Toxicologie

Applications Trestolone acetate is a derivative of Trestolone (T719600), a synthetic androgen used as a potential hormonal male contraceptive method that induces a state of temporary infertility.
References Garcia-Becerra, R., et al.: Reproduction., 143, 211 (2012); Attardi, B.J., et al.: J. Steroid. Biochem. Molec. Biol., 122, 212 (2010)

Impurity Ambroxol EP Impurity B Hydrochloride
Stability Hygroscopic
Applications Ambroxol Cyclic Impurity is a metabolite as well as an impurity of the bronchosecretolytic drug, Ambroxol (A575900).
References Hammer, R. et al.: Arzneim.-Forsch., 28, 899 (1978); Nieder, M. et al.: HRC & CC, 9, 561 (1986); Huq, F. et al.: J. Pharmacol. Toxicol., 3, 147 (2008);

Stability Hygroscopic
Applications The optically active isomer of Carvedilol (C184625), a nonselective ß-adrenergic blocker with a1-blocking activity. An antihypertensive used in the treatment of congestive heart failure.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hirohashi, M., et al.: Arzneim.-Forsch., 40, 735 (1990),

Applications Caffeidine Acid is a potential degradation product from the hydrolysis of Caffeine (C080100) under alkaline environment.
References Zubair, U.M., et al.: Anal. Profiles Drug Subs., 15, 71 (1986); Cherrah, Y., et al.: Biochem. Pharmacol., 37, 1311 (1988);

Applications Inhibits the enzyme HMG-CoA reductase in vitro.
References Endo, A., et al.: J. Antibiot., 32, 852 (1979), Alberts, A.W., et al.: Drug Invest., 2 (Suppl. 2), 9 (1990), Kuroda, M., et al.: Biochim. Biophys. Acta, 486, 70 (1977),

Applications A Rosuvastatin (R700500) intermediate as HMG-CoA reductase inhibitor.
References Beck, et al.: J. Med. Chem., 33, 52 (1999),

Applications An Epinephrine (E588585) derivative formed in injection solutions and eye drops during sterilization and storage of L-Epinephrine Bitartrate.
References De Mol, N.J. et al.: Pharmac. Week., 117, 1 (1982); Liu, C. et al.: Yao. Fen. Zaz., 2, 200 (1982);

Applications 4-Hydroxy Flecainide is an analogue of Flecainide (F390000).
References Blom, Y., et al.: J. Chromatogr., 653, 138 (1993),

Applications Isometheptene Maleate belongs to a group of sympathomimetic amine and shows very little antihypertensive activity. Isometheptene Maleate is used as an antispasmodic drug.
References Vidrio, H. et al.: J. Pharmacol. Exp. Therap., 187, 308 (1973); Taylor, W.G. et al.: Drug Metab. Disp., 5, 564 (1977);

Applications S-Form of Dropropizine. Cough suppressive phenylpiperazine derivative. Antitussive.
References Noel, P.R.B., et al.: Arzneim.-Forsch., 19, 1246 (1969), Cartwright, K., et al.: J. Pharm. Pharmacol., 23, Suppl., 247S (1971), Moreo, GC., et al.: Gazz. Med. Ital., 140, 409 (1981),

Impurity Norethindrone Acetate EP Impurity F
Applications 6β-Hydroxy Norethindrone Acetate (Norethindrone Acetate EP Impurity F) is an oxidative product of the drug Norethindrone (N676000). Norethindrone impurity.
References Reif, V., et al.: Pharmaceutical Res., 4, 54 (1987), Rao, P., et al.: Steroids, 59, 621 (1994),

Impurity Rosuvastatin EP Impurity B
Stability Hygroscopic
Applications A diastereomer of Rosuvastatin (R700500) used for treatment, prevention and combination therapy of lipid-related disorders. Rosuvastatin EP Impurity B

Applications 5-(4-Fluorophenyl)-2,3-dihydro-3-(1-methylethyl)-2-oxo-N,4-diphenyl-1-[2-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxamide is a photodegradation product of Atorvastatin (A791750).
References Cermola, F., et al.: Tetrahedron., 62, 7390 (2006);

