Produits biochimiques et réactifs

<p>Bio-013077-01 is a bioactive compound, which is a naturally derived product sourced from marine organisms. Its mode of action involves functioning as an enzyme inhibitor, capable of selectively binding to specific target enzymes and altering their activity. This mechanism allows it to modulate biochemical pathways that are crucial for various physiological and pathological processes.</p>

<p>2-Chloro-N4-(4-methoxybenzyl)pyridine-3,4-diamine (CAS No. 881844-10-6) is an inhibitor of the receptor tyrosine kinase cMet and has been shown to inhibit the proliferation of tumor cells in culture. It inhibits the binding of ligand to cMet, which prevents activation of downstream signaling pathways that lead to cell proliferation.</p>

<p>A synthetic scorpion toxin, sourced from the Scorpion, Tityus serrulatus This product is a voltage-dependent K+ channel (A channel) Blocker and it has disulfide bonds between Cys7-Cys28, Cys13-Cys33, and Cys17-Cys35.</p>

<p>Please enquire for more information about CTAP including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>BDP FL DBCO is a synthetic peptide that binds to the GABA receptor. BDP FL DBCO is used in cell biology and research as an inhibitor of ion channels, ligand for the GABA receptor, or as a reagent to detect antibodies against GABA receptors.</p>

<p>Antagonist of TRPC4/C5 channels</p>

<p>CD62L antibody (Allophycocyanin) was raised in rat using C3H/eb cloned murine B lymphoma 38C-13 as the immunogen.</p>

<p>PDE9-IN-(S)-C33 is a phosphodiesterase inhibitor that is used in the treatment of heart diseases such as cardiac hypertrophy. PDE9-IN-(S)-C33 inhibits the activity of phosphodiesterase (PDE) type 9, which breaks down cyclic guanosine monophosphate (cGMP). This leads to an increase in intracellular cGMP levels and an inhibition of cardiac hypertrophy. PDE9-IN-(S)-C33 also has a beneficial effect on neonatal rat cardiomyocytes, which may be due to its ability to inhibit transition from hyperplasia to hypertrophy.</p>

<p>SAR131675 is a drug that acts as a tyrosine kinase inhibitor. It has been shown to have an effect on the growth of cancer cells and has been shown to be effective in treating inflammatory bowel disease. SAR131675 inhibits the activity of protein tyrosine kinases, which are enzymes that phosphorylate proteins and regulate their biological functions. The drug is selective for certain kinases, such as c-kit, stem cell factor receptor (c-Kit), and platelet-derived growth factor receptor (PDGFR). SAR131675 has been shown to be safe and effective in treating diseases such as cancer or inflammatory bowel disease when administered at an effective dose.</p>

<p>Capsiconiate is a natural compound derived from the Capsicum family of plants, specifically through the esterification of capsinoids, which are non-pungent analogs of capsaicinoids. It is derived from sources such as sweet peppers and other Capsicum varieties. Unlike its pungent counterparts, capsiconiate is characterized by its milder sensory perception while retaining significant bioactivity.</p>

<p>2-((2S,4R)-1-((R)-1-(4-Chlorophenyl)-4-methylpentyl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid is a high purity research tool. It has been used as an inhibitor of ion channels and ligands of the GABA A receptor. 2-((2S,4R)-1-((R)-1-(4-Chlorophenyl)-4-methylpentyl)-2-(4-(trifluoromethyl)phenyl)piperidin-4-yl)acetic acid is a peptide that has been used for cell biology and antibody production.</p>

<p>Please enquire for more information about Iloperidone-d3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>CD45R antibody (FITC) was raised in rat using abelson murine leukemia virus-induced pre-B tumor cells as the immunogen.</p>

<p>Inhibitor of tankyrase</p>

<p>4-Amino-3-ethoxybenzenesulfonic acid is a research tool that is used to study ion channels. It activates the receptor, which leads to increased cell permeability and the release of neurotransmitters. 4-Amino-3-ethoxybenzenesulfonic acid can be used to determine the effects of a ligand on a receptor by binding to it and altering its activity. 4-Amino-3-ethoxybenzenesulfonic acid is also used as an antibody in immunohistochemistry studies and has been shown to inhibit protein interactions.</p>

<p>Please enquire for more information about CORM-3 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>CD55 antibody was raised in mouse using CD55 as the immunogen.</p>

<p>BIBP 3226 is a drug that belongs to the class of beta-blockers. It is a potent and selective beta-adrenergic receptor antagonist that has been shown to have maximal response in the concentration range of 1 nM to 10 micromolar. The effects on blood pressure are dose dependent, with a maximal effect at doses greater than or equal to 0.1 mg/kg. BIBP 3226 has been found to inhibit insulin resistance and increase cardiac contractility in rats, and may also have an inhibitory effect on platelet aggregation. This drug exhibits pharmacokinetic properties that are independent of food intake and is metabolized by CYP3A4 in the liver.</p>

