Toxicologie

<p>Applications Bifenazate is a selective miticide for the control of a variety of mite pests on crops. Used in Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sipes, N.S., et al.: Chem. Res. Toxicol., 26, 878 (2013); Sbartai, I., et al.: Adv. Environ. Biol., 6, 2249 (2012);<br></p>

<p>Impurity Ipratropium EP Impurity E<br>Applications N-Isopropyl Noratropine is a Noratropine derivative, an intermediate in the production of Ipratropium.<br>References Simms, P., et al.: J. Pharm. Biomed. Anal., 17, 841 (1998),<br></p>

<p>Applications Labelled 7α-Hydroxy-4-cholesten-3-one (H825130). 7α-Hydroxy-4-cholesten-3-one is a metabolite of Cholesterol (C432501).<br>References Connor, W., et al.: J, Clin. Invest., 48, 1363 (1969),<br></p>

<p>Stability Hygroscopic<br>Applications Sodium 17beta-Estradiol-2,4,16,16-d4 3-Sulfate (Stabilized with TRIS, 50% w/w) (CAS# 352431-50-6) is a useful isotopically labeled research compound.<br></p>

<p>Applications Labelled analogue of Indeno[1,2,3-cd]pyrene, a polycyclic aromatic hydrocarbon (PAH) and a known carcinogen. Indeno[ 1,2,3-cd]pyrene is listed as a priority pollutant by the Environmental Protection Agency (EPA). Indeno[1,2,3-cd]pyrene has been detected in automobile engine exhaust, charcoal broiled foods, ground water, river sediments as well as cigarette smoke condensate.<br>References Rice, J.E. et al.: J. Org. Chem., 51, 2428 (1986); Smith, C.J. et al.: Food Clin. Toxicol., 38, 637 (2000); Panalaks, T.: J. Environ. Sci. Health. Part B Pest. Food Cont. Agric. Wastes, B11, 299 (1976);<br></p>

<p>Applications A metabolite of Mifepristone (M343975).<br>References Ringler, I., et al.: Metabolism, 13, 37 (1964), Gagne, D., et al.: J. Steroid. Biochem., 25, 315 (1986), Jang, G., et al.: Biochem. Pharmacol., 52, 753 (1996), Hild, S., et al.: Hum. Reprod., 15, 822 (2000), Gainer, E., et al.: Steroids, 68, 1005 (2003),<br></p>

<p>Applications A labelled inhibitor of glucose synthesis.<br>References Garcia-Salguero, L. et al.: Arch. Int. Physiol., Biochim. Biophys., 99, 237, (1991); Martirosyan, A., et al.: Biochem. Pharmacol., 68, 1729 (2004);<br></p>

<p>Stability Hygroscopic<br>Applications 3-Sulfoglycolithocholic Acid Disodium Salt is a derivative of Lithocholic acid (L469180). Lithocholic acid (LCA) is a putative tumor promoter,that is shown to be able to inhibit mammalian DNA polymerase β.<br>References Ogawa, A., et al.: Jap. J. Canc. Res., 89, 1154 (1998)<br></p>

<p>Applications Fursultiamine is an oral source of thiamine, used in comparative pharmacokinectic analysis of thiamine and it’s phosphorylated metabolites administered as multivitamin preparations, identification of drug candidate against prostate cancer from aspect of somatic cell reprogramming, therapeutic tool in number of human neurological diseases.<br>References Park, W., et al.: Clin. Ther., 38, 2277 (2016); Kosaka, T., et al.: Cancer Sci., 104, 1017 (2013); Lonsdale, D., et al.: Med. Sci. Monit., 10, 199 (2004)<br></p>

<p>Applications 2-(3-Ethylureido)-2-oxoacetic Acid is a degradation product of Cymoxanil (C988995), which is a fungicide applied as a seed treatment or as a foliar application to the plants to control late blight.<br>References Morrica, P., et al.: J. Agric. Food Chem. 52, 99 (2004); Dhingani, J. C., et al.: J. Pure. App. Microbiol., 6, 1683 (2012); Bakirici, G.T., et al.: Food. Chem., 135, 1901 (2012)<br></p>

