Toxicologie

<p>Applications Used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.<br>References Gillet, Y., et al.: Lancet, 359, 753 (2002), Turos, E., et al.: Bioorg. Med. Chem. Lett., 2002, 12, 2229 (2002),<br></p>

<p>Applications Deguelin exhibits potent apoptotic and antiangiogenic activities in a variety of transformed cells and cancer cells. Deguelin also exhibits potent tumor suppressive effects in xenograft tumor models for many human cancers.<br>References Chang, D.J.. et al.: J. Med. Chem., 55, 10863 (2012);<br></p>

<p>Applications A steroid used as a probe in the detection of different viruses.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lin, L. et al., J. Virol. Methods, 171, 91 (2010); Finnegan, C.J. et al., J. Virol. Methods, 121, 223 (2004); Rubio, L. et al., J. Virol. Methods, 114, 105 (2003)<br></p>

<p>Applications Isotope labelled Resiquimod (R144680) is an imidazoquinoline derivative that acts as an immune response modifier. Resiquimod shows antitumor and antiviral activity and is used in the treatment of skin lesions such as herpes simplex virus. Resiquimod is a toll-like receptor 9 (TLR7) agonist.<br>References Wu, J.J. et al.: Antivir. Res., 64, 79 (2004); Fife, K.H. et al.: Antimicrob. Agents Chemother., 52, 477 (2008); Szeimies, R.M. et al.: Brit. J. Dermatol., 159, 205 (2008);<br></p>

<p>Applications Brodifacoum is a highly lethal vitamin K antagonist anticoagulant poison. In recent years, Broadifacoum, has become one of the world's most widely used pesticides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Scordo, M., et al.: Clin. Pharmacol. Ther., 72, 702 (2002), Meijer, W., et al.: Eur. J. Clin. Pharmacol., 60, 57 (2004), Jones, D., et al.: Chem. Res. Toxicol., 23, 939 (2010),<br></p>

<p>Applications Niraparib is a novel oral poly(ADP-ribose)polymerase (PARP) inhibitor efficacious in BRCA-1 and -2 mutant tumors.<br>References Jones, P., et al.: J. Med. Chem., 52, 7170 (2009); Giannini, G., et al.: Bioorg. Med. Chem. Lett., 24, 462 (2014)<br></p>

<p>Stability Hygroscopic<br>Applications Thionazin is a highly toxic organophosphorus pesticide used to protect crops and gardens from microorganisms and pests (such as the glasshouse whitefly and wireworms).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Critchley, B.: Bull. Entomol. Res., 62, 327 (1972); French, N., et al.: Plant Pathol., 22, 99 (1973); Griffiths, D.: Entomol. Exp. Appl., 10, 171 (1967); Lloyd, G. &amp; Bell, G.: Analyst, 91, 808 (1966)<br></p>

<p>Applications Ruxolitinib is a selective Janus tyrosine kinase (JAK1 and JAK2) inhibitor used in the treatment of myeloproliferative neoplasms and psoriasis. Potent JAK2 inhibitor.<br>References Shilling, A.D. et al.: Drug Metab. Disp., 38, 2023 (2010); Mesa, R.A.: IDrugs, 13, 394 (2010); Campas-Moya, C.: Drugs Fut., 35, 457 (2010);<br></p>

<p>Applications Bromoxynil is a nitrile herbicide. Bromoxynil is effective in post-emergent control of broad leaf weeds in cereal, corn, sorghum, onions, flax, mint, turf, and on non-cropland.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bhattacharya, S.P. et al.: Pesticides, 22, 7 (1988); Culpepper, A.S. et al.: Weed Technol., 12, 554 (1998); Rosales-Robles, E. et al.: Weed Technol., 19, 385 (2005);<br></p>

<p>Applications Labelled rac-Nicotine (N412420). Nicotine is an alkaloid isolated from plants. Nicotine is an active stimulant, having both addictive and carcinogenic properties. Nicotine can be absorbed through the alimentary canal, respiratory tract and intact skin. Nicotine is used in the treatment of smoking withdrawal syndrome. Nicotine has been used as an anthelmintic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Guillen, M., et al.: J. Agric. Food Chem., 53, 1093 (2005), Alburges, M., et al.: Eur. J. Pharmacol., 573, 124 (2007), Roy, K., et al.: Eur. J. Med. Chem., 44, 1941 (2009),<br></p>

<p>Applications Isotope labelled Acetamide (A133060) which is often used as plasticizer and as industrial solvent (1). It can also be used for the transamidation of carboxamides in 1,4-dioxane in the absence of a catalyst (2) . Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Ma, X. et al.: Carb. Polym. 2004 Aug:57(2):197-2032. Vanjari, R. et al.: Tetrahedron. Lett. 2013 MayL54(20):2553-5<br></p>

<p>Applications Acrivastine is an allergy medication that is histamine H2 antagonists.<br>References Manna, V.K., et al.: J. Int. Med. Res., 20, 106 (1992);<br></p>

<p>Stability Hygroscopic<br>Applications EPTC is a pesticide, S-Ethyl-N,N-dipropylthiocarbamate<br></p>

<p>Applications An isotopically labelled version of Valsartan (V095750), a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.<br>References Criscione, L., et al.: Brit. J. Pharmacol., 110, 761 (1993), Muller, P., et al.: Eur. J. Clin. Pharmacol., 47, 231 (1994)<br></p>

<p>Stability Hygroscopic<br>Applications An alpha agonist, causing constriction of conjunctival blood vessels. Used in over-the-counter eye drops, this compound relieves the redness left by ocular irritants.<br>References Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13, 2881 (2005), Sandri, G., et al.: Eur. J. Pharm. Biopharm., 62, 59 (2006), Rosenthal, R., et al.: J. Ocular Pharmacol. Ther., 22, 440 (2007), Sabio, S., et al.: J. App. Oral Sci., 16, 280 (2008),<br></p>

<p>Applications Antiarrhythmic (class IA). Sodium channel blocker.<br>References Adelstein, et al.: J. Med. Chem., 16, 309 (1973), Czeisler, J.L., et al.: J. Pharm. Sci., 74, 750 (1985), Taylor, E.H., et al.: Ann. Clin. Lab. Sci., 16, 289 (1986),<br></p>

<p>Stability Hygroscopic<br>Applications Labelled Loperamide, which is used as an antidiarrheal.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Stokbroekx, et al.: J. Med. Chem., 1, 782 (1973), Carter, J.E., et al.: Anal. Profiles Drug Subs., 19, 341 (1990),<br></p>

<p>Applications Dimethyldimyristylammonium Chloride is used as a surfactant.<br>References Cipiciani, A., et al.: Austr. J. Chem., 44, 1505 (1991); Hueck, H., et al.: Appl. Microbiol., 14, 308 (1966)<br></p>

<p>Applications Ethoxysulfuron<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>