Toxicologie

<p>Applications Rimantadine-d4 Hydrochloride is an isotope labeled version of Rimantadine Hydrochloride, an antiviral agent.<br>References Hayden, F.G., et al.: Antimicrob. Ag. Chemother., 19, 226 (1981), Zlydnikov, D.M., et al.: Rev. Infect. Dis., 3, 408 (1981),<br></p>

<p>Applications Picloram is used as a herbicide. Studies show that Picloram can reduce seed germination rate and vigor as well as seedling growth in Bidens pilosa L.<br>References Freitas, M.R., et al.: RSC Adv., 5, 7547 (2015); Tian, X., et al.: Nongyao, 53, 485 (2014)<br></p>

<p>Applications Mono N-Desmethyl Disperse Polyester Dark Blue is a disperse dye for synthetic polyester fibers. It has good heat and light resistance and is used for thermal transfer recording.<br>References Peters A. T., et al.: J. Soc. Dyers Colour, 108(7-8), 344-8 (1992)<br></p>

<p>Applications Dazomet is a as fumigant used for the control of brown root rot disease. Dazomet was shown to be a possible agent in preventing pest incursion in agriculture, gardening and agroforestry.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fu, C.H., et al.: Pest. Mange. Sci., 68, 959 (2012); Liberatore, L., et al.: Water. Air. Soil Poll., 223, 4751 (2012); Sande, D., et al.: Int. J. Enviro. Res. Pub. Health., 8, 4649 (2011);<br></p>

<p>Stability Hygroscopic<br>Applications Antiepileptic; increases levels of GABA in the brain.<br>References Chang, Z.L., et al.: Anal. Profiles Drug Subs., 8, 529 (1979), Nau, H., et al.: Pharmacol. Toxicol., 69, 310 (1991), Loscher, W., et al.: Prog. Neurobiol., 58, 31 (1999)<br></p>

<p>Applications Anhydrovinblastine showed significant cytotoxic potential against a panel of human cancer cell lines and significant activity against the human H460 non-small cell lung carcinoma tumor xenograph in mice.<br>References Koiso, Y., et al.: J. Antibiot., 51, 418 (1998), Olver, I., et al.: Eur. J. Cancer, 43, 1829 (2007), Shao, Y., et al.: Bioorg. Med. Chem., 15, 5061 (2007).<br></p>

<p>Applications Propamocarb-N-oxide is an impurity of Propamocarb (P758460), a carbamate fungicide used in the agriculture industry.<br>References Judelson, H., et al.: Mol. Plant Pathol., 7, 17 (2005), Grunwald, N., et al.: Phytopathol., 96, 1397 (2006),<br></p>

<p>Applications Labelled Menthol. Used for oral gel patch or film containing herb extracts or Chinese medicine, fruit extract, spearmint, and menthol for smoking cessation.<br>References Ikaheimo, I., et al.: J. Antimicrob. Chemother., 46, 287 (2000), Gillet, Y., et al.: Lancet, 359, 753 (2002), Turos, E., et al.: Bioorg. Med. Chem. Lett., 2002, 12, 2229 (2002),<br></p>

<p>Applications Fenquinotrione is commonly involved in herbicidal mixtures and is commonaly used in soybean and cotton cultures.<br>References Zagar, C., et al.: PCT Int. Appl. 32 (2020)<br></p>

<p>Stability Hygroscopic<br>Applications A new nitrification inhibitor to be used on solid and in liquid fertilizers and slurry.<br></p>

<p>Stability Hygroscopic<br>Applications β-Nicotyrine-d3, is the labeled analogue of β-Nicotyrine (N445002), which is an alkaloid derived from the dehydrogenation of nicotine and its analog, nornicotine. An alkaloid occurring in cigaret smoke.<br>References Swain, M.L., et al.: J. Am. Chem. Soc., 71, 1341 (1949);<br></p>

<p>Applications Second generation purine nucleoside analog; antimetabolite that inhibits DNA synthesis and resists deamination by adenosine deaminase. Antineoplastic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gandhi, V., et al.: Clin. Cancer Res., 9, 6335 (2003), Kantarjian, H., et al.: Blood, 102, 2379 (2003), Faderl, S., et al.: Cancer, 103, 1985 (2005),<br></p>

<p>Applications Ethylmorphine impurity.<br>References Pfeifer, S., et al.: Pharmazie, 27, 648 (1972),<br></p>

