Toxicologie

<p>Impurity Ganciclovir EP Impurity I<br>Applications O,O'-Dipropanal Ganciclovir (Ganciclovir EP Impurity I) is derived from Ganciclovir (G235000), which is a nucleoside analog structurally related to Acyclovir (A192400). Ganciclovir is an antiviral.<br>References Halloran, P.J. and Fenton, R.G.: Cancer Res., 58, 3855 (1998), Rubsam, L.Z., et al.: Cancer Res., 59, 669 (1999), Yamasaki, H., et al.: C.R. Acad. Sci. III, 322, 151 (1999)<br></p>

<p>Applications Methylparaoxon is used in esterase detoxication of acetylcholinesterase inhibitor pesticides using human liver samples in vitro.<br>References Moser, V. C., et al.: Toxicology, 353, 11 (2016)<br></p>

<p>Applications Oxamyl is a carbamate pesticide used to control nematode in protected crops and potato cultivation (1). Oxamyl metabolites are useful compounds to characterize omxamyl-degrading microbes and to investigate metabolic pathway of Oxamyl. Oximino Oxamyl is a metabolite of Oxamyl (O845140) in apple, orange, and tomato (2,3).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Rousidou, K., et al.: Front Microbiol. 29, 7 (2016)(2) Salama, A. K.: J Environ Sci Health B 33, 569 (1998)(3) Baines, R. C., and Small, R. H.: J Nematol. 8, 122 (1976)<br></p>

<p>Applications Prazosin is a useful α1 and α2B-adrenoceptor antagonist.<br></p>

<p>Applications Used in the synthesis of labelled 5'-modified 2'-deoxyadenosine analogues as anti-hepatitis C virus agents.<br>References Gordon, C., et al.: J. Med. Chem., 48, 1 (2005), Ikejiri, M., et al.: Bioorg. Med. Chem., 15, 6882 (2007),<br></p>

<p>Applications A potent growth inhibitor and cytotoxic agent. It acts as a demethylating agent by inhibiting DNA methyltransferase.<br>References Kusaba, H., et al.: Eur. J. Biochem., 262, 924 (1999), Broday, L., et al.: Mol. Cell Biol., 19, 3198 (1999), Qian, X., et al.: Am. J. Pathol., 153, 1475 (1999), Canova, C., et al.: Mech. Ageing Dev., 101, 153 (1998)<br></p>

<p>Stability Hygroscopic<br>Applications Metabolite of Flurbiprofen (F598700).<br>References Van Breemen, R., et al.: Drug Metab. Disposition, 14, 197 (1986), Spraul, M., et al.: J. Pharm. Biomed. Anal., 11, 1009 (1993),<br></p>

<p>Applications An antihypertensive, with affinity for multiple GPCR receptors.<br>References Zhu, Y., et al.: Biol. Pharm. Bull., 32, 1173 (2009), Shen, K., et al.: J. Pharm. Pharmacol., 61, 517 (2009), Brea, J., et al.: Mol. Pharmacol., 75, 1380 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),<br></p>

<p>Applications Labelled Dopamine. Endogenous catecholamine with α and β-adrenergic activity. Cardiotonic; antihypotensive.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Carter, J.E., et al.: Anal. Profiles Drug Subs., 11, 257 (1982), Dasta, J.F., et al.: Pharmacotherapy, 6, 304 (1986),<br></p>

<p>Applications A metabolite of Caffeic acid.<br>References Zhu, B., et al.: J. Biol. Chem., 269, 292 (1994), Azuma, K., et al.: J. Agric. Food Chem., 48, 5496 (2000), Stark, T., et al.: J. Agric. Food Chem., 54, 5530 (2006), Hensel, A., et al.: Planta Med., 73, 142 (2007),<br></p>

<p>Applications 1-Docosanol-d45 is the labelled form of 1-Docosanol (D678855). 1-Docosanol works as a surfactant in cosmetics. 1-Docosanol cream has also been approved by the US Food and Drug Administration as a safe and effective topical treatment for herpes labialis.<br>References Noweck, K., et al.: Ullmann's Encyclopedia of Industrial Chemistry (2006); McKeough, M., et al.: Arch. Dermatol., 137, 1153 (2001)<br></p>

