Produits biochimiques et réactifs

<p>(4S)-Hexahydro-1-methyl-2,6-dioxo-4-pyrimidinecarbonyl-L-histidyl-L-proline is a prodrug that is metabolized by esterases in the gastrointestinal tract to form the active drug L-(3,5 dimethoxybenzyl)histidylprolinamide. This compound has been shown to inhibit thyroid hormone biosynthesis and may be useful for the treatment of thyroid disease. The compound also has neuroprotective properties and may be beneficial for the treatment of Alzheimer's disease.</p>

<p>Human-monoBiotin (PheB1) is a peptide that activates the acetylcholine receptor and may be used as an inhibitor for ion channels. This peptide has been shown to inhibit the binding of acetylcholine to its receptor, which may lead to therapeutic benefits for diseases associated with protein interactions, such as Alzheimer's disease. It also has a role in cell biology and pharmacology.</p>

<p>CGP 52608 is a synthetic compound that inhibits the activity of transcription-polymerase chain. It is a potent inhibitor of the tumor suppressor protein p21 and thus has potential for treating cancer. CGP 52608 also has anti-inflammatory effects in experimental models of inflammatory bowel disease and rheumatoid arthritis. The inhibition of p21 may be mediated by binding to its response elements in DNA, which prevents the binding of transcription factors.<br>CGP 52608 also blocks melatonin's role in regulating cellular proliferation and differentiation, which may explain its effects on cancer cells.</p>

<p>2-[2-(2-Hydroxyethoxy)ethylamino]benzo[H]chromen-4-one is a research tool that is used to study the function of ion channels and receptor interactions. It has been shown to inhibit the activation of calcium channels in cell culture, which may be due to its ability to inhibit ligand binding. 2-[2-(2-Hydroxyethoxy)ethylamino]benzo[H]chromen-4-one also binds to antibodies and peptides, which may be an indication of its use as a pharmacological agent.</p>

<p>Anti Somatostatin (Human, Rat) Serum is a research tool that can be used to activate or suppress the function of cells by binding to their receptors. This antibody binds to somatostatin receptors and blocks their ability to bind to the ligand. It is also used for the detection of ion channels in cell biology. Antibody against somatostatin can be used as an inhibitor in pharmacological studies.</p>

<p>Inhibitor of O-GlcNAcase</p>

<p>The enzyme is a glycohydrolase that catalyzes the hydrolysis of gamma-glutamyl peptide bonds. It is a member of the family of enzymes that catalyze the hydrolysis of peptide bonds in proteins, polypeptides, and oligopeptides. The enzyme has been purified from Escherichia coli and characterized by chromatographic techniques and molecular mass determination. The gene encoding this protein has been cloned into prokaryotic expression vectors or eukaryotic expression vectors for use in protein studies or other investigations.</p>

<p>3-(4-Bromo-3,5-dimethoxyphenyl)-2-(methoxymethyl)-2-propenenitrile-d6 is a research tool for receptor binding. It is a ligand that binds to the ion channels and may be an inhibitor of protein interactions. 3-(4-Bromo-3,5-dimethoxyphenyl)-2-(methoxymethyl)-2-propenenitrile-d6 is used in pharmacology and biochemistry as a ligand for the study of protein interactions. It has been used to characterize the structure and function of ion channels and antibodies. The chemical name is 3-(4-bromo-3,5-dimethoxyphenyl)-2-(methoxymethyl)propene nitrile d6 and it has CAS No. 56518-39-9.</p>

<p>LCH-7749944 is a selective receptor modulator, which is derived from synthetic chemical processes. Its mode of action involves specifically binding to receptors on cellular membranes, thereby altering the signaling pathways within the cell. This alteration can lead to enhanced or suppressed cellular responses depending on the receptor type it interacts with.</p>

<p>14:0-14:0-d27 Pc is a peptide that belongs to the group of activator peptides. It has been shown to act as an ion channel inhibitor in rat dorsal root ganglion neurons and to inhibit protein interactions in vitro. 14:0-14:0-d27 Pc also has the ability to act as an antibacterial agent and a ligand for the GABA receptor. 14:0-14:0-d27 Pc is soluble in water, making it useful for use in cell biology and pharmacology experiments.</p>

<p>Inhibitor of PDE2A enzyme</p>

<p>NSC109555 is a small molecule that is chemically synthesized. It has been shown to inhibit the uptake of sodium citrate by mitochondria, which inhibits cellular energy production. NSC109555 also has anti-cancer properties and may be used as a diagnostic agent for cancer. It is activated when it binds to DNA as a template and prevents the formation of dna strands, which prevents the replication of cells. NSC109555 can also cross cell membranes and enter into cells, where it prevents repair mechanisms such as DNA repair from occurring. The chemical structure of this drug is not yet known, but its mechanism of action may involve the response pathway in cancer cells that regulates cell cycle progression, gene expression, and apoptosis.</p>

<p>Lissamine Rhodamine B Sulfonamide-dPEG®4-Acid is a PEG compound containing a rhodamine used for tagging biomolecules, and serving as fluorescent probe for bioimaging applications.</p>

