Toxicologie

<p>Applications Dichlofenthion is used as a pesticide and nematicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ragnarsdottir, K.: J. Geo. Soc., 157, 859 (2000)<br></p>

<p>Applications A novel, potent, and highly selective SGLT2 inhibitor that has been shown to improve glycemic control in diabetic mice and rats.<br></p>

<p>Applications Labelled Hydroxy Atrazine (H828600). Hydroxy Atrazine is a major metabolite of Atrazine (A794600).<br>References Thurman, E., et al.: Environ. Sci. Technol., 26, 2440 (1992), Evgenidou, E., et al.: J. Agric. Food Chem., 50, 6423 (2002), Namiesnik, J., et al.: Anal. Bioanal. Chem., 381, 279 (2005), Hultgren, S., et al.: Anal. Bioanal. Chem., 393, 929 (2009),<br></p>

<p>Applications N,N-Dimethyl-2-aminosulfonyl-4-formamidobenzamide is a key intermediate in the preparation of the sulfonylurea herbicide Foramsulfuron (F685003).<br>References Liu, Q., et al.: Xiandai Nongyao, 11, 19 (2012); Ford, M. J., et al.: From PCT Int. Appl. (2001), WO 2001042226 A1 20010614<br></p>

<p>Applications 4-Phenylphenol is a reagent used in the synthesis of pyrrolo[1,2-c]imidazole dione derivatives as selective serotonin 5-HT1A receptor agonists with antinociceptive activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Valhondo, M., et al.: J. Med. Chem., 56, 7851 (2013); Nichols, D., et al.: Chem. Rev., 108, 1614 (2008)<br></p>

<p>Applications Hexanoyl-d11 Glycine is labelled Hexanoyl Glycine (H281200) which is an acylaminoacid derivative as antipsychotic drug.<br>References Willard, H., et al.: J. Clin. Invest., 65, 690 (1980), Huang, S., et al.: J. Pharm. Exp. Therap., 298, 264 (2001), Reihl, P., et al.: J. Biol. Chem., 280, 39809 (2005),<br></p>

<p>Applications A metabolite of Ranolazine (R122500).<br></p>

<p>Applications Triadimenol-d4 (4-chlorophenoxy-d4) (mixture of stereoisomers) (CAS# 2121989-56-6) is a useful isotopically labeled research compound.<br></p>

<p>Stability Light Sensitive<br>Applications (1R,​3S)​-3-​(2,​2-​Dichloroethenyl)​-​2,​2-​dimethylcyclopropanecarboxam​ide is a useful research chemical.<br></p>

<p>Applications A tryptamine derivative; shows α-adrenolytic activities.<br>References Ishida, Yukio., et al.: Chem. Pharma. Bull., 25, 1851 (1977),<br></p>

<p>Applications: Labelled Almotriptan (A575200). Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.<br>References Fleishaker, J.C., et al.: Clin. Pharmacol. Ther., 67, 498 (2000), Kamali, F., et al.: Curr. Opin. Cent. Peripher. Nerv. Syst. Invest. Drugs, 2, 197 (2000), Dodick, D.W., et al.: Expert Opin.Pharmacother., 4, 1157 (2003)<br></p>

<p>Applications 2'-O-Methyl-d3 Paclitaxel is a labeled analogue of 2'-O-Methyl Paclitaxel (M326135), a potential cytotoxic agent.<br>References Kant, J., et. al.: Bioorg. med. Chem. Lett., 3, 2471 (1993)<br></p>

<p>Applications 2,3,5-Trimethylphenol is a reagent used in the synthesis of antibiotics. Also used in the preparation of vitamin E synthesis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Velema, W. et al.: Nat. Chem., 5, 924 (2013); Carril, M. et al.: J. Catal., 283, 55 (2011);<br></p>