<p>Applications The major metabolite of Norflurazon (N684500) in soil.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Mazzola, E.P. , et al.: J. Agric. Food Chem., 32, 1102 (1984),<br></p>

<p>Applications Diphenylamine is an aromatic amine that was shown to exhibit antioxidant activities and is now used as an anti-scald agent.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sugihara, T., et al.: Free. Radic. Biol. Med., 14, 381 (1993); Hanthorn, J.J., et al.: J. Am. Chem. Soc., 134, 8306 (2012);<br></p>

<p>Applications Sulfentrazone is an herbicide used for controlling sedges in turfgrass.<br>References Shaner, D.L., et al.: Weed. Technol., 26, 633 (2012); Menezes, C.W.G. et al.: Weed. Res., 52, 520 (2012); Graber, E.R., et al.: Plant. Soil. 353, 95 (2012);<br></p>

<p>Applications Fenobuccarb is a carbamate insecticide used as an agricultural insecticide on rice and cotton.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Strempel, S., et al.: Envrion. Toxicol. Chem., 32, 1187 (2013); Xu, X.M., et al.: Food. Chem., 135, 161 (2012);<br></p>

<p>Stability Light Sensitive<br>Applications Disperse Polyester Dark Blue causes photocontact dermatitis in workers engaged in its manufacturing.<br>References Davies, Keith A., et al.: J. Appl. Chem. Biotechn., 25(3), 195-204 (1975)<br></p>

<p>Applications Tebuconazole is an ergosterol biosynthesis inhibitor present in most pesticide formulations (1,2). Various uptake is observed in plants (3). Drinking water Contaminant Candidate List 3 - CCL 3 as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants. Useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Grimalt S. et al.: Anal Bioanal Chem. 2015 Apr;407(11):3083-912. Gent, D. et al.: Plant Dis. 2003 May:87(5) p591-5973. Wang, C. et al.: Pest. Biochem. Physiol. 2007 Jan:87(1) p1-8<br></p>

<p>Applications Labelled Linezolid. Prototype of the oxazolidinone antimicrobials; inhibits bacterial mRNA translation.<br>References Brickner, S.J., et al.: J. Med. Chem., 39, 673 (1996), Ford, C.W., et al.: Antimicrob. Agents Chemother., 40, 1508 (1996), Rybak, M.J., et al.: Pharmacotherapy, 18, 456 (1998), Stevens, D.L., et al.: Clin. Infect. Dis., 34, 1481 (2002),<br></p>

<p>Applications Chlorsulfuron blocks the biosynthesis of valine [72-​18-​4] and isoleucine [73-​32-​5] in plants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Thomas, R.: Plant Physiol., 75, 827 (1984);<br></p>

<p>Applications Brivaracetam-d7, is the labeled analogue of Brivaracetam (B677645), which is a 4-n-propyl analog of levetiracetam (L331500), and a racetam derivative with anticonvulsant properties.<br>References Rosenstiel, P., et al.:Neurotherapeutics, 4 (1), 84 (2007);<br></p>

<p>Applications An anticonvulsant, hypnotic. A metabolite of Mephentoin.<br>References Knabe, J., et al.: Arch. Phar., 313, 538 (1980)<br></p>

<p>Applications Labelled Cortisol (H714615). Cortisol, or Hydrocortisone, is a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.<br>References Hechter, O., et al.: Arch. Biochem. Biophys., 25, 457 (1950), Colingsworth, D.R., et al.: J. Biol. Chem., 203, 807 (1953), Florey, K., et al.: Anal. Profiles Drug Subs., 12, 277 (1983),<br></p>

<p>Applications An insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Genualdi, S., et al.: Environ. Sci. Technol., 44, 5534 (2010), Bhhatarai, B., et al.: Chem. Res. Toxicol., 23, 528 (2010), Liu, B., et al.: J. Agric. Food Chem., 58, 2673 (2010),<br></p>

<p>Impurity Doxycycline Related Compound A<br>Stability Hygroscopic, Light Sensitive, Temperature Sensitive<br>Applications 6-Epi Doxycycline is an antibiotic used in the treatment of bacterial and certain parasitic infections. Doxycycline Related Compound A<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jutglar, M., et al.: J. Pharm. Biomed. Anal., 159, 60 (2018); Metsemakers, W., et al.: J. Control. Release, 209, 47 (2015)<br></p>