<p>Antibody which blocks the CD95 death receptor which have the ability to elicit apoptosis.</p>

<p>Isoleucyl-Seryl-Bradykinin is a peptide that activates the bradykinin receptor, which is involved in pain sensation and inflammation. This compound is a potent inhibitor of ion channels and also interacts with protein receptors. Isoleucyl-Seryl-Bradykinin has been used as a research tool for studying the function of bradykinin receptors, as well as for pharmacological studies. The CAS number for this product is 86030-63-9.</p>

<p>A synthetic snake toxin peptide sourced from the Green Mamba, Dendroaspis angusticeps. It is an agonist for Muscarinic Acetylcholine Receptor-1 (M1) and has disulfide bonds between Cys3-Cys24, Cys17-Cys42, Cys46-Cys58, and Cys59-Cys64. This product is available as a 0.1mg vial.</p>

<p>AT 1001 is a drug that has been demonstrated to be effective in the treatment of bowel disease. It is specifically designed to bind to acetylcholine receptors on the cell membrane, thereby blocking the action of acetylcholine and reducing inflammation. AT 1001 has been shown to be effective in animal models of autoimmune diseases, such as multiple sclerosis and inflammatory bowel disease. This drug has also been shown to have some effect on otoacoustic emissions and locomotor activity in animals. The binding site for this drug is known, but its exact mechanism of action is not yet clear.</p>

<p>LR3 IGF1 Human is a cytokine that is a member of the interleukin family. It is one of the two forms of human insulin-like growth factor 1 (IGF-1), which plays an important role in regulating cell growth and differentiation. LR3 IGF1 Human has been shown to stimulate the proliferation of various cells, such as lymphocytes and fibroblasts, in vitro. In addition, this cytokine has been shown to inhibit apoptosis induced by serum deprivation.</p>

<p>Roscovitine is a ligand that binds to voltage-gated potassium channels. It has been shown to inhibit the function of these channels, which are involved in the regulation of neuronal excitability and muscle contraction. Roscovitine is used as a research tool in pharmacology and cell biology, and can be used as a high purity reagent for antibody production.</p>

<p>NSC 81178 is a sulfur-containing chemical that was found to be capable of inducing mutations in the DNA of Neurospora crassa. The mutant strain of N. crassa, which responded positively to NSC 81178, had a reduced capacity for conversion of 5-formyluracil to 5-hydroxymethyluracil and showed a decreased level of glutarate synthesis. This suggests that NSC 81178 may be capable of inducing mutations by chemically reacting with DNA and altering its structure. <br>In addition, the KM values for pyrimidines were significantly higher in the mutant strain than in the wild type strain, indicating that NSC 81178 has an effect on nucleotide synthesis.</p>

<p>VCH-759 is a nucleoside analog that is a potential treatment for chronic hepatitis C. VCH-759 inhibits the NS5B polymerase of the hepatitis C virus, an enzyme responsible for viral replication. It binds to the active site of NS5B and prevents it from functioning. VCH-759 has shown antiviral effects in cell culture and animal models and has a safety profile comparable to other nucleoside analogs. The drug also appears to be effective against other types of viruses, including HIV, influenza A, and herpes simplex virus type 2. VCH-759 may be used as a single agent or in combination with other antivirals to treat patients with chronic viral infections.</p>

<p>4-Hydroxy-α-(((3-(2-methoxyphenyl)-1,1-dimethylpropyl)amino)methyl)benzenemethanol is a synthetic compound classified as a beta-adrenergic agonist. This chemical is derived from laboratory synthesis, involving the modification of phenylethanolamine structures to achieve specific adrenergic properties.</p>

<p>ML095 hydrochloride is a phosphatase inhibitor that has shown anti-tumour activity in vitro and in vivo. It inhibits the enzyme placental alkaline phosphatase (PLAP) by binding to it, thereby preventing the removal of phosphate groups from substrates. This leads to an accumulation of substrate molecules, which may have an effect on cell signalling pathways and biological functions such as cell proliferation and migration. ML095 hydrochloride has been shown to modulate cancer cell growth in vitro and in vivo. This molecule also inhibits the activity of other phosphatases including pancreatic, testicular, and intestinal enzymes.<br>The compound is a potent inhibitor of bladder cancer cell growth in vitro and in vivo, as well as bladder carcinoma cells that express high levels of PLAP. The compound has been shown to be safe for use by children with cancer or those who have undergone surgery for bladder cancer at doses up to 10 mg/kg body weight.</p>

<p>CID-1067700 is a small molecule that is able to inhibit the ubiquitin proteasome system (UPS) and effector proteins. This drug has been shown to be active against wild-type strains of bacteria, such as Mycobacterium tuberculosis. CID-1067700 also inhibits autophagy in mycobacteria, which may be a potential therapeutic target for the treatment of mycobacterial infections. It has been shown to reduce ischemic brain damage in mice and may have therapeutic potential for stroke patients. CID-1067700 binds to the ubiquitin ligase Rsp5 and inhibits its ability to activate transcription factors that regulate cell cycle progression. This inhibition of transcriptional regulation leads to apoptosis, or programmed cell death.</p>