<p>Applications Sethoxydim is a neuroplastin isoforms, a member of Ig superfamily. It is expressed and important in stereocilia of outer hair cells function. Also, it is derived from Crotonaldehyde (C818650), which is an αβ-unsaturated aldehyde and an alkylating agent that is commonly found in tobacco smoke and some foods. Crotonaldehyde is also a known mutagen and carcinogen.<br>References Zeng, W., et al.: J. Neurosci., 36, 9201-9216 (2016); Scherer, G., et al.: Hum. Exp. Toxicol., 26, 37 (2007); Zhang, S., et al.: Chem. Res. Toxicol., 19, 1386 (2006)<br></p>

<p>Applications Allopurinol-13C,15N2, is the labeled analogue of Allopurinol (A547300), acting as an Xanthine oxidase inhibitor, and used in treatment of hyperuricemia and chronic gout.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Benezra, S.A., et al.: Anal. Profiles Drug Subs., 7, 1, (1978), Dalbeth, N., et al.: Rheumatology, 44, 1090 (2005), Dinarello, C., et al.: J. Exp. Med., 201, 1355 (2005),<br></p>

<p>Applications Bedaquiline is a diarylquinoline derivative that acts as a mycobacterial inhibitor. Bedaquiline shows promise as potential drug in the treatment of tuberculosis.<br>References de Jonge M.R. et al.: Proteins, 67, 971 (2007); Diacon A.H. et al.: N. Eng. J. Med., 360, 2397 (2009);<br></p>

<p>Applications Used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.<br>References Denny, W., et al.: J. Med. Chem., 33, 814 (1990), Maurya, M., et al.: J. Chem. Res., 446 (1998),<br></p>

<p>Applications Thifensulfuron is used as a herbicide, a chemical compound that function by inhibiting the action of a plant enzyme, stopping plant growth, and eventually killing the plant.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Battaglin, W. A., et al.: Sci. Total Environ., 248, 123(2000)<br></p>

<p>Applications A natural product with significant antitumor activities.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Sah, N., et al.: J. Biol. Chem., 278, 20593 (2003), Lu, D., et al.: J. Int. Med. Res., 32, 488 (2004), Yunmbam, M., et al.: Oncol. Rep., 11, 833 (2004), Shao, S., et al.: Cell Biol. Int., 32, 893 (2008),<br></p>

<p>Applications cis-9-Hexadecenoylcarnitine Inner Salt is an L-carnitine metobolite which are often used to diagnose specific inherited metabolic diseases.<br>References Yang, S. et l.: J. Chrom. B., Anal. Tech. Biomed. Life Sci., 857, 251 (2007); Minkler, P. et al.: J. Chrom. B., Anal. Tech. Biomed. Life Sci. 1061, 128 (2017);<br></p>

<p>Applications 2,6-Diisopropylnaphthalene, is a building block used for the synthesis of more complex compounds. 2,6-Diisopropylnaphthalene (2,6-DIPM) is also used in the manufacturing of pesticide products intended to prevent sprouting of stored potatoes.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Beaver, R. G., et al.: American Journal of Potato Research, 80, 311 (2013);<br></p>

<p>Applications Trimethadione is an anticonvulsant and antiepileptic agent used in the treatment of pregnant women. Prenatal exposure to anti-epileptic drugs (AEDs) has indicated increased risk of major or minor congenital malformation.<br>References Ahir, B. et al.: Toxicol. Vitro., 28, 948 (2014); Pastore, V. et al.: Bioorg. Med. Chem., 21, 841 (2013);<br></p>

<p>Applications Saflufenacil is a herbicide of the pyrimidinedione chemical class used for the preplant burndown and selective preemergence dicot weed control in different field crops. It was found to inhibit protoporphyrinogen IX oxidase (PPO) enzyme.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Knezevic, S., et al.: Crop Prot., 29, 148 (2010); Grossmann, K., et al.: Weed Sci., 58, 1 (2010);<br></p>

<p>Stability Light Sensitive<br>Applications Semisynthetic antibiotic. Antibacerial (tuberculostatic).<br>References Furesz, et al.: Antibiot. Chemother., 16, 316 (1970), Gallo, G.G., et al.: Anal. Profiles Drug Subs., 5, 467 (1976),<br></p>

<p>Applications N-Decarboxymethylated Indoxacarb is used in HPLC determination of DCJW in rat plasma and also has its application to pharmacokinetics studies<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhang. H., et al.: Chromatographia, 66, 493 (2007);<br></p>

<p>Applications Dexketoprofen Trometamol is an non-steroidal anti-inflammatory drug used for the treatment of mild to moderate pain.<br>References Gokce, B., et al.: J. Enzyme. Inhibit. Med. Chem., 27, 37 (2012); Sagiroglu, G., et al.: Eurosian. J. Med., 43, 23 (2011);<br></p>

