Toxicologie

Impurity Anastrozole Monoamide Impurity
Applications Anastrozole Monoamide is a derivative of Anastrozole (A637425), an aromatase inhibitor. Used as an antineoplastic.
References Plourde, P.V., et al.: Breast Cancer Res. Treat., 30, 103 (1994), Buzdar, A.U., et al.: Cancer, 79, 730 (1997)

Stability Hygroscopic
Applications Gentiopicroside is an anticonvulsant agent present in plant extracts.
References Mahendran, G. et al.: Biomed. Res. Int., 2015, 542385 (2014);

Applications A nonsteroidal estrogen antagonist.
References Gladek, A., et al.: J. Biol. Chem., 264, 16847 (1989), Han, X., et al.: Cancer Res., 52, 1360 (1992), Williams, G., et al.: Carcinogenesis, 14, 315 (1993),Coradini, D., et al.: Anticancer Res., 14, 1059 (1994),

Stability Moisture Sensitive
Applications Oxyfedrine acts as a vasodilator affecting the coronary base flow.
References Baraka, Y. et al.: J. Drug Res., 12, 161 (1980);

Impurity Fluocinolone Acetonide EP Impurity B
Applications (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-3-oxoandrosta-1,4-diene-17-carboxylic Acid, is a derivative of Fluocinolone Acetonide (F455800), which is a Corticosteroid, used in dermatology to reduce skin inflammation and relieve itching.
References Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964), Emerson, M.V., et al.: BioDrugs, 21, 245 (2007),

Applications (2R,3S)-N-Benzoyl-3-phenyl Isoserine Methyl Ester is an intermediate in the preparation of potent anticancer drug Paclitaxel (P132500) used to study the location of the binding sites.
References Paal, K. et al.: Bioorg. Med. Chem., 15, 1323 (2007); Krawczyk, E. et al.: J. Pharm. Pharmacol., 57, 791 (2005);

Applications (aS,bR)-Bedaquiline is a diarylquinoline derivative that acts as a mycobacterial inhibitor. Bedaquiline shows promise as potential drug in the treatment of tuberculosis.
References Cheepsattayakorn, A., et al.: Anti-Infect. Drug. Discover.,7, 141 (2012); de Jonge M.R. et al.: Proteins, 67, 971 (2007); Diacon A.H. et al.: N. Eng. J. Med., 360, 2397 (2009);

Applications 4-Hydroxy Flecainide is an analogue of Flecainide (F390000).
References Blom, Y., et al.: J. Chromatogr., 653, 138 (1993),

Stability Hygroscopic
Applications Used as a herbicide.
References Abbas, H., et al.: J. Agric. Food Chem., 50, 5246

Applications Antihistaminic.
References Roth, F.E., et al.: J. Pharmacol. Exp. Ther., 124, 347 (1958), Smith, R.B., et al.: Toxicol. Appl. Pharmacol., 28, 240 (1974), Eckhart, C.G., et al.: Anal. Profiles Drug Subs., 7, 43 (1978)

Applications A major active metabolite related to the adverse effects of Sulfasalazine in human serum.
References Stenson, W., et al.: J. Clin. Invest., 69, 494 (1982), Bissonnette, E., et al.: J. Immunol., 156, 218 (1996), Hirohata, S., et al.: J. Neurol. Sci., 67, 115 (1985), Pullar, T., et al.: Br. Med. J., 290, 1535 (1985), Ireland, A., et al.: Clin. Sci., 78, 119 (1990),

Applications Herbicide safener.
References Lee, H., et al.: Eur. J. Med. Chem., 40, 862 (2005), Wright, S., et al.: Bioorg. Med. Chem. Lett., 17, 5638 (2007), Brazier-Hicks, M., et al.: J. Biol. Chem., 283, 21102 (2008), Vinggaard, A., et al.: Chem. Res. Toxicol., 21, 813 (2008),

Applications Auxin-type herbicide.
References Ecker, J., et al.: Science, 268, 667 (1995), Grossmann, K., et al.: Pestic. Sci., 52, 111 (1998), Martin, P., et al.: Environ. Toxicol. Chem. 19, 2987 (2000), Grossmann, K., et al.: J. Exp. Bot., 52, 1811 (2001), van Eerd, L., et al.: Weed Res., 44, 355 (2004),

Stability Hygroscopic
Applications Tixocortol is an anti-inflammatory agent. Tixocortol is used in fluorescent chemoaffinity labeling.
References Torossian, D.R., et al.: Arzneim.-Forsch., 31, 453 (1981),