<p>Applications N-Methyl Esomeprazole-d3 is the isotope labelled analog of N-Methyl Esomeprazole (M304640); an impurity of Omeprazole (O635000) which a compound that binds covalently to proton pumps and inhibits gastric secretion. Also used as an antiulcerative.<br>References Muller, P., et al.: Arzneimittel-Forsch., 33, 1685 (1983); Wallmark, B., et al.: Biochim. Biophys. Acta., 778, 549 (1984); Morii, M., et al.: J. Biol. chem., 268, 21553 (1993); Ritter, M., et al.: Br. J. Pharmacol., 124, 627 (1998)<br></p>

<p>Applications The R-enantiomer of Penbutolol (P220500).<br>References Armstrong, D., et al.: Anal. Chem., 66, 1473 (1994), Kato, M., et al.: J. Pharm. Biomed. Anal., 30, 1845 (2003),<br></p>

<p>Applications (1R,2S,3S,4R,5S)-1-(Acetoxymethyl)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6,8-dioxabicyclo[3.2.1]octane-2,3,4-triyl Triacetate is an antidiabetic agent and an Ertugliflozin (1210344-57-2) intermediate.<br>References Bowles, P., et al.: Org. Process Res. Dev., 18, 66-81 (2014);<br></p>

<p>Applications NLG919-d10 is the isotope labelled analog of NLG919 (N630000). NLG919 is a potent indoleamine-2,3-dioxygenase (IDO) pathway inhibitor and is suitable for the treatment of immunosuppression associated with cancer.<br>References Mautino, M.R., et al.: Cancer Res., 73, no pp. (2013); Li, M., et al.: J. Immunother. Cancer, 2, no pp. (2014)<br></p>

<p>Applications Chlorhexidine Digluconate Impurity N-d4 Hydrochloride, is labelled Chlorhexidine Digluconate Impurity N (C377660), which is a degradation product found in chlorhexidine digluconate solution.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Revelle, L., et. al.: Pharmaceut. Res., 10, 1777 (1993)<br></p>

<p>Applications Gatifloxacin derivative; a new antimycobacterial.<br>References Sanchez, J., et al.: J. Med. Chem., 35, 361 (1992), Cecchetti, V., et al.: Bioorg. Med. Chem., 7, 2465 (1999), Alovero, F., et al.: Antimicrob. Agents Chemother., 44, 320 (2000),<br></p>

<p>Applications Chlorflurenol-methyl is an auxin polar transport inhibitor that effects elongation growth of the excised fourth internode of tulips. As well as a pesticide.<br>References Wegrzynowicz-Lesiak, E., et al.: J. Hort. Res., 21, 31-39 (2013);<br></p>

<p>Applications Bosentan Acetate is a mixed endothelin receptor antagonist. Used as a vasodilator. Antihypertensive.<br>References Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994), Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1996), Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1996), Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)<br></p>

<p>Applications L-Amoxicillin-d4 is a labeled isomer of Amoxicillin (A634235), a semi-synthetic antibiotic related to penicillin. Antibacterial.<br>References Brogden, R.N., et al.: Drugs, 18, 169 (1979), Bird, A.E., et al.: Anal. Profiles Drug Subs. Excip., 23, 1 (1994),<br></p>

<p>Applications 4-Hydroxy Darunavir is a metabolite of Darunavir (D193500), a novel inhibitor of human immunodeficiency virus protease and used in the treatment of HIV infection. It is a COVID19-related research product.<br>References Vermeir, M., et al.: Drug. Meta. Disp., 37, 809 (2009); Koh, Y., et al.: Antimicrob. Agents Chemother., 47, 3123 (2003), Arasteh, K., et al.: AIDS, 19, 943 (2005), Surleraux, D.L.N.G., et al.: J. Med. Chem., 48, 1813 (2005),<br></p>

<p>Applications 3-(3-Chlorophenyl)-1,1-dimethylurea has been to study, the quantitative structure-activity relations of substituted phenylureas on the Hill inhibitory activity; Simple and rapid screening method for photosystem II inhibitory herbicides using photoautotrophically cultured plant cells with chlorophyll fluorescence monitoring.<br>References Takemoto I., et al., Nippon Noyaku Gakkaishi, 9, 517-21 (1984); Yoneyama K., et al., Biosci. Biotechnol. Biochem., 57, 1389-90 (1993)<br></p>

