Toxicologie

<p>Applications 17β-Hydroxy Exemestane 17-O-β-D-Glucuronide is the glucuronidated conjugate of the hydroxy metabolite of Exemestane (E957000).<br>References Sun, D. et al.: Pharmacogen. Genom., 20, 575 (2010);<br></p>

<p>Stability Light Sensitive<br>Applications (1R,​3S)​-3-​(2,​2-​Dichloroethenyl)​-​2,​2-​dimethylcyclopropanecarboxam​ide is a useful research chemical.<br></p>

<p>Applications 2-Amino-N-isopropylbenzamide is a metabolite formed from Bentazon (B120580), a post-emergence, acidic herbicide used for selective control of broadleaf weeds and sedges in beans, rice, corn, peanuts and mint.<br>References Pinto, G. &amp; Jardim, I.: J. Chromatogr. A, 846, 369 (1999); Salman, J. &amp; Hameed, B.: J. Hazard Mater., 175, 133 (2010)<br></p>

<p>Stability Hygroscopic<br>Applications Diquat Dibromide is a herbicidal desiccant.<br>References Ergin, N.: Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 48, 1465 (2020); Nagai, T.: J. Pestic. Sci., 44, 225 (2019)<br></p>

<p>Stability Air Sensitive<br>Applications MGK 11 is an insect repellent most commonly used commercially as a mosquito repellent.<br>References Rutledge, L., et. al.: J. Med. Entomol., 20, 506 (1983);Steltenkamp, R., et. al.: Eur. Pat. Appl. 9 pp. Patent (1994) CODEN:EPXXDW;Buescher, M., et. al.: J. Med. Entomol., 19, 176 (1982)<br></p>

<p>Applications Caffeine-D10 is the labeled compound of Caffeine(C080100). Caffeine (Pentoxifylline EP Impurity F) is a bitter, white crystalline xanthine alkaloid that acts as a stimulant drug and a reversible acetylcholinesterase inhibitor (1,2,3). Caffeine is found in varying quantities in the seeds, leaves, and fruit of some plants, where it acts as a natural pesticide that paralyzes and kills certain insects feeding on the plants. In humans, caffeine acts as a central nervous system stimulant, temporarily warding off drowsiness and restoring alertness. Caffeine is a cardiac and respiratory stimulant; diuretic. Caffeine is toxic at sufficiently high doses. Caffeine is a non-competitive inhibitor of acetylcholinesterase (3).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zubair, U.M., et al.: Anal. Profiles Drug Subs., 15, 71 (1986); Cherrah, Y., et al.: Biochem. Pharmacol., 37, 1311 (1988);<br></p>

<p>Applications Dabigatran Etexilate Propanoate is an impurity of Dabigatran Etexilate (D100140). Dabigatran Etexilate is a nonpeptide, direct thrombin inhibitor. Antithrombotic.<br>References Mangiafico, R. et al.: Curr. Med. Chem., 19, 4688 (2012); Hu, Z. et al.: Anal. Bioanal. Chem., 405, 1695 (2013);<br></p>

<p>Applications Methoprene, is a juvenile hormone (JH) analog which can be used as an insecticide that acts as a growth regulator. Useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Xiao-li, M., et al.: Nongyao, 52, 380 (2013); Anon.IP.com Journal, 12, 9 (2012);<br></p>

<p>Applications Digoxin O-Tetra-acetate is an intermediate used in the synthesis of (3β,5β,12β)-3-[2-[[6-[(2,5-Dioxo-1-pyrrolidinyl)oxy]-6-oxohexyl]amino]-2-oxoethoxy]-12,14-dihydroxycard-20(22)-enolide (D486968), which is a digoxin (D446575) cross-linking reagent.<br></p>

<p>Applications Metsulfuron is a powerful herbicide used in the control of pests and protection of crops and produce.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Anderson, J. et al.: J. Agric. Food Chem., 37, 1429 (1989); Ivany, J. et al.: Can. J. Plant Sci., 67, 1083 (1987);<br></p>

<p>Applications Hecogenin Acetate, is a derivative of Hecogenin (H129945), which is a sapogenin present in the leaves of species from the Agave genus, possessing wide spectrum of pharmacology activities, such as having antinociceptive properties.<br>References Gama, K. B., et al.: J. Natural Prod., 76, 559 (2013);<br></p>

<p>Applications A metabolite of Venlafaxine, a selective serotonin noradrenaline reuptake inhibitor. Used as an antidepressant.<br>References Kelsey, J., et al.: J. Clin. Psychopharmacol., 16, 21 (1996), Long, C., et al.: J. Anal. Toxicol., 21, 166 (1997), Deecher, D., et al.: J. Pharmacol. Exp. Ther., 318, 657 (2006)<br></p>