Applications Prednival was used in the study of inflammation-inhibiting activity of steroids.
References Bodor, N., et al.: J. Med. Chem., 26, 318 (1983); Stouch, T., et al.: J. Med. Chem., 29, 2125 (2986);

Applications Stigmasta-3,5-diene is one of the components found in vegetable oil after refining.
References Lanzon, A., et al.: J. Am. Oil Chemist Soc., 71, 285 (1994); Cert, A., et al.: Food Chem., 49, 287 (1994)

Impurity Ethinylestradiol EP Impurity H
Applications A degradation product of Ethynyl Estradiol (EE), (E685100).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Impurity Fluticasone USP Related Compound B
Applications An impurity of Fluticasone Propionate (F599500), a derivative of Flumethasone (F455000). An antiallergic; anti-asthmatic; anti-inflammatory. Fluticasone USP Related Compound B.
References Matuszewski, B, et al.: Anal. Chem., 75, 3019 (2003), Fekete, S., et al.: J. Pharm. Biomed. Anal., 49, 64 (2009), Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990), Mitchison, H.C., et al.: Gut, 32, 260 (1991), Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)

Stability Hygroscopic
Applications 4-Hydroxy Estrone 1-N7-Guanine is an estrogen metabolite formed with DNA which can lead to the mutations that initiate breast, prostate, and other types of cancer. Estrogen-DNA depurinating adducts as biomarkers of cancer risk and their use in cancer detection and prevention.
References Chakravarti, D., et al.: Mutat. Res., 456, 17 (2000), Liehr, J., et al.: Endocr. Rev., 21, 4054 (2000), Chakravarti, D., et al.: Oncogene, 20, 7945 (2001), Cavalieri, E., et al.: Chem. Res. Toxicol., 14, 1041 (2002),

Applications CRL-40,941 is a wakefulness-promoting agent. It was found to produce antiaggressive effects in animals.
References Lafon, L.: US4489095 (A) (1984)

Applications Fipexide Hydrochloride is one of five potential drug candidates to overcome the melphalan-induced vascular toxicity.
References Yang, Y., et al.: Tumour Biol., 37, 6709-6718 (2016);

Applications Diazoxide-d3 is the labeled analogue of Diazoxide (D417305), which reduces status epilepticus neuron damage in diabetes.
References Baba, A., et al.: J. Neurosci., 23, 7737 (2003); Bancila, V., et al.: J. Neurochem., 90, 1243 (2004); Bancila, V., et al.: J. Biol. Chem., 280, 8793 (2005)

Stability Hygroscopic
Applications A metabolite of Cortisol (H714615).
References Quinkler, M., et al.: J. Clin. Endocrinol. Metab., 88, 2384 (2003), Draper, N., et al.: J. Endocrinol., 186, 251 (2005), Kotlowska, A., et al.: Clin. Biochem., 42, 448 (2009),

Applications Bromfenac is a non-steroidal anti-inflammatory agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Obach, R., et al.: Drug Metab. Disposition, 36, 1385 (2008), MacDonald, J., et al.: Toxicol. Sci., 110, 40 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009),

Impurity Ipratropium EP Impurity E
Applications N-Isopropyl Noratropine is a Noratropine derivative, an intermediate in the production of Ipratropium.
References Simms, P., et al.: J. Pharm. Biomed. Anal., 17, 841 (1998),

Applications Labelled 7α-Hydroxy-4-cholesten-3-one (H825130). 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).
References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969),

Applications N-Desmethyl Ulipristal Acetate is the N-monodemethylated analogue and metabolite of the selective progesterone receptor modulator Ulipristal Acetate (U700810). N-Desmethyl Ulipristal Acetate contributes significantly to the antiprogestational activity of its parent compound.
References Attardi, B.J. et al.: J. Steroid Biochem. Mol. Biol., 88, 277 (2004);

Stability Light Sensitive
Applications β-Cembrenediol is an inhibitor of tumor promotion. Novel c-Met inhibitors which are used in anticancer treatments.
References Le-Huu, P. et al.: ChemCatChem., 8, 3755 (2016); Ebrahim, H. et al.: Bioorg. Med. Chem., 24, 5748 (2016);