<p>Applications (9α,13α,14α)-3-(Methoxy-d3)-17-methyl-morphinan Hydrobromide is the labeled analogue of Dextromethorphan Hydrobromide Monohydrate (D299455), an antitussive drug. Orally active synthetic morphine analog. Analgesic (narcotic). Racemethorphan and levomethorpham are controlled substances (opiates).<br>References Hafliger, et al.: Helv. Chim. Acta, 39, 2053 (1956); Cox, B.M., et al.: Br. J. Pharmacol. Chemother., 27, 81 (1966); Hou, Chia-Hui; Tzeng, J., et al.: Eur. J. Pharmacol., 544, 10 (2006)<br></p>

<p>Stability Hygrscopic<br>Applications Emtricitabine Tenofovir Monosoproxil is a derivative of Emtricitabine (E525000). Emtricitabine is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner.<br>References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)<br></p>

<p>Stability Hygroscopic<br>Applications Semisynthetic aminoglycoside antibiotic, related to sisomicin. Antibacterial.<br>References Miller, G.H., et al.: Antimicrob. Agents Chemother., 10, 827 (1976), Raab, W., et al.: Adv. Clin. Pharmacol., 15, 91 (1978), Noone, P., et al.: Drugs, 27, 548 (1984),<br></p>

<p>Applications Clindamycin is a semi-synthetic antibiotic. Antibacterial.<br>References Birkenmeyer, R.D., et al.: J. Med. Chem., 13, 616 (1970); Oesterling, et al.: J. Pharm. Sci., 59, 63 (1970); Gray, J.E., et al.: Toxicol. Appl. Pharmacol., 21, 516 (1972); Brown, L.W., et al.: Anal. Profiles Drug Subs., 10, 75 (1981);<br></p>

<p>Applications A normal mammalian metabolite of Cortisone (C696500).<br>References Schneider, et al.: J. Biol. Chem., 183, 365 (1950), Barkemeyer, et al.: Appl. Microbiol., 8, 237 (1960),<br></p>

<p>Impurity Propafenone EP Impurity D<br>Applications Depropylamino Hydroxy Propafenone (Propafenone EP Impurity D) is a metabolite of the sodium channel blocker Propafenone (P757500).<br>References Hege, H.G. et al.: Arzneim.-Forsch., 34, 972 (1984); Hollmann, M., et al.: Arzneim.-Forsch., 33, 763 (1983); Bryson, H. M., et al.:Drugs, 45, 85 (1993);<br></p>

<p>Applications rac Fosfomycin-13C3 Benzylamine Salt is an antibiotic.<br>References Goto, M., et al.: Antimicrob. Agents Chemother., 20, 393 (1981);<br></p>

<p>Applications Diagnostic aid (radiopaque medium).<br>References Bourrinet, P., et al.: Invest. Radiol., 29, 1057 (1994), Donadieu, A.-M., et al.: Acta Radiol., 37, 400 (1996),<br></p>

<p>Applications Carcinogen.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Knize, M.G., et al: Envir. Health Perspectives, 67, 17 (1986), Stavric, B., et al.: Fd. Chem. Toxic., 31, 981 (1993), Sugimura, T., et al.: Mutation Res., 290, 43 (1993), van Herwaarden, A.E, et al.: Cancer Res., 63, 6447 (2003),<br></p>

<p>Applications A labelled metabolite of Chloroquine. It is a COVID19-related research product.<br>References Ohkuma, S., et al.: J. Cell. Biol., 90, 656 (1981), Araki, N., et al.: J. Biol. Chem., 267, 10211 (1992), Projean, D., et al.: Drug Metab. Dispos., 31, 748 (2003), Traebert, M., et al.: Eur. J. Pharmacol., 484, 41 (2004),<br></p>

<p>Applications It is listed as a known human carcinogen. Used in manufacturing of dyes, as antioxidant in rubber.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References IARC Monographs, 4, 97 (1974),<br></p>

<p>Stability Hygroscopic<br>Applications A labelled form of Clofentezine which is used in agriculture for the protection of ornamentals, food and non-food crops in the field. Used as a standard for Pesticide detection. Clofentezine is used in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bakirci, G.T., et al.; Food. Chem., 135, 1901 (2012); Ay, R., et al.: Insect. Sci., 18, 503 (2011);<br></p>