<p>Applications PSI 7411 is used in biological studies as nucleotide analog polymerase inhibitor for hepatitis C virus QS-9851.<br>References Denning, J., et al.: Antimicrob. Agents Chemother., 57, 1201 (2013)<br></p>

<p>Applications Endothion is an insecticide. A hazardous material.<br>References Faris, F., et al.: Agric. Res. Rev., 48, 71 (1970), Anon.: Dangerous Prop. of Ind. Mater. Rep., 13, 527 (1993), Mortensen, S. R., et al.: Toxicology of Organophosphate and Carbamate Compounds, 673 (2006),<br></p>

<p>Applications 3,5-Dibromo-4-hydroxybenzonitrile-2,6-d2 (CAS# 1219798-95-4) is a useful isotopically labeled research compound.<br></p>

<p>Applications Phenobarbital Sodium is a barbital drug that can be used to synthesize antiepileptic pharmaceutical compounds.<br>References An, L., et al.: Faming Zhuanli Shenqing, CN 105250316 A, 20160120 (2016)<br></p>

<p>Applications CP 55,940 is a cannabinoid agonist which is considerably more potent than Δ9-THC in both behavioral tests and receptor binding assays. Displays high and roughly equal affinity for both central and peripheral cannabinoid receptors (Ki = 0.6 - 5.0 and 0.7 - 2.6 nM at CB1 and CB2 respectively; EC50 values are 0.2, 0.3 and 5 nM at CB1, CB2 and GRP55 respectively).Controlled substance. Synthetic Cannabinoids<br>References Wiley, et al.: Neuropharmacology, 34, 669 (1995); Griffin, et al.: J. Pharmacol. Exp. Ther., 285, 553 (1998); Thomas, et al.: J. Pharmacol. Exp. Ther., 285, 285 (1998); Ryberg, et al.: Br. J. Pharmacol., 152, 1092 (2007);<br></p>

<p>Applications 7,8,9,10-Tetrahydro-8-methyl-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine is a secondary amine drug varenicline impurity. It is a part of the pharmaceutical formulation of varenicline tartrate tablet.<br>References Waterman, K., et al.: J. Pharm. Sci., 97, 1499 (2008); Watheesh, B., et al.: Acta Chromatogr., 22, 207 (2010);<br></p>

<p>Applications Protected rac Zearalenone-d6<br></p>

<p>Applications Deacetylvinblastine hydrazide sulfate salt is the sulfate salt of Deacetylvinblastine hydrazide, a cytotoxic vinca alkaloid often conjugated with folic acid to produce EC145, a novel folate-receptor targeted agent that is currently under development as an anti-cancer agent.<br>References Pribble, P. &amp; Edelman, M.: Expert Opin. Invest. Drugs, 21, 755 (2012); Reddy, J., et al.: Cancer Res., 67, 4434 (2007); Roy, M., et al.: Dev. Biol Stand., 74, 323 (1991)<br></p>

<p>Applications Labelled Isoproturon. Pre-and post-emergence herbicide for control of annual grasses and broad-leaved weeds. Herbicide.<br>References Fournier, J.-C., et al.: Chemosphere, 4, 207 (1975), Gonzales, P., et al.: Weed Res., 23, 39 (1983),<br></p>

<p>Applications 4-Chloro-2-isopropyl-6-methylpyrimidine, is an intermediate used for the synthesis of some novel pyrimidine derivatives, having antifungal activities.<br>References Sun, L., et al.: Molecules, 16, 5618 (2011);<br></p>

<p>Applications Intermediate in the preparation of corticosteroids.<br></p>

<p>Applications Tetrabromobisphenol S Dimethyl Ether-d6 is the isotope labelled analog of Tetrabromobisphenol S Dimethyl Ether (T291115); a useful insecticide against house flies and sugar beet aphids. Also found in coating mixtures used for fireproofing of polyester fibers.<br>References Pisanenko, D. A., et al.: Vestn. Kievskogo Politekhnicheskogo Instituta Khimicheskoe Mashinostroenie i Tekhnologiya, 25, 79 (1988); Tomita, M., et al. Fireproofing of polyester fibers and their blends. Jpn. Kokai Tokkyo Koho. JP 54006996 A 19790119. Jan 19, 1979<br></p>

