Toxicologie

<p>Applications A glucuronide metabolite of Chlorpyrifos (C425300).<br>References Barron, M.G., et al.: Environ. Toxicol. Chem., 12, 1469 (1993), Tang, J., et al.: Drug Metab. Dispos., 29, 1201 (2001),<br></p>

<p>Applications Labelled Tazarotene (T010050). An acetylenic retinoid prodrug converted to the active metabolite, Tazarotenic acid, with selective affinity for retinoic acid receptors RARβ and RARγ. Antiacne; antipsoriatic. Used in treatment of photodamaged skin.<br>References Tang-Liu, D.D.-S., et al.: Clin. Pharmacokinet., 37, 273 (1999), Roeder, A., et al.: Skin Pharmacol. Physiol., 17, 111 (2004),<br></p>

<p>Stability Hygroscopic<br>Applications Tubercidin is used as a chemotherapeutic agent in the treatment of cancer. Also used in the treatment of cardiovascular disorders.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Murray, V. et al.: Exp. Parasitol., 132, 440 (2012); Szentmiklosi, A. et al.: Curr. Med. Chem., 18, 1164 (2011);<br></p>

<p>Applications A metabolite of 6β-Naltrexol (N285700). Narcotic antagonist.<br>References Portoghese, P. et al,: J. Med. Chem., 37, 579 (1994); Ohkawa, S., et al.: J. Med. Chem., 41, 4177 (1998);<br></p>

<p>Applications Nafronyl is a selective inhibitor of serotonin receptors. Nafronyl is a vasodilator used in the treatment of intermittent claudication.<br>References Fontaine, et al.: Chim. Ther., 4, 44 (1969), Bessin, P., et al.: Eur. J. Med. Chem., 10, 291 (1975), Clyne, C.A., et al.: Br. J. Surg., 67, 347 (1980),<br></p>

<p>Applications 4-Fluoroaniline is a degradation product of Ezetimibe (E975000). 4-Fluoroaniline is used as an analytical reagent in the enzymic detection of glucose.<br>References El-Moghazy, S.M. et al.: J. Chin. Chem. Soc., 56, 360 (2009); Gorski, L. et al.: Anal. Bional. Chem., 389, 533 (2007);<br></p>

<p>Applications Mancozeb is a mixture of Maneb (M163500) and Zineb, a manganese and zinc (1:1) complex mixture with the ethylene bis(dithiocarbamate) anionic ligand. Mancozeb is a foliate fungicide used to protect crops in agriculture. Mancozeb has a broader and more effective fungacidal activity than either of its component on their own. Mancozeb also significantly enhances the copper activity against several bacteriosis.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Tang, M. et al.: Turang Tong., 41, 1365 (2010); Navneet; M. et al.: J. Ind. Botan. Soc., 74, 19 (1995); Lecigne, P. et al.: Phytoma, 531, 13 (2000);<br></p>

<p>Stability Hygroscopic<br>Applications Empagliflozin is a novel, potent and selective SGLT-2 inhibitor. It improves glycaemic control syndrome in diabetic rats.<br>References Thomas, L., et al.: Diabetes. Obesity. Metabol. 14, 94 (2012); Grempler, R., et al.: Diabetes. Obesity. Metabol., 14, 83 (2012);<br></p>

<p>Applications Didecyl Dimethyl Ammonium Chloride is a compound that exhibits some fungacidal and antimirobial functions.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Kanazawa, A. et al.: Antimicrob. Agents Chemother., 38, 945 (1994)l; Schultz, T.P. et al.: Phytochem., 54, 47 (2000);<br></p>

<p>Applications Opioid receptor agonist. Antispasmodic.<br>References Delvaux, M., et al.: J. Int. Med. Res., 25, 225 (1997), Lavit, M., et al.: Arzneim.-Forsch., 50, 640 (2000),<br></p>

<p>Applications Glyphosate-C2-d2 is an isotopic analog of Glyphosate (G765000) which is used as a herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Davis, V., et al.: Weed Sci., 57, 494 (2009), Bellaloui, N., et al.: J. Agric. Food Chem., 57, 9050 (2009),<br></p>

<p>Applications Bezafibrate-d4 (cas# 1189452-53-6) is a compound useful in organic synthesis.<br></p>

<p>Applications Paclitaxel-13C is the labeled analogue of Paclitaxel (P132500). Paclitaxel is an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.<br>References Letourneau, P.C., et al.: J. Cell Biol., 98, 1355 (1984), Manfredi, J.J., et al.: Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al.: Mol. Pharmacol., 47, 1106 (1995), Markman, M., et al.: Expert. Opin. Pharmacother., 3, 755 (2002), Stone, G.W., et al.: N. Engl. J. Med., 350, 221 (2004),<br></p>

<p>Applications Herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Nelieu, S., et al.: Environ. Toxicol. Chem., 29, 2644 (2010), Aguilera-Luiz, M., et al.: Anal. Bioanal. Chem., 399, 2863 (2011),<br></p>