Toxicologie

<p>Impurity Azithromycin EP Impurity B<br>Applications Azithromycin B (Azithromycin EP Impurity B), is an impurity of Azithromycin (A927000), a semi-synthetic macrolide antibiotic, and related to Erythromycin A.<br>References Langtry, H.D., et al.: Drugs, 56, 273 (1998),<br></p>

<p>Applications A metabolite of Levofloxacin.<br>References Sudo, K., et al.: Xenobiotica, 16, 72 (1986), Wong, F., et al.: Drug Metab. Dispos., 18, 1103 (1990), Aminimanizani, A., et al.: J. Clin. Pharmacokinet., 40, 169 (2001), Athamna, A., et al.: J. Antimicrob. Chemother., 53, 247 (2004), Tanaka, M., et al.: J. Pharmacol., 56, 463 (2004),<br></p>

<p>Applications N-Acetyl-S-phenyl-d5-DL-cysteine is the deuterium labelled form of N-Acetyl-S-phenyl-DL-cysteine, which is used as a reactant in the preparation of potent HIV-1 protease inhibitors that use D-amino acids as P2/P3 ligands.<br>References Jungheim, L., et al.: J. Med. Chem., 39, 96 (1996);<br></p>

<p>Applications 6-(Aminocarbonyl)-3-cyclohexene-1-carboxylic Acid is a useful building block for organic synthesis.<br></p>

<p>Applications Methyl 1-naphthaleneacetate (cas# 2876-78-0) is a useful research chemical.<br></p>

<p>Applications Brexpiprazole S-Oxide is an impurity and potential metabolite of Brexpiprazole (B677385), a drug candidate useful in treatment and prevention of mental disorders including CNS disorders.<br>References Yamashita, H., et al.: PCT Int. Appl., WO 2006112464 A1 20061026 (2006);<br></p>

<p>Applications Dihydrosafrole is a Safrole derivative. Carcinogenic.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gold, L. et al.; Mutat. Res. 286, 75 (1993)<br></p>

<p>Applications A stable labelled selective HIV protease inhibitor Ritonavir (R535000). It is a COVID19-related research product.<br>References Daluge, S., et al.: Antimicrob. Agents Chemother., 38, 1590 (1994), Ammaranond, P., et al.: J. Clin. Virol., 26, 153(2003), Harrigan, P., et al.: J. Infect. Dis., 191, 339 (2005), Miller, J., et al.: Bioorg. Med. Chem. Lett., 16, 1788 (2006)<br></p>

<p>Applications O,O,S-Trimethyl Dithiophosphate is a metabolite resulting from the degradation of Dimethoate (D460505), isolated from treatment wastewater.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Li, R., et al.: Int Biodeterior Biodegradation, 64, 51 (2010);<br></p>

<p>Applications Bictegravir, is a novel, potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.<br>References Tsiang M. et al.: Antimicrob Agents Chemother. 2016 Nov 21;60(12):7086-7097;<br></p>

<p>Applications Diuron is a phenyl urea herbicide (1,2). Pre-emergent herbicide which may find its way into aquatic environments, and consumable fruit/vegetation (3,4). Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Noseworthy, J. et al.: Weed. Tech. 2010 Jul:24(1) pp64-702. Armenta, S. et al.: Anal. Bioanal. Chem. 2010 May;397(1):297-308.3. Neuwoehner, J. et al.: Aquat. Toxicol. 2010 Apr 1;97(1):58-67.4. Wong, J. et al.: J. Agric. Food. Chem. 2010 May 26;58(10):5897-9034<br></p>

<p>Applications 1-(1-Ethylpropyl)-5,6-dimethyl-7-nitro-1H-benzimidazole is a metabolite of Pendimethalin(P221900). Pendimethalin herbicide used to control the spread of weedgrass.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Haith, D., et al.: Environ. Sci. Technol., 44, 6496 (2010), Jabran, K., et al.: Int. J. Agric. Biol., 12, 335 (2010)<br></p>

<p>Applications A new Sildenafil (S435000) analogue detected as food adulterant.<br>References Gratz, S., et al.: J. Pharm. Biomed. Anal., 36, 525 (2004), Lai, K., et al.: J. Food Drug Anal., 14, 19 (2006), Oh, S., et al.: J. Toxicol. Environ. Health, 69, 1951 (2006),<br></p>

<p>Applications Azafenidin is a weed controlling herbicide used in various crops.<br>References Chandran, R.S., et al.: Weed. Technol., 14, 556 (2000); Sharma, S.D., et al.: Bull. Environ. Contamin. Toxiciol., 67, 594 (2001);<br></p>

<p>Applications Labelled Pyruvic acid (P998900). Intermediate in sugar metabolism and in enzymatic carbohydrate degradation (alcoholic fermentation) where it is converted to acetaldehyde and CO2 by carboxylase. In muscle, Pyruvic acid (derived from glycogen) is reduced to lactic acid during exertion, which is reoxidized and partially retransformed to glycogen during rest. The liver can convert Pyruvic acid to alanine by amination. A diagnostic agent for Parkinson disease.<br>References Wenzel, A., et al.: J. Neurosci., 21, 53 (2001), Martinez., et al.: Development, 6, 851 (2002), Nakayama, K., et al.: J. Biochem., 146, 757 (2009), Tanaka, T., et al.: J. Pharmacol. Sci., 109, 24 (2009),<br></p>

<p>Applications Isotope labelled Tebufenozide (T013200), which is a synthetic nonsteroidal ecdysone agonist used in pesticide formulations (1) that causes premature molting; novel insect growth regulator (2,3,4) specific to lepidopteran species. Drinking water Contaminant Candidate List 3 (CCL3) as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Jordan TB, et al.: Anal Bioanal Chem. 2009 Aug;394(8):2257-66.2. Vianna UR. Et al.: Ecotoxicology. 2009 Feb;18(2):180-6.3. Rose, G. et al. Food. Chem. 2009 Dec;117(4) pp634-6404. Wang, J. et al.: J. Agric. Food Chem. 2009 Mar 25;57(6):2162-73.<br></p>

<p>Applications Fonofos is an organothiophosphate insecticide primarily used on corn.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Fillion, J., et al.: J. AOAC Int., 83, 698 (2000); Liu, W., et al.: Proc. Nat. Acad. Sci. U. S. A., 102, 701 (2005)<br></p>