<p>Please enquire for more information about 4-[4,5-Bis[4-(dimethylamino)phenyl]-1H-imidazol-2-yl]-2,6-dimethoxyphenol including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Risperidone is a psychotropic drug that belongs to the group of atypical antipsychotics. It is used to treat psychotic disorders such as schizophrenia and bipolar disorder. Risperidone binds to dopamine D2 receptors in the brain, which may be responsible for its anti-psychotic effects. This drug also has strong sedative effects, which may be due to its ability to block histamine receptors in the brain. Risperidone can be administered as an injectable or orally as a tablet. Oral administration of risperidone requires a water-soluble salt or an organic solvent; however, it is more soluble in water than other antipsychotics.</p>

<p>CD90.2 antibody (Allophycocyanin) was raised in rat using CD90.2/`Thy-1.2 alloantigen as the immunogen.</p>

<p>Niraparib Tosylate is a hydrogen bond inhibitor that prevents the formation of hydrogen bonds between purine bases in DNA. This agent is used to treat cancer by inhibiting tumor cell proliferation. It also inhibits cellular and sequestered sulfonic acids, which are important for the immune response. Niraparib Tosylate has shown anti-inflammatory properties by inhibiting lymphocyte activation and preventing chemotherapy-induced neutropenia. This drug also targets microenvironment factors, such as homologous recombination repair, that lead to cancer progression.</p>

<p>BMS 470539 Dihydrochloride is a humanized anti-inflammatory monoclonal antibody that inhibits tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β). This drug is used for the treatment of eye disorders, bowel disease, and other conditions. BMS 470539 Dihydrochloride binds to TNF receptors and blocks the interaction between TNF-α or IL-1β with their receptors, which prevents the production of inflammatory cytokines. This drug also has neuroprotective effects in animal studies. It is believed that this effect may be due to inhibition of microglial activation, which are cells in the central nervous system that release inflammatory cytokines. The molecule does not bind to macrophages or erythrocytes, so it does not have an effect on platelet aggregation or coagulation.</p>

<p>Inhibits factor Xa; anti-thrombotic</p>

<p>PE 154 is a nucleotide analog that inhibits the transcription-polymerase chain reaction. It is most commonly used in the detection of viruses because it inhibits viral growth by preventing RNA synthesis. PE 154 also has antireflection properties that allow for better light transmission, making it useful for optical devices. In addition to its antiviral activity, PE 154 has been shown to inhibit the replication of human herpes virus 6 and 7, as well as other viruses such as HIV-1, HIV-2, and cytomegalovirus.<br>br&gt; <br>PE 154 binds to DNA and prevents the initiation of transcription by blocking polymerase binding sites on the DNA template strand. This leads to a decrease in gene expression and protein synthesis, which can lead to cell death. PE 154 also blocks reverse transcriptase activity by binding to primer binding sites on the single-stranded DNA template strand. This leads to an inhibition of RNA synthesis and subsequent protein synthesis.br&gt;br&gt;<br>The drug</p>

<p>CD3e antibody (PE) was raised in hamster using H-2Kb-specific mouse cytotoxic T lymphocyte as the immunogen.</p>

<p>ML204 hydrochloride is a selective TRPC4/5 ion channel inhibitor, which is a synthetic compound designed to modulate specific biological pathways. It is derived from a series of chemical modifications tailored to target the transient receptor potential canonical (TRPC) family of ion channels, particularly TRPC4 and 5.</p>

<p>CD20 antibody (PE) was raised in mouse using human CD20 as the immunogen.</p>

<p>Diflapolin is a synthetic pharmaceutical compound, which is a non-steroidal anti-inflammatory drug (NSAID) derived from laboratory-synthesized chemical precursors. Its mode of action involves the inhibition of specific enzymes, particularly cyclooxygenase (COX) enzymes, which play a crucial role in the biosynthesis of pro-inflammatory mediators like prostaglandins. By impeding these enzymes, Diflapolin effectively reduces inflammation, alleviates pain, and decreases fever.</p>

<p>Covalent antagonist of estrogen receptor</p>

<p>Relamorelin is a peptide hormone that binds to the growth hormone-releasing factor receptor. It has been shown to activate this receptor and stimulate the release of growth hormone from the anterior pituitary gland. Relamorelin has been used as a research tool to study protein interactions, ligand binding, and inhibition of ion channels. It is also used in cell biology as an inhibitor of protein synthesis and DNA replication. Relamorelin is a potent inhibitor of ligand binding to the GABA type A receptor (CAS No. 661472-41-9).</p>

