Toxicologie

Applications Labelled 3-Hydroxy-4-methoxycinnamic Acid (Isoferulic acid), a hypoglycemic agent.
References Liu, I.-M., et al.: J. Pharmacol. Exp. Ther., 307, 1196 (2003);

Applications Triadimefon is an triazole fungicide is used for the management of mango powdery mildew in South Gujarat.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Wang, S., et al.: Environ. Sci. Technol., 47, 4768 (2013); Sharma, H., et al.: J. Mycol. Plant. Pathnol., 42, 494 (2012);

Applications ((2S,3S,4R,5S)-4-Fluoro-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl)methyl Benzoate is an impurity of antiviral drug Clevudine (C574150), which is used for the treatment of Hepatitis B.
References Kwon, S., et al.: J. Virol., 84, 4494 (2010); Daga, P., et al.: Protein Sci., 19, 796 (2010);

Applications Methabenzthiazuron is a benzothiazole and urea based herbicide used to control a spectrum of broad-leaved weeds and grasses crops. Methabenzthiazuron works via the inhibition of photosynthetic electron transport chain.
References Dalkmann, P., et al.: Environ. Toxicol. Chem., 31, 556 (2012);

Applications N7-Des[2-(1H-tetrazol-1-yl)acetyl]-N7-(tert-butylcarbonyl) Cefazolin Sodium Salt is an impurity of the semi-synthetic antibiotic Cefazolin (C242500).

Applications D-(+)-Carnitine Benzyl Ester Perchlorate is an intermediate used in the synthesis of 3-Hydroxybutyrylcarnitine Chloride (H830900), which is a reagent used to study acylcarnitine profile in thyroid disease.
References Wong, S., et al.: Clinical Biochem., 46, 180 (2013); Alu, F., et al.: Heredity, 110, 253 (2013); Adam, B., et al.: Clinical Biochem., 44, 1445 (2011)

Applications 3-Acetyl-1-Boc-pyrrolidine is a boc protected reagent that is used for selective inhibitors of H. influenzae TrmD that mimic tRNA interaction by inducing TrmD lid domain ordering.
References Hill, P.J., et al.: J. Med. Chem., 56, 7278 (2013);

Applications Propachlor is an acylanilide herbicide that is used to maintain crop protection from weeds. Propachlor is also known to induce Glutathione (G597951)-dependent cytotoxicity and sister chromatid exchanges in human cells.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Bartha, R. & Pramer, D.: Adv. Appl. Microb., 13, 317 (1970); Dierickx, P.: Cell Biol. Toxicol., 15, 325 (1999); Hill, A., et al.: Mut . Res.-Gen. Tox. En., 295, 159 (1997); Novick, N., et al.: J. Agr. Food Chem., 34, 721 (1986); Robert, H. & Bond, W.: Weed Res., 15, 195 (1975); Villarreal, D. & Turco, R.: Appl. Env. Microb., 57, 2135 (1991)

Applications rac-Naproxen 2-Propyl Ester is an impurity of Naproxen (N377520) an non-steroidal antiinflammatory agent.
References Mermerian, A.H., et al.: J. Am. Chem. Soc., 127, 5604 (2005); Melgar-Fernande., et al.: Tetrahedron. Lett., 46, 1221 (2005);

Applications Protected Testosterone (T155000) metabolite.
References Hosoda, H., et al.: Chem. Pharm. Bull., 25, 2650 (1977),

Applications Penicillin DF Potassium Salt, is used to characterize phenylacetate-CoA ligase from Penicillium chrysogenum.
References Koetsier, M., et al.: Biochem. J., 417, 467 (2009);

Applications Estradiol 4-Carboxymethyl, is a metabolite of 17β-Estradiol (E888000). Estradiol is the major estrogen secreted by the premenopausal ovary.
References Bucala, R., et al.: J. Clin. Endocrinol. Metab., 60, 841 (1985), Telang, N., et al.: Anticancer Res., et al.: 11, 1021 (1991), Seeger, H., et al.: Med. Sci. Res., 26, 481 (1998), Bolton, J., et al.: Chem. Res. Toxicol., 13, 135 (2000),

Applications Propicillin, is a derivative of penicillin. Properties are similar to benzylpenicillin particularly used in streptococcal infections, not resistant to penicillinase.
References Fleming, A., et al.: Br. J. Exp. Pathol., 10, 226 (1929), Clutterbuck, P.W., et al.: Biochem. J., et al.: 26, 1907 (1932), Chain, E., et al.: Lancet, 2, 226 (1940),

Applications (±)-2-(2,4-Dichlorophenoxy-d3)propionic Acid (CAS# 1219803-66-3) is a useful isotopically labeled research compound.

Applications Diethyl α-Acetylglutarate is used in the preparation of furocoumarins as potential HIV-1 integrase inhibitors.
References Olomola, T.O., et. al.: Bioorg. Chem., 57, 1 (2014)

Applications Phosacetim is a toxic organophosphate compound which acts as an acetylcholinesterase inhibitor and is used as a rodenticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Rennison, B.: Pest. Sci., 8, 405 (1977); Ming, S., et al.: J. Anal. Toxicol., 12, 287 (1988)

Applications 1,1'-Sulfonylbis[2-(methylthio)ethane]-d6 is the labelled analgoue of 1,1'-Sulfonylbis[2-(methylthio)ethane] which is an intermediate in synthesizing Bis(methylsulfinylethyl)sulfone (B494850), a sulfur mustard metabolite found in urine.
References Black, R., et al.: Xenobiotica, 22, 405 (1992); Li, C., et al.: J. Chromatogr. B, 917-918, 100 (2013);

Applications 9-Methylstreptimidone is a member of the glutarimide family that exhibits antifungal and prophylactic antiviral activity.

Applications [1,3]Dioxolo[4,5-g]cinnolin-4-ol is an intermediate used in the synthesis of Cinoxacin (C475700), which is an antibacterial quinolone previously known for its use in the treatment of urinary tract infections.
References Vargas, F. et al.: Toxicol. Mec. Meth., 13, 221, (2003); Vargas, F. et al.: J. Photochem. Photobiol. B., 92, 83 (2008); Sisca, T. et al.: Drugs., 25, 544 (1983);