Toxicologie

<p>Stability Light Sensitive<br>Applications Maytansine inhibits in vitro polymerization of tubulin and is used in the treatment of advanced breast cancer.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Remillard, S., et. al.: Science, 189, 1002 (1975); Prota, A.E., et. al.: P. Natl. Acad. Sci. USA, 111, 13817 (2014)<br></p>

<p>Applications An anti-inflammatory and analgesic agent. Anesthetic (local).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Reynolds, et al.: Br. J. Anaesth., 43, 33 (1971), Tullar, et al.: J. Med. Chem., 14, 891 (1971), Aberg, G., et al.: Acta Pharmacol. Toxicol., 31, 273 (1972),<br></p>

<p>Applications Sedative, hypnotic.Controlled substance (depressant).<br>References Lomen, P., et al.: J. Int. Med. Res., 4, 55 (1976), Allens, G.S., et al.: J. Int. Med. Res., 6, 343 (1978), Pakes, G.E., et al.: Drugs, 22, 81 (1981)<br></p>

<p>Applications Aminopyralid is used as a herbicide for control weeds and arthropods.<br>References Mitich, L., et al.: Weed Technol., 14, 231 (2000), Berisford, Y., et al.: Weed Sci., 54, 391 (2006), Westra, P., et al.: Proc. Weed Sci. Soc. America, 49, 407 (2009),<br></p>

<p>Stability Hygroscopic<br>Applications MCPA-L-carnitine is a derivative of L-Carnitine (C184110); an essential cofactor of fatty acid metabolism required for the transport of fatty acids through the inner mitochondrial membrane.<br>References Mitchell, M.E., et al.: Am. J. Clin. Nutr., 31, 293 (1978); Lango, R., et al.: Cardiovasc. Res., 51, 21 (2001); Vaz, F.M., et al.: Biochem. J., et al.: 361, 417 (2002); Karlic, H., et al.: Nutrition, 20, 709 (2004)<br></p>

<p>Applications (±)-Fluazifop-d4 is a labeled analogue of (±)-Fluazifop (F407430), a grass-selective herbicide which inhibits acetyl-CoA carboxylase in sensitive plant species.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Walker, K.A., et. al.: Biochem. J., 254, 307 (1988); Hajslova, J., et. al.: J. Chrom., 438, 55 (1988)<br></p>

<p>Applications Xanthine derivative with diuretic, cardiac stimulant and smooth muscle relaxant activities; isomeric with theobromine. Small amounts occur in tea. Bronchodilator.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Cohen, J.L., et al.: Anal. Profiles Drug Subs., 4, 466 (1975), Svedmyr, K., et al.: Allergy, 37, 111 (1982),<br></p>

<p>Applications cis-1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantantane Chloride is a quaternary ammonium salt used as a preservative in many cosmetics and industrial substances.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Marouchoc, S.: Cosm. Sci. Technol. Series, 1, 143 (1984); Cheng, J., et al.: J. Toxicol. Cutan. Ocul. Toxicol., 14, 287 (1995);<br></p>

<p>Applications Amfenac is an antibacterial agent for the treatment of otitis externa.<br>References Sofia, R.D., et al.: Pharmacol. Res. Communications, 11, 179 (1979),<br></p>

<p>Applications Flupyradifurone (F598615), the unlabelled version of Flupyradifurone-d5, can be used as an insecticide.<br>References Anon, IP.com J., 12, 19 (2011)<br></p>

<p>Applications Hydroxy Tyrosol 3-Sulphate is a metabolite of Hydroxy Tyrosol (H977000).<br>References Owen, R., et al.: Eur. J. Cancer., 36, 1235 (2000), Bakalbassis, E., et al.: Lipids, 36, 181 (2001), Nenadis, N., et al.: J. Agric. Food Chem., 51, 1874 (2003),<br></p>

<p>Applications LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models.<br>References Kim, S., et al.: Mol. Cancer Ther., 12, PR02 (2013); Rader, J., et al.: Clin. Cancer Res., 19, 6173 (2013)<br></p>

