Toxicologie

Applications Hopantenate Calcium-d6 is labeled analogue of Hopantenate Calcium (H669565), which is a central nervous system drug. In its calcium salt form, it used to be used for a variety of neurological, psychological and psychiatric conditions in Russia. Hopantenic Acid is also the amide of D-pantoate and γ-aminobutyric acid (GABA).
References Kopelevich, V.M., et al.: Pharm. Chem. J., 5, 534 (1971)

Impurity Lamivudine EP Impurity J
Applications (2R-cis)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]-2,4(1H,3H)-pyrimidinedione (Lamivudine EP Impurity J) is an impurity of Lamivudine (L172500). (2R-cis)-1-[2-(Hydroxymethyl)-1,3-oxathiolan-5-yl]-2,4(1H,3H)-pyrimidinedione is also being further studied to determine its potential as an anti-HIV agent.
References Jeong, L., et al.: J. Med. Chem., 36, 181 (1993)

Applications Atraton is a toxic herbicide and an environmental contaminants.
References Lu, Y. C., et al.: Chemosphere, 165, 487 (2015); Dong, X., et al.: Soil Sediment Contam., 24,573 (2015); Gonzalez-Cadena, J., et al.: Sustainable Environment Research, 23, 253 (2013)

Applications 17β-Estradiol 2-Acetate is an intermediate in synthesizing Estradiol Valerate Impurity I (E888865), a derivative of Estradiol (E888000) and Estradiol 17-Valerate (E888860) which is an estrogen.
References Salole, E.G., et al.: Anal. Profiles Drug Subs., 15, 283 (1986); Lievertz, R.W., et al.: Am. J. Obstet. Gynecol., 156, 1289 (1987)

Applications 2,2'-Dinaphthyl Ether and ethers exhibit antifungal activity against A. niger, A. flavus, A. alternata and F. oxysporum.
References Pawar, N., et al.: Asian J. Biochem. Pharm. Res., 2, 157 (2012)

Applications 2-(1-Ethylpropyl)-2,4-dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-3H-1,2,4-triazol-3-one is an intermediate in the synthesis of Deshydroxy Posaconazole Impurity (A6480252), which is a 2,2,5-tetrahydrofuran regioisomers of SCH 51048 (A648025) that exhibit antifungal activity.
References Lovey, R.G.; et al.: Bioorganic Med. Chem. Lett, 12, 1739 (2002)

Applications A prototypical BCRP inhibitor. Inhibits the Bcrp1-mediated transport.
References Neville, K., et al.: Clin. Cancer Res., 10, 2525 (2004), Reardon, D., et al.: J. Clin. Oncol. 23, 9359 (2005), Pan, G., et al.: Drug Metab. Dispos., 35, 1165 (2007).

Applications 3-​Methoxy-​4-​methyl-​1H-​1,​2,​4-​triazol-​5(4H)​-​one Hydrate, is a Triazole (T767410) derivative that was used in microwave synthesis of 1,2,4-triazolone derivatives possessing antifungal activity. 3-​Methoxy-​4-​methyl-​1H-​1,​2,​4-​triazol-​5(4H)​-​one is also a key intermediate for sulfonylurea herbicides, such as flucarbazone.
References Su, J., Shang, Z.: Nongyao, 49, 563 (2010); Sun, N., et al.: BioMed Res. Int., 1 (2015);

Applications N4-Anisoyl-2'-deoxycytidine (cas# 48212-99-3) is a useful research chemical.

Applications N-[(2,4-Difluorophenyl)methylene]-2,4-difluoro-benzenemethanamine is derived from 2,4-Difluorobenzylamine (D450850), which acts as a reagent for the design of pyrazole derivatives as non-nucleoside heptatitis B virus inhibitors. It is also used as a reagent in the preparation, HIV antiviral activity, SAR, and molecular modelling of hydroxypyridonecarboxylic acids as HIV reverse transcriptase inhibitors.
References Jia, H., et al.: Eur. J. Med. Chem., 123, 202 (2016); Kankanala, J., et al.: J. Med. Chem., 59, 5051 (2016)