Toxicologie

<p>Applications Labelled Lapatinib (L175800). Reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.<br>References Kim, T.E., et al.: Drugs, 6, 886 (2003), Wood, E.R., et al.: Cancer Res., 64, 6652 (2004), Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005),<br></p>

<p>Applications (1R)-trans-Bifenthrin is pyrethoid and a stereoisomer of B383000, which is a third generation synthetic pyrethroid. Insecticide, acaricide. Used in Pesticide detection<br>References Plummer, E.L., et al.: Pestic. Sci., 14, 560 (1983), Trumble, J.T., et al.: J. Econ. Entomol., 81, 608 (1988), Ross, M., et al.: Biochem. Pharmacol., 71, 657 (2006), Hillegass, J., et al.: Toxicol. Sci., 102, 413 (2008),<br></p>

<p>Stability Moisture Sensitive<br>Applications cis-Crotoxyphos is an insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Potter, J.C., Burton, W.B.: J. Agr. Food Chem., 12, 439 (1964)<br></p>

<p>Applications A deuterated substrate for CYP2B6.<br>References Kabumoto, H., et al.: Biosci., Biotechnol., Biochem., 73, 1922 (2009), Maresca, A., et al.: J. Med. Chem., 53, 335 (2010), Si-Ahmed, K., et al.: J. Pharm. Biomed. Anal., 51, 225 (2010),<br></p>

<p>Applications 4,4'-DDM is a common pesticidal residue found as contaminants in various environmental systems.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Berger, M. et al.: Water Air Soil Poll., 227, 1 (2016);<br></p>

<p>Stability Hygroscopic<br>Applications Dopexamine is a synthetic dopamine analog and acts as a a β2-adrenergic receptor agonistt as well as an agonist at peripheral dopamine receptors. Dopexamine has been used to improve myocardial and renal performance in patients suffering from low cardiac output states.<br>References Brown, R.A. et al.: Br. J. Pharmacol., 85, 599 (1985); Napoleone, P. et al.: Nephron, 65, 385 (1993);<br></p>

<p>Applications Propachlor ESA Sodium Salt is an amido sulfonate compound used as an analytical standard.<br>References Cheng, X., et al.: J. Agric. Food Chem., 58, 4588-4593 (2010);<br></p>

<p>Applications 4,4'-Dichlorodiphenyltrichloroethane - D8 is a synthetic organochlorine insecticide. 4,4'-Dichlorodiphenyltrichloroethane - D8 functions by opening sodium ion channels in the insects’ neurons, causing them to fire spontaneously which in turn leads to death. 4,4'-Dichlorodiphenyltrichloroethane - D8 is banned for agricultural use in North America, it is still commonly used in some countries and particularly as a means of malaria control.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Balkew, M. et al.: Paras. Vect., 3, No pp. given (2010); Kikankie, C.K. et al.: Malaria J., 9, No pp. given. (2010); Battu, R.S. et al.: Sci. Total Environ., 78, 173 (1989).<br></p>

<p>Applications Present in opium from 0.7% to 2.5%, depending on the source. Weak narcotic analgesic, perhaps due to conversion to morphine, with minimal hypnotic properties; potent antitussive.Controlled substance (opiate).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Eddy, S., et al.: J. Pharmacol. Exp. Ther., 67, 127 (1939), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 10, 93 (1981),<br></p>

<p>Applications Dibutyldiethyltin belongs to a class of organotin compounds that are commonly used as pesticides and fungicides and as plastics additives.<br>References Krupp, E.M. et al.: Environ. Sci. Technol., 45, 943 (2011)<br></p>

<p>Applications Adenosine A2 receptor agonist.<br>References Matova, M., et al.: J. Med. Chem., 32, 505 (1997), Matova, M., et al.: Drug Des. Discov., 16, 255 (2000), Adachi, H., et al.: J. Med. Chem., 50, 1810 (2007),<br></p>