<p>Applications A labelled Phentolamine (P302550). An adrenergic blocking agent. An antihypertensive. Used for the treatment of pheochromocytoma.<br>References Meier, R., et al.: Proc. Soc. Exp. Biol. Med., 71, 70 (1949), Spergel, G., et al.: J. Am. Med. Assoc., 211, 266 (1970), Gould, L. and Reddy, C.V.R.: Am. Heart J., 92, 397 (1976)<br></p>

<p>Applications Labelled Carbamazepine (C175840). Used in treatment of pain associated with trigeminal neuralgia. Anticonvulsant.<br>References Stenger, E.G., et al.: Med. Exp., 11, 191 (1964), Pynnonen, S., et al.: Ther. Drug Monit., 1, 409 (1979), Sidebottom, A., et al.: J. Clin. Pharm. Ther., 20, 31 (1995)<br></p>

<p>Applications Metriram is a polymeric dithiocarbamic fungicide used in agriculture. Metiram is present as a mixture rather than a complex and is not assigned an ISO name. Metiram is used commonly in the protection of grapevines, apples, tomatoes, potatoes as well as other crops.<br>References Golyshin, N.M&gt; et al.: Khim. Sel. Khoz., 4, 897 (1965); Ross, R.G. et al.: Can. J. Plant Sci., 58, 601 (1978); Newsome, W.H. et al.: J. Agric. Food Chem., 24, 999 (1976);<br></p>

<p>Applications Baricitinib is a JAK1 and JAK2 inhibitor and have been used as a promising treatment for rheumatoid arthritis.<br>References Greenwald, L.J., et al.: Int. J. Clin. Rheumatol., 6, 401 (2011); Fridman, J.S., et al.: J. Immunol., 184, 5298 (2010);<br></p>

<p>Applications N,N-Dimethylformamide Di-tert-butyl Acetal is used as a reagent in the synthesis of fused bicyclic ethers which act as herbicides on broad-leaved weeds. It is also used as a reagent in the preparation and biological evaluation of cystobactamide 507 which is bacterial topoisomerase inhibitor.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Schaetzer, J., et al.: Bioorg. Med. Chem. Lett., 24, 4643 (2014); Casalini, F., et al.: Moreno, M., et al.: Synlett, 26, 1175 (2015)<br></p>

<p>Applications Fluometuron is an phenylurea based herbicide used on cotton and sugarcane crops.<br>References Can, A., et al.: Environ. Toxicol. Pharmacol., 35, 369 (2013); Reiss, R., et al.: Food. Chem. Toxicol., 50, 4421 (2012); Bibi, A.C., et al.: J. Agri. Sci., 150, 365 (2012);<br></p>

<p>Applications Oxyisofenphos is a stable degredation product of Isofenphos, a soil insecticide.<br>References Felsot, A.: J. Environ. Sci. Health. B, B19, 13 (1984); Hsin, C.Y., Coats, J.R.: Pestic. Biochem. Phys., 25, 336 (1986)<br></p>

<p>Applications Isotope labelled S-Enantiomer of Pregabalin (P704790). A GABA analogue used as an anticonvulsant. Anxiolytic analgesic used to treat peripheral neuropathic pain and fibromyalgia.<br>References Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)<br></p>

<p>Stability Hygroscopic<br>Applications A vitamin needed to synthesize DNA, conduct DNA repair and methylate DNA, it also acts as a cofactor in biological reactions involving folate.<br>References Xu, L., et al.: Mol. Pharm., 7, 1311 (2010), Everette, J., et al.: J. Agric. Food Chem., 58, 8139 (2010), Alshatwi, A., et al.: Food, Chem., Toxicol., 48, 1881 (2010), McKay, D., et al.: Nut. J., 9 (2010),<br></p>

<p>Applications Bevantolol is a cardioselective β-adrenergic blocker. Bevantolol is used as an antianginal, antihypertensive, antiarrhythmic.<br>References Hoefle, M.L., et al.: J. Med. Chem., 18, 148 (1975), Dukes, I.D., et al.: Br. J. Pharmacol., 84, 365 (1985), Lucas, C.P., et al.: Clin. Ther., 8, 49 (1985),<br></p>