Applications Ibogaine Hydrochloride is a naturally occurring psychoactive substance. It is a β-carboline derivative that cause both hallucinations and tremor.
References O’Hearn, E., et al.: Neurosci., 55, 303 (1993)

Applications A metabolite of 13-cis-Retinoic Acid (R250000).
References Samokyszyn, V., et al.: J. Biol. Chem., 262, 14119 (1987), Oldfield, N., et al.: Drug Metabol. Dispos., 18, 1105 (1990), Samokyszyn, V., et al.: Chem. Res. Toxicol., 10, 795 (1997),

Applications Tecloftalam Imide is a derivative of Tecloftalam (T013700), an agrochemical fungicide. Tecloftalam is used for the control of rice bacterial leaf blight.
References Nakagami, K. et al.: Nip. Noyak. Gak., 5, 511 (1980); Kirkpatrick, D. et al.: J. Agric. Food Chem., 29, 608 (1981); Takahi, Y. et al.: Jap. Past. Info., 46, 25 (1985);

Applications Triphenyltin Acetate is an organotin compound. Triphenyltin Acetate much like its hydroxide analogue is used as a fungicide and antifeeding compound for insect control. Recent studies show that Triphenyltin Acetate may have adverse effects on the reproductive and immune systems and may disrupt the endocrine system.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Soderquist, J.S. et al.: J. Agric. Food Chem., 28, 111 (1980); J. Toxicol. Environ. Health, 7, 281 (2004); Livingston, J.M. et al.: J. Georgia Entamol. Soc., 13, 148 (1978); Sarpa, M. et al.: J. Toxicol. Environ. Health, 73, 965 (2010);

Applications Celecoxib-d7 is the labeled analogue of Celecoxib (C251000), a selective cyclooxygenase-2 (COX-2) inhibitor. Anti-inflammatory. Used in treatment of familial adenomatous polyposis.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Simon, L.S., et al.: Arthritis Rheum., 41, 1591 (1998); Silverstein, F.E., et al.: J. Am. Med. Assoc., 284, 1247 (2000); Steinbach, G., et al.: N. Engl. J. Med., 342, 1946 (2000)

Applications Zineb is a fungicide that is a potential contaminant in food and has been under biological studies to evaluate the adverse effect and toxicity of low doses on thyroid function in male rat.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Nebbia, C., et al.: Bull. Environ. Contam. Toxicol., 56, 847 (1996)

Applications Cefodizime is a third generation cephalosporin with a broad spectrum of antibacterial activity. Cefodizime maybe useful in the treatment of otitis media, sinusitis and gynaecological infections, and for the prophylaxis or treatment of surgical infections.
References Barradel, L.B. et al.: Drugs, 44, 800 (1992); Kasai, K. et al.: Jap. J. Antibiot., 37, 1306 (1984);

Applications Isopyridoxal Hydrochloride is an active vitamer of the B6 complex in humans, and a metabolite standard in the determination of all seven vitamin B6-related compounds. It is also a metabolite in a pyridoxine degradation pathway by soil bacteria.
References Edwards, P., et. al.: Clinica Chimica Acta: Int. J. Clin. Chem., 190, (1990); Lee, Y. C., et. al.: J. Bio. Chem., 261, (1986); Argoudelis, C. J.: J. Chromatogr. A, 790, (1998)

Stability Unstable in Solution
Applications Sulfosulfuron is used in the synthetic preparation of herbicidal mixed compositions containing 2-chloro-3-(methylsulfanyl)-N-(1-methyl-1H-tetrazol-5-yl)-4-(trifluoromethyl)benzamide or its salt towards weed control.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lorentz, L.; et al.: PCT Int. Appl. 340pp. Patent 2017 CODEN:PIXXD2

Applications Labelled derivative of Artemisinin. Antimalarial.
References Zhao, Y., et al.: J. Nat. Prod., 49, 139 (1986), Lin, A.J., et al.: J. Med. Chem., 30, 2147 (1987), Price, R. N., et al.: Expert Opin. Invest. Drugs, 9, 1815 (2000),

Applications di(2-Hydroxy Atorvastatin) Calcium Salt is a metabolite of Atorvastatin Calcium Salt (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)

