2400 (2011); Berkley, S., et al.; Nat. Med. 16, 981 (2010)<br></p>

<p>Applications N-Desdecanoyl, N-(dodeca-2,6,9-trienoyl) Daptomycin Trifluoroacetic Acid Salt is an impurity of Daptomycin (D193350), cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial.<br>References Allen, N.E., et al.: Antimicrob. Agents Chemother., 31, 1093 (1987), Tully, F.P., et al.: Expert Opin. Invest. Drugs, 8, 1223 (1999),<br></p>

<p>Applications Labelled Eflornithine. Irreversible inhibitor of ornithine decarboxylase, an enzyme involved in polyamine biosynthesis. Antineoplastic; antipneumocystic; antiprotozoal (Trypanosoma). Used in the treatment of hirsutism.<br>References Bacchi, C.J., et al.: Science, 210, 332 (1980), Haegele, K.D., et al.: Clin. Pharmacol. Ther., 30, 210 (1981), Meyskens, F.L., et al.: Clin. Cancer Res., 5, 945 (1999),<br></p>

<p>Applications Used in the preparation of triazole antifungal agents.<br></p>

<p>Stability Hygroscopic<br>Applications Antibacterial.<br>References Iwahi, T., et al.: Antimicrob. Agents Chemother., 36, 1358 (1992), Miyake, A., et al.: J. Antibiot., 45, 709 (1992),<br></p>

<p>Stability Hygroscopic<br>Applications α-​(4-​Chlorophenyl)​-​α-​(1-​cyclopropylethyl)​-1H-​1,​2,​4-​triazole-​1-​ethanol is a diastereomer of Cyproconazole (C989070), a fungicide treatment for wood preservative that prevents decay from fungi in above-ground applications.<br>References Aiello, D., et al.: Plant. Disease., 97, 37 (2013); Bakirci, G.T., et al.: Food. Chem., 135, 1901 (2012); Sugitate, K., et al.: J. Pesticides. Sci., 37, 148 (2012);<br></p>

<p>Applications An active insecticidal constituent of pyrethrum flowers. Oxidizes rapidly and becomes inactive in presence of air.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Okey, A., et al.: Pharmacol. Ther., 45, 241 (1990), Barter, R., et al.: Toxicol. Appl. Pharmacol., 113, 36 (1992), Hood, A., et al.: Toxicol. Sci., 49, 263 (1999),<br></p>

<p>Applications Malonic Acid-2-13C is labelled Malonic Acid (M158005) which is a small bioactive molecule, that can be used in variuos reactions. It is the classic example of a competitive inhibitor, which acts against succinate dehydrogenase (complex II) in the respiratory electron transport chain.<br>References Weiner, N., "Malonic acid", Org. Synth.; Coll. Vol. 2: 376;<br></p>

<p>Stability Aq. Solutions Cannot be Stored<br>Applications Phentolamine Methanesulfonate Salt is an adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma.<br>References Meier, R., et al.: Proc. Soc. Exp. Biol. Med., 71, 70 (1949); Spergel, G., et al.: J. Am. Med. Assoc., 211, 266 (1970); Gould, L. and Reddy, C.V.R.: Am. Heart J., 92, 397 (1976);<br></p>

<p>Applications A labelled Tamoxifen; a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen (H954725) are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.<br>References Sutherland, R., et al.: Nature, 267, 434 (1977); Lerner, L., et al.: Cancer Res., 50, 4177 (1990); Love, R., et al.: J. Clin. Oncol., 20 2559 (2002);<br></p>

<p>Applications 2-Oxo-mirabegron N-Carbamoylglucuronide is a metabolite of Mirabegron (M364900) which is a potent bladder relaxant and reagent for diabetes remedy.<br>References van Teijlingen, R., et al.: J. Chromat. B Anl. Technol. Biomed. Life Sci., 887, 102 (2012)<br></p>

<p>Applications Labelled 2,4'-Dichlorodiphenyltrichloroethane (D434205). 2,4'-Dichlorodiphenyltrichloroethane is a chlorinated organic pesticide having estrogenic activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Iwata, H., et al.: Environ. Sci. Technol., 27, 1080 (1993), Beyer, A., et al.: Environ. Toxicol. Chem., 21, 941 (2002), Cunningham, S., et al.: Science, 317, 935 (2007),<br></p>

<p>Applications (±)-Tramadol-d6 HCl (N,N-dimethyl-d6) (cis/trans mixture) (CAS# 1189374-50-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled, primary metabolite of Tianeptine.<br>References Dresse, A., et al.: J. Clin. Pharmacol., 28, 1115 (1988), Grislain, L., et al.: Drug Metab. Dispos., 18, 804 (1990),<br></p>

<p>Applications Birinapant is a bivalent SMAC mimetic compound antagonist of TRAF2 associated cIAP1 and cIAP2.<br>References Benetatos, C.A., et. al.: Mol. Cancer Ther., 13, 867 (2014)<br></p>

<p>Applications Tiafenacil is a uracil herbicide used as a pesticide for the prevention and control of plants.<br>References Peng, X., et al. Faming Zhuanli Shenqing, 68pp Patent 2018 CODEN:CNXXEV<br></p>