<p>Impurity Adapalene USP Related Compound B<br>Applications Adapalene intermediate, an ester of Adapalene. Adapalene USP Related Compound B.<br>References Charpentier, B., et al.: J. Med. Chem., 38, 4993 (1995),<br></p>

<p>Stability Hygroscopic<br>Applications A isothiazolidin-3-one derivative as antimicrobial. It was tested for inhibition of PCAF activity. 5-Chloroisothiazolinones showed the most potent inhibition of PCAF.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sadhale, P.P., et al.: J. Biol. Chem., 279, 33716 (2004), Thomsen, R., et al.: J. Med. Chem., 49, 3315 (2006),<br></p>

<p>Applications 5,6-Dichloroindole-3-acetic acid and 4-Chloroindole-3-acetic acid are potent candidates for new rooting promoters without estrogenic activity. Plant growth stimulators.<br>References Pless, T., et al.: Plant Physiol., 74, 320 (1984), Igarashi, A., et al.: Biol. Pharm. Bull., 29, 2120 (2006), Liu, L., et al.: J. Agric. Food Chem., 56, 824 (2008),<br></p>

<p>Applications Mesosulfuron is used in synergistic herbicidal combinations.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Baur, P., et al.: PCT Int. Appl. (2020), WO 2020173719 A1<br></p>

<p>Applications Bromadiolone is an anticoagulant rodenticide used on non-crop areas.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cherry, L., et al.: Toxicologist, 2, 108 (1992), Park, B., et al.: Biochem. Pharmacol., 31, 3635 (1992), Thijssen, H., et al.: Pestic Sci., 43, 73 (1995), Howald, G., et al.: Conserv. Biol., 21, 1258 (2007),<br></p>

<p>Applications (-)-Donepezil is an isomer of Donepezil (D531750), a nootropic, acting as an inhibitor of acetylcholinesterase.<br>References Ohnishi, A., et al.: J. Clin. Pharmacol., 33, 1086 (1993), Galli, A., et al.: Eur. J. Pharmacol., 270, 189 (1994)<br></p>

<p>Applications A B-Adrenergic receptor agonist. A Bronchodilator.<br>References Akhtar, S., et al.: J. Vet. Pharmacol. Ther., 21, 388 (1998), Kasprowicz, D.J., et al.: J. Immunol., 165, 680 (2000)<br></p>

<p>Applications The (S)-isomer of Viloxazine (V312440). Antidepressant.<br>References Howe, R., et al.: J. Med. Chem., 19, 1074 (1976), Pinder, R.M., et al.: Drugs, 13, 401 (1977),<br></p>

<p>Applications Pipamazine is a drug od the phenothiazine class which used to be used as an antiemetic.<br>References Bhargava, K. et al.: Br. J. Pharmacol. Chemother., 22, 154 (1964); Bhargava, K. et al.: Br. J. Pharmacol. Chemother., 21, 436 (1963);<br></p>

<p>Applications An intermediate for the preparation of (3S,5S)-Atorvastatin.<br></p>

<p>Applications Fomesafen is a protoporphyrinogen oxidae (PPO) inhibitor.<br>References Peng, X., et al.: Faming Zhuanli Shenqing (2018), CN 107836452 A 20180327<br></p>

<p>Stability Hygroscopic<br>Applications Lauroyl-L-carnitine-d3 Hydrochloride is labelled Lauroyl-L-carnitine (L178680) which is a long-chain fatty ester of carnitine which is accumulated and released into the circulation, in fatty-acid oxidation defects. Pattern of Lauroyl-L-carnitine can be diagnostic for a number of ß-oxidation defects.<br>References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications Benzovindiflupyr can be used in biological study of method to predict and understand fish survival under dynamic chemical stress using standard ecotoxicity data. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Ashauer, R., et al.: Environ Toxicol Chem., 32, 954-965 (2013)<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Diphenhydramine (D486900) in humans.<br>References Breyer-Pfaff, U., et al.: Drug Metab. Dispos., 25, 340 (1997),<br></p>

