Toxicologie

Applications Fumagillol is an analog of Fumagillin (F862650), a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis. Fumagillin shows promise as both an an anti-infective and antiangiogenic agent.
References Molina, J.M. et al.: N. Eng. J. Med., 346, 1963 (2002); Hou, L. et al.: Pathol. Int., 59, 448 (2009); Ingber, D. et al.: Nature, 348, 555 (1990);

Applications Gemfibrozil 1-O-β-(3,4,5-O-Triacetyl)glucuronide Methyl Ester is an intermediate in the synthesis of Gemfibrozil 1-O-β-Glucuronide (G305760), the major metabolite of Gemfibrozil (G305750), a serum lipid regulating agent used as an antihyperlipoproteinemic.
References Kissebach, A.H., et al.: Atherosclerosis, 24, 199 (1976); Lewis, J.E., et al.: Pract. Cardiol., 9, 99 (1983); Rubins, H.B., et al.: N. Engl. J. Med., 341, 410 (1999)

Applications GSK2656157 is an ATP-competitive and highly selective inhibitor of PKR-like endoplasmic reticulum kinase (PERK) enzyme activity. GSK2656157 also has anti-tumor and anti-angiogenic activity.
References Axten, J.M., et al.: ACS Med. Chem. Lett., 4, 964 (2013); Atkins, C., et al.: Cancer Res., 73, 1993 (2013)

Applications A selective cyclooxygenase-2 (COX-2) inhibitor. Use as an anti-inflammatory, analgesic.
References Catalla-Lawson, F., et al.: J. Pharmacol. Exp. Ther., 289, 735 (1999), Ehrich, E.W., et al.: Clin. Pharmacol. Ther., 65, 336 (1999), Langman, M.J., et al.: J. Am. Med. Assoc., 282, 1929 (1999),

Applications Labelled Diminazene (D479550). Antiprotozoal (Trypanosoma, Babesia).
References Braithwaite, A.W.

Applications Colestilan, is a copolymer of 2-methyl-1H-imidazole and epichlorohydrin, and a bile acid sequestrans, that can be used for the treatment of hypercholesterolemia and dyslipidemia.
References Handelsman, Y., et al.: Diabetes Care, 34, S244 (2011);

Applications Bendiocarb is a benzodioxolyl carbamate derivative. Bendiocarb is commonly used as an insecticide in agriculture against a wide range of pests and insects. Bendiocarb is one of the insecticides recommended by world health organization (WHO) for use in malaria control.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Sadasivaiah, S. et al.: Am. J. Trop. Med. Hyg., 77, 249 (2007); Brooker, P. J. et al.: Pest. Sci., 3, 735 (1972);

Applications 1,2,4,5-Tetrachloro-3-nitrobenzene, is a metabolite of pentachloronitrobenzene (P237990), used as fungicide, and pesticide.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Renner, G., et al.: Appl. Envi. Miroc., 46, 465 (1983);

Stability Hygroscopic
Applications A labelled metabolite of Mycophenolic Acid, an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.
References Senda, M., et al.: Transplantation, 60, 1143 (1995), Nimmesgern, E., et al.: J. Biol. Chem., 271, 19421 (1996), Gummert, J.F., et al.: J. Pharmacol. Exp. Ther., 291, 1100 (1999),

Applications Dolutegravir is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
References Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al.: Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al.: Exp. Opin. Invest. Drugs, 20, 537 (2011)

Applications Potassium channel blocker.
References Carmeliet, D., et al.: J. Pharmacol. Exp. Ther., 262, 809 (1992), Norgaard, B.L., et al.: Am. Heart J., 137, 1062 (1999), Torp-Pedersen, C., et al.: N. Engl. J. Med. 341, 857 (1999)

Applications 2-Chloro-5-(trifluoromethyl)pyridine is a starting material for the preparation of novel herbicide fluazifop-butyi. 2-Chloro-5-(trifluoromethyl)pyridine is a mutagenic compound.
References Lu, Y., et al.: Shijie Nongyao, 31, 32 (2009); Dearfield, K. L., et al.: Mutat. Res. Lett., 301, 57 (1993)

Applications A metabolite of Fenthion (FEN).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Buratti, F., et al.: Toxicol. Lett., 167, 245 (2006), Buratti, F., et al.: Drug Metab. Dispos., 33, 295 (2005), Buratti, F., et al.: Toxicology, 241, 33 (2007),

Stability Hygroscopic
Applications A metabolite of Amodiaquine (A634200), an antimalarial.
References Bayliss, M., et al.: Xenobiotica, 29, 253 (1999), Projean, D., et al.: Drug Metab. Dispos., 31, 748 (2003), Bray, P., et al.: Mol. Microbiol., 56, 323 (2005), Xiang, H., et al.: J. Pharm. Sci., 95, 2657 (2006),

Applications Bifenthrin intermediate.
References Hamed, M., et al.: J. Econ. Entomol., 81, 1295 (1988), Ruzo, Luis O., et al.: J. Agric. Food Chem., 36, 1040 (1988),

Applications Strobilurin fungicide; inhibits mitochondrial respiration by blocking electron transfer between cytochromes b and c1. Agricultural fungicide. Used in Pesticide detection. Useful in cannabis testing kits as a component of pesticide mixes (P698240).
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Smalling, K., et al.: Environ. Toxicol. Chem., 29, 2593 (2010), Lu, X., et al.: Phytopathol., 100, 1162 (2010), Schafer, R., et al.: Environ. Sci. Technol., 45, 1665 (2011),

Applications A nonsteroidal, selective estrogen receptor modulator (SERM). Antiosteoporotic.Insoluble in water.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Jone, C.D., et al.: J. Med. Chem., 27, 1057 (1984), Buelke-Sam, J., et al.: Reprod. Toxicol., 12, 217 (1998),

Applications Mezlocillin Sodium is an antibacterial agent. Penicillin antibiotic effective against gram negative and gram positive bacteria.
References Sanders, C. et al.: J. Antimicrob. Chemother., 9, 15 (1982); Gasca, M. et al.: Am. J. Hosp. Pharm., 44, 574 (1987);