Toxicologie

<p>Applications Trifluralin-(dipropyl-d14) is the deuterized or labeled form of Trifluralin (T793550), which is the pre-emergence herbicide used for grass control in crops.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Goldenthal, et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Robens, J.F., et al.: Vet. Hum. Toxicol., 22, 328 (1980)<br></p>

<p>Stability Hygroscopic<br>Applications Sodium 17beta-Estradiol-2,4,16,16-d4 3-Sulfate (Stabilized with TRIS, 50% w/w) (CAS# 352431-50-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled analogue of Benzo[ghi]perylene, one of the polycyclic aromatic hydrocarbons (PAH’s), an environmental pollutant with potential carcinogenic activity.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Alves, C. et al.: Atmos. Environ., 35, 5485 (2001); Jaward, F. et al.: Environ. Sci. Technol., 38, 2523 (2004); Lee, R. et al.: Environ. Sci. Technol., 39, 1436 (2005); Augusto, S. et al.: Environ. Pollut., 158, 483 (2010);<br></p>

<p>Applications Fursultiamine is an oral source of thiamine, used in comparative pharmacokinectic analysis of thiamine and it’s phosphorylated metabolites administered as multivitamin preparations, identification of drug candidate against prostate cancer from aspect of somatic cell reprogramming, therapeutic tool in number of human neurological diseases.<br>References Park, W., et al.: Clin. Ther., 38, 2277 (2016); Kosaka, T., et al.: Cancer Sci., 104, 1017 (2013); Lonsdale, D., et al.: Med. Sci. Monit., 10, 199 (2004)<br></p>

<p>Stability Hygroscopic<br>Applications A isothiazolidin-3-one derivative as antimicrobial. It was tested for inhibition of PCAF activity. 5-Chloroisothiazolinones showed the most potent inhibition of PCAF.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sadhale, P.P., et al.: J. Biol. Chem., 279, 33716 (2004), Thomsen, R., et al.: J. Med. Chem., 49, 3315 (2006),<br></p>

<p>Applications Tetrabromobisphenol S is a brominated flame retardant (BFR) and a derivative of Bisphenol-S. It can be used as a herbicide to control weeds such as Digitaria, Cyperus microiria, and Echinochloa crusgalli in cucumbers, tomatoes, and white radish.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wang, X.M., et al.: Anal. Chim. Acta, 753, 1 (2012); Liaw, D.-J., et al.: Angew. Makromol. Chem., 199, 171 (2003); Takamatsu, H., et al. Sulfones as herbicides. Jpn. Kokai Tokkyo Koho. JP 53109942 A 19780926. Sep 26, 1978<br></p>

<p>Impurity Prilocaine USP Related Compound A<br>Applications o-Toluidine Chloride is a carcinogenic and toxic aromatic amine contained in hair dye, henna and dyed hair samples. Prilocaine USP Related Compound A<br>References El-Bayoumy, K., et al.: Cancer Res., 46, 6064 (1986), Turesky, R., et al.: Chem. Res. Toxicol., 16, 1162 (2003), Andrew, A., et al.: Int. J. Cancer, 109, 581 (2004), Pinheiro, H., et al.: Dyes Pigments, 61, 121 (2004), Kirkland, D., et al.: Mutat. Res., 588, 88 (2005),<br></p>

<p>Applications Pre-emergence herbicide for use in rice and other food crops.<br>References Jurney, W., et al.: J. Neurosci., 22, 6019 (2002), Yap, C., et al.: J. Cell Biol., 180, 827 (2008),<br></p>

<p>Stability Hygroscopic<br>Applications Clencyclohexerol-d10 is a labelled analog of Clenbuterol, a β-agonist which can be used as a growth promoter in farm animals.<br>References Maistro, S., et al.: Lancet, 346, 180 (1995); Vanoosthuyze, K., et al.: J. Agric. Food Chem., 45, 3129 (1997); Fiori, M., et al.: Anal. Chim. Acta, 529, 207 (2005); Salquebre, G., et al.: J. Anal. Toxicol., 31, 114 (2007);<br></p>

<p>Applications Antimicrobial agent used as a substitute for chlorophenols in industrial applications.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Martin, I.D., et al.: Arch. Environ. Contam. Toxicol., 24, 381 (1993), Reemtsma, T., et al.: Environ. Sci. Technol., 29, 478 (1995),<br></p>

