Toxicologie

<p>Stability Hygroscopic<br>Applications Cyclopropanecarboxyl Carnitine Chloride is a salt derivative of Cyclopropanecarboxyl Carnitine (C179155), a metabolite of Cycloprate (C998970), an insecticide with ovicidal activity, in rats.<br>References Asano, S., et al.: Apl. Entomol. Zool., 17, 67 (1982); Asano, S., et al.: Nippon Oyo Dobutsu Konchu Gakkaishi, 23, 113 (1979)<br></p>

<p>Applications Bifenazate-d5 is the labelled analogue of Bifenazate (B383021), which is a selective miticide for the control of a variety of mite pests on crops. Used in Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240).<br>References Sipes, N.S., et al.: Chem. Res. Toxicol., 26, 878 (2013); Sbartai, I., et al.: Adv. Environ. Biol., 6, 2249 (2012);<br></p>

<p>Applications Isotope labelled N-Acetylaminomethylphosphoric Acid is been found to show inhibitory properties towards ureases.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Berlicki, L. et al.: Amino Acids, 42, 1937 (2012);<br></p>

<p>Applications Doxycycline-d3 Hyclate, is the labeled analogue of Doxycycline Hyclate (D561500), acting as an Antibacterial.<br>References Fabre, et al.: Chemotherapia, 11, 73 (1966), Goldenthal, et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), Polson, A.M., et al.: J. Periodontol., 68, 110 (1997),<br></p>

<p>Applications A urease inhibitor.<br>References Zaman, M., et al.: Soil Biol. Biochem., 41, 1270 (2009), Giovannini, C., et al.: J. Agric. Food Chem., 57, 4883 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications Fosfomycin Tromethamine is used as an antibiotic compound in the treatment of urinary tract infections.<br>References Keating, G. et al.: Drugs, 73, 1951 (2013); Demir, T. et al.: Int. J. Infect. Dis., 17, e966 (2013);<br></p>

<p>Stability Hygroscopic<br>Applications Cobicistat is a HIV protease inhibitor and has been coadministered with low-dose ritonavir (R535000) as a pharmacoenhancer, significantly increasing their plasma concentrations.<br>References Von, H., Exp. Rev. Clin. Pharmacol., 5, 557 (2012); Lepist, E.I., et al.: Antimicrob. Agent. Chemother., 56, 5409 (2012); Orr, S.T.M., et al.: J. Med. Chem., 55, 4896 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications Oseltamivir-d5 Phosphate is the isotope labelled analog of Oseltamivir (O701000); an orally active inhibitor of influenza virus neuraminidase; converted in vivo to the active acid metabolite. Also an antiviral drug. It is a COVID19-related research product.<br>References Oliyai, R., et al.: Pharm. Res., 15, 1300 (1998); Kim, C.U., et al.: Med. Chem. Res., 8, 392 (1998); Hayden, F.G., et al.: N. Engl. J. Med., 341, 1336 (1999); Treanor, J.J., et al.: J. Am. Med. Assoc., 283, 1016 (2000)<br></p>

<p>Applications β-Adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic; antiglaucoma.<br>References Nakagawa, K., et al.: J. Med. Chem., 17, 529 (1974), Morita, S., et al.: Biochem. Pharmacol., 25, 1836 (1976), Chu, S.Y., et al.: J. Pharm. Sci., 67, 1623 (1978), Chiba, S., et al.: Arzneim.-Forsch., 29, 895 (1979), Chrisp, P., et al.: Drugs Aging, 2, 58 (1992),<br></p>

<p>Applications Direct Blue 218 is an azo dye used in diagnostic imaging. Used in the prediction of rat carcinogenisis. Also used in textile dyes contributing to textile effluents and wastewaters.Environmental toxin on US EPA Toxic Release Inventory list (TRI) list.<br>References Baughman, G. et al.: Textile. Chemist. Color. Am. Dye. Rep., 32, 51 (2000);<br></p>

<p>Applications Methoxyfenozide-d9 is deuterium labelled Methoxyfenozide (M262765). It is used primarily as an insecticide, and pesticide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zhao, Q., et al.: J. Agricul, Food Chem., 56, 10799 (2008);<br></p>

