Toxicologie

<p>Applications O-Desacetyl O-Propionyl Famciclovir is an impurity of Famciclovir (F101125); a compound that is used as an antiviral and is a prodrug of Penciclovir (P221500).<br>References Hodge, V.R.A., et al.: Antimicrob. Ag. Chemother., 33, 1765 (1989)<br></p>

<p>Applications Emtricitabine O-β-D-Glucuronide Sodium Salt is a metabolite of (-)-Emtricitabine (E525000).<br>References Schinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992); Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996); Feng, J.Y., et al.: FASEB J., 13, 1511 (1999); Molina, J.-M., et al.: J. Infec. Dis., 182, 599 (2000);<br></p>

<p>Applications 4-Acetamidobenzene-d4-sulfonyl Chloride is the deuterium labelled form of 4-(Acetylamino)benzenesulfonyl Chloride (A170950), which is a sulfanilamide derivative of Chitosan with antifungal properties.<br>References Tashiro, T., et al.: Bioorg. Med. Chem., 16, 8896 (2008); Alcalde, E., et al.: J. Med. Chem., 52, 675 (2009);<br></p>

<p>Applications A labelled impurity of Estradiol (E888000).<br>References Zhu, B., et al.: Steroids, 70, 225 (2005), Enmark, E., et al.: J. Clin. Endocrinol. Metab., 82, 4258 (1997),<br></p>

<p>Applications A metabolite of Demeton-S (D231360).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Szeto, S.Y., et al.: J. Agric. Food Chem., 30, 1082 (1982),<br></p>

<p>Applications 1-Iodo-2,3-dimethoxybenzene-d6 is the isotope labelled analog of 1-Iodo-2,3-dimethoxybenzene. 1-Iodo-2,3-dimethoxybenzene is used in the preparation of fused heterocyclic amido compounds as a potential anti hepatitis C virus agents.<br>References Aoyama, H., et al.: Bioorg. Med. chem., 19, 2675 (2011);<br></p>

<p>Applications 2-(Ethyl-d3) Isonicotinamide is an intermediate in the synthesis of Ethionamide-d3 (E890422), a labelled antibacterial (tuberculostatic) agent.<br>References Banerjee, A., et al.: Science, 263, 227 (1994), Newton, G., et al.: J. Bacteriol., 178, 1990 (1996), Baulard, A., et al.: J. Biol. Chem., 275, 28326 (2000), Koledin, T., et al.: Arch. Microbiol., 178, 331 (2002), Cardoso, R., et al.: Antimicrob. Agents Chemother., 48, 3373 (2004),<br></p>

<p>Applications (R)-Chloropheniramine is an intermediate used in the synthesis of (R)-(-)-Chlorpheniramine Maleate (C424306), which is the R-enantiomer of Chlorpheniramine (C424300). Antihistaminic.<br>References Ishida, M., et al.: Int. J. Pharm., 359, 46 (2008), Moreno, R., et al.: Biomed. Chromatog., 24, 774 (2010), Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2010),<br></p>

<p>Applications N-Demethyl Erythromycin A-d7 is a labeled version of N-Demethyl Erythromycin A (D230930), which is a metabolite of Erythromycin (E649950).<br>References Rich, D.H., et al.: J. Med. Chem., 18, 1004 (1975), Itoh, Z,. et al.: Antimicrob. Agents Chemother., 26, 863 (1984), Omura, S., et al.: J. Antibiotics 38, 1631 (1985)<br></p>

<p>Applications Hydroxynaphthoquinone derivative that inhibits mitochondrial electron transport. Antipneumocystic.<br>References Hudson, A.T., et al.: Drugs Exp. Clin. Res., 17, 427 (1991), Fry, M., et al.: Biochem. Pharmacol., 43, 1545 (1992), El-Sadr, W.M., et al.: N. Engl. J. Med., 339, 1889 (1998),<br></p>

<p>Applications 5-Bromo-2-nitrophenol is a halonitrophenol with antifungal activity.<br>References Gershon, H., et al.: Monatshefte fuer Chemie, 126, 1161 (1995)<br></p>

<p>Stability Very unstable<br>Applications Cefixime Impurity is an impurity of Cefixime (C242800); an orally active third generation cephalosporin antibiotic.<br>References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984); Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985); Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986)<br></p>

<p>Applications 3-Cyano-6,7-dihydro-4-trifluoromethyl-1,5H-cyclopenta-[b]-pyrid-2-one (cas# 371967-27-0) is a useful research chemical.<br></p>

<p>Applications 3-Nitrophenylhydrazine Hydrochloride acts as a reagent in the preparation of isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents, preparation of pyrazolobenzothiazines as inhibitors of hepatitis C virus replication.<br>References Zhu, S., et al.: Eur. J. Med. Chem., 65, 70 (2013); Barreca, M. L., et al.: J. Med. Chem., 56, 2270 (2013);<br></p>

<p>Applications N-Deschlorobenzoyl Indomethacin-d3, is the labeled analogue of N-Deschlorobenzoyl Indomethacin (D288845), a metabolite of Indomethacin (I641000).<br>References O'Brien, W., et al.: Clin. Pharmacol. Ther., 9, 94 (1968), Duggan, D., et al.: J. Pharmacol. Exp. Ther., 181, 563 (1972), Abourashed, E., et al.: Curr. Med. Chem., 6, 359 (1999), Chatterjee, P., et al.: J. Nat. Prod., 62, 761 (1999);<br></p>

<p>Applications Triclopyr Butotyl is a herbicide. It s very effective in reducing the canopy of honey mesquite.<br>References El-Khodary, S., et al.: Cytologia, 54, 465 (1989); Bovey, R., et al.: J. Range Management, 34, 144 (1981)<br></p>

<p>Applications Aldicarb Sulfone is an analog of Aldicarb (A514650) detected in agricultural products as pesticide residue.<br>References Ashby, J., et al.: Environ. Mutagen., 7, 919 (1985), Ashby, J., et al.: Mutat. Res., 257, 229 (1991), Kazius, J., et al.: J. Med. Chem., 48, 312 (2005), Benigni, R., et al.: Mutagenesis, 25, 335 (2010),<br></p>

<p>Applications (R,R)-Sertraline acts as a selective serotonin reuptake inhibitor that displays minor antifungal activity as well.<br>References Young, T. et al.: J. Antimicrob. Chemother., 51, 1045 (2003);<br></p>

<p>Applications (4R)-2-Oxoclopidogrel is an essential intermediate metabolite from which the active metabolite of Clopidogel is formed.<br>References Feliste, R., et al.: Thromb. Res., 48, 403 (1987), Savi, P., et al.: Biochem. Pharmacol., 44, 527 (1992), Herbert, J., et al.: Cardiovasc Drug. Rev., 11, 180 (1993), Sugidachi, A., et al.: B. J. Pharmacol., 132, 47 (2001)<br></p>