<p>Rocacetrapib is an investigational drug that belongs to the class of cholesteryl ester transfer protein (CETP) inhibitors. It has been shown to have antiviral activity against SARS-CoV and may be useful in the treatment of other viruses, such as HIV and influenza. Rocacetrapib has also been shown to inhibit cell growth and induce apoptosis in human lung cancer cells, which are resistant to cisplatin. This compound also binds to proteinase 3, suggesting a potential use in the treatment of Alzheimer's disease.</p>

<p>sCD40L is a soluble form of CD40, which belongs to the TNF-alpha superfamily. It is an activator of CD40 receptors, which are found on the surface of B cells and other immune cells. The receptor-ligand interaction triggers a series of intracellular signaling events that lead to the proliferation and activation of B cells. sCD40L can be used as a research tool for studying cell biology and protein interactions.</p>

<p>This product is an antiserum targeting amino acids 34-40 of the amyloid beta-protein which is a key component of extracellular plaques found in the brains of patients with Alzheimer’s disease (AD). It may also be involved in the pathogenesis of other neurodegenerative diseases such as Huntington’s disease and Parkinson’s disease. Targeting this protein may be key to drug discovery and the treatment of AD and other diseases this protein is associated with. Furthermore amyloid beta peptides located in the cerebrospinal fluid are well known biomarkers used to diagnose AD. Although AD is not yet curable, an early diagnosis can be useful in that patients can be treated to delay or improve symptoms.</p>

<p>Diflufenican-d3 is a fluorescent molecule that belongs to the class of carotenoids. It has been used in the study of ecosystem function, as well as quantifying chlorophyll fluorescence and photosynthetic efficiency. Diflufenican-d3 can be applied to algal biofilms, which are important in aquatic ecosystems. This carotenoid has also been shown to have an effect on heterotrophic organisms, such as bacteria, by altering their metabolism during stressors.</p>

<p>Heliotrope B is a film-forming polymer that has been shown to have anticancer properties. It has been used in the treatment of brain tumors, and other cancers such as melanoma and lymphoma, by local administration. Heliotrope B inhibits the growth of cancer cells by binding to their surface membrane receptors. This binding leads to a loss of cell adhesion and prevents tumor cells from attaching to surrounding tissues. Heliotrope B also has antiviral effects against hepatitis viruses, including types A, B, and C. It binds to viral particles and inhibits virus entry into the cell. In addition, heliotrope B can be used in the treatment of HIV infection through its ability to block messenger RNA synthesis by inhibiting reverse transcriptase activity. The polymer is also effective against bacterial strains such as Staphylococcus aureus and Escherichia coli because it disrupts their outer membranes. Heliotrope B has an acidic pH level that makes it</p>

<p>Drotaveraldine is a chromophore, which means it has a fluorescence property. It is used as an excipient in pharmaceutical preparations to improve the appearance of granules and tablets. Drotaveraldine is also used as a pH indicator for citric acid. Drotaveraldine absorbs light at about 350 nm and emits light at about 460 nm when excited with ultraviolet light. The excitation-emission spectrum of drotaveraldine can be used to detect hydrogen chloride, caffeine, or chloride ions in organic solvents. Drotaveraldine is occasionally used for curing biliary calculi in humans, although this use has not been approved by the FDA.</p>

<p>Lamiidoside is a cytotoxic compound found in the ethanol extract of Verbascum thapsus. It has been shown to inhibit the growth of cervical cancer cells, and is a potential treatment for cancer. Lamiidoside is an iridoid glucoside with significant cytotoxicity against tumor cells. It also has antibacterial activity and can be used as a natural food preservative.</p>

<p>HIV-1 TAT Clade-B Recombinant is the recombinant protein that belongs to HIV-1. It is a regulatory protein that binds to the human immunodeficiency virus type 1 (HIV-1) RNA genome and regulates viral replication. HIV-1 TAT Clade-B Recombinant has been shown to be highly infectious and can be used for the study of HIV infection, pathogenesis, and transmission.sequence: MEPVDPRLEP WKHPGSQPKT ACTNCYCKKC CFHCQVCFIT KALGISYGRK KRRQRRRPPQ GSQTHQVSLS KQPTSQSRGD PTGPKE.</p>

<p>Brr2 inhibitor C9 is an antibody that blocks the activation of the Brr2 protein by binding to it. This antibody is a research tool that can be used in cell biology and pharmacology studies, as well as for the study of protein interactions and receptor ligands. The antibody has been shown to increase the amplitude of calcium-dependent currents in cultured rat neurons. It also inhibits voltage-gated potassium channels and enhances GABAergic transmission. This product is high purity, with a purity level of 98%.</p>

