Toxicologie

<p>Applications Paromomycin Deuterated Acetic Acid Salt is the isotope labelled analog of Paromomycin Sulfate. Paromomycin Sulfate is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis.<br>References Rehg, J.E. et al.: J. Infect. Dis., 170, 934 (1994); Fong, D. et al.: Am. J. Trop. Med. Hyg., 51, 758 (1994); Hafez, H.M. et al.: Arch. Anim. Nut., 64, 77 (2010);<br></p>

<p>Applications Furanylfentanyl is an opiod analgesic agent used which is an analog of Fentanyl (F275000).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zernig, G., et al.: Life Sci., 57, 2113 (1995), Bot, G., et al.: J. Pharmacol. Exper. Therap., 285, 1207 (1998),<br></p>

<p>Applications A benzyl halide as postemergence herbicides.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Singer, G.M., et al.: J. Med. Chem., 26, 309 (1983),<br></p>

<p>Applications A metabolite of Fenthion (FEN).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Buratti, F., et al.: Toxicol. Lett., 167, 245 (2006), Buratti, F., et al.: Drug Metab. Dispos., 33, 295 (2005), Buratti, F., et al.: Toxicology, 241, 33 (2007),<br></p>

<p>Applications A labelled metabolite of carboxylic acid.<br>References Bardsley, W., et al.: Biochem. J., 122, 557 (1971), Kim, J., et al.: Biosci. Biotechnol. Biochem., 69, 1331 (2005), Kopka, J., et al.: J. Biotechnol., 124, 312 (2006),<br></p>

<p>Applications Ginsenoside Re is an extract from ginger, responsible for some of the pharmacological functions. It displays cardiac contractility, anti-ischemic and anti-arrythmic activities.<br>References Peng, D. et al.: Chinese Med., 7, 2 (2012); Endale, M. et al.: Med. Inflamm., 748964/1 (2014);<br></p>

<p>Applications Amphetamine (A634240) analogue, a known hallucinogen,<br>References Tseng, L. et al. et al.: J. Pharmacol. Exp. Ther. 187, 263 (1976)<br></p>

<p>Applications 3-Chlorobenzotrichloride may be used as mosquito larvicide.<br>References Deonier, C.C., et. al.: Soap and Sanitary Chemicals, 22, 118 (1946)<br></p>

<p>Applications Antihistaminic, antiemetic, CNS depressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Edge, W., et al.: J. Pharm. Pharmacol., 5, 279 (1953), Huang, et al.: J. Pharm. Sci., 59, 772 (1970), Shearer, C.M., et al.: Anal. Profiles Drug Subs., 5, 429 (1976)<br></p>

<p>Applications 2-Cyano-2-(methoxyimino)acetic Acid is a cyano-oxime derivative used as a fungicide.<br>References Tellier, F., et al.: Pestic Biochem Physiol., 78, 151-160 (2004)<br></p>

<p>Applications 2-(Methylthio)Benzothiazole could be useful for removing pollutants in drinking water.<br>References Di Marcantonio, C., et al.: Chemosphere, 260, 127630 (2020)<br></p>

<p>Applications Amylocaine Hydrochloride, is used mostly in spinal anesthesia.<br>References Fourneau, E.: Bulletin des sciences pharmacologiques, 10, 141 (1904); Debue-Barazer, C., et al.: Gesnerus, 64, 24 (2007)<br></p>

<p>Applications Macitentan, is an orally active endothelin receptor antagonist used for pulmonary arterial hypertension.<br>References Emoto, N. Ensho to Men'eki, 20, 487 (2012);<br></p>

<p>Applications Thiometon-sulfone is a metabolite from Thiometon (D231370) pesticides, used as an insecticide. Cholinesterase inhibitor.<br>References Edson, E.F., et al.: Pharm. J., 185, 365 (1960); Pozo, O., et al.: Anal. Bioanal. Chem., 389, 1765 (2007); Mezcua, M., et al.: Anal. Chem., 81, 913 (2009);<br></p>