<p>Stability Hygroscopic<br>Applications Stearoyl-L-carnitine-d3 Hydrochloride is labelled Stearoyl Carnitine (S686515), A carnitine ester which was tested for its ability to inhibit protein kinase C (PKC).<br>References Sakata, K., et al.: Cardiovasc. Res., 23, 505 (1989), Fulceri, R., et al.: Biochem. J., 325, 423 (1997), Yu, L., et al.: J. Pharmacol. Exp. Ther., 286, (1998),<br></p>

<p>Applications Oxybenzone is an organic compound used in sunscreens. Oxybenzone is used as an ingredient in sunscreen and other cosmetics because it absorbs UVB and short-wave UVA (ultraviolet) rays. Oxybenzone was one of the first compounds incorporated into sunscreen formulations to offer enhanced UVA protection because its absorption spectrum extends to less than 350 nm.<br>References Auriol, M., et al.: Chemosphere, 70, 445 (2008); Balmer, M., et al.: Environ. Sci. Technol., 39, 953 (2005); Jeon, H., et al.: Toxicology, 248, 89 (2008); Campoy, S., et al.: Environ. Microbiol., 11, 99 (2009); Chem. and Eng. News page 22, Aug. 6 (2018)<br></p>

<p>Applications Labelled β-Hyodeoxycholic Acid. A potential bile acid metabolite.<br>References Abadie, C., et al.: Biochem. J., 299, 725 (1994), Taniguchi, T., et al.: J. Biol. Chem., 269, 10071 (1994), Davis, R., et al.: J. Lipid Res., 43, 533 (2002),<br></p>

<p>Applications Topramezone is a herbicide that belongs to the class of pyrazolones or benzoylpyrazoles. It can be used to control broad leaved weeds and grass weeds in maize crop protection.<br>References Gitsopoulos, K.T., et al.: Crop Protection, 29, 1091-1093 (2010); Zhang, J., et al.: Crop Protection, 52, 26-32 (2013)<br></p>

<p>Applications Labelled Ceftiofur (C244700). An antibacterial.<br>References Yancey, R.J., et al.: Am. J. Vet. Res., 48, 1050 (1987)<br></p>

<p>Applications Barbadin is a selective β-arrestin/β2-adaptin inhibitor. It selectively inhibits the interaction between b-arrestin and the b2-adaptin subunit of the clathrin adaptor protein AP2 without affecting the formation of receptor/b-arrestin complexes.<br>References Beautrait, A., et al.: Nat Commun. 8, 15054 (2017)<br></p>

<p>Stability Hygroscopic, Moisture Sensitive, Temperature Sensitive<br>Applications Labelled Myosmine (M835000). Myosmine is an alkaloid found in tobacco. Myosmine has been suspected to be a tobacco-independent carcinogenic source.<br></p>

<p>Applications: 3-Mesityl-2-oxo-1-oxaspiro[4.4]non-3-en-4-ol, is the metabolite of Spiromesifen, which is a Spirocyclic Tetronic Acid, environmentally friendly and novel structural pesticide.<br>Dangerous Goods Info: Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Jin-Hao, Zh., et al.: Pest Management Science, 68, 10 (2012);<br></p>

<p>Applications Used as an antiparkinsonian.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Hai, N., et al.: Int. J. Pharm., 357, 55 (2008), Sanderson, H., et al.: Toxicol. Lett., 187, 84 (2009),<br></p>

<p>Impurity Ropivacaine EP Impurity A<br>Applications (S)-(-)-Bupivacaine (Ropivacaine EP Impurity A) is used as a local anaesthetic used for epidural and intrathecal anaesthesia.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tullar, B., et al.: J. Med. Chem., 14, 891 (1971), Schmidt, A., et al.: Pharm. Res., 22, 2121 (2005),<br></p>

<p>Applications Thiodicarb is used as an insecticide (1,2). May cause systemic organ toxicity in mammals as tested in Wistar rats (3). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Powell, J. et al.: J. Econ. Entomol. (1986) 79 (5): 1343-1346.2. Armes, N. et al.: Pest Man. Sci. 1992. Jul:34(2);355-3643. Dias, E. et al.: J. Toxicol. Environ. Health A. 2013;76(9):533-9.<br></p>