<p>CD40 antibody (FITC) was raised in rat using CD40 as the immunogen</p>

<p>LGD-6972 is a molecule that binds to the drug target of metformin, which is an oral anti-diabetic drug. LGD-6972 has shown that it can reduce hyperglycemia and insulin resistance in rats, as well as decrease blood pressure in mice. LGD-6972 has also been shown to be safe in a clinical study with patients with type 2 diabetes. This compound will be used as an oral treatment for type 2 diabetes and is currently undergoing phase 1 clinical trials.</p>

<p>ML226 is a reaction product of linoleic acid, oleic acid, and palmitic acid. It has been shown to inhibit the enzyme fatty acid amide hydrolase (FAAH) in vitro and in vivo. ML226 has been found to be a potent inhibitor of FAAH with IC50 values of 0.5-1.0 μM in vitro and 1-2 μg/mL in vivo. ML226 also inhibits anandamide degradation by other enzymes such as N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD).</p>

<p>Potent inhibitor of the calcium-independent phospholipase A2 (GVIA iPLA2) with IC50 of 1 nM. GK 563 is 22000 times more active against GVIA iPLA2 than against the cytoplasmic phospholipase GVIA cPLA2. In β pancreatic cells from rat, GK 563 was shown to inhibit the β cell apoptosis when co-administered with pro-inflammatory cytokines.</p>

<p>Isodecyl citrate is an inhibitor of kinases, which are enzymes involved in cell signaling and regulation. It is an analog of donepezil, a medication used to treat Alzheimer's disease. Isodecyl citrate has been shown to inhibit the growth of cancer cells in Chinese hamsters and human tumors by inducing apoptosis, or programmed cell death. This compound also inhibits the activity of protein kinases, which are involved in the regulation of cell division and proliferation. Isodecyl citrate has potential as an anticancer agent due to its ability to selectively target cancer cells while sparing healthy cells. Additionally, it can be detected in urine samples, making it a promising biomarker for cancer diagnosis and treatment monitoring.</p>

<p>CD8b antibody (FITC) was raised in Mouse using the beta chain of chicken CD8 as the immunogen.</p>

<p>Galgravin is a natural compound that belongs to the family of antimicrobial agents. It is a protocatechuic acid glycoside derived from Ganoderma lucidum, which has been shown to have antitumor and anti-inflammatory properties. Galgravin is also an effective inhibitor of Leishmania parasites, inhibiting their growth and development by interfering with nucleic acid metabolism. This compound has been shown to inhibit the synthesis of dNTPs in rat neuronal cells, resulting in neuronal death and neuroprotection. Galgravin is a chemical substance that can be found in many food items such as wine, tea, chocolate, and cheese.</p>

<p>CD3e antibody (Spectral Red) was raised in hamster using H-2Kb-specific murine cytotoxic T lymphocyte as the immunogen.</p>

<p>CD45 antibody (FITC) was raised in mouse using chicken CD45 as the immunogen.</p>

<p>CD19 antibody (PE-CY7) was raised in mouse using human CD19 as the immunogen.</p>

<p>CD62E antibody (PE) was raised in mouse using human CD62E/E-selectin as the immunogen.</p>

<p>CD8a antibody (biotin) was raised in mouse using the alpha chain of chicken CD8a as the immunogen.</p>

<p>CGRP, humanAntiserum is a peptide that is the major peptide in the calcitonin gene-related peptide family. CGRP inhibits the activation of certain ion channels, which are proteins in cell membranes that allow ions to cross the membrane. It is also known to be an activator of certain G protein-coupled receptors, as well as a ligand for some receptor types. CGRP has been shown to play a role in vascular smooth muscle contraction and pain regulation.</p>

<p>Polyvinyl chloride (PVC) is a polymer that is typically used in the production of plastic products. PVC can be made into a variety of shapes and sizes, such as sheets and pipes. The most common type of PVC is polyvinyl chloride with a density range from 0.91 to 0.94 g/cm3. PVC has excellent heat resistance, electrical properties, and chemical resistance, which makes it an ideal material for manufacturing many types of items. Polyvinyl chloride is also resistant to mold or mildew growth.</p>

<p>Mannose binding lectin is a host defense protein which has the ability to recognize a variety of infectious agents. This Mannose Binding Lectin Light Tryptic Peptide Standard can be used in protein identification and quantitation studies.</p>

<p>Brazzien (2-54) is a peptide that binds to the extracellular domain of the human receptor for Advanced Glycation Endproducts (RAGE). This receptor plays an important role in many cellular processes, including tissue damage and inflammation. Brazzien (2-54) is a potent inhibitor of RAGE activity and has been shown to inhibit the binding of RAGE ligands to RAGE.</p>

<p>The HIV-1 p24 Recombinant, His Tag (abbreviated as HIV-1 HRP) is a recombinant protein that is purified from the culture supernatant of transfected HEK293 cells. It has been immobilized on a His-tagged protein A column for purification. The recombinant protein has been proven to be an effective inhibitor of the human immunodeficiency virus type 1 (HIV-1).<br>HRP binds to the CD4 receptor, which is a major component of the cellular membrane. This binding causes conformational changes in the HRP and initiates signal transduction pathways in the cell, leading to an antiviral state.</p>