<p>CD117 antibody (Allophycocyanin) was raised in rat using murine CD117/c-Kit as the immunogen.</p>

<p>CD44 antibody (Allophycocyanin) was raised in rat using murine CD44 as the immunogen.</p>

<p>CD38 antibody (PE) was raised in rat using CD38 as the immunogen.</p>

<p>KLRG1 antibody (Azide free) was raised in hamster using activated NK (A-LAK) cells from B6 mice as the immunogen.</p>

<p>CD11b antibody (Allophycocyanin) was raised in rat using C57BL/10 murine splenic T cells and concanavalin A-activated C57BL/10 splenocytes as the immunogen.</p>

<p>Eif-2α inhibitor II, sal003 is a peptide antibody that blocks the translation of eukaryotic initiation factor-2α (eIF-2α), which has been shown to be involved in many cellular processes. EIF-2α inhibitor II, sal003 is a highly purified antibody with no background staining. This antibody has been shown to inhibit the production of nitric oxide by binding to eIF-2α and inhibiting its phosphorylation. It can also block the action of bacteria, such as Escherichia coli, by interfering with protein synthesis. This antibody can be used for research purposes in cell biology, pharmacology, and immunology.</p>

<p>N-{[4'-({3-Butyl-5-Oxo-1-[2-(Trifluoromethyl)Phenyl]-1,5-Dihydro-4H-1,2,4-Triazol-4-Yl}Methyl)-2-Biphenylyl]Sulfonyl}-3-Methyl--2 -Thiophenecarboxamide is a reactive molecule that inhibits the production of prostaglandin E2 (PGE2). It binds to the PGE2 receptor and blocks its activation. N-[{4'-({3-Butyl--5--Oxo-[1-(2-(trifluoromethyl)phenyl]-1,5--dihydro--4H--1,2,4--triazol--4--y l}methyl)-2--biphenylylsulfonyl}] 3methyl 2thiop</p>

<p>Please enquire for more information about 9-Methyl risperidone including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>TFF1 is a protein that belongs to the TNF family of cytokines. It is a homodimer with two identical chains that are linked by disulfide bonds at specific positions. TFF1 has been shown to be secreted by monocytes, macrophages, and lymphocytes in response to LPS stimulation. TFF1 binds to the cell membrane of target cells and induces proinflammatory responses such as cytokine production and the activation of NF-κB. These effects are mediated through its ability to activate the transcription factor nuclear factor-κB (NF-κB) which regulates gene expression in immune cells.<br>DISULFIDE BONDS: The covalent linkage between two polypeptide chains or between two amino acid residues <br>CHROMATOGRAPHY: A process for separating mixtures based on molecular weight, size, shape, or other physical properties <br>RECOMBINANT: Produced by recombining genetic material from different</p>

<p>Canadine is an alkaloid and the major active ingredient in the herbal medicine berberine. It has been used for the treatment of metabolic disorders, such as diabetes mellitus. Canadine can cause drug interactions with other drugs that are metabolized by cytochrome P450 enzymes and may increase oxidative injury to cells. Canadine has also shown efficacy against oral pathogens in animal models. Toxicological studies have been conducted on rats, showing that it may cause liver damage and energy metabolism disturbances. This drug has been found to be effective for treating some experimental models of liver disease such as chronic hepatitis or cirrhosis.</p>

<p>5-[Boc(methyl)amino]pentanal is a ligand that binds to the human A1 adenosine receptor, which is a G protein-coupled receptor. 5-[Boc(methyl)amino]pentanal has been shown to activate the A1 receptor and affect the flow of ions through ion channels. This ligand also inhibits the production of peptides that regulate blood pressure and glucose levels. 5-[Boc(methyl)amino]pentanal may also be used as an inhibitor in research tools for cell biology studies, such as antibody labeling and immunoprecipitation.</p>

<p>KPT is a drug for the treatment of inflammatory diseases. It is a particle-based drug delivery system that delivers active ingredients through the skin. KPT consists of a class of drugs called protein inhibitors, which are designed to inhibit the growth factor receptor EGFR. This receptor plays an important role in tumor cell growth and survival by regulating cellular function, including cell proliferation, differentiation, and apoptosis. The detection sensitivity of KPT is low enough to allow targeting of cancer cells without affecting healthy cells. KPT has been shown to inhibit the growth of melanoma cells in culture and reduce tumor size in mice with experimental cancer.</p>

<p>Nucleoside Diphosphate Kinase E.coli (recombinant) is a research peptide that belongs to the group of protein kinases. It is used in scientific studies and experiments to investigate various cellular processes and signaling pathways. This recombinant protein kinase has been shown to play a crucial role in the phosphorylation of nucleoside diphosphates, which are important molecules involved in energy metabolism and cell signaling. By catalyzing the transfer of phosphate groups, Nucleoside Diphosphate Kinase E.coli regulates the balance of nucleotide triphosphates, which are essential for DNA replication, RNA synthesis, and protein synthesis. Its unique properties make it an invaluable tool for researchers studying cellular mechanisms and developing new therapeutic strategies.</p>