<p>Applications N-Desmethyl-6-O-methylerythromycin (9E)-Oxime is a derivative of Clarithromycin (C559750); a semi-synthetic macrolide antibiotic and derivative of Erythromycin (E650000).<br>References Benson, C., et al.: Eur. J. Clin. Microbiol., 6, 173 (1987); Boyanova, L., et al.: J. Med. Microb., 61, 85 (2012); Lin, Z., et al.: Toxicol. Sci., 126, 114 (2012)<br></p>

<p>Stability Moisture Sensitive<br>Applications Isotope labelled Potassium Thiocyanate has been used as a catalyst in a one-pot reaction of dialkyl acetylenedicarboxylates with indane-1,3-dione. Potassium Thiocyanate has been used as a selective bacterial inhibitor to create ESS-3 broth to allow co-​enrichment of the target pathogens and suppress growth of some non-​target pathogens<br>References Hassanabadi, A., Zhiani, R., et. al.: J. Chem. Res., 37, 458 (2013); Zhang, Q., et. al.: Plant. Biotech., 29, 103 (2012)<br></p>

<p>Applications Isotope labelled Linoleoyl Carnitine (L486200), a carnitine ester of unsaturated fatty acid. Used in the studies of fibroblasts in long-chain 3-hydroxyacyl-CoA dehydrogenase deficiency and fatty acid oxidation disorders.<br>References Gross R.W., et al.: J. Biol. Chem., 258, 5221 (1983),<br></p>

<p>Applications Bromoxynil Octanoate is a herbicide which possesses control effect and security against weeds in summer corn field.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Feng, Y., et al.: Nongyao, 54, 375-377 (2015)<br></p>

<p>Applications Protopine is a Ca2+ channel blocker and antiplatelet agent (1,2,3). It is also an immunomodulator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References (1) Janbaz, K., et al.: Pharmacol. Res., 38, 215 (1998)(2) Lai, C., et al.: Clin. Chem., 45, 229 (1999)(3) Ma, H., et al.: J. Pharm. Biom. Anal., 49, 440 (2009)<br></p>

<p>Applications SAR131675 is a potent and selective VEGFR-3 inhibitor. It inhibited VEGFR-3 tyrosine kinase activity and VEGFR-3 autophosphorylation in HEK cells. SAR131675 also dose dependently inhibited the proliferation of primary human lymphatic cells, induced by the VEGFR-3 ligands VEGFC and VEGFD.<br>References Alam, A., et al.: Mol. Cancer. Ther., 11, 1637 (2012);<br></p>

<p>Applications (R)-(-)-Carvone, is an antinociceptive monoterpene found as the main active constituent of essential oils obtained from plants of the genus Mentha. It is a novel agonist of TRPV1 channels. It can also be used as a chiral starting material.<br>References Goncalves, J.C., et al.: Cytometry part A., 83(2), 212 (2013); Liebigs ann., Chem., 403 (1993);<br></p>

<p>Impurity Ceftazidime EP Impurity E<br>Applications Ceftazidime t-Butyl Ester (Ceftazidime EP Impurity E) Ceftazidime t-Butyl ester is an impurity of Ceftazidime (C244100). Ceftazidime impurity C.<br>References Miyake, A., et al.: Antimicrob. Agents Chemother., 486, 182 (1989), Seibert, G., et al.: Arzneim.-Forsch., 33, 1084 (1983),<br></p>

<p>Applications Favipiravir is used for the treatment of advanced Ebola virus infection in a small animal model. Favipiravir suppressed the replication of Zaire Ebola virus and prevented a lethal outcome in 100% of the animals. Based on the studies, Favipiravir can be a candidate for the treatment of Ebola hemorrhagic fever. It is a COVID19-related research product.<br>References Oestereich, L., et al.: Antiviral Res., 105, 17 (2014); Baranovich, T., et al.: J. Virol. 87, 3741 (2013); Chem. and Eng. News p.8, Dec. 1 (2014)<br></p>