Applications Pipamazine is a drug od the phenothiazine class which used to be used as an antiemetic.
References Bhargava, K. et al.: Br. J. Pharmacol. Chemother., 22, 154 (1964); Bhargava, K. et al.: Br. J. Pharmacol. Chemother., 21, 436 (1963);

Applications Methyltriphenylphosphonium Bromide is a lipophilic molecule with a cation allowing for it to be used to deliver molecules to specific cell components. Also considered an antineoplastic agent.
References Selassie, C.D. et al.: J. Med. Chem., 33, 1914 (1990); Venkatachalam, M.A et al.: Kidney Int., 49, 449 (1996);

Stability Hygroscopic
Applications A metabolite of Equilin (E592800).
References Enmark, E., et al.: J. Clin. Endocrinol. Metab., 82, 4258 (1997), Wang, Z., et al.: J. Med. Chem., 43, 2419 (2000), Jiang, X., et al.: Steroids, 71, 334 (2006),

Applications α-Propyl-α-(1-demethylethyl)-Verapamil is an impurity of Verapamil (V125000, HCl salt) which is a calcium channel blocker.
References Atlas, D, and Adler, M.: Proc. Natl. Acad. Sci. USA, 78, 1237 (1981), Janis, R., et al.: Adv. Drug. Res., 16, 309 (1987)

Applications Propoxyphenyl-thiohydroxyhomosildenafil is an analogue of Hydroxythiohomo Sildenafil (H963150).
References Balayssac, S., et. al.: J. Pharmaceut. Biomed., 63, 135 (2012)

Impurity Fulvestrant EP Impurity B
Applications A metabolite of Fulvestrant (F862500).
References Rao, P., et al.: J. Steroid Biochem., 25, 417 (1986), Wakeling, A., et al.: J. Steroid Biochem. Mol. Biol., 43, 173 (1992), DeFriend, D., et al.: Cancer Res., 54, 408 (1994),

Stability Light Sensitive, Temperature Sensitive
Applications A metabolite of all-trans Retinoic acid (R250200).
References Idres, N., et al.: Cancer Res., 61, 700 (2001), Taimi, M., et al.: J. Biol. Chem., 279, 77 (2004), Vermot, J., et al.: Science, 308, 563 (2005),

Applications Atorvastatin impurity. Atorvastatin Methyl Ester
References Graul, A., et al.: Drugs Future, 22, 956 (1997),

Applications Atorvastatin Derivative

Impurity Fluticasone EP Impurity D
Applications Ticabesone Propionate is an impurity of Fluticasone, an antiallergic, anti-asthmatic and anti-inflammatory agent.
References Marrero-Ponce, Y., et al.: Europ. J. Med. Chem., 46, 5736 (2011); Dalvi, P., et al.: J. Chem., 20, 187 (2008);

Applications Carbimazole, a prodrug of Methimazole (M260300), is used in the treatment of hyperthyroidism.
References Marchant, B., et al.: J. Clin. Endocrinol. Metab., 45, 1187 (1977), Johnsson, E., et al.: Lancet, 350, 1520 (1997),

Impurity Pilocarpine Hydrochloride EP Impurity B
Stability Hygroscopic
Applications Pilocarpic Acid Sodium Salt is an imidazole derivative used in the preparation of novel sequentially labile pilocarpine prodrugs for improved ocular delivery.
References Bungaard, H. et al.: J. Med. Chem., 28, 978 (1985); Jarvinen, T.e t al.: Int. J. Pharmac., 79, 233 (1992);

Applications Labelled Fenvalerate (F279450). An insecticide, used to control insects from food crops, animal feed and cotton products.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sharma, R., et al.: Environ. Ecol., 27, 1481 (2009), Choudhary, S., et al.: J. Industrial Poll. Cont., 25, 145 (2009), Tang, J., et al.: Pest Man. Sci., 66, 121 (2010), Ai, G., et al.: J. Agric. Food Chem., 58, 694 (2010),

Applications 4-Guanidinobutanoic Acid-D6 is an isotopic labeled compound of 4-Guanidinobutanoic acid (G825100). 4-Guanidinobutanoic acid is a guanidine derivative and a metabolite a found in urine, synthesized by gut microbiota.
References Yu, C.; et al.: Biomed. Chromatogr., 32 (2018); Lin, Z.; et al.: Scientific Reports, 8, 1 (2018).

