Toxicologie

<p>Impurity Erythromycin EP Impurity E<br>Applications Erythromycin A Enol Ether (Erythromycin EP Impurity E) is an impurity of Erythromycin.<br>References McGuire, J.M., et al.: Antibiot. Chemother., 6, 281 (1952), Steffansen, B., et al.: Int. J. Pharm., 56, 159 (1989), Goldman, R.C., et al.: Antimicrob. Agents Chemother., 34, 1973 (1990),<br></p>

<p>Applications 6-Hydroxy Etodolac is an Etodolac (E933100) metabolite.<br>References Humber, L., et al.: J. Med. Chem., 32, 2582 (1989), Koupai-Abyazani, M., et al.: J. Anal. Toxicol., 23, 200 (1999),<br></p>

<p>Impurity Beclomethasone Dipropionate EP Impurity B<br>Applications Beclomethasone 21-Acetate 17-Propionate (Beclomethasone Dipropionate EP Impurity B) is an impurity of Beclomethasone Dipropionate (B131030).<br></p>

<p>Applications Clocortolone Acetate is an intermediate in the synthesis of Clocortolone (C583800), an corticosteroid used in the treatment of skin inflammmation and other skin conditions arising for dermatoses.<br>References Rehm, K. et al.: Pharmaz. Zeit., 127, 888 (1982);<br></p>

<p>Applications 6-Oxo Simvastatin is an analog of Simvastatin (S485000), a HMG-CoA reductase inhibitor.<br>References Joshua, H., et al.: J. Antibiot., 44, 366 (1991),<br></p>

<p>Impurity Betamethasone Dipropionate EP Impurity J<br>Applications Betamethasone 9,11-Epoxide 17,21-Dipropionate (Betamethasone Dipropionate EP Impurity F) is an impurity of Betamethasone (B327000), an antiinflammatory agent.<br>References Shou, M., et al.: J. Pharm. Biomed. Anal., 50, 356 (2009),<br></p>

<p>Applications A degradation and metabolic intermediate of Dexamethasone (D298800). A Dexamethasone enol aldehyde as inflammation inhibitor.<br>References Weiss, G., et al.: J. Clin. Endocrinol. Metab., 43, 696 (1976), Hirschmann R., et al.: Steroids, 57, 579 (1992),<br></p>

<p>Applications Betamethasone 17-Butyrate is an impurity of Clobetasone 17-Butyrate (C583550), an glucocorticoid used for anti-inflammatory purposes.<br></p>

<p>Applications S-Ramelteon Metabolite M-II is a metabolite of Ramelteon in serum (M-II).<br>References Karim, A., et al.: J. Clin. Pharmacol., 44, 1210 (2004); Prescott, E., et al.: Drug Metab. Rev., 36, 203 (2004); Kato, K., et al.: Neuropharmacology, 48, 301 (2005); Karim, A., et al.: J. Clin. Pharmacol., 46, 140 (2006)<br></p>

<p>Applications Potassium bromide is an ionic compound that is commonly used in chemistry to form a pellet that can be used to analyze a number of compounds by means of infrared spectroscopy. Potassium bromide is also used as an anticonvulsant to treat refractory seizures in humans and dogs.<br>References Kirkland, J.: Anal. Chem., 27, 1537 (1955); Korinthenberg, R., et al.: J. Child Neuro., 22, 414 (2007); Wilberley, S., et al.: Anal. Chem., 29, 210 (1957); Yohn, S., et al.: J. Am. Vet. Med. Ass., 201, 468 (1992)<br></p>

<p>Applications 19-Norandrosterone is the oxidized byproduct of Nandrolone (N315000), an anabolic steroid that is present naturally in the human body.<br>References Jiang, J.Q., et al.: J. Food. Sci., 77, 63 (2012); Delgadillo, M.A., et al.: J. Chromatograph. Anal. Technol. Biomed. Life. Sci., 897 (2012);<br></p>

<p>Stability Hygroscopic<br>Applications An intermediate in the production of Rosuvastatin (R700500) derivatives.<br></p>

<p>Applications The major metabolite of Deflazacort.<br>References Bernareggi, A., et al.: J. Pharma. Biomed. Anal., 5, 177-81 (1987), Assandri, A., et al.: Xenobiotica, 13(3), 185 (1983), Martinelli, E., et al.: Drug Metab. Dispos., 7, 335 (1979),<br></p>

<p>Applications Droxicam is a non-steroidal anti-inflammatory drug.<br>References Lapeyre-Mestre, M., et. al.: Fundam. Clin. Pharm., 20, 391 (2006)<br></p>

<p>Applications A related compound of Desloratadine (D290250).<br>References Krishna, K., et al.: J. Pharm. Biomed. Anal., 32, 29 (2003), Qi, M., et al.: J. Pharm. Biomed. Anal., 38, 355 (2005),<br></p>