Toxicologie

Applications Flometoquin is a pesticide. It is also used in other insecticidal compositions containing flometoquin and anabasine as active ingredients. An agrochemical compound.
References Anon.: Fain Kemikaru, 41, 34 (2012); Anon.: IP.com J., 12, 19 (2011); Ren, T., et al.: From Faming Zhuanli Shenqing (2014), CN 103814939 A 20140528; Jeanmart, S., et al.: Bioorg. Med. Chem., 24, 317 (2016)

Applications 2,3,4-Trihydroxybenzophenone-2’,3’,4’,5’,6’-d5 is the isotope labelled analog of 2,3,4-Trihydroxybenzophenone; a trihydroxy derivative of Benzophenone (B204980) which is a compound used in the manufacturing of antihistamines, hypnotics, and insecticides.
References Wallace, W., et al.: Environ. Toxicol. Chem., 19, 962 (2000); Hayashi, T., et al.: Toxicol. Lett., 167, 1 (2006); Bechard, K., et al.: Aquat. Toxicol., 90, 310 (2008)

Applications Xanthine oxidase/xanthine dehydrogenase inhibitor. Used for treatment of hyperuricemia and chronic gout. 40-120 mg/day febuxostat was proven effective in lowering serum urate levels when administered to manage hyperuricemia in patients with gout.
References Osada, Y., et al.: Eur. J. Pharmacol., 241, 183 (1993), Okamoto, K., et al.: J. Biol. Chem., 278, 1848 (2003), Mayer, M.D., et al.: Am. J. Therap., 12, 22 (2005), Tomlinson, B., et al.: Curr. Opin. Invest. Drugs, 6, 1168 (2005),

Applications Orally active H1-hystamine receptor antagonist. Antihistaminic.
References Tasaka, K., et al.: Arzneim.-Forsch., 29, 488 (1979), Chand, N., et al.: Int. J. Immunopharmacol., 7, 833 (1985),

Applications Albuterol-d4, is the labeled analogue of Albuterol (A514500), a β2-adrenoceptor agonist, bronchodilator, and tocolytic.
References Brittain, R.T., et al.: Nature, 219, 862 (1968), Cullum, V.A, et al.: Br. J. Pharmacol. 35, 141 (1969), Martin, L.E., et al.: Eur. J. Pharmacol., 14, 183 (1971), Aboul-Enein, H.Y., Anal. Profiles Drug Subs., 10, 665 (1981)

Applications Ancymidol is a growth retardant found in plants. It affects a gibberellin-induced growth response, most likely by inhibiting gibberellin biosynthesis.
References Shive Jr., J.B., Sisler, H.D., Plant Physiol., 57, 640-644 (1976)

Stability Hygroscopic
Applications an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed additive in turkey poults experimentally infected with Histomonas meleagridis.
References Rehg, J.E. et al.: J. Infect. Dis., 170, 934 (1994); Fong, D. et al.: Am. J. Trop. Med. Hyg., 51, 758 (1994); Hafez, H.M. et al.: Arch. Anim. Nut., 64, 77 (2010);

Applications An organophosphate pesticide that is an inhibitor of acetylcholinesterase (AChE).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Yan, D. et al.: Zhong. Huan. Kex., 26, 364 (2006); Wood, S.J. et al.: Pest. Sci., 32, 485 (1991);

Applications Pentachloronitrobenzene is used in the synthesis of chlorodibenzo-p-dioxins for toxilogical studies. Its a pesticide used in the protection of crops from fungal bacterium. Useful in cannabis testing kits as a component of pesticide mixes (P698235).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Munoz, E. et al.: J. AOAC Int., 95, 1777 (2012); Pohland, A. et al.: J. Agri. Food Chem., 20, 1093 (1972);

Impurity Ribavirin EP Impurity D
Applications N-Des-1-β-D-ribofuranosyl Ribavirin (Ribavirin EP Impurity D) is an impurity in the synthesis of Ribavirin (R414475), a purine nucleoside analog; inhibits inosine monophosphate dehydrogenase (IMPDH). Used as an antiviral agent.This compound is suitable for pyruvate dehydrogenase (PDH) related research.
References Fernandez, H., et al.: Eur. J. Epidemiol., 2, 1 (1986), Liao, H.J. and Stollar, V.: Antiviral Res., 22, 285 (1993), Honda, Y., et al.: Antimicrob. Agents Chemother., 38, 653 (1994), Reichard, O., et al.: Lancet, 351, 83 (1998)

Stability Hygroscopic
Applications Phenethicillin is a semisynthetic penicillin based β-lactam antibiotic and are used in the treatment of bacterial infections caused by susceptible, usually Gram-positive bacteria.
References Lucien, C., et al.: Can. med. Assoc. J., 84, 535 (1961); Timmers, G.J., et al.: Clin. Microbiol. Infect., 13, 497 (2007);

Applications 3-Hydroxy Niclosamide is a metabolite of Niclosamide(N395500) which is used as an anthelmintic drug (Cestodes).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Loftsson, T., et al.: J. Pharm. Sci., 85, 1017 (1996), Malik, N., et al.: Anti. Cancer Drugs, 10, 767 (1999), El-Sayed, M., et al.: Pharm. Res., 18, 23 (2001),

Applications Daptomycin is a Cyclic lipopeptide antibiotic derived from a fermentation product of Streptomyces roseosporus; disrupts plasma membrane function in gram-positive bacteria. Antibacterial.
References Allen, N.E., et al.: Antimicrob. Agents Chemother., 31, 1093 (1987), Tully, F.P., et al.: Expert Opin. Invest. Drugs, 8, 1223 (1999),

Applications 4-Chlorosalicylic Acid is a metabolite of the herbicide Benthiocarb. 4-Chlorosalicylic Acid shows antifungal activity.
References Nakamura, Y. et al.: Agric. Biol. Chem., 41, 1613 (1977); Patel, H.S. et al.: J. Macromol. Sci. Chem., A20, 453 (1983); Amborabe, B.-E. et al.: Plant Physiol. Biochem., 40, 1051 (2002);