<p>Stability Hygroscopic<br>Applications Kasugamycin Hydrochloride is an aminoglycoside antibiotic that inhibits the initiation of translation. It is also a type of fungicide that controls leaf and neck blast disease caused by Pyricularia oryzae and increases rice yields.<br>References Okuyama, A., et al.: J. Antibiot., 28, 903 (1975); Shinabarger, D., et al.: Antimicrob. Agents Chemother., 41, 2132 (1997); Reddy, A., et al.: Pesticides, 22, 21 (1988);<br></p>

<p>Applications Dabigatran-d7, is the labeled analogue of Dabigatran (D100090), Nonpeptide, direct thrombin inhibitor. Antithrombotic.<br>References Hauel, N., et al.: J. Med. Chem., 45, 1757 (2002), Mungall, D., et al.: Curr. Opin. Invest. Drugs, 3, 095 (2002), Stangier, J., et al.: J. Clin. Pharmacol., 45, 555 (2005),<br></p>

<p>Stability Hygroscopic, Light Sensitive, Moisture Sensitive, Temperature Sensitive<br>Applications trans-Deltamethrin, is trans isomer of Deltamethrin (D230700), a synthetic pyrethroid insecticide, which acts as a potent inhibitor of calcineurin (protein phosphatase 2B) and has an IC50 of about 100pM.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kavlock, R., et al.: J. Environ. Pathol. Toxicol., 2, 751 (1979), Enan, E., et al.: Biochem. Pharmacol., 43, 1777 (1992), Tan, J., et al.: Mol. Biol., 32, 445 (2002);<br></p>

<p>Applications Pantoprazole-d3 is the labeled analogue of Pantoprazole, an antiulcerative. Gastric pump inhibitor.<br>References Simon, W.A., et al.: Biochem. Pharmacol., 39, 1799 (1990)<br></p>

<p>Applications Metahexamide is used in biological studies to evaluate the elevation of blood urea nitrogen level in dogs and human subjects by administering chloral hypnotics.<br>References Wieg, H., Am. J. Med. Tech., 26, 11 (1960);<br></p>

<p>Applications Flubromazepam is a designer benzodiazepine drug structurally related to Phenazepam (P295300); a drug used in the treatment of neurological disorders such as epilepsy, alcohol withdrawal and insomnia. Phenazepam (P295300) can also be used as a premedication before surgery as it augments the effects of anesthetics and reduces anxiety.<br>References Moosmann, B., et al.: J. Mass Spectrom., 48, 1150 (2013); Ogiso, T., et al.: Chem. Pharm. Bull., 37, 446 (1989); Gu, Q., et al.: J. Med. Chem., 36, 1001 (1993); Bekhterev, V.N., et al.: Pharm. Chem. J., 42, 95 (2008)<br></p>

<p>Applications Sisapronil is Fluorinated Cyclopropylphenylpyrazole injectable compound.<br>References Derose, Guy F., et al.: U.S. Pat. Appl. Publ., (2015);<br></p>

<p>Applications Aldicarb is used as an insecticide. Used in Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ashby, J., et al.: Environ. Mutagen., 7, 919 (1985), Ashby, J., et al.: Mutat. Res., 257, 229 (1991), Kazius, J., et al.: J. Med. Chem., 48, 312 (2005), Benigni, R., et al.: Mutagenesis, 25, 335 (2010),<br></p>

<p>Stability Hygroscopic<br>Applications A phenethylamine derivative as sympathomimetics. Adrenergic.<br>References Lee, P., et al.: Mol. Pharmacol., 4, 498 (2007), Coan, K., et al.: J. Med. Chem., 52, 2067 (2009),<br></p>