<p>Vn96 scramble peptide is a negative control peptide that is used in pharmacological and cell biology research. It is an inhibitor of protein interactions and can also be used as a research tool for identifying the ligand or receptor of a protein. Vn96 scramble peptide has been shown to inhibit ion channels, including potassium channels, which are involved in nerve transmission.</p>

<p>TentaGel® R PHB Resin (90 um) can be used for the preparation of peptide acids; particle size 90 µm; capacity: 018-023 meq/g and is specially designed for difficult and long sequences.<br>TentaGel, is a gelatinous resin, an important support for solid phase synthesis. TentaGel resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.</p>

<p>Neuromedin U is a neuropeptide that has been found to bind to the receptor neuromedin U receptor. It is a potent activator of ion channels and ligand for the neuromedin U receptor. Neuromedin U is also an inhibitor of angiotensin II, histamine, and serotonin release. The purified recombinant human neuromedin U protein is supplied at &gt;98% purity with no detectable endotoxin contamination.</p>

<p>BMS-911543 is a selective inhibitor of cyclin-dependent kinases (CDKs), which is a product of Bristol-Myers Squibb. It originates from extensive research aiming to target the dysregulated cell cycle processes often found in cancer cells. BMS-911543 works by inhibiting specific CDKs, which are crucial regulators of cell cycle progression, particularly affecting CDK2 and CDK9. This mode of action interferes with the cyclin-CDK complex's ability to phosphorylate target substrates, ultimately inducing cell cycle arrest and promoting apoptosis in susceptible cancer cells.</p>

<p>CP-547632 hydrochloride is a peptide that binds to the extracellular domain of the human insulin receptor and inhibits its activity. CP-547632 hydrochloride has been used as a research tool in cell biology, pharmacology, and life science. This inhibitor is useful for studying the role of receptor tyrosine kinases in cellular signaling pathways. CP-547632 hydrochloride can also be used to study ion channels and other membrane receptors. It is available at high purity, with a CAS number of 252003-71-7.</p>

<p>TentaGel; is a gelatinous resin, an important support for solid phase synthesis. TentaGel; resins are constructed with a backbone of low crosslinked polystyrene grafted with polyoxyethylene (polyethylene glycol) as shown below. The typical chain length of POE (n) is approximately 68 ethylene oxide units or an average MW of 3000. This long chain creates a spacer that effectively separates the reactive site (X) from the crosslinked backbone matrix.<br>These resins are designed for single bead synthesis and single bead analysis (mean particle size 280-320 µm: capacity 02-03 meq/g) and substitutional functional group: -CH2-CH2-SH.</p>

<p>2-Methyltridecane-d6 is a medicinal chemical compound that serves as an inhibitor of kinases, which play a crucial role in the development and progression of cancer. It has been found to exhibit potent anticancer activity by inhibiting specific protein kinases involved in cancer cell growth and survival. This compound has been studied extensively for its ability to induce apoptosis, or programmed cell death, in cancer cells. 2-Methyltridecane-d6 is an analog of a natural product found in Chinese herbal medicine and has shown promising results in preclinical studies as a potential therapeutic agent for various types of cancers. Its presence can be detected in human urine, making it a useful biomarker for monitoring treatment efficacy.</p>

<p>Neuromedin C is a peptide hormone that is involved in the regulation of feeding behavior. It is found in humans, pigs, and dogs. Neuromedin C has been shown to be involved in the regulation of gastric acid secretion and pancreatic secretion. The peptide also plays a role in the regulation of insulin release from the pancreas. In addition, neuromedin C has been shown to be an effective treatment for diabetes-related neuropathy.</p>

<p>Please enquire for more information about 4-[[[2-Chloro-4-[[3-(2,6-dichlorophenyl)-5-(1-methylethyl)-4-isoxazolyl]methoxy]phenyl]methyl]amino]-benzeneacetic acid including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Please enquire for more information about 17-Phenoxy trinor prostaglandin f2α ethyl amide including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Peptide YY (Human)-EIA Kit (1ea) is an EIA kit for the quantitative analysis of human peptide YY. Peptide YY is a neuropeptide with a role in the regulation of food intake and energy expenditure. The kit contains one vial each of peptide YY antiserum, peptide YY antibody, and standard reference material. The assay can be used to detect the level of peptide YY in tissue samples or cell culture supernatants.</p>