<p>Stability Hygroscopic<br>Applications Indigosol O is an indigo dye used for cotton.<br>References Ruggli, P., et al.: Helv. Chim. Acta, 23, 689 (1940),<br></p>

<p>Applications (R)-Diclofop-methyl is a stereo-isomer of Diclofop-methyl(D431555) which isused as the active ingredient in many herbicides that are used to control weed growth in plants such as wheat and wild oats.<br>References Marzouk, E., et al.: J. Appl. Sci. Res., 9, 4907 (2013)<br></p>

<p>Applications N-Desmethyl Regorafenib-d3 is the isotope labelled analog of N-Desmethyl Regorafenib (D293270); a synthetic metabolite of Regorafenib (R143000) used for treatment and prevention of cancer.<br>References Wilhelm, S.: PCT Int. Appl. WO 2011130728 A1 20111020. Oct 20, 2011<br></p>

<p>Applications Thiophanate Ethyl-d10 is the isotope labelled analog of Thiophanate Ethyl; a systemic fungicide used in plant protection. Thiophanate Ethyl was shown to be effective against Botryotinia [ Sclerotinia] fuckeliana and Uncinula necator on grapevines, Mycosphaerella fragariae on strawberries, and powdery mildew of cucumber.<br>References Baicu, T., et al.: Analele Institutului de Cercetari pentru Protectia Plantelor, 8, 227 (1970)<br></p>

<p>Applications 2’,3’,4’-Tri-O-benzoyl Propofol-d17 β-D-Glucuronide Methyl Ester is an protected metabolite of Propofol (P829750), an anesthetic used in veternary medicine.<br>References Fujiwara, R., et al.: Drug Metab. Dispos., 35, 747 (2007), Soars, M., et al.: J. Pharmacol. Toxicol. Methods, 47, 161 (2002),<br></p>

<p>Applications Morphine Methylsulfonate is a derivative of Morphine (M652285), which is the principle alkaloid of opium and an analgesic used to treat both acute and chronic pain.<br>References Stefano, G., et. al.: Folia Biol, 58, 49 (2012);Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 17, 259 (1988)<br></p>

<p>Applications Labelled Bexarotene (B336750). Used as an antineoplastic. A selective retinoid X receptor (RXR) agonist.<br>References Boehm, M.F., et al.: J. Med. Che., 37,2930 (1994), Gottardis, M.M., et al.: Cancer Res., 56, 5566 (1996), Mukherjee, R., et al.: Nature, 386, 407 (1997), Miller, V.A., et al.: J. Clin. Oncol., 15, 790 (1997)<br></p>

<p>Applications Labelled Eltenac (E507000). A nonsteroidal anti-inflammatory drug.<br>References Allen, A., et al.: Gut, 21, 249 (1980), Tobin, T., et al.: J. Vet. Pharmacol. Therap., 9, 1 (1986),<br></p>

<p>Applications Herbicide.<br>References Oehler, D.D., et al.: J. Agric. Food Chem., 28, 685 (1980),<br></p>

<p>Applications Khellin is a compound present in the kella or picktooth fruit, used as a muscle relaxant.<br>References Shinde, P. et al.: Indian J. Nat. Prod. Res., 5, 40 (2014); Sztiller-Sikorska, M. et al.:<br></p>

<p>Applications Antiepileptic; Anticonvulsant that also acts as a mood stabilizer for those with bipolar disorder.<br>References Chang, Z.L., et al.: Anal. Profiles Drug Subs., 8, 529 (1979), Della Paschoa, O.E., et al.: Br. J. Pharmacol., 125, 1610 (1998), Grimes, C.A., et al.: J. Neirochem., 73, 1384 (1999), Loscher, W., Prog. Neurobiol., 58, 31 (1999),<br></p>

<p>Applications 3,5-Dichloroaniline-2,4,6-d3 (CAS# 1219795-03-5) is a useful isotopically labeled research compound.<br></p>