Applications The main metabolite of Nimesulide (N477500).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Facino, R.M., et al.: Drugs, 46 (Suppl1),15 (1993), Westphal, J., et al.: J. Antimicrob. Chemother., 33, 387 (1994), Castell, J., et al.: Cell Biol. Toxicol., 13, 331 (1997), Georges, H., et al.: Life Sci., 65, 151 (1999), Singla, A.K., et al.: J. Pharm. Pharmacol., 52, 467 (2000),

Applications A novel semi-synthetic taxane with antitumor activity used for the treatment of castration-resistant prostate cancer. A microtubule inhibitor.
References Agarwal, N. et al.: Fut. Oncol., 7, 15 (2011); Mita, A. et al.: Clin. Cancer Res., 15, 723 (2009); Figg, W.D. et al.: Cancer Biol. Ther., 10, 1233 (2010);

Applications A metabolite of Mifepristone.
References Heikinheimo, O., et al.: J. Steroid Biochem., 26, 279 (1987), Brogden, R., et al.: Drugs, 45, 384 (1993), Shi, Y., et al.: Contraception, 48, 133 (1993), Jang, G., et al.: Biochem. Pharmacol., 52, 753 (1996), Gainer, E., et al.: Steroids, 68, 1005 (2003),

Stability Hygroscopic
Applications Metabolites of butadiene.
References Heavner, D., et al.: J. Pharm. Biomed. Anal., 40, 928 (2006), Carmella, S., et al.: Chem. Res. Toxicol., 22, 734 (2009),

Applications A synthetic adrenocorticosteroid that acts as an anti-inflammatory and anti-pruritic agents. It is used as a topical for the treatment of dermatologic disorders such as atopic dermatitis and psoriasis.
References Mason, J. et al.: Br. J. Dermatol., 146, 351 (2002); Sears, H.W. et al.: Clin. Therap., 19, 710 (1997); Otomo, Y.Z. et al.: Nip. Yakur. Zas., 78, 647 (1981);

Applications Labelled Telmisartan (T017000). Telmisartan is an angiotensin II receptor antagonist.
References Wienen, W. et al.: Br. J. Pharmacol., 110, 245 (1993); Neutel, J.M. et al: Adv. Therap., 15, 206 (1998);

Applications Nicergoline-d3 is the labeled analogue of Nicergoline(N394550), a drug used for age-dependent cognitive impairment such as Alzheimers disease and other types of dementia.
References Caraci, F., et. al.: Brain Res., 1047, 30 (2005); Mizuno, T., et. al.: Brain Res., 1066, 78 (2005)

Applications A labelled metabolite of Nitazoxanide (N490100); a potent inhibitor of hepatitis B virus and hepatitis C virus. Kills Mycobacterium tuberculosis.
References Allen, M., et al.: Hepatology, 27, 1670 (1998), Blight, K., et al.: Science, 290, 1972 (2000), Blight, K., et al.: J. Virol., 77, 3181 (2003), Courcambeck, J., et al.: Antivir Ther., 11, 847 (2006), Hoffman, P., et al.: Antimicrob. Agents Chemother., 51, 868 (2007); de Carvalho et. al., J. Med. Chem., 52, 5789 (2009)

Applications A metabolite of Clomipramine.
References McTavish, D., et al.: Drugs, 39, 136 (1990), Chauret, N., et al.: Drug Metab. Dispos., 25, 1130 (1997), Gex-Fabry, M., et al.: Ther. Drug Monit., 22, 701 (2000), Herrera, D., et al.: J. Clin. Pharmacol., 40, 1488 (2000),

Impurity Ezetimibe Ketone (USP)
Applications Phase-I metabolite of Ezetimibe (E975000).
References Shah, V., et al: J. Pharm. Sci., 17, 1551 (2000), Van Heek, M., et al.: Br. J. Pharmacol., 134, 409 (2001), Watts, G., et al.: Clin. Sci.,103, 595 (2002), Ghosal, A., et al.: Drug Metab. Dispos., 32, 314 (2004), Sistla, R., et al.: J. Pharm. Biomed. Anal., 39, 517 (2005),

Applications (±)-Sibutramine is a serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure.
References Hanotin, C., et al.: Int. J. Obesity, 22, 32 (1998)

Applications di(4-Hydroxy Atorvastatin-d5) Calcium Salt is a labeled metabolite of Atorvastatin Calcium Salt (A791750), a selective, competitive HMG-CoA reductase inhibitor. Atorvastatin is the only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia.
References Kearney, A.S., et al.: Pharm. Res., 10, 1461 (1993); Heinonen, T.M., et al.: Clin. Ther., 18, 853 (1996); Whitfield, L.R., et al.: Eur. J. Drug Metab. Pharmacokinet., 25, 97 (2000)