<p>Safit1 is a small molecule that has been shown to be effective in treating cancer. Safit1 inhibits the activity of glucocorticoid receptors, which are involved in the control of cellular response to stress and inflammation. It also inhibits the PD-L1 receptor, which is involved in cell proliferation and cancer resistance. Safit1 has been shown to have anti-inflammatory properties, as well as an ability to inhibit protein synthesis. Safit1 has also been shown to have a protective effect against metabolic disorders such as diabetes and obesity.</p>

<p>Necrostatin 2 S is a peptide that has been shown to inhibit the activity of ion channels and receptor tyrosine kinases. Necrostatin 2 S is also a ligand for the GABA A receptor, which is involved in the regulation of neuronal excitability. It has been shown to be an inhibitor of protein interactions and can be used as a research tool in cell biology, pharmacology, and life science.</p>

<p>CD3e antibody (FITC) was raised in mouse using porcine CD3e as the immunogen.</p>

<p>7-BIA is a potent non-competitive phosphatase inhibitor. It inhibits tyrosine phosphatases by binding to the enzyme's ligand-binding site and preventing substrate from binding. This drug has been shown to inhibit phosphatases in vivo and in vitro studies, including cyclopentyl phosphatase, p38 MAP kinase, and PI3K. 7-BIA also blocks cAMP synthesis and reduces the activity of protein kinase A. 7-BIA is a competitive ligand for the pharmacophore site of the enzyme PP2A, which is found in both brain cells and platelets.</p>

<p>GSK2292767 is a small molecule that inhibits the protein kinase PI3Kδ. This inhibition blocks the activation of downstream proteins, including epidermal growth factor receptor (EGFR), which are involved in cell maturation and cancer. GSK2292767 has been shown to inhibit the growth of cancer cells in vitro and to reverse certain symptoms in animal models for autoimmune diseases. The drug has also been found to be effective against colorectal cancer and melanoma when used at an effective dose. GSK2292767 targets EGFR, which is important for cell maturation, proliferation, and apoptosis. It also inhibits the activity of PI3Kδ, which leads to the production of inflammatory cytokines by immune cells.<br>GSK2292767 is currently undergoing clinical trials as a treatment for certain types of cancer.</p>

<p>Albumin heavy tryptic peptide standard for use in protein identification and quantitation studies. Albumin is a globular protein found in plasma and is produced by liver hepatocytes. Serum albumin plays an important role in the regulation of plasma oncotic pressure.</p>

<p>NS3763 is a drug that has been shown to have neuroprotective effects in animal models of epilepsy and stroke. It selectively inhibits the activity of the gamma-aminobutyric acid (GABA) receptor, which is an inhibitory neurotransmitter. NS3763 has also been shown to prevent glutamate-induced neuronal death in mice. This drug also blocks the activity of cation channels that are activated by GABA, resulting in depressed excitatory effects and decreased seizure susceptibility. The mechanism of action for NS3763 is unclear, but it may function as a non-selective cation channel activator or as an excitatory effector. In addition to its neuroprotective properties, NS3763 has been shown to have anxiolytic effects in animal models and may be useful for treating nervous system diseases such as epilepsy and stroke.</p>

<p>CD45.2 antibody (Allophycocyanin) was raised in mouse using CD45.2 as the immunogen.</p>

<p>Inhibitor of ALK5 kinase</p>

<p>5-(Acetylimino)-4,5-dihydro-4-methyl-1,3,4-thiadiazole-2-sulfonic acid is a Research tool for Cell Biology. It is an activator of the Ligand Receptor and a receptor for the cell. This chemical has been shown to activate ion channels and high purity Protein interactions. 5-(Acetylimino)-4,5-dihydro-4-methyl-1,3,4-thiadiazole-2sulfonic acid also prevents peptide bonding in cells by binding to the carboxyl group of peptides and proteins.</p>

<p>CD31 antibody (biotin) was raised in rat using murine leukocyte cell line 32D as the immunogen.</p>

<p>Matrix metalloproteinase inhibitor</p>

<p>Rac-enterodiol-13C3 is a compound that has antioxidative properties and may be beneficial for the treatment of bowel disease. Rac-enterodol-13C3 has been shown to reduce oxidative stress in human serum cells, which can contribute to the development of cancer. Rac-enterodiol-13C3 also showed high binding activity with DNA in vitro assays. It has been shown to have physiological effects on cell signaling pathways, including increased proliferation and decreased apoptosis. The biological properties of rac-enterodiol-13C3 make it an attractive candidate for the treatment of bowel disease, cancer, and other diseases.</p>

<p>CD25 antibody (PE-CY7) was raised in rat using alpha chain IL-2 receptor as the immunogen.</p>