<p>Applications Cymoxanil is a fungicide applied as a seed treatment or as a foliar application to the plants to control late blight.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Dhingani, J. C., et al.: J. Pure. App. Microbiol., 6, 1683 (2012); Bakirici, G.T., et al.: Food. Chem., 135, 1901 (2012);<br></p>

<p>Applications Octopamine-13C2,15N Acetic Acid is the salt form of Octopamine-13C2,15N(O239752). Labelled Octopamine (O239750). A biogenic amine that is the phenol analog of Noradrenaline. It is a neurosecretory product found in several vertebrates and invertebrates. Adrenergic.<br>References Pisano, et al.: Biochim. Biophys. Acta., 43, 566 (1960), Breen, C.A., et al.: Nature, 303, 716 (1983);<br></p>

<p>Applications 3-(2,2-Dichloroethenyl)-2,2-dimethylcyclopropanecarboxylic Acid is a reagent used in the preparation of hapten and immunogen for the production of polyclonal antibodies, specific to Cypermethrin (C989000).<br>References Lee, N. et al.: J. Agri. Food Chem., 46, 520 (1998); Hongsibsong, S. et al.: Int. J. Agri. Biol., 14, 246 (2012);<br></p>

<p>Applications The main labelled metabolite of o-xylene.<br>References Gregus, Z., et al.: Drug Metab. Dispos., 26, 1082 (1998), Gregus, Z., et al.: Xenobiotica, 29, 547 (1999), Gonzalez-Reche, L., et al.: Arch. Toxicol., 77, 80 (2003),<br></p>

<p>Applications An agonist to both GHB and GABAB neural receptors, exhibiting neurotransmitter-like effects. It has been used as a general anesthetic in treatment for sleep disorders and clinical depression, but also has been identified as a “date rape drug”.<br>References Mamelak, M., et al.: Prog. Neurobiol., 89, 193 (2009), Zhang, L., et al.: App. Microbiol. Biotechnol., 84, 909 (2009), Pedraza, C., Int. J. Neuropsychopharmacol., 12, 1165 (2009), McGonigle, I., et al.: Biochem., 49, 2897 (2010),<br></p>

<p>Applications Indoleacetic Acid is the most common and naturally occuring plant hormone in the auxin class of hormones. It effects cell elongation, cell division as well as plant growth and development.<br></p>

<p>Stability Hygroscopic<br>Applications Sodium Stibogluconate is an intermediate used to prepare Dihydropyrido[2,3-d]pyrimidines as a new class of antileishmanial agents.<br>References Agarwal, A., et al.: Bioorg. Med. Chem., 13, 6678 (20050<br></p>

<p>Applications (-)-trans-Phenothrin is used in exhaustive parallel conformational search of pyrethroids and structural similarity study. Also used as an active compound combination having insecticidal properties, a synthetic reagent in the preparation and optical purity of benzylic ester pyrethroid enantiomers.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Bertok, B., et al.: J. Environ. Sci. Health, Part B., 31, 495 (1996); Chuman, H., et al.: Journal of Chemical Software, 4, 143 (1998); Thielert, W., et al.: PCT Int. Appl. (2015), WO 2015132140 A1 20150911;<br></p>

<p>Applications Methyl Paraben-13C5, is the labeled analogue of Methyl Paraben (M325660), used as preservative in foods, beverages and cosmetics.<br>References Goodwin, M., et al.: Science, 203, 559 (1979);<br></p>

<p>Applications Diethofenacarb is a pesticide used on crops. It is a fungicide commonly used in China.<br>References Sun, H. et al.: Plant DIsease, 94, 551 (2010); Boulard, T. et al.: Agro. Sust. Develop., 31, 757 (2011);<br></p>

<p>Applications Imazamox is an imidazolinone based acetolactate synthase inhibitor that is utilized as a herbicide for weed control.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Riar, D.S., et al.: Int. J. Agron., 8 (2012); Grey, T.L., et al.: Weed. Technol., 26, 405 (2012); Rousonelos, S.L., et al.: Weed. Sci., 60, 335 (2012);<br></p>