Stability Unstable in Solution
Applications Meropenem-d6 is the labeled analogue of Meropenem, a carbapenem antibiotic. Antibacterial.
References Adams, M.D., et al.: J. Bacteriol., 190, 8053 (2008); Pattanaik, P., et al.: J. Biol. Chem., 284, 945 (2009); Mendes, R., et al.: J. Antimicrob. Chemother., 63, 55 (2009)

Applications Diamino-5-phenylthiazole Hydrobromide is an phenylthiazole derivative used in the preparation of antiallergic and antiinflammatory agents.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ban, M. et al.: Bioorg. Med. Chem., 6, 1069 (1998);

Applications 2-Oxo-Zoniporide is an metabolite of Zoniporide, a potent and selective inhibitor of human sodium-hydrogen exchanger isoform1(NHE-1) and protects against cardiac ischemia-reperfusion injury.
References Ross, T.W., et al.: Cardiovascular. Drug. Reviews., 21, 17 (2003); Deepak, D., et al.: Drug. Metabol. Dispos., 38, 641 (2010);

Applications 2-Hydroxydesipramine Dihydrochloride is a metabolite of Desipramine (D290050), a tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter than the serotonin transporter.
References De Jongh, G.D., et al.: Drug Metab. Dispos., 2, 48 (1981); Suckow, R.F., et al.: J. Pharm. Sci., 73, 1745 (1984); Fraser, A.D., et al.: J. Anal. Toxicol., 11,168 (1987); Checkley, S.A, et al.: Br. J. Psychiatry, 138. 248 (1981); Zhu, M.Y., et al.: J. Neurochem., 70, 1547 (1998); Okugawa, G., et al.: J. Neuroindocrinol., 11, 887 (1999); Torres, G.E., et al.: Nat. Rev. Neurosci., 4, 13 (2003)

Applications Cyhalofop is used as a pesticide for controlling pests.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sada, Y. et al.: Jpn. Kok. Tok. Koh. 408 pp. (2020)

Stability Hygroscopic
Applications Thiamine (T344185) impurity.
References Warnock, L., et al.: Anal. Biochem., 126, 394 (1982), Royer-Morrot, J., et al.: Eur. J. Clin. Pharmacol., 42, 219 (1992),

Applications A Nicotine metabolite. Carcinogen.

Applications Quintrione is herbicidal compound comprising Heterocyclic Amide compound and use thereof.
References Wang, Z., et al.:PCT Int. Appl., (2020);

Impurity Bisoprolol EP Impurity L (Metoprolol EP Impurity C)
Stability Hygrscopic
Applications 4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzaldehyde (Bisoprolol EP Impurity L (Metoprolol EP Impurity C)) is a Metoprolol impurity .
References Baldwin, J.J. , et al.: J. Med. Chem., 29, 1065 (1986), Ravelet, C., et al.: J. Sep. Sci., 29, 1322 (2006),

Applications Paichongding is a type of neonicotinoid insecticide.
References Xie, Hui, et al.: Turang Xuebao, 53(1), 232-240 (2016)

Stability Light Sensitive, Temperature Sensitive
Applications An oxidized derivative of the visual pigment carotenoid.
References Wada, A., et al.: Chem. Pharm. Bull., 56, 112 (2008), Smolensky, E., et al.: Biochem., 48, 9170 (2009),

Applications Melphalan is an antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Ross, W.C.J., et al.: Biochem. Pharmacol., 13, 969 (1964); Donelli, M.G., et al.: J. Pharm. Pharmacol., 18, 760 (1966), Furner, R.L., et al.: Cancer Treat. Rep., 64, 559 (1980),

Applications Nithiazine is a useful building block and insecticide.
References Quaranta, L.; et al.: WO 2018149851 (2018).

Applications Spiromesifen is a useful insecticide and miticide in plant breeding. Also useful in cannabis testing kits as a component of pesticide mixes (P698240).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package

Applications Rosuvastatin ethyl ester (CAS# 851443-04-4) is an intermediate formed during the synthetic preparation of rosuvastatin, a pharmaceutical used to manage LDL cholesterol.
References Sterk, D.; et al.: Tetrahedron Lett., 57, 1338 (2016); Olsson, A. G.; et al.: Am. Heart J., 144, 1044 (2002).

Applications An enantiomeric impurity of Ezetimibe (E975005), an antihyperlipoproteinemic and cholesterol absorption inhibitor.