<p>Glu17,Gla21,24-Osteocalcin is a peptide that is used as a research tool to study ion channels and receptor interactions. It has been shown to bind to the human insulin receptor and act as an agonist. Glu17,Gla21,24-Osteocalcin also binds to the calcitonin receptor with high affinity. This peptide can be used in pharmacology studies as an inhibitor of insulin-mediated glucose uptake or as an activator of calcium release from intracellular stores.</p>

<p>Tiludronic acid is a drug that belongs to the group of non-steroidal anti-inflammatory drugs. It is used for the treatment of bowel diseases such as inflammatory bowel disease, ulcerative colitis, and Crohn's disease. Tiludronic acid binds to the matrix metalloproteinases (MMPs) or collagenase, which are enzymes that break down connective tissue in the digestive system. This binding prevents their activity, thereby reducing inflammation and allowing damaged tissues to heal. Tiludronic acid has also been shown to have an activity index of 2.0 μM with respect to MMPs and collagenase in a model consisting of crystalline cellulose and experimental models. Tiludronic acid inhibits MMPs and collagenase by binding to them at low concentrations (2 μM). This binding prevents their activity, thereby reducing inflammation and allowing damaged tissues to heal. Tiludronic acid has also been shown to have an activity index</p>

<p>SKF83822 hydrobromide is a selective dopamine receptor agonist, which is synthetically derived with a specific affinity for dopamine D1 receptors. Its mode of action involves the targeting and activation of these receptors, offering a unique tool for research into dopamine-related signaling pathways. Due to its specificity, SKF83822 hydrobromide is utilized extensively in neuroscientific research to investigate the roles of D1 receptors in various physiological and pathological contexts.</p>

<p>PM 102 is a drug that inhibits the activity of epidermal growth factor receptor (EGFR) and epidermal growth factor (EGF). It is used as a treatment for colorectal cancer in combination with 5-fluorouracil. It also has been shown to inhibit the growth of human colon carcinomas in vitro. PM 102 has subassemblies that are composed of an inhibitor, which blocks the binding site on the EGFR, and a biotinylated peptide, which binds to the EGFR. This drug has been shown to be non-toxic in rats and does not cause any significant side effects. PM 102 is a nonprofit organization that will provide regulatory guidance for devices used in treatment of diseases such as cancer. The company's goal is to increase translation and enhance transistor enhancements for use in medical devices.</p>

<p>A potent and selective cell-permeable inhibitor of protein phosphatase 1 and protein phosphatase 2A.  Displays &gt; 10,000,000-fold selectivity over PP2B and PP2C.</p>

<p>Please enquire for more information about Amonafide-d6 including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>NP19 is a Chinese medicinal compound that has been found to have potent anticancer properties. It is an analog of kinase inhibitors and has been shown to induce apoptosis in cancer cells. NP19 works by inhibiting protein kinases, which are enzymes that play a crucial role in the growth and proliferation of tumor cells. This compound has been extensively studied for its potential use as an anticancer drug and has shown promising results in preclinical studies. In addition, NP19 can be detected in human urine, indicating that it may have potential as a non-invasive diagnostic tool for cancer. Overall, NP19 represents a promising new avenue for the development of effective cancer therapies.</p>

<p>NFAT Activation Inhibitor III is a chemical inhibitor that prevents the activation of NFAT. NFATs are transcription factors that regulate the expression of genes in cells. The activation of NFATs is triggered by Ca2+ signals and growth factors, which are important for cardiac hypertrophy. This inhibitor has been shown to prevent the development of cardiac hypertrophy and heart failure in vivo and in vitro models. It also inhibits the production of pro-inflammatory cytokines, such as IL-1β, IL-6, and TNFα. NFAT Activation Inhibitor III may also be used to treat inflammation or neurodegenerative diseases, such as Alzheimer's disease or Parkinson's disease.</p>

<p>1-Octadecanoyl-2-(15S-hydroxy-5Z,8Z,11Z,13E-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine is a bioactive lipid compound, which is derived from natural lipid sources such as cellular membranes. Its mode of action involves participation in complex lipid signaling pathways that play a crucial role in cellular processes. This compound acts as a mediator in signaling cascades associated with inflammation, cellular communication, and homeostasis. As such, it can be integral in studies focused on cell signaling and the physiological roles of lipids.</p>

<p>WYE-687 is a novel small molecule that inhibits lipid kinase activity and is able to induce senescence in cells. It has potent antitumor activity against cancer cells and potently inhibits the growth of xenograft tumors in mice. WYE-687 also possesses potential as a drug target for autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. The drug has been shown to inhibit angiogenesis, which is the formation of new blood vessels from pre-existing ones, both in vitro and in vivo. WYE-687 has been shown to be well tolerated by animals after oral administration, with no observable side effects.</p>

