Toxicologie

Applications (4S)-Efavirenz 2-Desoxo-2-methyl is an analog of Efavirenz (E425000); a nonnucleoside HIV-1 reverse transcriptase inhibitor and antiviral agent.
References Young, S.D., et al.: Antimicrob. Ag. Chemother., 39, 2602 (1995)

Applications Bisphenol AP Mono-β-D-glucuronide is a metabolite of Bisphenol AP (B519485), which is used to prepare triphenylmethane derivatives as inhibitors of hepatitis C virus helicase. Bisphenol AP is a derivative of Bisphenol A (B519495) which is a monomer used for policarbonate and epoxy resins.
References Krishnan, A.V., et al.: Endocrinology, 132, 2279 (1993); Steinmetz, R., et al.: Trends Endocrinol. Metab., 9, 124 (1998); Petersen, H., et al.: Eur. Food Res. Technol., 216, 355 (2003); Chen, C., et al.: J. Med. Chem., 52, 2716 (2009);

Applications Emtricitabine Amadori Rearrangement Product is an impurity of Emtricitabine(E525000) which is a reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine (L172500).
References FASEB J., 13, 1511 (1999), Molina, J.-M., et al.: J. InfecSchinazi, R.F., et al.: Antimicrob. Ag. Chemother., 36, 2423 (1992), Shockeor, J.P., et al.: Xenobioica, 26, 189 (1996), Feng, J.Y., et al.: . Dis., 182, 599 (2000)