<p>Applications A labelled metabolite of 1-Hydroxypyrene, which is found in human urine after exposure to coal tar and a coal derived product.<br>References Jongeneelen, F.J., et al.: Int. Arch. Occup. Environ. Health, 57, 47 (1985)<br></p>

<p>Impurity Ganciclovir EP Impurity I<br>Applications O,O'-Dipropanal Ganciclovir (Ganciclovir EP Impurity I) is derived from Ganciclovir (G235000), which is a nucleoside analog structurally related to Acyclovir (A192400). Ganciclovir is an antiviral.<br>References Halloran, P.J. and Fenton, R.G.: Cancer Res., 58, 3855 (1998), Rubsam, L.Z., et al.: Cancer Res., 59, 669 (1999), Yamasaki, H., et al.: C.R. Acad. Sci. III, 322, 151 (1999)<br></p>

<p>Stability Moisture Sensitive<br>Applications (Z)-Metominostrobin (cas# 133408-51-2) is a compound useful in organic synthesis.<br></p>

<p>Applications The trans-isomer of the third generation synthetic pyrethroid insecticide, Bifenthrin (B383000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br></p>

<p>Stability Hygroscopic<br>Applications An impurity in the synthesis of Erythromycin (E649950). An antibacterial.<br>References Zhang, L. et al.: J. Antibio., 64, 243 (2011); Koch, W.L., et al.: Anal. Profiles Drug Subs., 8, 157 (1979),<br></p>

<p>Stability Hygroscopic<br>Applications Ethanolamine-13C2 Hydrochloride is the labeled analogue of Ethanolamine (E676500), which is used in the preparation of various pharmaceutical compounds and inhibitors. Ethanolamine-13C2, is also a 13C-labeled lipid precursor, used for the detection of phospholipid metabolism and the synthesis of phosphatidylethanolamine in T47D human breast cancer cells.<br>References Ronen, S. M., et al.: Magnetic Resonance Med., 25, 384 (1992); Lombardo, L. et al.: J. Med. Chem., 47, 6658 (2004); Egan, T.: J. Med. Chem., 43, 283 (2000);<br></p>

<p>Applications Spirodiclofen is a tetronic acid acaricide fungicide used in controlling red mites. Spirodiclofen is used in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Kramer, T., et al.: Pest. Manage. Sci., 67, 1285 (2011); Ilias, A., et al.: Crop. Protect., 42, 305 (2012); Bretschneider, T., et al.: Modern. Crop. Protect. Compounds., 3, 1108 (2012)<br></p>

<p>Applications Felodipine-13C4, d3 is the labeled analogue of Felodipine (F232375), a dihydropyridine calcium channel blocker.<br>References Berntsson, P.B., et al.: Acta Pharm. Suec., 18, 221 (1981); Kratochwil, N., et al.: Biochem. Pharmacol., 64, 1355 (2002); O'Brien, S., et al.: J. Med. Chem., 48, 1287 (2005); Castilho, M., et al.: Bioorg. Med. Chem., 14, 516 (2006)<br></p>

<p>Applications A urease inhibitor.<br>References Zaman, M., et al.: Soil Biol. Biochem., 41, 1270 (2009), Giovannini, C., et al.: J. Agric. Food Chem., 57, 4883 (2009),<br></p>

<p>Impurity Clindamycin Phosphate EP Impurity A<br>Stability Hygroscopic<br>Applications Lincomycin (Clindamycin Phosphate EP Impurity A) is a lincosamide antibiotic that forms cross-links within the peptidyl transferase loop region of the 23S rRNA. Inhibits bacterial protein synthesis. Antibacterial.This compound is a contaminant of emerging concern (CECs).<br>References Mason, D.J., et al.: Antimicrob. Agents Chemother., 555 (1962), Gray, et al.: Toxicol. Appl. Pharmacol., 6, 476 (1964), Muti, H.Y., et al.: Anal. Profiles Drug Subs. Excip., 23, 269 (1994),<br></p>

<p>Applications Fungicide. Iprodione is also used in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Lacroix, L., et al.: Phytiatr.-Phytopharm., 23, 165 (1974), Brenneman, T.B., et al.: Plant Dis., 71, 546 (1987),<br></p>