<p>Stability Not Stable in hot solution<br>Applications Muscarinic receptor antagonist. Bronchodilator.<br>References Haddad, E.-B., et al.: Mol. Pharmacol., 45, 899 (1994), Donohue, J. F., et al.: Chest, 122, 47 (2002), Profita, M., et al.: Allergy, 60, 1361 (2005), Dusser, D., et al.: Eur. Respir. J., 27, 547 (2006),<br></p>

<p>Applications Labelled Tolperisone, a muscle relaxant.<br></p>

<p>Stability Air Sensitive<br>Applications Used for detecting the presence of hydrolytic analytes, such as leukocytes, esterase, and protease. The detection of leukocytes is especially important in medical diagnostics.<br>References Jackson, D.S., et al.: Arch. Biochem. Biophys., 20, 323(1), 108 (1995)<br></p>

<p>Applications Profenofos is a broad-spectrum organophosphorous pesticide that is used widely in cotton fields for insect control (1). Acetylcholinesterase inhibiting organophosphoric pesticide (2). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Martin, T. et al.: J. Econ. Entomol. 2003 Apr;96(2):468-74.2. Kushwaha, M. et al.: J Environ Qual. 2016 Sep;45(5):1478-1489.<br></p>

<p>Impurity Ofloxacin EP Impurity E<br>Applications Desmethyl Ofloxacin (Ofloxacin EP Impurity E) is a metabolite of Ofoxacin (O245750), a fluorinated quinolone antibacterial.<br>References Leysen, D., et al.: Antimicrob. Agents Chemother., 33, 1 (1989); Polk, R., et al.: J. Antimicrob. Chemother., 27, 17 (1991); Todo, Y., et al.: Chem. Pharm. Bull., 42, 2049 (1994); Furuhata, K., et al.: Biol. Pharm. Bull., 21, 456 (1998); Monk, J.P., et al.: Drugs, 33, 346 (1987); Drlica, K., Curr. Opin. Microbiol. 2, 504 (1990)<br></p>

<p>Stability Hygroscopic<br>Applications Clarithromycin 9-Oxime is an impurity of Clarithromycin (C559750), a macrolide antibiotic.<br>References Stephanic, V. et al.: J. Med. Chem., 54, 719 (2011); Chen, X. et al.: Zhong. Yao., 17, 32 (2008);<br></p>

<p>Applications Ribavirin-13C2 is the labeled analogue of Ribavirin (R414475), a purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.<br>References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986); Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993); Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994); Reichard, O., et al.: Lancet, 351, 83 (1998)<br></p>

<p>Applications (1S,2R)-2-((Benzyloxy)methyl)cyclopent-3-enol is an intermediate in the synthesis of Entecavir (E558900), an oral antiviral drug used in the treatment of hepatitis B infection.<br>References Gathergood, N., et al.: J. Org. Chem., 66, 1014 (2001);<br></p>

<p>Applications Pre and post emergence foliar absorbed herbicide for winter weed control in cereal crops; carotenoid biosynthesis inhibitor.<br>References Conte, E., et al.: J. Agric. Food Chem., 46, 4766 (1998),<br></p>

<p>Applications Cholinesterase inhibitor. Use as systemic insecticide, acaricide, nematocide. Used in Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698235).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dorough, W.H., et al.: J. Agric. Food Chem., 16, 319 (1968),<br></p>

<p>Stability Hygroscopic<br>Applications (+)-Tubocurarine Chloride, is a a long-duration antagonist for nicotinic acetylcholine receptor, used widely in anesthesia to provide skeletal muscle relaxation during surgery or mechanical ventilation.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bren, N., et al.: J. Biol. Chem., 272, 30793 (1997); Fu, D.X., et al.: J. Biol. Chem., 269 (1994); Gronert, G.A.,et al.L J, App. Physiol. Resprat. Envrion. Exercise. Physiol., 57, 1502 (1984); Hughes, R., et al.: Brit. J. Anaesthesia., 48, 847 (1976);<br></p>

<p>Applications Controlled substance (depressant). Anxiolytic.<br>References Schwartz, M.A., et al.: J. Pharm. Sci., 62, 1776 (1973), Chalmers, P., et al.: Anesthesia, 39, 370 (1984), Hassan, M.M., et al.: Anal. Profiles Drug Subs., 16, 1 (1987),<br></p>