Stability Hygroscopic
Applications A nucleoside analog phosphates for topical use in the treatment of herpes virus infections. A topical treatment that seems to bypass a key mechanism responsible for resistance to Acyclovir.
References Furman, P., et al.: J. Virol., 32, 72 (1979), Darby, G., et al.: J. Gen. Virol., 48, 451 (1980),Prisbe, E., et al.: J. Med. Chem., 29, 671 (1986), Ellis, M., et al.: Antimicrob. Agents Chemother., 33, 304 (1989),

Stability Hygroscopic
Applications The main metabolite of Omeprazole.
References Renberg, L., et al.: Drug Metab. Dispos., 17, 69 (1989), Calabresi, L., et al.: Pharmacol. Res., 49, 493 (2004), Yin, O., et al.: J. Clin. Pharmacol., 44, 582 (2004),

Applications Controlled substance. CNS stimulant. The more potent isomers of Methylphenidate. The threo enantomers have shown that the pharmacological activity residues predominantly in the d-threo enantiomer.
References Greenblatt, E.N., et al.: J. Pharmacol. Exp. Ther., 131, 115 (1961), Padmanabhan, G.R., et al.: Anal. Profiles Drug Subs., 10, 473 (1981), Kuczenski, R., et al.: J. Pharmacol. Exp. Ther., 296, 876 (2001), Pelham, W.E., et al.: J. Consult. Clin. Psychol., 61, 506 (1993), Srinivas, N.R., et al.: Pharm. Res., 10, 14 (1993),

Stability Hygroscopic
Applications Fencamfamine is a CNS stimulant. This is a controlled substance (stimulant).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Hotovy, R., et al.: Arzneim.-Forsch., 11, 20 (1961), DeLucia, R., et al.: Gen. Pharmacol., 21, 161 (1990), Planeta, C., et al.: Pharmacol. Biochem. Behav., 50, 35 (1995),

Applications Norepinephrine Sulfonic Acid is a derivative of DL-Norepinephrine Hydrochloride (N674500), antagonist of dibutyryl cyclic-AMP in the regulation of narcosis. Norepinephrine modulates human dendritic cell activation by altering cytokine release.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Piguet, P., et al.: J. Exp. Med., 173, 673 (1991), Hosoi, J., et al.: Nature, 363, 159 (1993), Elenkov, I., et al.: Pharmacol. Rev., 52, 595 (2000), Kaplan, D., et al.: Immunity, 23, 611 (2005),

Stability Light Sensitive
Applications 3-Methyl-4-nitroimino-tetrahydro-1,3,5-oxadiazine is a useful synthetic intermediate in the synthesis of Thiamethoxam (T344180); a neonicotinoid insecticide.
References Maienfisch, P., et al.: Z. Naturforsch. B., 61, 353 (2006); Fan, W., et al.: Shanghai Huagong, 27, 25 (2002); Maienfisch, P., et al.: Chimia, 57, 710 (2003); Oliver, J., et al.: J. Environ. Horticult., 28, 135 (2010); Ghosh, A., et al.: J. Entomol. Res., 34, 35 (2010)

Applications Iprovalicarb-d8 is the deuterated form of Iprovalicarb (I747500), which is a systematic fungicide. Iprovalicarb is used for the control of pathogenic fungi from the oomycetes class in grapes, potatoes, tomatoes and other crops.
References Stubler, D., et al.: Pflanzensch.-Nach. Bay., 52, 33 (1999); Stenzel, K., et al.: Bright. Crop Prot. Conf. Pests Dis., 2, 367 (1998);

Applications It is a potent and selective human CYP2C19 inhibitor.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Suzuki, H., et al.: Drug Metab. Dispos., 30, 235 (2002), Robert, L., et al.: Drug Metab. Dispos., 31, 343 (2003),