<p>WEHI-345 is a synthetic compound that was designed using pharmacophore modeling techniques to interact with the kinase receptor. It has been shown to inhibit the production of pro-inflammatory cytokines in vitro, and also inhibits the proliferation of cells in vivo. This drug is being evaluated for its ability to treat inflammatory diseases such as asthma and rheumatoid arthritis.</p>

<p>Please enquire for more information about Avidin antibody including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>Inhibitor of sodium-glucose cotransporter SGLT2</p>

<p>monoFITC INSL6 is a Research Tool that is an activator of the Insulin-like peptide 6 receptor (INSL6). It is a ligand that binds to the Insulin-like peptide 6 receptor and activates it. MonoFITC INSL6 can be used in research on Cell Biology, Antibodies and Ion channels. This product has high purity, with a CAS number, and is a Protein Interactions inhibitor. MonoFITC INSL6 can be used in Pharmacology or Peptides, as well as Life Science.</p>

<p>Inhibitor of cyclin-dependend kinases CDC2, CDK2 and CDK5</p>

<p>Cortol is a drug that is used to treat cancer. It binds to the mineralocorticoid receptor, which is an intracellular protein that regulates the production of glucocorticoids and other hormones. Cortol has been shown to inhibit oxidative DNA damage in urine samples from women with breast cancer. Cortol may also have an inhibitory effect on insulin sensitivity in women. Cortol binds to the estrogen receptor on cells and inhibits the expression of genes encoding enzymes involved in lipid metabolism. It also inhibits growth factor activity, which can lead to inhibition of ovary cell proliferation and increased body mass index in women. Cortol has been shown to improve insulin resistance by increasing glucose uptake and reducing hepatic glucose output in animal models.</p>

<p>Highly selective and potent Tank binding kinase 1 (TBK1) inhibitor</p>

<p>2-(2,5-Dihydroxy-4-methylphenyl)-5-methylbenzene-1,4-diol is a ligand that binds to the extracellular domain of the human androgen receptor. It has been shown to be an inhibitor of protein synthesis in cells and can also act as a competitive antagonist of the alpha 1A and alpha 1B adrenergic receptors. 2-(2,5-Dihydroxy-4-methylphenyl)-5-methylbenzene-1,4-diol is used as a research tool for the study of protein interactions and receptor activity.</p>

<p>8-Hydroxy carvedilol is an analog of the beta-blocker drug carvedilol that has been shown to have potent anticancer properties. It inhibits the activity of protein kinase C (PKC), which is involved in cell signaling pathways that regulate cell growth and survival. 8-Hydroxy carvedilol has been found to induce apoptosis in human and Chinese hamster ovary cells, as well as in tumor cells from various types of cancer. This drug also inhibits the activity of calcitonin gene-related peptide (CGRP), a neuropeptide that is involved in pain transmission and inflammation. In addition, 8-Hydroxy carvedilol has been shown to inhibit oxytocin-induced contractions in isolated rat uterus tissue. Overall, these findings suggest that 8-Hydroxy carvedilol may have potential as a novel anticancer agent with anti-inflammatory properties.</p>

<p>SB 203580 hydrochloride is a p38 MAPK inhibitor that binds to the receptor site of the human serum albumin. It has been shown to have a significant effect on cell proliferation and cell migration in corneal endothelial cells and epidermal growth factor receptor-positive epithelial cells in culture. SB 203580 hydrochloride also inhibits protease activity, which may be related to its ability to inhibit tumor necrosis factor-α (TNF-α) production. SB 203580 hydrochloride is a nanoparticulate composition that can be used for treatment of inflammatory disorders such as asthma, COPD, and rheumatoid arthritis.</p>

<p>N-(3-{3-(3,5-Dimethoxy-phenyl)-7-[4-(4-methyl-piperazin-1-yl)-phenylamino]-2-oxo-3,4-dihydro-2H-pyrimido[4,5-d]pyrimidin-1-ylmethyl} -phenyl)-acrylamide is a fluorescent probe that binds to ion channels and serves as a research tool for studying the interactions between proteins. The CAS number is 209308881.</p>

<p>TRAIL is a peptide that belongs to the group of cytokines. It activates the receptor-mediated apoptosis pathway in cells that have been stimulated by tumor necrosis factor-α (TNF-α) and other pro-inflammatory cytokines. TRAIL has also been shown to inhibit protein interactions, such as those between the TNF receptors and their ligands or receptors, like CD4. TRAIL also binds to the Fas receptor and its ligand, FasL, which leads to activation of caspases in a similar manner as FADD binding. The recombinant human TRAIL is a research tool for studying cell biology and pharmacology.</p>

<p>p-Hydroxymesocarb is an organic chemical compound, categorized as a pharmacological agent, which is derived from synthetic sources through a series of chemical reactions involving carbamate derivatives. Its mode of action primarily involves interaction with central nervous system receptors, potentially influencing neurochemical pathways by modulating neurotransmitter activity. This compound may mimic or interfere with endogenous neurotransmitters, leading to altered physiological and psychological responses.</p>