<p>Applications (4S)-4-Hydroxy Pravastatin Lactone is an intermediate in the synthesis of Pravastatin 6'-Ketone Sodium Salt (P702050), which is an impurity of Pravastatin Sodium (P702000), which is a competitive inhibitor of HMG-CoA reductase. It can be used as a drug to for lowering cholesterol and preventing cardiovascular disease.<br>References Serizawa, N., et al.: J. Antibiot., 36, 604 (1983), Yoshino, G., et al.: Lancet, 2, 740 (1986), White, H.D, et al.: N. Engl. J. Med., 343, 317 (2000);<br></p>

<p>Applications Mometasone Furoate-d8 is the isotope labelled analog of Mometasone Furoate (M490000); a topical corticosteroid used as an anti-inflammatory.<br>References Shapiro, E.L., et al.: J. Med. Chem., 30, 1581 (1987); Graft, D., et al.: J. Allergy Clin. Immunol., 98, 724 (1996)<br></p>

<p>Applications CP 55,940 is a cannabinoid agonist which is considerably more potent than Δ9-THC in both behavioral tests and receptor binding assays. Displays high and roughly equal affinity for both central and peripheral cannabinoid receptors (Ki = 0.6 - 5.0 and 0.7 - 2.6 nM at CB1 and CB2 respectively; EC50 values are 0.2, 0.3 and 5 nM at CB1, CB2 and GRP55 respectively).Controlled substance. Synthetic Cannabinoids<br>References Wiley, et al.: Neuropharmacology, 34, 669 (1995); Griffin, et al.: J. Pharmacol. Exp. Ther., 285, 553 (1998); Thomas, et al.: J. Pharmacol. Exp. Ther., 285, 285 (1998); Ryberg, et al.: Br. J. Pharmacol., 152, 1092 (2007);<br></p>

<p>Applications 7,8,9,10-Tetrahydro-8-methyl-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine is a secondary amine drug varenicline impurity. It is a part of the pharmaceutical formulation of varenicline tartrate tablet.<br>References Waterman, K., et al.: J. Pharm. Sci., 97, 1499 (2008); Watheesh, B., et al.: Acta Chromatogr., 22, 207 (2010);<br></p>

<p>Applications A metabolite of Cevimeline (C283500).<br></p>

<p>Applications N-Deethoxymethyl Chlorfenapyr is a primary metabolite of Chlorfenapyr (C428500). Chlorfenapyr is a halogenated pyrrole based pro-insecticide. Chlorfenapyr functions by metabolizing into an active insecticide after entering the host. Chlorfenapyr is used primarily as a means of pest control on cotton.<br>References Lovell, J.B. et al.: Bright. Crop Prot. Pests Dis., 1, 37 (1990); Wier, A.T. et al.: J. Agric. Entemol., 11, 311 (1994); Black, B.C. et al.: Pest. Biochem. Physiol., 50, 115 (1994); Albers, P. H., et al.: Environ. Toxicol. Chem., 25, 438 (2006)<br></p>

<p>Applications Ethofumesate is a herbicide.<br></p>

<p>Stability Hygroscopic<br>Applications Isomalathion is a major impurity in the synthesis of Malathion (M111000), a commonly used insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Josse, R et al.: Chem. Bio., Interact., 209, 76 (2014); Buratti, F. et al.: J. Biochem. Mol. Toxicol., 19, 406 (2009);<br></p>

<p>Applications Dimension can be employed as a herbicide.<br>References Zhang, R., et al.: Sepu., 36, 1228-1237 (2018)<br></p>

<p>Applications Erythromycin Ethyl Succinate-13C,d3 is the deuterated form of Erythromycin Ethyl Succinate (E649985), which is a derivative of Erythromycin (E649950), an antibiotic.<br>References Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979); Serisier, D. et al.: J. Am. Med. Assoc., 309, 1206 (2013);<br></p>

<p>Applications Protected metabolite of Mycophenolic Acid.<br>References Nelson, P., et al.: J. Med. Chem., 39, 4181 (1996), Ubukata, M., et al.: Bioorg. Med. Chem. Lett., 17, 4767 (2007),<br></p>

<p>Applications Imiprothrin is an analytical standard that is also used in insect neurotoxin research.<br></p>

<p>Applications (3S,5S)-Dihydroxy Simvastatin is a derivtive of Simvastatin (S485000). Simvastatin is a synthetic derivative of a fermentation product of Aspergillus terreus. A competitive inhibitor of HMG-CoA reductase. A synthetic analog of Lovastatin. Antilipemic. Simvastatin, the drug, is sold under the trade name Zocor.<br>References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986), Mol, M.J., et al.: Lancet, 2, 936 (1986)<br></p>

<p>Applications Ethion is an organophosphate pesticide that is commonly used for crop protection against pests, such as mites and aphids. Ethion is highly toxic if ingested, as it can cause acute cyanosis and flaccid paralysis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Comstock, E., et al.: Tex. Med., 63, 71 (1967); Dickinson, B.: J. Econ. Entomol., 51, 354 (1958); Riehl, L., et al.: J. Econ. Entomol., 52, 857 (1959)<br></p>