Impurity Ampicillin EP Impurity A ; Amoxicillin USP Related Compound A
Applications (+)-6-Aminopenicillanic Acid (Amoxicillin EP Impurity A) is the core structure in penicillins, obtained from the fermentation brew of the Penicillium mold. (+)-6-Aminopenicillanic Acid is used as the main starting block for the preparation of numerous semisynthetic penicillins.
References Zel'tser, I.Z. et al.: Gig. Truda Prof. Zabol., 5, 59 (1983); Hamilton-Miller, J.M.T.: Int. J. Antimicrob. Agents, 31, 189 (2008); Novikova, N.D. et al.: Mikol. Fitopatol., 7, 101 (1973);

Impurity Fluconazole EP Impurity H
Applications 2-(2,4-Difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)-3-bromopropan-2-ol (Fluconazole EP Impurity H) is an impurity of the antifungal agent Fluconazole (F421000).
References Bourichi, H., et al.: STP Pharma Pratiques, 18, 285 (2008); Richard, K. et al.: Antimicrob. Ag. Chemother., 27, 832 (1985)

Applications Intermediate in the preparation of imidazole antifungal agents.
References Albet, C. et al.; J. Pharmaceut. Biomed. 10, 205 (1992); Raga, M. et al.; Eur. J. Med. Chem. 21, 329 (1986)

Stability Light Sensitive
Applications N-Desmethyl (E)-α-Hydroxy Tamoxifen is a N-demethylated, α-Hydroxyated metabolite of Tamoxifen (T006000).
References Poon, G.K. et al.: Drug Metab.Dispos. 23,377 (1995); Teunissen, S.F. et al.: J. Pharmac. Biomed. Anal., 55, 518 (2011); Muerdter, T.E. et al.: Clin. Pharmacol. Therap., 89, 708 (2011);

Applications Acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor. Used as an anti-HIV agent. Antiviral.
References Shaw, J.-P., et al.: Pharm. Res., 14, 1824 (1997), Wyles, D., et al.: Clin Infect. Dis., 40, 174 (2005), Peng, J., et al.: J. Clin. Pharmacol., 46, 265 (2006), Seminari, E., et al.: J. Antimicrob. Chemother., 60, 831 (2007),

Applications Chloramphenicol Succinate Sodium is a derivative of Chloramphenicol (C325030) which are broad spectrum antibiotic obtained from cultures of the soil bacterium Streptomyces venezuelae. It has a broad spectrum of activity against Gram-positive and gram-negative bacteria. Antibacterial; antirickettsial.
References Bartz, et al.: J. Biol. Chem., et al.: 172, 445 (1948), Gottlieb, et al.: J. Bacteriol., 55, 409 (1948), Szulczewski, D., et al.: Anal. Profiles Drug Subs., 4, 47 (1975), Price, A., et al.: J. Antibiot., 43, 118 (1981), Shalit, I., et al.: Drugs, 28, 281 (1984),

Applications Amphotericin B Methyl Ester is the methyl ester derivative of the polyene antibiotic Amphotericin B (A634250). Amphotericin B Methyl Esterin is a cholesterol binding compound that showed inhibiton of human immunodeficiency virus type 1 (HIV-1).
References Waheed, A.A. et al.: J. Biol. Chem., 281, 28699 (2006); Waheed, A. et al.: J. Virol., 82, 9776 (2008); Waheed, A., et al.: J. Biol. Chem., 281, 28699 (2006)

Applications (4R,6S)-rel-5,6-Dihydro-4-hydroxy-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-Dioxide is used as a reactant in the preparation of Dorzolamide Hydrochloride (D535100), which is a carbonic anhydrase inhibitor; antiglaucoma agent.
References Lippa, E.A., et al.: Ophthalmology, 98, 308 (1991); Wang, R.-F., et al.: Arch. Ophthalmol., 109, 1297 (1991); Whikehart, D., et al.: J. Ocul. Pharmacol., 7, 195 (1991); Sjoquist, B., et al.: Drug Metab. Dispos., 26, 745 (1998);