<p>Applications (R)-Baclofen is the R-Enantiomer of Baclofen, a specific GABA-B receptor agonist and a muscle relaxant (1,2).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Brogden, R.N., et al.: Drugs, 8,1 (1974) (2) Song, Y., et al.: Endocrinology. en.2016-1776 (2017)<br></p>

<p>Applications (R,S)-Equol 7-β-D-Glucuronide is a glucuronide metabolite of isoflavone Daidzein (D103500).<br>References Heinonen, S., et al.: Anal. Biochem., 274, 211 (1999), Setchell, K., et al.: J. Nutr., 132, 3577 (2002), Thigpen, J., et al.: Comp. Med., 53, 607 (2003), Yee, S., et al.: Food Chem. Toxicol., 46, 2713 (2008)<br></p>

<p>Applications Testosterone (T155000) derivative. Intermediate in the preparation of Epostane (E588850).<br></p>

<p>Applications Flonicamid is a novel insecticide with rapid inhibitory effect against aphid feeding. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Morita, M., et al.: Pest. Manag. Sci.,63, 969 (2007); Sabatino, L., et al.: Food. Additive. Contamin., 6, 11 (2013);<br></p>

<p>Stability Light Sensitive<br>Applications Trichlorfon is an irreversible organophosophate acetylcholinesterase inhibitor and the prodrug of Dichlorvos (D435950) (1,2). Trichlorfon have also shown potential actions to be utilized as an effective organophosphorus pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Li, R., et al.: App. Microbiol. Biotechnol., 94, 1553 (2012) (2) Bakirci, G.T., et al.: Food. Chem., 135, 1901 (2012)<br></p>

<p>Stability Air Sensitive, Moisture Sensitive<br>Applications Organophosphate pesticide used in the agriculture industry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Abou-Donia, M., et al.: Toxicol. App. Pharmacol., 53, 439 (1980), Francis B., et al.: Neurotoxicol., 4, 139 (1983),<br></p>

<p>Applications Allobarbital is a barbiturate derivative that is primarily used as an anticonvulsant. Allobarbital also shows hypnotic activity and is used to boost the activity of analgesic drugs. Studies show that Allobarbital is an effective promoters of hepatocarcinogenesis. Allobarbital is a Controlled Substance.<br>References Tateoka, Y. et al.: Yakug. Zas., 106, 504 (1986); Crawford, J.M. et al.: Neuropharmacology, 9, 31 (1970); Rice, J.M. et al.: Carcinogenesis, 15, 395 (1994);<br></p>

<p>Applications Coproporphyrin III can be used as a biomarker for environmental toxicity and susceptibility in autism.<br>References Geier, D. A., et al.: J. of the Neuro. Sci., 280(1-2), 101-108 (2009)<br></p>

<p>Applications N-Acetyl Mesalazine-d3 is the labeled analogue of N-Acetyl Mesalazine (A168320), a metabolite of Mesalazine. A Salicylic Acid derivative. Inhibitor of recombinant human thiopurine methyltransferase (hTPMT).<br>References Bondesen, S., et al.: Br. J. Clin. Pharmacol., 25, 269 (1988); Brogden, R., et al.: Drugs, 38, 500 (1989); Jensen, J., et al.: Biochem. Pharmacol., 45, 1201 (1993); Liu, Z., et al.: Drug Metab. Dispos., 23, 246 (1995); Vree, T., et al.: Clin. Drug Invest., 20, 35 (2000)<br></p>

<p>Applications Controlled substance (depressant). Anxiolytic. Prototype of the benzodiazepine anxiolytics.<br>References MacDonald, A., et al.: Anal. Profiles Drug Subs., 1, 15 (1972); Greenblatt, D.J., et al.: Clin. Pharmacokinet., 3, 381 (1978);<br></p>