<p>Applications A metabolite of 17β-Estradiol.<br>References Cushman, M., et al.: J. Med. Chem., 38, 2041 (1995), D’Amato, R.J., et al.: Proc. Natl. Acad. Sci. USA, 91, 3964 (1994), Forsis, T., et al.: Nature, 368, 237 (1994)<br></p>

<p>Applications Labelled Stearalkonium chloride. A compound used in products for promoting skin cleanliness and health.<br>References Lin, J., et al.: Biotechnol. Bioeng., 83, 168 (2003), Gabriel, M., et al.: Bioconjug. Chem., 17, 548 (2006),<br></p>

<p>Stability Hygroscopic<br>Applications Carmoterol is a highly potent β2-selective adrenoceptor agonist having a long-lasting bronchodilating effect.<br>References Abagyan, R., et al.: J. Mol. Biol., 235, 983 (1994), Matsukawa, M., et al.: J. Pharm. Biomed. Anal., 17, 245 (1998), Cole, P., et al.: Nat. Chem. Biol., 4, 590 (2008),<br></p>

<p>Applications Labelled Rasagiline. A selective irreversible MAO-B inhibitor. Rasagiline is an Antiparkinsonian agent.<br>References Rabey, J.M., et al.: Clin. Neuropharmacol., 23, 324 (2000), Glezer, S., et al.: Eur. J. Pharmacol., 472, 173 (2003), Youdim, M.B.H., et al.: Biochem. Pharmacol., 66, 1635 (2003), Chen, J.J., et al.: J. Clin. Pharmacol., 45, 878 (2005),<br></p>

<p>Applications (1R,2S,5R)-(-)-Menthol β-D-Glucuronide is a metabolite of L-(-)-Menthol (M218875), the natural form of Methanol.<br>References Eccles, R., et al.: J. Pharm. Pharmacol., 46, 618 (1994), Feng, S., et al.: Toxicol. Lett., 173, 101 (2007), Dempsey, D., et al.: Clin. Pharmacol. Ther., 76, 64 (2004),<br></p>

<p>Applications Acetylmethadol Hydrochloride is a synthetic opioid similar in structure to Methadone (M225865, HCl) used in the treatment of opiate dependence. It acts as a μ-opioid receptor agonist. It also acts as a potent, noncompetitive α3β4 neuronal nicotinic acetylcholine receptor antagonist.<br>References Billings, R.E., et al.: Life Sci., 14, 1437 (1974); Galici, R., et al.: Pharmacol. Biochem. Behav., 81, 626 (2005); Xiao, Y., et al.: J. Pharmacol. Exp. Therap., 299, 366 (2001)<br></p>

<p>Applications Betulinic Acid-d3 is the isotope labelled analog of Betulinic Acid (B330250); a natural pentacyclic triterpenoid that displays anti-inflammatory and anti-HIV activity. Betulinic Acid selectively induces apoptosis in tumor cells by directly activating the mitochondrial pathway of apoptosis through a p53- and CD95-independent mechanism. Betulinic Acid also exhibits TGR5 agonist activity.<br>References Pisha, E. et al.: Nat. Med., 1, 1046 (1995); Fulda, S. et al.: Cancer Res., 57, 4956 (1997); Kashiwada, Y. et al.: J. Med. Chem., 39, 1016 (1996); Genet, C. et al.: J. Med. Chem., 53, 178 (2010)<br></p>

<p>Impurity Albendazole EP Impurity E<br>Applications Carbendazim (Albendazole EP Impurity E) is a fungicide and an impurity of Albendazole.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Zeng, Z., et al.: J. Agric. Food Chem., 44, 3374 (1996), Lewis, D., et al.: Xenobiotica, 28, 235 (1998), Hodgson, E., et al.: J. Biochem. Mol. Toxicol., 21, 182 (2007),<br></p>