<p>Impurity Clarithromycin EP Impurity C<br>Applications Clarithromycin 9-Oxime (Clarithromycin EP Impurity C) is an impurity of Clarithromycin (C559750), a macrolide antibiotic.<br>References Stephanic, V. et al.: J. Med. Chem., 54, 719 (2011); Chen, X. et al.: Zhong. Yao., 17, 32 (2008);<br></p>

<p>Applications Potent, non-competitive CCR5 receptor antagonist; inhibits binding of HIV viral coat protein gp120. Antiviral.<br>References Fumero, E., et al.: Clin. Microbiol. Infect., 9, 1077 (2003), Walker, D.K., et al.: Drug Metab. Dispos., 33, 587 (2005), Wood, A., et al.: Prog. Med. Chem., 43, 239 (2005),<br></p>

<p>Applications Labelled Ceftiofur (C244700). An antibacterial.<br>References Yancey, R.J., et al.: Am. J. Vet. Res., 48, 1050 (1987)<br></p>

<p>Applications Barbadin is a selective β-arrestin/β2-adaptin inhibitor. It selectively inhibits the interaction between b-arrestin and the b2-adaptin subunit of the clathrin adaptor protein AP2 without affecting the formation of receptor/b-arrestin complexes.<br>References Beautrait, A., et al.: Nat Commun. 8, 15054 (2017)<br></p>

<p>Applications 6-Hydroxy Bromantane is a metabolite of Bromantane (B678450).<br>References Bi, H., et al.: J. Steroid Biochem. Mol. Biol., 42, 229 (1992), Pozo, O., et al.: Anal. Bioanal. Chem., 389, 1209 (2007), Kiousi, P., et al.: Bioanalysis, 1, 1209 (2009),<br></p>

<p>Applications Labelled Prostaglandin biosynthesis inhibitor. Analgesic; anti-inflammatory.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rooks, W.H., et al.: Agents Actions, 12, 684 (1982), Guzman, A., et al.: J. Med. Chem., 29, 589 (1986), McQuary, H.J., et al.: Clin. Pharmacol. Ther., 39, 89 (1986),<br></p>

<p>Applications Fipronil Sulfone is a sulfone metabolite of the insecticide Fipronil (F342200). Fipronil Sulfone blocks γ-aminobutyric acid- and glutamate-activated chloride channels in mammalian and insect neurons.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhao, X. et al.: J. Pharmacol. Exp. Therap., 314, 363 (2005); Mulrooney, J.E. et al.: J. Econ. Entomol., 92, 1364 (1999); Hainzl, D. et al.: Chem. Res. Toxicol., 11, 1529 (1998);<br></p>

<p>Applications Imatinib-III is derived from Imatinib (I268023), which is an inhibitor of multiple tyrosine kinases. It is a COVID19-related research product.<br></p>

<p>Applications Minor constituent of wine, correlated with serum lipid reduction and inhibition of platelet aggregation. Resveratrol is a specific inhibitor of COX-1, and it also inhibits the hydroperoxidase activity of COX-1. It has been shown to inhibit events associated with tumor initiation, promotion and progression.<br>References Powell, R.G., et al.: Phytochemistry, 35, 335 (1994), Jeandet, P., et al.: J. Phytopathol., 143, 135 (1995), Mattivi, F., et al.: J. Agric. Food Chem., 43, 1820 (1995),<br></p>

<p>Applications 2-Imidazolidinethione is a pesticide used in production of fruits and vegetables. It is also used as a new contrast agent for MRI studies based on proton chemical exchange dependent saturation transfer (1) . 2-Imidazolidinethione is also a corrosion inhibitor (2) due to the adsorption of the mol. species. Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br>References 1. Ward, K. et al.: J. Magn. Reson. 2000 Mar:143(1) 79-872. Pillai, K. et al.: J. Electrochem. Soc. 1978 Aug:125(9) 1393-1397<br></p>

<p>Applications Flumorph can be used in analytical study of simultaneous determination of 106 pesticides in nuts by LC-​MS​/MS using freeze-​out combined with dispersive solid-​phase extraction purification.<br>References Wang, J., et al.: J Sep Sci, 40, 2398 (2017)<br></p>

<p>Applications Dichloroprop is a herbicide used for the post-emergence control of annual and perennial broad-leaved weeds and some brush species.<br>References Freitas, M.R., et al.: RSC Adv., 5, 7547 (2015); Aizawa, H.: Handbook of Metabolic Pathways of Xenobiotics, 3, 1212 (2014)<br></p>