<p>Applications: (R)-Apomorphine-11-sulfate Potassium Salt-d5 is the isotope labelled analog of (R)-Apomorphine-11-sulfate Potassium Salt (A727520); a derivative of (R)-Apomorphine (A727500) which is a dopamine (D1 and D2) receptor agonist, emetic, and antiparkinsonian.<br>References Neumeyer, J.L., et al.: J. Pharm. Sci., 59, 1850 (1970); Ginos, J.Z., et al.: J. Med. Chem., 18, 1194 (1975); Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 20, 121 (1991)<br></p>

<p>Stability Hygroscopic<br>Applications Insecticidal, acaricidal, and fungicidal combinations of carboxamides and other pesticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dugo, G., et al.: Food Chem., 16, 435 (2005), Caldas, E., et al.: Toxicology, 222, 132 (2006), Cabras, P., et al.: J. Agric. Food Chem., 45, 2244 (1997), Wilkinson, C., et al.: Regul. Toxicol. Pharmacol., 31, 30 (2000),<br></p>

<p>Applications Methyl 1,4-Dihydro-4-(2’-trifluoromethyl)phenyl-pyridine-3-carboxylate-5-ethyl Carboxamide (cas# 887407-06-9) is a compound useful in organic synthesis.<br></p>

<p>Applications Fludiazepam is a drug which is a benzodiazepine derivative. Fludiazepam possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.<br>References Fang, S.Y., et al.: Drug. Alcohol. Depend., 104, 140 (2009); Esteki, M., et al.: Chem. Biol. Drug. Design., 72, 409 (2008);<br></p>

<p>Applications Isotope labelled 1’-Hydroxy Midazolam (H948424), metabolite of Midazolam (M343000).<br>References Dundee, J., et al.: Drugs, 28, 519 (1984), Galetin, A., et al.: Drug Metab. Dispos., 30, 1512 (2002), Uchaipichat, V., et al.: Drug Metab. Dispos., 34, 449 (2006), Lewis, B., et al.: Biochem. Pharmacol., 73, 1463 (2007),<br></p>

<p>Applications 1,2-Epoxy GA3, is a derivative of Gibberellic Acid (G3774500), a hormone that is found in plants which promotes the growth and elongation of cells. Gibberellic acid acts as a plant growth regulator on account of its physiological and morphological effects in extremely low concentrations. Generally Gibberellic acid affects only the plant parts above the soil surface.<br>References Bayle, J. et al.: Chem. Biol., 13, 99 (2006); Ihara, S. et al.: J. Cell Sci., 119, 500 (2006); Suh, B. et al.: Science, 314, 1454 (2006); Rinaudo, K. et al.: Nat. Biotechnol., 25, 795 (2007);<br></p>

<p>Stability Very Hygroscopic<br>Applications DL-Lactic Acid-13C2 Sodium Salt is the isotope labelled sodium salt of DL-Lactic Acid. DL-Lactic Acid occurs in small quantities in the blood and muscle fluid of man and animals. The lactic acid concentration increases in muscle and blood after vigorous activity.<br>References He, W. et al.: Comp. Biochem. Phys. Part A: Mol. Int. Phys., 166, 308 (2013); Borsook, et al.: J. Biol. Chem., 102, 449 (1933); Brin, M., et al.: Ann. N.Y. Acad. Sci., 119, 851 (1965);<br></p>

<p>Applications A labelled metabolite of Cortisol.<br>References Abel, S., et al. J. Steroid Biochem. Mol. Biol., 45, 445 (1993), Yates, C., et al.: Pharm. Res., 20, 1794 (2003),<br></p>

<p>Applications Benzyl-alpha-alpha-d2 Chloride (CAS# 33712-34-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Nor Dihydrocodeine is a metabolite of Dihydrocodeine (D448850).This is a controlled substance.<br>References Lahti, R., et al.: Eur. J. Pharmacol., 109, 281 (1985), Schwanstecher, M., et al.: J. Neurochem., 59, 1325 (1992), Bartlett, S., et al.: Life Sci., 57, 609 (1995), Ammon, S., et al.: Brit. J. Clin. Pharmacol., 48, 317 (1999),<br></p>