<p>Applications Lamivudine epimer.<br>References Chang, C., et al.: J. Biol. Chem., 267, 13938 (1992), Jeong, L., et al.: J. Med. Chem., 36, 181 (1993),<br></p>

<p>Stability Very Hygroscopic<br>Applications The major metabolite of herbicidal Glufosinate (G596950).<br></p>

<p>Applications L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase.<br></p>

<p>Applications Methyprylon is a sedative/hypnotic drug used for treating insomnia.<br>References Reinke, L. A., et al.: Res. Commun. Chem. Path., 11, 45 (1975); Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976)<br></p>

<p>Applications Isotope labelled Cefalonium (C236800) is a first-generation cephalosporin antibiotic used as a long-acting intramammary cerate for infusion of dairy cows.<br>References Endo, T.: Kach. Kokin. Kenk., 12, 8 (1991); Berry, E.A. et al.: J. Dairy Sci., 90, 760 (2007); Bradley, A.J. et al.: J. Dairy Sci., 93, 1566 (2010);<br></p>

<p>Applications (-)-Quinic Acid γ-Lactone is an intermediate in the synthesis of 4-O-(E)-Feruloylquinic Acid (F308985). 4-O-(E)-Feruloylquinic Acid is a phenolic acid with potential antioxidant and antifungal activities. Secondary metabolite in the coffee brewing process.<br>References Matei, M. et al.: J. Agri. Food Chem., 60, 12105 (2012); Dokli, I. et al.: Tetrahedron Asymm., 24, 785 (2013)<br></p>

<p>Applications 3,5-Dihydroxybenzoic Acid 3-O-Sulfate is a possible metabolite of alkylresorcinol in humans.<br></p>

<p>Applications 2,3,5-Trichloropyridin-4-amine (cas# 28443-69-8) is a useful research chemical.<br></p>

<p>Applications A metabolite of Chlorpyrifos (C425300).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Barron, M.G., et al.: Environ. Toxicol. Chem., 12, 1469 (1993), Tang, J., et al.: Drug Metab. Dispos., 29, 1201 (2001),<br></p>

<p>Applications Labelled antilipemic.<br>References Fuccella, L.M., et al.: Clin. Pharmacol. Ther., 28, 790 (1980), Lovisolo, P.P., et al.: Pharmacol. Res. Commun., 13, 151 (1981), Aktories, K., et al.: Arzneim.-Forsch., 33, 1525 (1983), Boatman, P., et al.: J. Med. Chem., 51, 7653 (2008), Rigazio, S., et al.: Am. J. Physiol., 295, E413 (2008),<br></p>

<p>Applications Isoxaflutole is an pesticide used to selectively control both grass and broad-leaved weeds in maize and sugar cane. Isoxaflutole is known to work by inhibiting the enzyme 4-Hydroxyphenylpyruvate dioxygenase (HPPD) which results in the disruption of pigment biosynthesis.<br>References Fillosls, E.F., et al.: Int. Sugar. J., 115, 135 (2013); Laini, A., et al.: Sci. Total. Environ., 438, 312 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications Used as a herbicide.<br>References Abbas, H., et al.: J. Agric. Food Chem., 50, 5246<br></p>

<p>Applications Triphenyltin Acetate is an organotin compound. Triphenyltin Acetate much like its hydroxide analogue is used as a fungicide and antifeeding compound for insect control. Recent studies show that Triphenyltin Acetate may have adverse effects on the reproductive and immune systems and may disrupt the endocrine system.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Soderquist, J.S. et al.: J. Agric. Food Chem., 28, 111 (1980); J. Toxicol. Environ. Health, 7, 281 (2004); Livingston, J.M. et al.: J. Georgia Entamol. Soc., 13, 148 (1978); Sarpa, M. et al.: J. Toxicol. Environ. Health, 73, 965 (2010);<br></p>

<p>Applications Celecoxib-d7 is the labeled analogue of Celecoxib (C251000), a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998); Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000); Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000)<br></p>

<p>Applications Zineb is a fungicide that is a potential contaminant in food and has been under biological studies to evaluate the adverse effect and toxicity of low doses on thyroid function in male rat.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nebbia, C., et al.: Bull. Environ. Contam. Toxicol., 56, 847 (1996)<br></p>