<p>Applications Ethofumesate is a herbicide.<br></p>

<p>Stability Hygroscopic<br>Applications Isomalathion is a major impurity in the synthesis of Malathion (M111000), a commonly used insecticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Josse, R et al.: Chem. Bio., Interact., 209, 76 (2014); Buratti, F. et al.: J. Biochem. Mol. Toxicol., 19, 406 (2009);<br></p>

<p>Applications A metabolite of Midazolam (M343000).<br></p>

<p>Applications 17α-Vinyltestosterone Acryl Ester is an intermediate in synthesizing 20,21-Dehydro Spironolactone (D229405), which is an impurity of Spironolactone (S683000), a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conn’s syndrome.<br>References Sutter, J.L., et al.: Anal. Profiles Drug Subs., 4, 431 (1975);<br></p>

<p>Stability Light and temperature Sensitive<br>Applications A glucuronide metabolite of Fluoxetine (F597100) in humans.<br>References Lemberger, L., et al.: J. Clin. Psychiatry, 46, 14 (1985),<br></p>

<p>Applications Neuroleptic agent related structurally to thiothixene. Antipsychotic; neuroleptic agent; dopamine receptor antagonist.<br>References Nielsen, et al.: Acta Pharmacol. Toxicol., 32, 363 (1973), Post, M.L., et al.: Nature, 256, 342 (1975), Peuch, et al.: Neuropharmacology, 20, 1279 (1981),<br></p>

<p>Applications Linezolid Dimer is an impurity of the antibacterial agent Linezolid (L466500).<br></p>

<p>Applications Analgesic.<br>References Viaud, et al.: J. Pharm. and Pharmacol., 6, 361 (1954),<br></p>

<p>Applications N-Hydroxyphenylglycyl Cefadroxil-d4 is the isotope labelled analog of N-Hydroxyphenylglycyl Cefadroxil. N-Hydroxyphenylglycyl Cefadroxil is a derivative of Cefadroxil (C235750), which is a semi-synthetic cephalosporin antibiotic.<br>References Muggleton, et al.: Antimicrob. Agents Chemother., 253 (1968), Marrelli, L.P., et al.: Anal. Profiles Drug Subs., 4, 21 (1975),<br></p>

<p>Applications N2-Des(L-valinyl) N2-Formal Lopinavir is an impurity of Lopinavir (L469480), which is a selective HIV protease inhibitor. An analogue of Ritonavir. Antiviral. It is a COVID19-related research product.<br>References Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998), Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1999), Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)<br></p>

<p>Applications Labelled Olmesartan Medoxomil (O550000). Olmesartan Medoxomil is an angiotensin II receptor antagonist. Olmesartan Medoxomil is used as an anti-hypertensive.<br>References Yanagisawa, H., et al.: J. Med. Chem., 39, 323 (1996), Puchler, K., et al.: J. Hypertens., 15, 1809 (1997),<br></p>

<p>Applications Atazanavir-8-(N-methoxycarbonyl)-L-tert-leucine Ester is an impurity of the drug Atazanavir (A790051). Atazanavir is a novel azapeptide HIV protease inhibitor (PI). Antiviral. Like other antiretrovirals, it is used to treat infection of human immunodeficiency virus (HIV). Newer research has been investigating the potential anticancer effects of atazanavir<br>References Palella, F.J. Jr., et al.: N. Engl. J. Med., 338(13), 853 (1998), Nolan, D., et al.: Drugs, 63(23), 2555 (2003), Musial, B.L., et al.: Am. J. Health Syst. Pharm., 61, 1365 (2004), Wood, R., et al.: J. Acquir. Immune Defic. Syndr., 36, 684 (2004),<br></p>