<p>Applications A novel labelled HIV reverse transcriptase inhibitor useful in treatment of HIV infection.<br>References Scholler-Gyure, M., et al.: J. Clin. Pharmacol., 48, 322 (2008), Thakur, A., et al.: Eur. J. Med. Chem., 43, 471 (2008),<br></p>

<p>Applications Carbapenem is an antibiotic and antibacterial.<br>References Sunagawa, M., et al.: J. Antibiot., 43, 519 (1990), Hurst, M., et al.: Drugs, 59, 653 (2000),<br></p>

<p>Applications Analgesic (narcotic). Preparation by electrolytic reduction of Morphine.Controlled substance (opiate).<br>References Buchwald, M.E., et al.: J. Pharmacol. Exp. Ther., 71, 197 (1941), Zernig, G., et al.: Life Sci., 57, 2113 (1995), Keith, D., et al.: J. Biol. Chem., 271, 19021 (1996), Pawar, M., et al.: Eur. J. Pharmacol., 563, 92(2007),<br></p>

<p>Stability Hygroscopic<br>Applications Chlorhexidine Digluconate Impurity K was found in a study of the kinetics of chlorhexidine hydrolysis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zong, Z., Lee, E.K.: J. Pharm. Sci., 101, 2417 (2012)<br></p>

<p>Stability Very Hygroscopic<br>Applications A labelled metabolite of the pesticide Glyphosphate (G765000).<br>References Siehl, D.L. et al.: J. Biol. Chem., 282, 11446 (2007); Env. Prot. Agen. EPA: Fed. Reg., 74, 67129 (2009);<br></p>

<p>Applications (1R-cis)-Cyhalothric Acid is an intermediate in the synthesis of Bifenthrin (B383000), a third generation synthetic pyrethroid.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Faming Zhuanli Shenqing (2012), CN 102827004 A 20121219. Wei, W. J., et al.: Chirality., 22, 604 (2010);<br></p>

<p>Stability Hygroscopic<br>Applications A metabolite of Lamivudine (L172500).<br>References Burgess, K., et al.: Chem. Rev., 100, 2047 (2000), Gallois-Montbrun, S., et al.: Biochem. Pharmacol., 68, 1749 (2004),<br></p>

<p>Applications Pyrisoxazole is a novel fungicide, inhibitor of Sterol 14α-demethylase.<br>References Chen, F., et al.: Plant Dis., 96, 416 (2012); Chen, F., et al.: Sci. Rep., 4, 6473 (2014);<br></p>

<p>Applications A vasodilator.<br>References Varga, J., et al.: Mol. Immunol., 28, 641 (1991), Marrero-Ponce, Y., et al.: Bioorg. Med. Chem., 13, 2881 (2005),<br></p>

<p>Applications A stable labelled selective HIV protease inhibitor Ritonavir (R535000). It is a COVID19-related research product.<br>References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153(2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788 (2006)<br></p>

<p>Applications A metabolite of Levofloxacin.<br>References Sudo, K., et al.: Xenobiotica, 16, 72 (1986), Wong, F., et al.: Drug Metab. Dispos., 18, 1103 (1990), Aminimanizani, A., et al.: J. Clin. Pharmacokinet., 40, 169 (2001), Athamna, A., et al.: J. Antimicrob. Chemother., 53, 247 (2004), Tanaka, M., et al.: J. Pharmacol., 56, 463 (2004),<br></p>

<p>Applications Labelled Ezetimibe (E975000), an antihyperlipoproteinemic. A Cholesterol absorption inhibitor.<br>References van Heek, M., at al.: J. Pharmacol. Exp. Ther., 283, 157 (1997), van Heek, M., at al.: Brit. J. Pharmacol., 129, 1748 (2000)<br></p>

<p>Applications Isotope labelled Nonacetylated aspirin analog. Analgesic, anti-inflammatory.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Harrison, L.L., et al.: J. Pharm. Sci., 69, 1268 (1980), Dromgoole, S.M., et al.: J. Pharm. Sci., 73, 1657 (1984),<br></p>

<p>Applications Methyl-1-Testosterone is a derivative of dihydrotestosterone. Methyl-1-Testosterone is a designer anabolic steroid that is on the world anti-doping agency’s (WADA) prohibited list.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Parr, M.K. et al.: Endocrinology, 152, 4718 (2011); Liu, Y. et al.: Drug Test. Anal., 3, 54 (2011); Jeon, B.W. et al.: Anal. Bioanal. Chem., 401, 1353 (2011);<br></p>