<p>Applications Inhibitor for the treatment of Parkinson's disease.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Biggs, S., et al.: Eur. J. Pharmacol., 299, 83 (1996), Mannisto, P., et al.: Pharmacol. Rev., 51(4), 593 (1999), Fisher, A., et al.: Neuroscience, 95(1), 97 (2000),<br></p>

<p>Applications Molinate is a herbicide that is used to control broad-leaved and grassy plants in rice and other crops (1,2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Nacher-Mestre, J. et al.: J. Agri. Food. Chem. 2014 Mar 12;62(10):2165-742. Sugrue, E. et al.: Appl. Environ. Microbiol. 2015 Apr;81(7):2612-24.<br></p>

<p>Applications Labelled Fenthion Sulfone (F278015). Fenthion Sulfone is a metabolite of the organothiophosphate insecticide Fenthion (F278000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Oh, C., et al.: Bull Environ. Contam. Toxicol., 78, 314 (2007); Wang, W., et al.: Anal. Chim. Acta, 602, 211 (2007);<br></p>

<p>Applications Cilostazol-d4 is the labeled analogue of Cilostazol (C441500), a potent phosphodiesterase III A (PDE3A) inhibitor (IC50=0.2uM) and inhibitor of adenosine uptake. Has antimitogeni, antithrombotic, vasodilatory and cardiotonic properties in vivo. Also affects lipid levels in vivo.<br>References Suri, A., et al.: J. Clin. Pharmacol., 38, 144 (1998); Park, S.-W., et al.: Am. J. Cardiol., 84, 511 (1999); Tsuchikane, E., et al.: Circulation, 100, 21 (1999)<br></p>

<p>Applications Lorcainide Hydrochloride is an inhibitor of sodium voltage-gated channels. Effective anti-arrhythmic agents in patients.<br>References Lynch, J. J., et al.: J. Pharm. Exp. Ther., 273, 554-560 (1995); Heykants, J.: Int. Congr. Symp., 49, 35-39 (1981)<br></p>

<p>Applications Rizatriptan Benzoate is a selective serotonin 5-HTID receptor agonist and used to treat migraine (1,2,3). It is structurally derived from tryptamine.<br>References (1) Cheng, H., et al.: Biopharm. Drug Dispos., 17, 17 (1996) (2) Su, M., et al.: Eur J Neurosci. 44, 2129 (2016)(3) Millson, D. S., et al.: Expert Opin Pharmacother. 1, 391 (2000)<br></p>

<p>Applications (6R,7S)-Cefoperazone Sodium Salt is the enantiomer of Cefoperazone (C242900) as an impurity.<br>References Fabre, H., et al.: J. Pharm. Sci., 73, 611 (1984), Strasters, J., et al.: Anal. Chem., 63, 2503 (1991), Chen, Z., et al.: World Notes Antibiot., 25, 249 (2004),<br></p>

<p>Applications Fluoronitrofen contains pesticidal utility.<br>References Zhang, Y., et.al.: PCT Int. Appl. WO 2019236274 A1, 63, (2019);<br></p>

<p>Applications Tatenoquine is a new 8-aminoquinoline with an improved therapeutic index and safety profile as compared to primaquine (P733500).Tafenoquine has the potential to become a widely used drug in the prevention and treatment of malaria infection and could replace some currently used drugs as resistant strains of Plasmodium species increase.<br>References McIntyre, J. A., et al.: Drugs. Future., 28, 859 (2003); LaMontagne, M.P., et al.: J. Medn. Chem., 32, 1728 (1989);<br></p>

<p>Applications A metabolite of Quinine.<br>References Small, D.L., et al.: J. Chem. Med., 22, 1014 (1979), Guentert, T.W., et al.: Eur. J. Drug Metab. Pharmacokinet., 7, 31 (1982), Rakhir, A., et al.: J. Pharmacokinet. Biopharm., 12, 1 (1984), Christie, D.J., et al.: J. Lab. Clin. Med., 112, 92 (1988),<br></p>

<p>Applications A Nicorandil (N398500) derivative<br></p>

<p>Applications Physostigmine Salicylate is a cholinesterase inhibitor with the potential to improve cognitive ability in individuals with alzheimers. In addition, as a parasympathomimetic, it is used to treat glaucoma, dry mouth, and delayed gastric emptying.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Thal, L. et al.: Neurol., 47, 1389 (1996); Hedner, E. et al.: Eur. J. Oral Sci., 109, 374 (2001);<br></p>

<p>Applications FR 901379 is an impurity of Micafungin (M342350), a lipopeptide compound that acts as an antifungal agent with activity against Aspergillus and Candida species.<br>References Denning, D., et al.: J. Infection, 53, 337 (2006); Queiroz-Telles, F., et al.: Pediatr. Infect. Dis. J., 27, 820 (2008)<br></p>