Toxicologie

Applications Fenamidone Metabolite

Applications Isotope labelled Sacubitril is an antihypertensive drug used in combination with Valsartan (V095750). The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
References McMurray, J., et al.: N. Eng. J. Med., 371 (2014);

Applications L-Anserine (cas# 584-85-0) is a useful research chemical.

Applications Albuterol-d4, is the labeled analogue of Albuterol (A514500), a β2-adrenoceptor agonist, bronchodilator, and tocolytic.
References Brittain, R.T., et al.: Nature, 219, 862 (1968), Cullum, V.A, et al.: Br. J. Pharmacol. 35, 141 (1969), Martin, L.E., et al.: Eur. J. Pharmacol., 14, 183 (1971), Aboul-Enein, H.Y., Anal. Profiles Drug Subs., 10, 665 (1981)

Applications Imazamox Methyl Ester is a derivative of Imazamox (I268550), an imidazolinone based acetolactate synthase inhibitor that is utilized as a herbicide for weed control.
References Riar, D.S., et al.: Int. J. Agron., 8 (2012); Grey, T.L., et al.: Weed. Technol., 26, 405 (2012); Rousonelos, S.L., et al.: Weed. Sci., 60, 335 (2012);

Stability Moisture Senitive
Applications 2,4'-Dichlorodiphenyltrichloroethane is a chlorinated organic pesticide having estrogenic activity.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Iwata, H., et al.: Environ. Sci. Technol., 27, 1080 (1993), Beyer, A., et al.: Environ. Toxicol. Chem., 21, 941 (2002), Cunningham, S., et al.: Science, 317, 935 (2007),

Applications Labelled Azithromycin, a semi-synthetic macrolide antibiotic; related to Erythromycin A. Antibacterial.
References Langtry, H.D., et al.: Drugs, 56, 273 (1998),

Applications Niclosamide is used as an anthelmintic drug (Cestodes).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Loftsson, T., et al.: J. Pharm. Sci., 85, 1017 (1996), Malik, N., et al.: Anti. Cancer Drugs, 10, 767 (1999), El-Sayed, M., et al.: Pharm. Res., 18, 23 (2001),

Applications Isotope labelled herbicide
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hollender, J., et al.: Environ. Sci. Technol., 43, 7862 (2009), Bollman, S., et al.: Weed Technol., 23, 264 (2009), Goudarzi, N., et al.: J. Agric. Food Chem., 57, 7153 (2009),

Impurity Ribavirin EP Impurity D
Applications N-Des-1-β-D-ribofuranosyl Ribavirin (Ribavirin EP Impurity D) is an impurity in the synthesis of Ribavirin (R414475), a purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.
References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986), Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993), Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994), Reichard, O., et al.: Lancet, 351, 83 (1998)

Applications Labelled Sulbactam (S699185). A semi-synthetic β-lactamase inhibitor. It is used in combination with β-lactam antibiotics as antibacterial.
References English, A.R., et al.: Antimicrob. Agents Chemother., 14, 414 (1978), Stromberg, B.V., Surg. Gynecol. Obstet., 162, 575 (1986), Mehtar, S., et al.: J. Antimicrob. Chemother., 17, 389 (1986), Campoli-Richards, D.M., et al.: Drugs, 33, 577 (1987),

Applications Daptomycin is a Cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial.
References Allen, N.E., et al.: Antimicrob. Agents Chemother., 31, 1093 (1987), Tully, F.P., et al.: Expert Opin. Invest. Drugs, 8, 1223 (1999),

Applications A novel neonicotinid insecticide against Holotrichia consanguinea in sugarcane. Reports show that when exposed to neonicotinid pesticides honeybees have problems returnibg home after foraging and bumblebee colonies grow poorly and produce fewer queens. Used in Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Srivastava, A., et al.: Indian Sugar, 32, 673 (1983), Fleming, R., et al.: J. Econ. Entomol., 78, 1179 (1985), Rao, Ch.V., et al.: Pestology, 35, 47 (2011), Chem. and Eng. News 90: 10 (2012)

Applications A labelled metabolite of Metronidazole (M338880).
References Haller, I., et al.: Antimicrob. Agents Chemother., 22, 165 (1982), Gibson, R., et al.: Clin. Chem., 30, 784 (1984), Kuti, J., et al.: Pharmacotherapy, 25, 935 (2005),

Applications An endogenous estrogen metabolite, risk-factor for development of breast cancer.
References Beral, V., et al.: Lancet, 362, 419 (2003), Nelson, R., et al.: Clin. Chem., 50, 373 (2004), Malekinejad, H., et al.: J. Agric. Food Chem., 54, 9785 (2006),

Stability Hygroscopic
Applications A major biodegradation product of Malathion (M111000).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Kim, Y. et al.: Chemosphere, 60, 1349 (2005); Yoshii, K. et al.: J. Health Sci., 54, 535 (2008); Hayasaka, M. et al.: Jap. J. Forensic Toxicol., 12, 15 (1994);

Applications 2-Amino-4-(methylsulfonyl)benzoic Acid is a reagent used in the synthesis of anthranilic diamides containing fluorinated groups as potential ryanodine receptors activators.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wu, C. et al.: Chem. Lett., 28, 1248 (2017);