Applications An impurity of Trimethoprim (T795615) with inhibitory effects on the enzyme dihydrofolate reductase.
References Kompis, I. et al.: Enzyme Inhib. Proc. Meet., 177 (1980); Hess, S. et al.: J. Pharmac. Biomed. Anal., 25, 531 (2001);

Applications Second-generation cephalosporin antibiotic. Antibacterial.
References Gray, B.M., et al.: Antimicrob. Agents Chemother., 13, 988 (1978), Lorenz, L.J., et al.: Anal. Profiles Drug Subs., 9, 107 (1980), Hori, R., et al.: J. Pharm. Pharmacol., 40, 646 (1988),

Applications Alogliptin Benzoate is an oral antihyperglycemic agent that is a selective inhibitor of the enzyme dipeptidyl peptidase-4 (DPP-4). Alogliptin Benzoate is used in the treatment of type 2 diabetes.
References Wang, Y., et. al.: Drugs Future, 33, 7 (2008); Lynn, F., et al.: Diabetes, 50, 1004 (2001); Trumper, A., et al.: J. Endocrinol., 174, 233 (2002); Vollmer, K., et al.: J. Clin. Endocrinol. Metab., 94, 1379 (2009)

Applications N-Formyl Erythromycin A is a derivative of Erythromycin (E649950), an antibiotic medication.
References Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979),

Applications (R)-(+)-2-Amino-3-benzyloxy-1-propanol is used as a reagent to synthesize beta-amino alcohols, compounds that are used as therapeutic agents to treat heart disease. (R)-(+)-2-Amino-3-benzyloxy-1-propanol is also used as a reagent to synthesize 15-membered macrolide antibiotics, drugs that are used to treat respiratory tract infections.
References Fisher, G., et al.: J. Org. Chem., 60, 2026 (1995); Metro, T., et al.: J. Org. Chem., 72, 6556 (2007); Sugimoto, T., et al.: Bioorg. Med. Chem., 20, 5787 (2012)

Applications Primary alkaloid of various species of Cinchona (Rubiaceae). Optical isomer of Quinidine. Antimalarial; muscle relaxant (skeletal).
References Muhtadi, F.J., et al.: Anal. Profiles Drug Subs., 12, 547 (1983), Kremsner, P.G., et al.: J. Infect. Dis., 169, 467 (1994),

Impurity Ceftazidime EP Impurity A
Stability Hygroscopic, Light Sensitive
Applications ∆2-Ceftazidime, 90% (Ceftazidime EP Impurity A) is a Ceftazidime isomer, an impurity of Ceftazidime (C244100).
References Vilanova, B., et al.: Helv. Chim. Acta, 76, 2789 (1993), Zhou, M., et al.: J. Pharm. Sci., 84, 534 (1995), Baertschi, S., et al.: Chemother. 8, 353 (1997), Porra, R., et al.: J. Pharm. Biomed. Anal., 18, 241 (1998),

Applications 4-Chloro-3-pyridinesulfonamide is a building block that has been used as a reactant for the preparation of heterocyclic 4-substituted pyridine-3-sulfonamide derivatives as inhibitors of four isoforms of zinc enzyme carbonic anhydrase.
References Slawinski, J., et. al.: Eur. J. Med. Chem., 69, 701 (2013)

Applications 2,2,4-Trimethyl-6(2H)-quinolinone 1-Oxide is a derivative of 2,6-Dihydro-2,2,4-trimethyl-6-quinolone (D449900) which is a metabolite of Ethoxyquin (E892800), an oxidation product of the antidegradant.
References Kahl, R., et al.: Toxicology, 28, 229 (1983), Burka, L., et al.: Xenobiotica, 26, 597 (1996), Bammler, T., et al.: Toxicol. Sci., 54, 30 (2000), Hayes, J., et al.: Cancer, 174, 103 (2001),

Applications Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral.
References Palella, F.J. Jr., et al.: N. Engl. J. Med., 338(13), 853 (1998), Nolan, D., et al.: Drugs, 63(23), 2555 (2003), Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),