Applications trans-2-Decenoyl-L-carnitine is a metabolite of L-Carnitine (C184110), which is a essential cofactor of fatty acid metabolism; required for the transport of fatty acids through the inner mitochondrial membrane. Synthetized primarily in the liver and kidney; highest concentrations found in heart and skeletal muscle. Dietary sources include red meat, dairy products, beans, avocado.
References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978), Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001), Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002), Karlic, H., et al.: Nutrition, 20, 709 (2004),

Applications Methyl Lithocholate is an derivative of Lithocholic Acid (L469180),a cholic acid derivative as TGR5 modulator. Found in ox bile, human bile, rabbit bile, and in ox and pig gallstones.
References Roleira, F.M., et al.: Lett. Drug. Design. Discovery., 7, 610 (2010);

Stability Hygroscopic
Applications A bile salt formed in the liver from chenodeoxycholate and glycine, usually as the sodium salt. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is a cholagogue and choleretic.
References Parmentier, G. , et al.: Steroids, 30, 583 (1977), Tserng, K.Y., et al.: Lipids, 13, 479 (1978),

Stability Hygroscopic
Applications Anorexic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Pinder, et al.: Drugs, 10, 241 (1975), Caccia, S., et al.: Eur. J. Clin. Pharmacol., 29, 221 (1985), Finner, N., et al.: Curr. Ther. Res., 38, 847 (1985),

Applications A metabolite of Benzydamine (B209950).
References Kataoka, S., et al.: Chem. Pharma. Bull., 21, 358 (1973),

Applications Labelled analogue of Axitinib, a tyrosine kinase inhibitor. Axitinib is used in cancer therapy.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wasser, K. et al.: Eur. Radiol., 13, 80 (2003),; Park, J. et al.: Clin. Cancer Res., 8, 1172 (2002); Bergers, G. et al.: J. Clin. Invest., 111, 1287 (2003);

Applications Labelled Ouabain (O714500). A cardiac glycoside that inhibits Na(+)/K(+) ATPase. It regulates transcription of MDR (increase, Pgp) and MRP (increase MRP1 and decrease CFTR, cyctic fibrosis transport receptor or cAMP-activated Cl- channel) genes, also alters localization of MRP1.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Padilha, A.S. et al.: Clin. Exp. Pharmacol. Physiol., 35, 801 (2008); Blaustein, M.P. et al.: Clin. Exp. Hypertens. 20, 691 (1998); van Huysse, J.W. et al.: Clin. Exp. Hypertens. 20, 657 (1998);

Stability Hygroscopic
Applications Labelled Ropivacaine (R675000). Anesthetic (local).
References Cederholm. I., et al.: Reg. Anesth., 19, 18 (1994), Johansson, B., et al.: Anesth. Analg., 78, 210 (1994), Oda, Y., et al.: Anesthesiology, 82, 214 (1995),

Applications (±)-Haloxyfop-d4 is the labeled analogue of (±)-Haloxyfop (H104040) a herbicide.
References Manalil, S., et. al.: Weed Sci., 59, 210 (2011);

Applications 4-Hydroxy Propofol sulfate sodium salt is a derivative of Propofol, a hypnotic intravenous agent that is commonly used as an anasthetic for conscious sedation.
References GüLCIN, I., et al.: Chem. Pharm. Bull., 53, 281 (2005); Koshy, G., et al.: Am. J. Gastroenterol., 95, 1476 (2000)

Applications Isotope labelled 24 Bisphenol S (B519620) is a material used in thermal printing. 24 Bisphenol S is also used in the development of black leuco dyes.
References Shima, H. et al.: J. Imag. Sci. Technol., 54, 020502 (2010)

Applications N2-(1-Ethylpropyl)-4,5-dimethyl-3-nitro-1,2-benzenediamine is a metabolite of Pendimethalin (P221900), an herbicide used to control the spread of weedgrass.
References Haith, D., et al.: Environ. Sci. Technol., 44, 6496 (2010); Jabran, K., et al.: Int. J. Agric. Biol., 12, 335 (2010); Rahaman, S., et al.: Environ. Ecol., 28, 1 (2010); Smith, R.H., et al.: Chemosphere, 8, 855-61 (1979);

Applications Prednisolone 21-Valerate was used to detect corticosteroid in pharmaceuticals and cosmetics via TLC, LC/MS, and HPLC.
References Park, M., et al.: Yakhak Hoechi, 55, 289 (2011); Kamano, Y., et al.: Tokyo Ika Daigaku Kiyo, 6, 25 (1980);