<p>Applications 2'-O-Benzoylpaclitaxel is a derivative of Paclitaxel (P132500) which has anticancer properties.<br>References Zhong, T., et al.: Bioconjugate Chem., 29, 437-444 (2018)<br></p>

<p>Applications Labelled Eltenac (E507000). A nonsteroidal anti-inflammatory drug.<br>References Allen, A., et al.: Gut, 21, 249 (1980), Tobin, T., et al.: J. Vet. Pharmacol. Therap., 9, 1 (1986),<br></p>

<p>Applications MRX-2843, is an orally available small-molecule inhibitor of both MERTK and FLT3.<br>References Minson, K. A. et al.: JCI Insight. 2016 Mar;1(3):e85630.;<br></p>

<p>Applications Herbicide.<br>References Oehler, D.D., et al.: J. Agric. Food Chem., 28, 685 (1980),<br></p>

<p>Applications Bupirimate is a pyrimidine based fungicide with protective and curative activity for the control of fungal diseases by interfearing with nucleic acid synthesis.<br>References Belmonte, V. N., et al.: J. Chromatograph. A., 1264, 110 (2012); Attallah, E.R., et al.: J. Food. Agri. Envrion., 10, 755 (2012);<br></p>

<p>Applications Phosalone is a organophosphate compouund used as insecticide and acaricide. Phosalone is a weak inhibitor of acetylcholinesterase.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Munj, A.Y., et al.: Pestol., 36, 35 (2012); Andrascikova, M., et al.: Food. Add. Contamin. Chem. Anal. Control. Exposure. Risk. Assess., 30, 286 (2013);<br></p>

<p>Applications A labelled metabolite of Warfarin (W498500) in humans.<br>References Barbato, F., et al.: J. Pharm. Sci., 86, 225 (1997), Kavana, M., et al.: Biochemistry, 42, 10238 (2003), Franco, A., et al.: Environ. Toxicol. Chem., 28, 458 (2009),<br></p>

<p>Applications Methyl 2-((((Benzyloxy)carbonyl)amino)methyl)-5-hydroxy-6-oxo-1,6-dihydropyrimidine-4-carboxylate is an intermediate used in the synthesis of N-((5-Hydroxy-6-oxo-4-((2,4,6-trifluorobenzyl)carbamoyl)-1,6-dihydropyrimidin-2-yl)methyl)-1,3,4-oxadiazole-2-carboxamide (H950690), which is a derivative of Raltegravir (R100305), a potent integrase (IN) inhibitor for WT and S217Q PFV IN.<br>References Hare, S., et al.: Proc. Natl. Acad. Sci. U. S. A., 107, 20057 (2010); Hicks, C., et al.: Clin. Infect. Dis., 48, 931 (2009); Moss, D., et al.: Antimicrob. Agents Chemother., 56, 3020 (2012); Hare, S., et al.: Mol. Pharmacol., 80, 565 (2011)<br></p>

<p>Applications A metabolite of Dipyridamole.<br>References Zak, S.B., et al.: J. Pharmacol. Exp. Ther., 141, 392 (1963),<br></p>

<p>Applications Isotope labelled Diethyl Oxalate is used in the synthesis of novel indole β-diketo acid derivatives as HIV-1 integrase inhibitors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sechi, M., et al.: J. Med. Chem., 47, 5298 (2004);<br></p>

<p>Applications N2-(1-Ethylpropyl)-4,5-dimethyl-3-nitro-1,2-benzenediamine is a metabolite of Pendimethalin (P221900), an herbicide used to control the spread of weedgrass.<br>References Haith, D., et al.: Environ. Sci. Technol., 44, 6496 (2010); Jabran, K., et al.: Int. J. Agric. Biol., 12, 335 (2010); Rahaman, S., et al.: Environ. Ecol., 28, 1 (2010); Smith, R.H., et al.: Chemosphere, 8, 855-61 (1979);<br></p>

<p>Applications LY 364947, is a potent ATP-competitive inhibitor of Tgf-β signaling.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ichida, J.K., et al.: Cell Stem Cell, 5, 491 (2009);<br></p>

<p>Applications SN-38 4-Deoxy-glucuronide is a byproduct formed during the preparation of SN-38 Glucuronide.<br></p>

<p>Applications Terbufos-d10 (O,O-diethyl-d10) (CAS# 1276197-42-2) is a useful isotopically labeled research compound.<br></p>

<p>Applications Isotope labelled (2R)-3-Carboxy-2-[(9-carboxy-1-oxononyl)oxy]-N,N,N-trimethyl-1-propanaminium Inner Salt is a useful intermediate that is often used in the metabolic studies of insulin production in humans.<br>References Shah, S.H.; et al.: Diabetologia, 55, 321 (2012)<br></p>

<p>Applications A metabolite of Phenobarbital (P316760).<br>References Soine, W.H., et al.: Drug Metab. Dispos., 12, 792 (1984), Soine, W.H., et al.: J. Pharmac. Sci., 80, 99 (1991),<br></p>