<p>CD24 antibody (FITC) was raised in rat using murine heat stable antigen as the immunogen.</p>

<p>4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxydihydrofuran-2(3H)-one is a potent inhibitor of Caspase 1. It binds to the active site of the enzyme and prevents it from cleaving its substrate. This chemical is also an activator of Protein Kinase A, which is involved in the regulation of many cellular processes. 4-(Benzo[b]thiophen-2-yl)-3-bromo-5-hydroxydihydrofuran-2(3H)-one is a ligand for Beta1 adrenergic receptors and can be used as a research tool to study protein interactions, receptor activation, and ion channels.</p>

<p>Maltose Binding Protein E.coli Recombinant is a maltose binding protein derived from E. coli that can be used as a research tool in pharmacology and cell biology. Maltose Binding Protein E.coli Recombinant is an antibody that binds to the maltose receptor on the surface of cells, which are found on the outer membrane of most bacteria. Maltose Binding Protein E.coli Recombinant is a high-purity recombinant protein with a molecular weight of about 31 kDa, and has been shown to be an activator and inhibitor of ion channels, depending on its concentration. This protein also interacts with various proteins in the cytoplasm and binds to peptides that have been identified as ligands for this receptor.</p>

<p>Substance P is a member of the tachykinin neuropeptide family which is produced in the central nervous system (CNS) and acts through its specific receptor neurokinin 1 receptor (NK-1R). NK-1R is present in neurons and on glial cell types. Substance P is involved in: pain perceptions as a neurotransmitter; gut motility; increased inflammation in the lungs, gastrointestinal tract and the skin and neuroinflammation. Interestingly the levels of Substance P are raised in inflammatory bowel diseases and through its involvement in cytokine release, it contributes to asthma pathology. These diverse selection of functions makes substance P a target for therapeutic research.</p>

<p>Anti P2X4 (370-388) (Rat) Serum is a research tool that can be used to measure the activation of P2X4 receptors. It is suitable for use in antibody-based applications, such as Western blotting and immunohistochemistry. Anti P2X4 (370-388) (Rat) Serum is a high purity product that has been extensively characterized by NMR spectroscopy, mass spectrometry, and amino acid analysis. The purified peptide is supplied at a concentration of 1 mg/mL in phosphate buffered saline with 0.02% sodium azide as preservative and 50% glycerol as cryoprotectant. The product is sold under reference number CAS No. 74941-79-6 and has the molecular weight of 3199.87 Da. Anti P2X4 (370-388) (Rat) Serum can be used to study protein interactions, receptor ligand pharmacology, ion</p>

<p>H-Arg-Pro-OH sulfate salt is a synthetic peptide that binds to the receptor for filtrates. It is used to treat skin conditions such as dermatitis, eczema, and psoriasis. H-Arg-Pro-OH sulfate salt has been shown to be effective in inhibiting clostridium from producing proteins. This drug also inhibits the uptake of these proteins by blocking the binding of phosphorylated lysine residues to their receptors on the cell membrane. It has been shown to hydrolyze amide bonds and can be used as a catalyst for bond cleavage reactions.</p>

<p>DMPP is a pharmacological tool for the study of protein interactions, receptor-ligand interactions, and ion channels. It is also used in the synthesis of peptides and antibodies. DMPP is a high-purity compound with an acetamide functional group at each end. It has CAS number 2182653-84-3 and molecular weight of 474.5 g/mol. DMPP interacts with its ligands by binding to the active site pocket of the target protein, which can be a receptor or ion channel. It is an inhibitor that blocks enzymatic activity by binding to a reactive site on an enzyme molecule.</p>

<p>ACT-389949 is a novel small molecule that has been shown to be a potent inhibitor of neutrophil recruitment. It has been shown to inhibit the chemotaxis of neutrophils and leukocytes in vitro by binding to granule proteins and preventing their release. ACT-389949 is an orally active, potent, selective, and reversible inhibitor of neutrophil recruitment with a terminal half-life of approximately 24 hours. The pharmacodynamics of this drug are dose-dependent with an EC50 value at the lower end of the therapeutic window. This profile may explain why it is effective in patients who have been exposed to other drugs that are ineffective due to resistance. In addition, ACT-389949 does not induce any known inflammatory cytokines or act as an immunosuppressant.</p>

<p>H3B-120 is a synthetic analog of histidine. It is a competitive inhibitor of the enzyme histidine decarboxylase, which catalyzes the conversion of histidine to orotic acid in the body. Administration of H3B-120 prevents the formation of orotic acid, thereby inhibiting tumor growth and prolonging life in transgenic animals with cancer. This drug has been shown to selectively inhibit cell growth in lung cancer cells, while not affecting normal cells. H3B-120 has also been shown to be advantageous for positioning as it can be administered orally and does not yield any side effects.</p>