<p>Applications A metabolite of the fluorinated quinolone antibacterial Ciprofloxacin.<br>References Tiefenbacher, E., et al.: J. Pharm. Sci., 83, 463 (1994), Parshikov, I., et al.: App. Microbiol. Biotechnol., 56, 474 (2001),<br></p>

<p>Applications L-Kynurenine is a tryptophan metabolite which is a precursor of kynurenic acid (K660500) and an antagonist of N-methyl-aspartate receptor.<br>References Swartz, K., et al.: J. Neurosci., 10, 2965 (1990);, Hasegawa, H., et al.: Anal. Bioanal. Chem., 377, 886 (2003); Tsai, Y., et al.: Anal. Biochem., 319, 34 (2003); Mitsuhashi, S., et al.: Anal. Chim. Acta, 584, 315 (2007)<br></p>

<p>Applications Lactofen is a complex ester derivative of Acifluoren, a diphenyl ether herbicide. Lactofen can be used in postemergence applications and is commonly used as foliar spray. Lactofen is used in agriculture to control broadleaved weeds in soybean, cereals, potatoes and peanuts.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kurtz, M.E.: Indust. Crop. Prod., 5, 119 (1996); Novo, M.C.S.S. et al.: Sci. Agric., 55, 276 (1998); Dann, E.K. et al.: Phytopathology, 89, 598 (1999);<br></p>

<p>Applications Risedronic Acid is a pyridinyl biphosphonate bone resorption inhibitor.<br>References Mortensen, L., et al.: J. Clin. Endocrinol. Metab., 83, 396 (1998); Harris, S.T., et al.: J. Am. Med. Assoc., 282, 1344 (1999); Boiser, S., et al.: Cancer Res., 60, 2949 (2000)<br></p>

<p>Stability Hygroscopic<br>Applications Antibiotic complex produced by Streptomyces kanamyceticus Okami &amp; Umezawa from Japanese soil. Comprised of three components, kanamycin A, the major component, and kanamycins B and C, two minor congeners. Antibacterial.A representative lot contains d4, d5, d6, d7, d8, and d9.<br>References Ito, et al.: J. Antibiot., 17, 189 (1964), Toda, S., et al.: J. Antibiot., 30, 1002 (1977), Claes, P.J., et al.: Anal. Profiles Drug. Subs., 6, 259 (1977),<br></p>

<p>Applications Semi-synthetic cephalosporin antibiotic. Antibacterial.A representative lot contains some d5.<br>References Buck, R.E., et al.: Antimicrob. Agents Chemother., 11, 324 (1977),<br></p>

<p>Applications Palmitoyl-16,16,16-d3-L-carnitine Hydrochloride is the isotope labelled analog of Palmitoyl-L-carnitine Hydrochloride (P155050); a long-chain fatty ester of carnitine which is accumulated and released into the circulation in fatty-acid oxidation defects.<br>References Ventura, F., et al.: Clinica Chimica Acta, 281, 1 (1999); Pourfarzam, M., et al.: Clinical Chem,, 40, 2267 (1994); Schaefer, J., et al.: Pediatric Res., 37, 354 (1995)<br></p>

<p>Applications A novel anti-tuberculosis drug.<br>References Diacon, A.H. et al.: Antimicrob. Anents Chemother., 54, 3402 (2010); Dogra, M. et al.: Br. J. Pharmacol., 162, 226 (2010); Ginsberg, A.M. et al.: Antimicrob. Agents Chemother., 53, 3720 (2009);<br></p>

<p>Stability Hygrscopic<br>Applications A metabolite of Caffeic acid.<br>References Zhu, B., et al.: J. Biol. Chem., 269, 292 (1994), Azuma, K., et al.: J. Agric. Food Chem., 48, 5496 (2000), Stark, T., et al.: J. Agric. Food Chem., 54, 5530 (2006), Hensel, A., et al.: Planta Med., 73, 142 (2007),<br></p>

<p>Applications Reversible dual inhibitor of ErbB1 and ErbB2 tyrosine kinases. Antineoplastic.<br>References Kim, T.E., et al.: Drugs, 6, 886 (2003), Wood, E.R., et al.: Cancer Res., 64, 6652 (2004), Spector, N.L., et al.: J. Clin. Oncol., 23, 2502 (2005),<br></p>