<p>Stability Light Sensitive<br>Applications Isodrine is a highly toxic compound that is used as a pesticide in the agricultural industry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gaines, T.: Toxicol. Appl. Pharm., 14, 515 (1969); Walton, I., et al.: Org. Lett., 14, 2686 (2012)<br></p>

<p>Stability Hygroscopic<br>Applications Imazalil Sulfate is an imidazole derivative used as a fungicide. Imazalil Sulfate controlled epidermis anthracnosis caused by Colletotrichum musae and crown rot in harvested bananas. Imazalil Sulfate is used for fungal protection of citrus fruits such as oranges and lemons as well as other fruits. Imazalil Sulfate is an effective fungicide allowing induction of barley callusin culture media.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Frossard, P. et al.: Fruits, 361 (1976); Van Gestel, J. et al.: Plant Dis. Rep., 63, 283 (1979); Laencina, J. et al.: EFCE Pub. Ser., 12, 295 (1980); Coppens, L. et al.: Meded. Fac. Landbouw. Uni. Gent., 49, 351 (1984);<br></p>

<p>Applications Ethylmorphine impurity.<br>References Pfeifer, S., et al.: Pharmazie, 27, 648 (1972),<br></p>

<p>Applications Methyl 3,6-dichloropyridine-2-carboxylate<br></p>

<p>Applications 2,3-Dichloropropanoic acid is an organochlorine herbicide<br>References Okochi, Yumiko, et al.: Kankyo Gijutsu, 26(4), 225-228 (1997)<br></p>

<p>Applications A labelled major (toxic) metabolite of Styrene (S687790), catalyzed by epoxide hydrolase.<br>References Shen, S. et al.: Drug Metab. Disp., 38, 1934 (2010); Carlson, G.P. et al.: J. Toxicol. Env. Health, 73, 1689 (2010)<br></p>

<p>Applications A metabolite of Methomyl, a carbamate pesticide, in post-mortem samples.<br>References Harvey, J., Jr., et al.: J. Agric. Food Chem., 21, 781 (1973), Pereira, W., et al.: Environ. Sci. Technol., 24, 1400 (1990),<br></p>

<p>Applications Veratridine is a voltage dependent Na+ channel opening agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nishizawa, Y., et al.: Agric. Biol. Chem., 25, 605 (1961),<br></p>

<p>Applications 1,1'-Sulfonylbis[2-(methylthio)ethane]-d6 is the labelled analgoue of 1,1'-Sulfonylbis[2-(methylthio)ethane] which is an intermediate in synthesizing Bis(methylsulfinylethyl)sulfone (B494850), a sulfur mustard metabolite found in urine.<br>References Black, R., et al.: Xenobiotica, 22, 405 (1992); Li, C., et al.: J. Chromatogr. B, 917-918, 100 (2013);<br></p>

<p>Applications Estradiol 4-Carboxymethyl, is a metabolite of 17β-Estradiol (E888000). Estradiol is the major estrogen secreted by the premenopausal ovary.<br>References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985), Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991), Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998), Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000),<br></p>

<p>Applications Propachlor is an acylanilide herbicide that is used to maintain crop protection from weeds. Propachlor is also known to induce Glutathione (G597951)-dependent cytotoxicity and sister chromatid exchanges in human cells.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bartha, R. &amp; Pramer, D.: Adv. Appl. Microb., 13, 317 (1970); Dierickx, P.: Cell Biol. Toxicol., 15, 325 (1999); Hill, A., et al.: Mut . Res.-Gen. Tox. En., 295, 159 (1997); Novick, N., et al.: J. Agr. Food Chem., 34, 721 (1986); Robert, H. &amp; Bond, W.: Weed Res., 15, 195 (1975); Villarreal, D. &amp; Turco, R.: Appl. Env. Microb., 57, 2135 (1991)<br></p>