<p>Cytostatin sodium is an inhibitor that blocks the activity of a protein called Janus kinase 1 (JAK1) and interferes with the production of cytokines. Cytostatin sodium inhibits the activation of TNF-α, which is an important mediator in inflammatory reactions. It has been shown to be effective against cancer cells and leukemias, as well as certain other types of cancer. Cytostatin sodium binds to a protein called cb2 receptor, which is expressed on cells, such as macrophages, lymphocytes and neutrophils, where it exhibits its inhibitory effect. Cytostatin sodium also binds to p-nitrophenyl phosphate (PNPP), a synthetic substrate used in enzyme assays to measure cytosolic phosphatases. The inhibition of PNPP hydrolysis by cytostatin sodium is used to determine the inhibitory effect on phosphatase activity.</p>

<p>CD86 antibody (biotin) was raised in rat using murine CD86 as the immunoge.</p>

<p>Please enquire for more information about Valdecoxib sulfonyl chloride-13C2,15N including the price, delivery time and more detailed product information at the technical inquiry form on this page</p>

<p>CY3 is a fluorescent dye, which is derived from the cyanine family of compounds with a specific excitation/emission spectrum. It operates by fluorescing when exposed to certain wavelengths of light, typically around 554 nm for excitation and 568 nm for emission. This spectral property allows it to be used as a powerful molecular probe.</p>

<p>CD25 antibody (PE) was raised in rat using alpha chain IL-2 receptor as the immunogen.</p>

<p>R-IMPP hydrochloride is a synthetic peptide that is an inhibitor of the ATP-sensitive potassium channel. It has been shown to inhibit the opening of this ion channel with high purity and high yield. R-IMPP hydrochloride has also been found to be a potent activator of the ligand-gated ion channels, such as nicotinic acetylcholine receptors. R-IMPP hydrochloride is used in research for studying protein interactions and for identifying new drug targets.</p>

<p>CD69 antibody (biotin) was raised in hamster using Y245 murine dendritic epidermal T cell line as the immunogen.</p>

<p>CD62L antibody (Spectral Red) was raised in rat using C3H/eb cloned murine B lymphoma 38C-13 as the immunogen.</p>

<p>Enkephalins are endogenous opioid peptides that inhibit pain and have a variety of other physiological effects. They bind to specific receptors on the surface of neurons, which are called opioid receptors. Enkephalin is a peptide consisting of two amino acids, D-Ala2,D-Leu5. Enkephalins can be produced by linking two amino acids together with an amide bond or by modifying one of the amino acids in the sequence. This drug has been shown to induce mitochondrial membrane depolarization in hippocampal cells and autophagy in neuronal cells. It also has antinociceptive properties and is able to penetrate the blood-brain barrier due to its absorption enhancer property. The drug is also able to induce locomotor activity in mice and cause neuronal death in vivo models.</p>

<p>S100 Calcium Binding Protein A13, human, recombinant is a recombinant protein that is used as a research tool. It can be used in immunological assays and to detect antibodies. S100 Calcium Binding Protein A13, human, recombinant has been shown to have an inhibitory effect on ion channels and protein interactions. CAS No.: 133902-01-8.</p>

<p>Lysyl-bradykinin (Kallidin) is a peptide that is a member of the kallikrein family. It has been shown to be an effective inhibitor of the enzyme lysyl oxidase, which is involved in the cross-linking of collagen and elastin. The inhibition of this enzyme leads to the breakdown of collagen and elastin, which are important components for maintaining healthy skin. Lysyl-bradykinin has been immobilized with covalent immobilization techniques and has been shown to be an effective inhibitor of lysyl oxidase in an enzymatic reaction.<br>BRADYKININ: Bradykinins are peptides that are generated from kininogens by kallikreins, including prekallikreins and kallikreins. They act as vasodilators by stimulating smooth muscle cells in the walls of blood vessels to release nitric oxide. Bradykinins also increase</p>

<p>Angiotensin converting enzyme (ACE) heavy tryptic peptide standard for use in proteomics studies. ACE is involved in the regulation of blood pressure through converting inactive angiotensin I to active angiotensin II and also degrading active Bradykinin.</p>

<p>This product is a Fibrinogen Heavy Tryptic Peptide Standard for protein identification and quantitation. Fibrinogen is glycoprotein produced by the liver and is a precursor to fibrin which makes up blood clots.</p>

<p>This is a vivitide catalogue product. Please send your vivitide product enquiry to sales@vivitide.com for an up-to-date price and availability.</p>

<p>Phebestin is a peptide that activates the immune system. It is an activator of antibodies and an inhibitor of ion channels. Phebestin has been shown to inhibit protein interactions and receptor binding, as well as ligand-receptor binding. It is used in research tools for studying cell biology, pharmacology, and protein interactions. Phebestin has a CAS number of 187402-73-9 and is available in high purity.</p>

<p>Parathyroid hormone (PTH) is a peptide hormone that regulates the calcium and phosphate levels in the blood. It is produced by the parathyroid glands, located near the thyroid gland in the neck. PTH increases blood calcium levels by increasing bone breakdown, stimulating bone formation, and increasing reabsorption of calcium. This protein also stimulates phosphaturia to increase serum phosphate levels.</p>