<p>Applications Cefodizime is a third generation cephalosporin with a broad spectrum of antibacterial activity. Cefodizime maybe useful in the treatment of otitis media, sinusitis and gynaecological infections, and for the prophylaxis or treatment of surgical infections.<br>References Barradel, L.B. et al.: Drugs, 44, 800 (1992); Kasai, K. et al.: Jap. J. Antibiot., 37, 1306 (1984);<br></p>

<p>Stability Unstable in Solution<br>Applications Sulfosulfuron is used in the synthetic preparation of herbicidal mixed compositions containing 2-chloro-3-(methylsulfanyl)-N-(1-methyl-1H-tetrazol-5-yl)-4-(trifluoromethyl)benzamide or its salt towards weed control.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lorentz, L.; et al.: PCT Int. Appl. 340pp. Patent 2017 CODEN:PIXXD2<br></p>

<p>Applications (±)-Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure.<br>References Hanotin, C., et al.: Int. J. Obesity, 22, 32 (1998)<br></p>

<p>Applications Oxamyl is a pesticide used in the treatment and protection of crops from parasites and insects. Oxamyl is also useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Applications Paichongding is a type of neonicotinoid insecticide.<br>References Xie, Hui, et al.: Turang Xuebao, 53(1), 232-240 (2016)<br></p>

<p>Stability Hygroscopic, Light Sensitive<br>Applications Dopamine (D1 and D2) receptor agonist. Emetic. Antiparkinsonian.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Neumeyer, J.L., et al.: J. Pharm. Sci., 59, 1850 (1970), Ginos, J.Z., et al.: J. Med. Chem., 18, 1194 (1975), Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 20, 121 (1991),<br></p>

<p>Applications Uric Acid-1,3-15N2 is the labeled analogue of Uric Acid (U829200), a heterocyclcic compound that is created when purine nucleotides are broken down of by the human body. High blood concetration of Uric Acid is known as hyperuricemia and is often associated with a wide range of disorders and medical conditions such as gout, diabetes and metabolic syndrome. Uric acid may be a marker of oxidative stress and may have a potential therapeutic role as an antioxidant.<br>References Heinig, M. et al.: Cle. Clin. J. Med., 73, 1059 (2006); Glantzounis, G.K. et al.: Curr. Pharmac. Des., 11, 4145 (2005); Dehghan, A. et al.: Diab. Care, 31, 361 (2008); Nakagawa, T. et al.: Am. J. Physiol. Renal Physiol., 290, F625 (2006)<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Ropivacaine (R675000). Anesthetic (local).<br>References Cederholm. I., et al.: Reg. Anesth., 19, 18 (1994), Johansson, B., et al.: Anesth. Analg., 78, 210 (1994), Oda, Y., et al.: Anesthesiology, 82, 214 (1995),<br></p>

<p>Applications (±)-Haloxyfop-d4 is the labeled analogue of (±)-Haloxyfop (H104040) a herbicide.<br>References Manalil, S., et. al.: Weed Sci., 59, 210 (2011);<br></p>

<p>Applications Cetrimonium Chloride, is a topical antiseptic. It is also used in hair conditioners and shampoos, as a conditioning agent<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zahang, M. et al.: Zoazhi Huaxueoin, 24, 13 (2012);<br></p>

<p>Applications Enrofloxacin-d5 is a labelled fluorinated quinolone antibacterial.<br>References Altreuther, P., et al.: Vet. Med. Rev., 2, 87 (1987),<br></p>

<p>Applications A sonic hedgehog inhibitor. Also a possible inhibitor of prostaglandin endoperodixide synthases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kalgutkar, A.S., et al.: J. Med. Chem., 39, 8, 1692 (1996), Biochem., 40, 4359 (2001),<br></p>

<p>Stability Hygroscopic<br>Applications Mefruside is a diuretic used for the treatment of edema and hypertension.<br>References Johansen, A., et al.: Euro. J. Epidemiol., 27, 63 (2012); Hasegawa, Y., et al.: Blood. Press. Supple., 1, 10 (2010);<br></p>

<p>Applications Reagent used in the preparation of antifungal agents and MDMA analogs.<br>References Obase, H., et al.: Chem. Pharm. Bull., 30, 462 (1982), Zacchino, S., et al.: J. Nat. Products, 62, 1353 (1999),<br></p>