Applications Cetrimonium Chloride, is a topical antiseptic. It is also used in hair conditioners and shampoos, as a conditioning agent
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Zahang, M. et al.: Zoazhi Huaxueoin, 24, 13 (2012);

Applications Enrofloxacin-d5 is a labelled fluorinated quinolone antibacterial.
References Altreuther, P., et al.: Vet. Med. Rev., 2, 87 (1987),

Applications 5α-Pregnane-3β,20(S)-diol, is a metabolite of Progesterone (P755900).
References Beall, et al.: Biochem. J., 31, 35 (1937), Okuda, A., et al.: J. Biol. Chem., 259, 7519 (1984), Russell, D., et al.: Biochemistry, 31, 4737 (1992), Kondo, K., et al.: Eur. J. Biochem., 219, 357 (1994), Westerbacka, J., et al.: J. Clin. Endocrinol. Metab., 88, 4924 (2003),

Applications Tebutam is used as herbicide and pesticide.

Impurity Azithromycin EP Impurity F / USP Azithromycin Related Compound F
Stability Hygroscopic
Applications Azithromycin impurity.
References Kirst, H., et al.: Antimicrob. Agents Chemother., 33, 1419 (1989), Fouda, H., et al.: Ther. Drug Monit., 17, 179 (1995), Gandhi, R., et al.: J. Pharm. Biomed. Anal., 23, 1073 (2000),

Impurity Fluticasone USP Related Compound B
Applications An impurity of Fluticasone Propionate (F599500), a derivative of Flumethasone (F455000). An antiallergic; anti-asthmatic; anti-inflammatory. Fluticasone USP Related Compound B.
References Matuszewski, B, et al.: Anal. Chem., 75, 3019 (2003), Fekete, S., et al.: J. Pharm. Biomed. Anal., 49, 64 (2009), Meltzer, E.O., et al.: J. Allergy Clin. Immunol., 86, 221 (1990), Mitchison, H.C., et al.: Gut, 32, 260 (1991), Phillipps, G.H., et al.: J. Med. Chem., 37, 3717 (1994)

Impurity Tranexamic EP Impurity A
Applications Tranexamic Acid Dimer (Tranexamic EP Impurity A) is a Tranexamic Acid (T714505) impurity.

Applications A metabolite of Acepromazine (A130900).
References Cossum, P., et al.: Drug Dispos., 9, 321 (1988), Stowell, L., et al.: J. Anal. Toxicol., 22, 166 (1998),

Stability Hygroscopic
Applications Mefruside is a diuretic used for the treatment of edema and hypertension.
References Johansen, A., et al.: Euro. J. Epidemiol., 27, 63 (2012); Hasegawa, Y., et al.: Blood. Press. Supple., 1, 10 (2010);

Applications Reagent used in the preparation of antifungal agents and MDMA analogs.
References Obase, H., et al.: Chem. Pharm. Bull., 30, 462 (1982), Zacchino, S., et al.: J. Nat. Products, 62, 1353 (1999),

Impurity Clobetasol Propionate EP Impurity J
Applications 9α-Fluoro-11β-hydroxy-16-β-methyl-3-oxoandrosta-1,4-diene-17(R)-spiro-2’-[4’-chloro-5’-ethylfuran-3’(2’H)-one (Clobetasol Propionate EP Impurity J) is an impurity in the synthesis of Clobetasol 17-Propionate (C583500), a topical corticosteroid. Glucocorticoid; anti-inflammatory.
References Olsen, E.A., et al.: J. Am. Acad. Dermatol., 15, 246 (1986),

Applications A labelled metabolite of Spironolactone.
References Gochman, N., et al.: J. Pharmacol. Exp. Ther., 135, 312 (1962), Tori, K., et al.: Steroids, 4, 713 (1964), Solymoss, B., et al.: Toxicol. Appli. Pharmacol., 18, 586 (1971),

Impurity Fluocinolone Acetonide EP Impurity E
Stability Hygroscopic
Applications (6α,9β,11β,16α)-9,11-Epoxy-6-fluoro-21-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione, can be used in the production of fluocinolone acetonide (F455800).
References Grinenko, G.S, Khimiko-Farmatsevticheskii Zhurnal, 12, 110 (1978), Sammul, et al.: J. Assoc. Off. Agric. Chem., 47, 952 (1964), Emerson, M.V., et al.: BioDrugs, 21, 245 (2007),