<p>Nma-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(Dnp)-D-Arg-D-Arg is a synthetic peptide that belongs to the group of activators. It is used as a research tool in studies on ion channels and protein interactions. The CAS number for this product is 106071, and it has a molecular weight of 567.1 Da and a purity of &gt;99%.</p>

<p>A synthetic scorpion toxin consisting of disulfide bonds between Cys3-Cys17, Cys10-Cys21, and Cys16-Cys32. It can be used as an activator of Ca2+ Release Channels/Ryanodine Receptors. It is important to understand the functions of Ryanodine receptors as they mediate Ca2+ release from intracellular reticular stores and this is imperative for signalling processes, namely muscle excitation-contraction coupling. If skeletal and cardiac Ryanodine receptor genes are mutated diseases such as congenital myopathy and metabolic disorders occur. Therefore Imperatoxin A is useful in investigating these diseases. This product is avaiable as a 0.1mg vial.</p>

<p>Anti Leptin (Rat) Serum is a peptide that is used as a research tool to activate the receptor. Anti Leptin (Rat) Serum has been shown to inhibit protein interactions and may be used in pharmacology to study the effects of leptin on ion channels. This antibody can be used for immunohistochemistry, Western blotting, and ELISA.</p>

<p>As a member of the Histatin family, Histatin 5 is a 24 amino acid, antimicrobial peptide rich in histidine. The Histatin family’s large histidine presence allow Histatins to associate with metal ions through the histidine side chains.Histatin 5 is found naturally in human saliva, and is a proteolytic fragment of Histatin 3. It exhibits antifungal properties and is thus useful in inhibiting the growth of yeast and C. albicans.<br>Histatin 5 contains a functional domain located at amino acids 11 to 24 and this is where the antimicrobial activity of Histatin 5 takes place. It also has a random secondary structure with α-helices which are believed to allow it to enter the cytoplasm of the pathogenic cell. Once it has gained entry into the cells of pathogens, it is known to induce an ATP influx and the production of reactive oxygen species.However it is important to note that while Histatin 5 displays potent antifungal activity, this is reduced when in saliva due to the exposure to interfering metals, proteins and salts.</p>

<p>Anti PTH (1-15) (Rat) Serum is a research tool that is used to study the activity of the parathyroid hormone. This product can be used as an activator or ligand in cell biology experiments. It has been shown to have a high affinity for the parathyroid hormone receptor and can be used to study protein interactions. Anti PTH (1-15) (Rat) Serum can also be used in pharmacological studies and may inhibit ion channels. This product has been shown to bind with peptides, which are small proteins, as well as antibodies and it may also inhibit protein synthesis.</p>

<p>Pentraxin-3 is a peptide that is an inhibitor of the activator protein. It is used in pharmacology and cell biology research to identify ligands, receptors, and ion channels. Pentraxin-3 has shown to be a useful research tool for learning about the activation of various types of ion channels, including nicotinic acetylcholine receptors, glutamate receptors, and voltage-gated potassium channels. It can also be used as an antibody to identify cells that have been activated by specific ligands or signaling pathways.</p>

<p>CD23 antibody (FITC) was raised in rat using CD23 low affinity IgE Fc receptor as the immunogen.</p>

<p>IL-5 is a mouse monoclonal antibody that is used as a research tool. This antibody binds to the IL-5 receptor and is an activator of the receptor. IL-5 has been shown to activate ion channels and inhibit protein interactions, among other things. IL-5 has been shown to inhibit the binding of Ligand to Receptor, which may be due to its ability to bind to both Ligand and Receptor simultaneously.</p>

<p>Anti PHI (Rat) Serum is a research tool that can be used in antibody detection, receptor binding, cell biology, ion channels and pharmacology. It is a high purity product with a CAS number of 613-12-5.</p>

<p>FGF13 is a protein that belongs to the FGF family of growth factors. It is a ligand for FGFR1 and FGFR2, two receptors that are involved in bone and cartilage formation. FGF13 also has been shown to be an activator of the receptor tyrosine kinase MET, which is important for cell proliferation and differentiation. This protein shows no activity against FGFR3 or FGFR4.<br>FGF13 can be used as a research tool for studying protein interactions and as an antibody for immunoprecipitation or Western blotting. It can also be used to block certain cellular pathways by inhibiting the activation of different receptors, such as the EGFR receptor.</p>

<p>The dystrophin protein is encoded for by the DMD gene which when mutated can result in a muscle-wasting diseases, Becker and Duchenne muscular dystrophy. As a member of the β-spectrin/α-actinin protein family the dystrophin cytoskeletal protein has a NH2 – terminal actin binding domain and spectrin-like repeats. This product can be used as a peptide calibrator for Mass Spectroscopy research.</p>