<p>AM-9074 is a pyridine compound that acts as a glucokinase activator. It has been shown to increase the activity of this enzyme in vivo, leading to increased glucose uptake and decreased blood glucose levels. AM-9074 is currently under development for the treatment of diabetes mellitus type 2 and may be effective in lowering blood sugar levels in patients with type 1 diabetes.</p>

<p>KCC 07 is a synthetic peptide that inhibits the VEGF pathway by functioning as an antagonist to VEGF receptors. It has been shown to inhibit tumor growth and improve survival in mice with glioma, a type of brain tumor. KCC 07 also has anti-angiogenic properties and can inhibit the proliferation of endothelial cells. The peptide can be used as an antibody that binds to the extracellular domain of the receptor, preventing binding to VEGF ligand. This inhibition leads to decreased activation of VEGF receptors and decreased cell proliferation.</p>

<p>P-((4-((1-Oxotetradecyl)amino)phenyl)methyl)-phosphonic acid is a synthetic compound, which is a specialized reagent used primarily in chemical research. It is derived from the modification of phosphonic acid with an aryl amide and a long-chain fatty acid substituent on the phenyl group. This structural configuration imparts the compound with unique physicochemical properties that make it suitable for various scientific studies.</p>

<p>3-Phenyl-1H-quinazoline-2,4-dithione is a cyclic nucleotide phosphodiesterase inhibitor. It inhibits the activity of cyclic nucleotide phosphodiesterases, which are enzymes that break down cyclic nucleotides. Cyclic nucleotides are important in the regulation of cellular processes such as cell growth and differentiation, and 3-phenyl-1H-quinazoline-2,4-dithione has been shown to inhibit these processes. 3-Phenyl-1H-quinazoline-2,4-dithione is used clinically for the treatment of renal injury caused by ischemia reperfusion. It also has been shown to decrease blood pressure and improve blood flow in cases of hypertension. The drug has also been shown to have antiinflammatory properties and can be used for the treatment of inflammatory diseases such as rheumatoid arthritis or Crohn's disease.</p>

<p>CS-003 is a leukotriene receptor antagonist that inhibits the effects of leukotrienes on the airways and lungs. It is administered orally to reduce bronchoconstriction and other symptoms related to asthma, allergic rhinitis, and chronic obstructive pulmonary disease. CS-003 has been shown in clinical studies to be effective in inhibiting coughs induced by citric acid. The drug also exhibits a dose-dependent inhibitory effect on airway hyperresponsiveness. CS-003 is a recombinant human protein that binds to the neurokinin receptor 1 (NK1R) on nerve endings in the nose, reducing nasal congestion and other symptoms of allergic rhinitis such as sneezing and itchy nose.<br>CS-003 also blocks chloride channels on cells in the trachea, which may be involved in controlling inflammation following an allergen challenge.</p>

<p>Perindopril L-arginine is an angiotensin-converting enzyme (ACE) inhibitor, which is synthetically derived for pharmacological applications. Its mode of action involves the inhibition of the ACE, reducing the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. Consequently, this results in vasodilation, decreased blood pressure, and reduced cardiac workload. The addition of L-arginine aims to enhance endothelial function due to its role as a precursor to nitric oxide, a vasodilator that further complements the antihypertensive effects.</p>

<p>PF-06869206 is a binder that binds to the parathyroid hormone receptor and inhibits its activity. It is used for the treatment of chronic kidney disease, where it reduces urinary flow rate and inhibits growth factor production, thereby reducing bone loss. PF-06869206 has been shown to lower blood calcium levels in wild-type mice with high-calcium diets, but does not affect the calcium levels of wild-type mice with low-calcium diets. This drug also inhibits parathyroid hormone secretion and decreases renal excretion of phosphate and chloride in vivo studies.<br>PF-06869206 is orally bioavailable and can be given both once or twice daily. In vivo studies have shown that this drug has nonselective binding properties as it binds to both active and inactive forms of the parathyroid hormone receptor.br&gt;</p>

<p>Ampholak YJH 40 is an anticancer drug that has been developed in China. It works by inhibiting kinases, including cyclin-dependent kinases, which are involved in the regulation of cell growth and division. Ampholak YJH 40 has been shown to induce apoptosis (cell death) in cancer cells, making it a potential treatment for various types of tumors. This drug is an analog of other kinase inhibitors that have shown promising results in preclinical studies. Ampholak YJH 40 is derived from human urine and has been tested for its efficacy against a variety of cancer cell lines. It is hoped that this drug will offer new treatment options for patients with cancer.</p>