Toxicologie

<p>Applications Fipronil- 13C2 15N2 is the labeled analogue of Fipronil (F342200), which is a broad spectrum insecticide which actively disrupts the CNS of contacted insects by blocking the passage of chloride ions through GABA receptors.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Ling, S., et al.: App. Entomol. Zool., 44, 543 (2009), Li, X., et al.: Environ. Toxicol. Chem., 29, 127 (2010), Savant, R., et al.: J. Agric. Food Chem., 58, 1447 (2010),<br></p>

<p>Applications An α2-Adrenergic agonist. Sedative; analgesic.<br>References Scheinin, M., et al.: Br. J. Clin. Pharmacol., 24, 443 (1987), Stenberg, D., et al.: J. Vet. Pharmacol. Ther., 10, 319 (1987), Virtanen, R., et al.: Eur. J. Pharmacol., 150, 9 (1988), Cullen, L.K., et al.: Br. Vet. J., 152, 519 (1996),<br></p>

<p>Applications It is a potent and selective inhibitor of Aurora B kinase. Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. It induces apoptosos in Hep2 cancer cells and in acute myeloid leukemia cell lines but its propensity to induce polyploidy does not inevitably result in apoptosis.<br>References Ditchfield, C., et al.: J. Cell Biol., 161, 267 (2003), Long, Z.J., et al.: J. Cell Cycle, 7, 1473 (2008), Walsby, E., et al.: Haematologica, 93, 662 (2008),<br></p>

<p>Applications 2-(Trifluoromethyl)benzoic Acid is used in biochemical genetics studies such as Plasmid-encoded phthalate catabolic pathway in Arthrobacter keyseri 12B.<br>References Eaton, Richard W., Journal of Bacteriology, 183, 3689-3703, (2001)<br></p>

<p>Stability Hygroscopic, Unstable in DMSO<br>Applications Post-emergence sulfonylurea herbicide.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Gubbiga, N.G., et al.: Weed Technol., 9, 574 (1995), Ukrainczyk, L., et al.: J. Agric. Food Chem., 43, 855 (1995)<br></p>

<p>Stability Light Sensitive<br>Applications Labelled Rifabutin (R505000). Semisynthetic derivative of Rifamycin S that inhibits nucleic acid synthesis. An antibacterial (tuberculostatic).<br>References O’Brien, R.J., et al.: Infect. Dis., 9, 519 (1987), Anand, R., et al.: Antimicrob. AG. Chemother., 32 (684 (1988), Skinner, M.H., et al.: Antimicrob. Agent Chemother., 33, 1237 (1989),<br></p>

<p>Applications Docetaxel is an antimitotic Taxol analog antibiotic.<br></p>

<p>Applications Labelled Ferulic acid (4-hydroxy-3-methoxycinnamic acid or, in IUPAC nomenclature, 3-(4-hydroxy-3-methoxy-phenyl)prop-2-enoic acid) which is a highly abundant phenolic phytochemical which is present in plant cell walls. It may have significant health benefits through its antioxidant and anti-cancer activity, and may also serve as a precursor in the manufacturing of useful aromatic compounds. Used as an antioxidant.<br>References Smart, M.G., et al.: Aust. J. Plant Physiol., 6, 485 (1979), Chen, C., et al.: J. Food Lipids, 2, 35,1995, Benzie, I., et al.: Anal. Biochem. 239, 70 (1996), Nardini, M., et al.: Food Chem., 79, 119 (2002), Lee, J., et al.: J. Agric. Food Chem., 52, 2647 (2004),<br></p>

<p>Applications Mevinphos is a pesticide used in the protection of crops. Insecticide. Useful in cannabis testing kits as a component of pesticide mixes (P698230).<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Rajski, L. et al.: Analyst, 138, 921 (2013); Lozano, A. et al.: J. Chrom. A., 1268, (2012);<br></p>

<p>Applications Solriamfetol is a selective dopamine and norepinephrine reuptake inhibitor used in the treatment of sleep apnea and narcolepsy.<br>References Baladi, Michelle G., et al.: J. of Pharmaco. and Exper. Therap., 366(2), 367-376 (2018);Abad, Vivien C., et al.: Expert Rev. of Resp. Med., 12(12), 1007-1019 (2018);Takahashi, Tatsunori, et al.: Exp. Opin. on Orphan Drugs, 6(10), 597-610 (2018)<br></p>

<p>Applications A spasmolytic agent related structurally to Tolperisone (T535475). Muscle relaxant (skeletal).<br>References Catterall, W., et al.: J. Biol. Chem., 256, 892 (1981), Farkas, S., et al.: Br. J. Pharmacol., 114, 1193 (1995), Xing, J., et al: Brain Res., 901, 128 (2001), Sakaue, A., et al.: J. Pharmacol. Sci., 95, 181 (2004),<br></p>

<p>Applications Oxythiamine Diphosphate is an inhibitor of pyruvate dehydrogenase complex.<br>References Zabrodskaya, S. V., et al.: Doklady Akademii Nauk BSSR, 31, 468 (1987), Chiger, M. B., et al.: Vestsi Akademii Navuk Belarusi, Seryya Biyalagichnykh Navuk, 2, 58 (1996), Strumilo, S., et al.: J. Enzyme Inhib., 10, 65 (1995)<br></p>

<p>Applications N-Isopropyl quaternary salt of Atropine. Nonselective muscarinic acetylcholine receptor antagonist; bronchodilator.<br>References Groeben, H., et al.: Anesthesiology, 85, 867 (1996), Haddad, et al.: Br. J. Pharmacol., 127, 413 (1999), Barnes, P. J., et al.: Chest, 117, 63S (2000),<br></p>

<p>Applications Labelled Febuxostat (F229000). Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout.<br>References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),<br></p>

<p>Applications N-Desmethyl Imatinib Mesylate is a metabolite of Gleevec, a tyrosine kinase inhibitor which is highly specific for BCR-ABL, the enzyme associated with chronic myelogenous leukemia (CML) and certain forms of acute lymphoblastic leukemia (ALL). It is a COVID19-related research product.<br>References Schindler, T., et al.: Science, 289, 1938 (2000), Drucker, B.J., et al.: N. Engl. J. Med., 344, 1031 (2001),<br></p>

<p>Applications Tebufenozide is a synthetic nonsteroidal ecdysone agonist used in pesticide formulations (1) that causes premature molting; novel insect growth regulator (2,3,4) specific to lepidopteran species. Drinking water Contaminant Candidate List 3 (CCL3) as per United States Environmental Protection Agency (EPA). Environmental contaminants; Food contaminants.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References 1. Jordan T, et al.: Anal Bioanal Chem. 2009 Aug;394(8):2257-66 2. Vianna U. Et al.: Ecotoxicology. 2009 Feb;18(2):180-6. 3. Rose, G. et al. Food. Chem. 2009 Dec;117(4) pp634-6404. Wang, J. et al.: J. Agric. Food Chem. 2009 Mar 25;57(6):2162-73.<br></p>