<p>PDGFD is a potent inhibitor of protein interactions. PDGFD has been shown to inhibit the interaction between Kv1.2 and its ligand, as well as inhibit the activation of potassium channels by ATP. PDGFD has also been used in research as a tool to study receptor-ligand interactions and ion channels. This product is a recombinant human protein that has been expressed in E. coli cells with an N-terminal hexahistidine tag for easy purification, and is &gt;95% pure.</p>

<p>FRETS-25Gly is a synthetic peptide that is used as a research tool in the study of ion channels and their ligands. This peptide is an activator of the feline erythrocyte receptor for thrombopoietin (FRETS). FRETS-25Gly has been shown to inhibit the binding of fluorescein isothiocyanate-labeled ligands to human cell membranes.</p>

<p>CD107a antibody (FITC) was raised in rat using murine CD107a (LAMP-1) as the immunogen.</p>

<p>CD94 antibody (FITC) was raised in rat using CHO cells transfected with the B6 allele of CD94 as the immunogen.</p>

<p>Gefitinib-d3 is a potent inhibitor of the protein kinase activity of the epidermal growth factor receptor (EGFR). It is used in medicinal chemistry research to study the mechanisms of apoptosis and cell cycle regulation. Gefitinib-d3 inhibits cyclin-dependent kinases, which play a key role in tumor growth and proliferation. This drug has been shown to be effective against several types of human cancer, including leukemia, lung cancer, and breast cancer. It works by blocking the signals that stimulate cell growth and division, leading to the death of cancer cells. Gefitinib-d3 is an important tool for researchers studying the molecular mechanisms underlying cancer development and progression.</p>

<p>Lipoprotein-associated phospholipase A2 (LP-PLA2) heavy tryptic peptide standard for protein identification and quantitation studies. LP-PLA2 is a phospholipase A2 enzyme known as platelet-activating factor acetylhydrolase and it is largely associated with low density lipoprotein in the blood.</p>

<p>Peroxiredoxin-2 is a protein that belongs to the peroxidase family of enzymes. It has been shown to be an activator of ion channels, which suggests that it may play a role in cell regulation. Peroxiredoxin-2 has also been shown to bind to peptides and antibodies, with potential therapeutic applications.</p>

<p>Atripla is a medication that works as a kinase inhibitor, targeting specific kinases involved in the cell cycle of cancer cells. It is an effective treatment for various forms of cancer and has been shown to induce apoptosis, or programmed cell death, in cancer cells. Atripla is made from a combination of medicinal compounds derived from Chinese medicine and other sources. This potent inhibitor has been tested on human cell lines and has shown significant anti-tumor activity. Its unique formulation makes it an ideal choice for patients seeking alternative cancer treatments that are both safe and effective.</p>

<p>NRGN is a protein that is encoded by the neurogranin gene. It is expressed in the human brain and has been shown to be involved in synaptic transmission and memory formation. NRGN binds to calmodulin and phosphorylates protein kinase C, which activates MAPK pathways. The molecular mass of NRGN is about 60 kDa for recombinant human proteins.</p>

<p>Argininosuccinate lyase is an enzyme that catalyzes the reaction of arginine and fumarate to form urea and ornithine. It is a homodimer with each subunit containing four domains. The active site of argininosuccinate lyase is located in domain 1, which contains a zinc ion coordinated by two histidine residues, a glutamate residue, and a water molecule. The enzyme is composed of one polypeptide chain that has three domains: the N-terminal domain (domain 1), the middle domain (domain 2), and the C-terminal domain (domain 3). Argininosuccinate lyase has been shown to be present in Escherichia coli as well as in human tissues.</p>

<p>Z-Leu-Arg-Gly-Gly-AMC is a peptide inhibitor of the human Kv2.1 potassium channel. It has been shown to inhibit current in Xenopus oocytes expressing Kv2.1 channels at concentrations of 10 μM and lower. Z-Leu-Arg-Gly-Gly-AMC can be used as a research tool or an antibody to study cell biology, protein interactions, and receptor functions.</p>

<p>Anti Galanin (1-15) (Rat) Serum is a peptide that is expressed in the rat brain and has an inhibitory effect on the release of galanin from neurons. The peptide interacts with high affinity to receptors for galanin, which are present in many tissues, including the central nervous system. Anti Galanin (1-15) (Rat) Serum is used as a research tool for the study of ion channels and ligands. This product can be used as an inhibitor for various activities such as receptor binding, enzyme inhibition, and cell signaling.</p>

<p>C-Peptide (Rat)-EIA Kit is a kit that contains the necessary components for the quantitative determination of rat C-peptide in serum or plasma. The kit includes antibodies against rat C-peptide and a standard reference material. It is suitable for use with all commercially available ELISA readers.</p>

<p>MOCA is a small peptide with anti-inflammatory properties that binds to the receptor IL-1R. It has been shown to inhibit sodium currents in neurons by binding to the Na+ channel and preventing the influx of sodium ions, which leads to an inhibition of action potentials. MOCA has also been shown to bind with high affinity to the IL-1R and blocks its activity. This inhibition of IL-1R leads to decreased production of proinflammatory cytokines.<br>MOCA has not been shown to have any affinity for other receptors or ligands.</p>