<p>Applications Phenethylamine-d4 is labelled phenethylamine (P321335) which is a psychoactive drug and stimulant that affects dopamine levels. It uses a mechanism of inverse agonism at the D2 dopamine receptor to achieve this effect. Phenylethylamine (P321335) functions as a neuromodulator or neurotransmitter in the mammalian central nervous system.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wilson, J. et al.: J. Neurochem., 77, 493 (2001); Sotnikova, T. et al.: J. Neurochem., 91, 362 (2004); Schmitt, K. et al.: J. Neurochem., 112, 1605 (2010); Sabelli, H., et al.: Biol. Psychiat., 11, 481 (1976)<br></p>

<p>Applications 3,3’,5-Triiodo-L-thyronine O-β-D-Glucuronide Sodium Salt is the sodium salt of T795405, which is the O-glucuronide derivative of 3,3’,5-Triiodo-L-thyronine (T795380); one of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.<br>References Gross, J., et al.: Lancet I, 439 (1952); Roche, J., et al.: Biochim. Biophys. Acta, 11, 215 (1953); Chacon, M.A., et al.: J. Pediatr., 99, 758 (1981); Chopra, I.J., et al.: Thyroid, 6, 255 (1996)<br></p>

<p>Applications N,N-Diethyl-3-(mesitylsulphonyl)-1H-1,2,4-triazole-1-carboximidamide (Cafenstrole) (cas# 125306-83-4) is a useful research chemical.<br></p>

<p>Applications Fluazifop-P-butyl<br></p>

<p>Applications A labelled selective serotonin reuptake inhibitor (SSRI). Used as an antidepressant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Wong, D.T., et al.: Life Sci., 15, 471 (1974), Goldstein, D.J., et al.: Br. J. Psychiat., 166, 660 (1995), Ni, Y.G., et al.: Proc. Nat. Acad. Sci. USA, 94, 2036 (1997)<br></p>

<p>Applications (8Z)-8-Dodecen-1-ol is a component of various insect sex pheromones.<br>References Kim, S.H., et al: Repub. Korean Kongkae Taeho Kongbo, KR 2015046436 A 20150430 (2015); Ma, R., et al.: Faming Zhuanli Shenqing, CN 104177256 A 20141203 (2014)<br></p>

<p>Applications N-Ethyl-N-(2-hydroxyethyl)perfluorooctylsulphonamide is a perfluorinated alkyl sulfonamide (PFAS) used in a variety of consumer products for surface protection. It is a pollutant found in the air.<br>References Shoeib, M., et al.: Environ. Sci. Technol., 39, 6599 (2005); Martin, J., et al.: Anal. Chem., 74, 584 (2002)<br></p>

<p>Applications Xanthohumol is found in the hop plant Humulus Lupulus. Xanthohumol decreases inflammation, oxidative stress, and angiogenesis during the healing of skin wounds in type 1 diabetic rats.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Costa, R., et. al.: J. Nat. Prod., 76, 2047 (2013) Yuan, Y., et. al.: Eur. J. Pharmaceut. Sci., 53, 55 (2014)<br></p>

<p>Applications Pigment Violet 23 is an organic pigment found in various colourings such as tattoo inks, visual art and archeological objects. Pigment Violet 23 is also used in the preparation of nano silica-filled color resists.<br>References Persechino, S.; et al.: Spectrochim. Acta, Part A, 206, 547 (2019); Domenech-Carbo, M. T.; et al.: ChemTexts, 2, 1 (2016); Lee, C.; et al.: Adv. Polym. Tech., 31, 163 (2012).<br></p>

<p>Stability Hygroscopic<br>Applications One of the bioactive forms of Riboflavin. Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, leafy vegetables. Richest natural source is yeast. Minute amounts present in all plant and animal cells. Vitamin (enzyme cofactor).<br>References Unna, K., et al.: J. Pharmacol. Exp. Ther., 76, 75 (1942), Rivlin, et al.: N. Engl. J. Med., 283, 463 (1970), Al-Shammary, F.J., et al.: Anal. Profiles Drug Subs., 19, 429 (1990),<br></p>

<p>Applications A new indicator for the determination of organic acid anhydrides by the morpholine method.<br>References Ruch, J.E., et al.: Anal. Chem., 47, 2057 (1975),<br></p>